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NMR spectroscopy for in-formulation state HOS characterization of Biopharmaceuticals 

Webinar Overview

Protein-based therapeutics (Biopharmaceuticals) is emerging as an important class of pharma products and are the fastest-growing segment of the pharmaceutical industry. The higher-order structure (HOS) of Biopharmaceuticals is a critical quality attribute that could affect the therapeutic efficacy and safety of these drugs. There is a growing need to prolong the stability of these drugs in high protein concentrations in the liquid or in suspension form. However, not many techniques can assess the structural attributes in their formulation state. Nuclear Magnetic Resonance (NMR) spectroscopy is one of the few powerful techniques that can enable the measurement of biopharmaceuticals structure and aggregation states to assess the drug quality and comparability in the formulation state. Additionally, NMR offers a highly sensitive fingerprinting approach for assessing conformational changes of biomolecules.

During this talk, Dr. Ashutosh Kumar, Professor from the Department of Biosciences and Bioengineering, IIT Bombay, Mumbai, will cover the exposition of high-resolution NMR techniques to understand the HOS of Biopharmaceuticals in their formulated states. Furthers, results obtained from the NMR spectra can be used to establish various similarity metrics for developing and assessing the biosimilarity of quality assurance or control. 

Monday, March 28, 2022

5:30 pm IST / 2:00 pm CEST / 8:00 am EDT

watch on demand

Speakers

Prof. Ashutosh Kumar

Associate Professor, Department of Bioscience and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai, India

His work involves studying the structure and mechanism of action of protein complexes such SCF complex and specialized Nucleosome and amyloids using state of the art solid- state and solution-state NMR spectroscopy along with other Biophysical tools. Ashutosh has made significant contribution in developing NMR methods and applying those on complex biological macromolecules to deduce structure and dynamics of these molecules. Prof. Kumar received his M.Sc. in chemistry from IIT. Delhi followed by his PhD at the Tata Institute of Fundamental Research, Mumbai supervised by Prof. R. V. Hosur. He did his postdoctoral research work under the supervision of Prof. Marc Baldus, Prof. Adam Lange and Prof. C. Griesinger at MPI for Biophysical Chemistry Gottingen before coming back to IIT Bombay.

Dr. Maksim Mayzel

Senior application scientist - Bruker Switzerland AG, Faellanden, Switzerland

Dr. Maksim Mayzel received his Ph.D. in biophysics from Moscow State University, under the supervision of Prof. Alexander Arseniev. In 2009 he moved to Sweden, Gothenburg, where he first did his postdoctoral research work under the supervision of Prof. Vladislav Orekhov and then worked as a senior researcher. Since 2018 Maksim has works at Bruker Switzerland as an application scientist covering various aspects of liquid state NMR.

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