Surveying the tumor milieu from tumorigenesis to chemotherapy
Surveying the tumor milieu from tumorigenesis to chemotherapy

Surveying the tumor milieu from tumorigenesis to chemotherapy

On Demand Session

Webinar Overview

Prof. Fahmeed Hyder’s work focuses on brain energy, physiology, chemistry, metabolism, and molecular imaging of cancer. In this webinar, he explains how tumor biology is intertwined with cancer metabolism, discussing how chemotherapy can change the pH of the tumor and what this means for treatment and diagnosis.
Prof. Hyder starts his talk with an introduction to the glucose metabolism pathway in healthy neuropil as opposed to aerobic glycolysis. He explains that low pH drives tumor cell invasion in vivo as tumor cells move in the direction of acidic environments.

He describes his Biosensor Imaging of Redundant Deviation in Shifts (BIRDS) method and discusses absolute pH mapping within tumor and differences in pH maps of various tumor types. He then shows how a modelling method based on 13C spectroscopy with 13C glucose for follow cycling of the neurotransmitter glutamate, 19F spectroscopy with fluoro deoxy glucose for glucose consumption, and ASL allow tumor temperature to be calculated.


He concludes with the unexpected result that temperature is decreased in a variety of tumor types and that such quantitative measures of tumor activity and chemistry, as opposed to the current common practice of considering tumor topography only, will be a vital a step towards personalized medicine.

Key Learnings

pH Imaging

  • Differentiation between inside and outside of tumor
  • Translation of tumor cells to areas of lower pH
  • Effect of chemotherapy on pH

 

Tumor Temperature

  • Modeling via 13C MRS, 19F MRS, and ASL
  • Decrease of temperature within tumors

Who should attend?

Oncologists will find the insights into alternatives to current tumor characterizing practices and effects of chemotherapy inspiring, and MRI scientists will learn more about current pH and temperature measurement methods.

Speakers

Fahmeed Hyder

Professor of Radiology and Biomedical Imaging and of Biomedical Engineering

Dr. Hyder is director of high-field horizontal small-bore systems at Yale’s MRRC, one of the most reputed in vivo magnetic resonance centers in the world conducting translational in vivo neuroscience and metabolism research. He is also founder and director of Yale’s QNMR Core Center, the only NIH-supported programmatic effort at Yale on neuroimaging with magnetic resonance technologies. He received a bachelor’s degree in physical chemistry in 1990 from Wabash and a doctoral degree in biophysical chemistry from Yale in 1995. He has been a faculty at Yale since 1999 and currently holds dual professor appointments in Diagnostic Radiology and Biomedical Engineering. He is a founding member of Yale’s Department of Biomedical Engineering. His work has produced over a hundred peer-reviewed publications. He has written and edited books on functional brain imaging. He holds several magnetic resonance patents on molecular imaging. He has had continuous NIH support since becoming an investigator. He has renewed grants from different scientific funding agencies. He has received early career awards from various scientific societies and funding scientific agencies. He sits on editorial boards of several international scientific journals and he reviews for many scientific journals spanning several disciplines. He has delivered numerous invited presentations around the globe. He serves on advisory panels of several scientific funding agencies.

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