Webinar Overview
Prof. Fahmeed Hyder’s work focuses on brain energy, physiology, chemistry, metabolism, and molecular imaging of cancer. In this webinar, he explains how tumor biology is intertwined with cancer metabolism, discussing how chemotherapy can change the pH of the tumor and what this means for treatment and diagnosis.
Prof. Hyder starts his talk with an introduction to the glucose metabolism pathway in healthy neuropil as opposed to aerobic glycolysis. He explains that low pH drives tumor cell invasion in vivo as tumor cells move in the direction of acidic environments.
He describes his Biosensor Imaging of Redundant Deviation in Shifts (BIRDS) method and discusses absolute pH mapping within tumor and differences in pH maps of various tumor types. He then shows how a modelling method based on 13C spectroscopy with 13C glucose for follow cycling of the neurotransmitter glutamate, 19F spectroscopy with fluoro deoxy glucose for glucose consumption, and ASL allow tumor temperature to be calculated.
He concludes with the unexpected result that temperature is decreased in a variety of tumor types and that such quantitative measures of tumor activity and chemistry, as opposed to the current common practice of considering tumor topography only, will be a vital a step towards personalized medicine.
On Demand Session
Key Learnings
pH Imaging
- Differentiation between inside and outside of tumor
- Translation of tumor cells to areas of lower pH
- Effect of chemotherapy on pH
Tumor Temperature
- Modeling via 13C MRS, 19F MRS, and ASL
- Decrease of temperature within tumors
Who should attend?
Oncologists will find the insights into alternatives to current tumor characterizing practices and effects of chemotherapy inspiring, and MRI scientists will learn more about current pH and temperature measurement methods.
Speakers
Fahmeed Hyder
Professor of Radiology and Biomedical Imaging and of Biomedical Engineering
