Bruker
Products & Solutions Applications Services & Support News & Events About Careers
Please use at least 2 characters (you are currently using 1 character)

Languages

Fluorescence Microscopy Webinars

Uncovering Transcription Condensate Organization With Single Molecule Resolution

Find out what single-molecule imaging can reveal about transcription condensate organization 


Discover how single-molecule imaging uncovers new insights on biomolecular condensates

During this webinar, guest speaker Dr. Jan Spille discusses his work using advanced fluorescence imaging techniques to investigate transcription condensates. Hear how the Vutara VXL super-resolution microscope supports this research by enabling the imaging of various biological structures below the diffraction limit. 

Watch On Demand Webinar Summary

Presenter's Abstract

Transcription factors, coactivators, and RNA polymerase II form biomolecular condensates at super enhancer-controlled genes in mouse embryonic stem cells. The small size of these condensates makes them difficult to study with conventional techniques. However, we overcome this limitation with single-molecule imaging in live and fixed cells to reveal structural and dynamic properties of transcription condensates. Multi-color single molecule localization microscopy allows us to dissect the chromatin architecture at transcription condensates below the diffraction limit. Furthermore, tracking of single molecules inside condensates complements these studies in live cells.

Find out more about the technology featured in this webinar or our other solutions for Single Molecule Resolution:

Input value is invalid.

The full-length recording of this presentation is available for on-demand viewing.

 

Please enter your first name
Please enter your last name
Please enter your e-mail address
Please enter a valid phone number
Please enter your Company/Institution
Please select your Country
Please select your State
What best describes your current interest?
Please add me to your email subscription list so I can receive webinar invitations, product announcements and events near me.
Please accept the Terms and Conditions

             Privacy Notice   Terms of Use


Note: Page will refresh upon submission; afterward, you may need to scroll down to see the video access link.

* Please fill out the mandatory fields.

Webinar Recording is Now Available.

Click Here to Access the Viewing Page


Note: If you close or exit this page, you will not be able to reopen this confirmation window without re-submitting the form. Please save this access link to bypass the form in future visits.

Featured Products and Technology

Guest Speaker

Dr. Jan Spille, Assistant Professor, Department of Physics, University of Illinois at Chicago

 

Dr. Spille is an Assistant Professor in the Department of Physics, University of Illinois at Chicago. Previously, he was a Postdoctoral Fellow at MIT. He received his undergraduate degree in Physics from the University of Wuerzburg and his PhD from the University of Bonn in Germany. He is an expert in advanced fluorescence imaging techniques. His interdisciplinary work on genome organization and biomolecular condensates in the cell nucleus is supported by the NSF, several NIH grants, and two Scialog Awards.

Past Webinars