Human Metabolomic Research - Insights
Human NMR-based Metabolomics Research: We interviewed different Metabolomics research institutes to find out more about their
research, daily work, and latest findings.
Enjoy these very interesting movies about the latest research in Metabolomics.
Innovative NMR Methods Driving Human Metabolomics Forward
In this interview, Prof. Patrick Giraudeau from Nantes University shares insights into his work with NMR spectroscopy in human metabolomics. He emphasizes that NMR spectroscopy stands out as an unparalleled tool for analyzing complex mixtures like body fluids because of its unique capacity to provide both structural and quantitative data with high reproducibility. Prof. Giraudeau's work focuses on fast 2D NMR methods and hyperpolarized NMR techniques and seeks to push NMR’s boundaries, enhancing its performance to reveal previously inaccessible information within complex mixture samples. Prof. Giraudeau also discusses his excitement about the upcoming installation of the standardized IVDr platform, known for its reproducibility, stability, and reliability, which opens opportunities for inter-laboratory studies and collaborations with other facilities equipped with the same technology. Lastly, he highlights the promising role of benchtop NMR systems in personalized healthcare.
Main research topics of the Metabolomics and Systems Medicine group at the Werner Siemens
Imaging Center - University Tübingen
Main research topics at the laboratory for Metabolomics and Systems Medicine at the Werner Siemens
Imaging Center & University of Tübingen
- Quantitative IVDr-NMR spectroscopy of human biofluids (serum/plasma, urine, liquor)
- Quantitative NMR spectroscopy of murine biofluids (serum, urine)
- Tissue metabolomics and lipidomics with human and murine samples (e.g. liver, brain, kidney)
- Cell culture and feces/stool metabolomics and lipidomics including multi-omics studies
- Biomarker discovery and personalized precision medicine
As highly interdisciplinary facility, the Werner Siemens Imaging Center is dealing with many studies within neurology, oncology, inflammation and more. Hereby, the laboratory for Metabolomics and Systems Medicine measures and analyses large-cohort samples from preclinical and clinical studies (e.g. Parkinson’s and Alzheimer’s disease, breast cancer, brain tumors, (post) Covid-19 syndrome, cardiovascular disease, rare diseases, (pre)diabetes and many more) upon their metabolite concentrations in blood, urine, liquor, feces or tissue and puts them together with their collaboration partners into a systems biological context.
For more Info about the Metabolomics Cancer Research at Uni Tübingen also watch this:
Main research topics at the Institute of Chemistry and Metabolomics at University Lübeck
- NMR studies of protein-carbohydrate interactions (monoclonal antibodies, lectins, selectins, siglecs, glycosyltransferases)
- NMR studies of ligand binding to native viruses and viral coat proteins. Design of novel entry inhibitors
- Recombinant production of isotope labeled glycosyltransferases for NMR spectroscopic experiments
- Studies of thermodynamic and kinetic aspects of carbohydrate-protein recognition reactions using NMR, surface plasmon resonance and microcalorimetry
- Structural and biophysical characterization of skin matrix proteins involved in autoimmunity
Bruker NMR Instruments are for Research Use only and are not intended for Use in Clinical Diagnostic Procedures.
