代谢组学研究：一种见解

In this interview, Prof. Patrick Giraudeau from Nantes University shares insights into his work with NMR spectroscopy in human metabolomics. He emphasizes that NMR spectroscopy stands out as an unparalleled tool for analyzing complex mixtures like body fluids because of its unique capacity to provide both structural and quantitative data with high reproducibility. Prof. Giraudeau's work focuses on fast 2D NMR methods and hyperpolarized NMR techniques and seeks to push NMR’s boundaries, enhancing its performance to reveal previously inaccessible information within complex mixture samples. Prof. Giraudeau also discusses his excitement about the upcoming installation of the standardized IVDr platform, known for its reproducibility, stability, and reliability, which opens opportunities for inter-laboratory studies and collaborations with other facilities equipped with the same technology. Lastly, he highlights the promising role of benchtop NMR systems in personalized healthcare.

沃纳-西门子成像中心和图宾根大学代谢组学和系统医学实验室的主要研究课题：

人类生物液体（血清/血浆、尿液、液体）的定量IVDr-NMR分析

小鼠生物液体（血清、尿液）的定量NMR分析

人类和鼠类样本的组织代谢组学和脂质组学（如肝、脑、肾）

细胞培养和粪便/工具代谢组学和脂质组学，包括多组学研究

生物标志物的发现和个性化的精准医疗

作为高度跨学科的计够，沃纳-西门子成像中心正在进行神经病学、肿瘤学、炎症等领域的多项研究。因此，代谢组学和系统医学实验室测量和分析来自临床前和临床研究（如帕金森氏症和阿尔茨海默氏症、乳腺癌、脑肿瘤、（后）Covid-19综合症、心血管疾病、罕见疾病、（前）糖尿病等）的大队样本，根据其在血液、尿液、液体、粪便或组织中的代谢物浓度，将其与合作者一起放入系统生物学背景中。

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• NMR studies of protein-carbohydrate interactions (monoclonal antibodies, lectins, selectins, siglecs, glycosyltransferases)
  
• NMR studies of ligand binding to native viruses and viral coat proteins. Design of novel entry inhibitors
• Recombinant production of isotope labeled glycosyltransferases for NMR spectroscopic experiments
• Studies of thermodynamic and kinetic aspects of carbohydrate-protein recognition reactions using NMR, surface plasmon resonance and microcalorimetry
• Structural and biophysical characterization of skin matrix proteins involved in autoimmunity