Bruker Applied Mass Spectrometry @ ASMS 2024

Innovative Chromatography-Free Analytical Techniques for Advanced Polymer Characterization and Manufacturing Optimization

Mass spectrometry (MS) plays a crucial role in polymer analysis, enabling comprehensive assessment of structure, composition, additives, and molecular weight distribution. However, traditional MS methods often necessitate chromatography for sample separation. 
This workshop focuses on the streamlined various chromatography-free approaches including DART, which analyzes complex polymeric materials without prior preparation, utilizing hot metastable He atoms to induce thermal desorption and degradation, followed by ionization for analysis of stable materials.

We will discuss recent case studies involving automotive tires and macro-/nano-plastics from Northeast Ohio illustrating the efficacy of DART-MS. Additionally, MALDI-MS, another chromatography-free MS method, is discussed for addressing performance issues in complex polyolefin-based materials, offering insights into reaction mechanisms and architectural distributions crucial for process optimization in manufacturing.

We are looking forward to seeing you at our workshop and discuss the latest developments in this exciting field.

Solving the PFAS challenge: novel targeted and non-targeted workflows on triple quads and ion mobility HRMS

PFAS, persistent chemicals used in consumer products since the 1940s, pose significant risks to both humans and the environment due to their persistent, bio-accumulative, and toxic properties. EPA regulations exist to monitor selected PFAS compounds, but the estimated total of 15,000 PFAS compounds, complicates comprehensive analysis.

Two workflows are presented:

• targeted analysis using a highly sensitive triple quadrupole for routine monitoring, exceeding EPA regulations, and 
• a non-targeted approach combining trapped ion mobility spectrometry (TIMS) with UHPLC-HRMS for broader PFAS detection and annotation of unknown PFAS using smart software tools. 

These methods aim to improve detection capabilities and understanding of PFAS exposure for better public health and environmental protection.

Rapid and Dynamic Quantitative Screening of Synthetic Cannabinoids with DART-MS Analysis: A Collaborative Case Study

Join us for a presentation of a novel rapid and quantitative screening approach for detection and measurement of 16 synthetic cannabinoids using DART-MS. Our novel approach resolves drawbacks associated with traditional immunoassay-based detection, such as cross-reactivity and low sensitivity.

Through comparative validation with LC-MS using confirmed positive urine samples, the DART-MS screening method demonstrates high selectivity and accuracy.

With a throughput of under 30 seconds per sample, this approach offers a cost-effective and efficient solution for detecting synthetic cannabinoids in urine samples.