On-Demand Session: Studying the Mechanics of DNA Rearrangements with Optical Tweezers

       _{PRESENTATION HIGHLIGHTS:}

• [00:00:00] Introduction
• [00:04:53] How does cohesin resist forces generated by the mitotic spindle?
• [00:14:59] How does cohesin generate force to move on DNA?
• [00:22:45] Summary

       _{PRESENTATION HIGHLIGHTS:}

[00:00:23] Technical Highlights of NanoTracker 2

[00:03:26] Sample Handling

[00:04:50] dsDNA overstretching overview

[00:06:01] NanoTracker 2 demonstration

       _{PRESENTATION HIGHLIGHTS:}

[00:00:00] Is it possible to use micro or gold substrates instead of Petri dishes?

[00:00:41] What are the advantages of optical tweezers over magnetic or acoustic tweezers?

[00:01:49] Is the laser impacting the temperature in the sample environment?

[00:03:09] Can you manipulate molecules other than DNA?

[00:04:06] Can you twist DNA with an optical trap?