Modelling 3D Tissue Flow Using Forces and Tissue Mechanics
Discover the fundamental processes underlying pattern formation and cellular motion in tissues
Join us as Prof. Dr. Timo Betz discusses mapping 3D flow in tissues to predict their driving forces and the processes regulating the formation of patterns in cancer spheroids and zebrafish embryos. Gain insights into how light-sheet microscopy is an imaging technique well-suited for investigating tissue mechanics and complementing mechanical force measurements.
Presenter's Abstract
From simple cellular aggregates up to the development of entire organisms, we see both local and global motion of cells and tissue. While it is obvious that mechanical forces in combination with the viscoelastic tissue properties are the underlying reason for such tissue flow, we only start to uncover the fundamental processes regulating the formation of patterns and complex cellular motion observed.
In this webinar, we describe how precise 3D mapping of tissue flow in cancer spheroids and zebrafish embryos can be used to predict the forces in the tissue driving these flows. Besides using fundamental physics to infer the force from the observed motion, we also exploit deformable hydrogel beads and tissue cutting to investigate the tissue mechanics using light-sheet microscopy.
Find out more about the technology featured in this webinar or our other solutions for Light Sheet Microscopy:
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Guest Speaker
Prof. Dr. Timo Betz, University of Göttingen, Germany.
