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Hyperpolarized 129Xe MRI of Pulmonary Gas-Exchange in Rodents

Hyperpolarized 129Xe MRI has emerged as a powerful technique to evaluate lung function and has found clinical application in several disorders like asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and more. Preclinical 129Xe MRI has the potential to find new applications and accelerate clinical research, but is challenging and limited to only a few centers worldwide.

In this webinar, Dr. Rohan Virgincar, MRI Applications Scientist at Bruker BioSpin, will give insight into the fundamentals and practical considerations for high-resolution hyperpolarized 129Xe MRI in rodents, based on his 7 years of research in this field at Duke University, USA. He will discuss important factors such as hyperpolarization, xenon gas-delivery using a hyperpolarized-gas-compatible ventilator, imaging considerations for ventilation and dissolved-phase imaging using the 3D ultrashort echo time method, image analysis techniques, and present examples of applications in clinically relevant rodent models of lung disease.

This webinar took place on May 7th, 2020

watch on demand

Key Learning Objectives

Imaging considerations

  • RF coils and calibrations
  • Key parameters for ventilation and dissolved phase imaging using UTE3D
  • 129Xe spectroscopy
  • Applications in lung disease models

Practical considerations

  • Animal set up, anesthesia, and physiological monitoring
  • Xenon polarization, and delivery using a custom hyperpolarized-gas compatible ventilator

Who Should Attend

Researchers focused on pulmonary diseases and pulmonary imaging techniques, MRI scientists working with X-nuclei, and those interested in hyperpolarization techniques.

Speakers

Dr. Rohan Virgincar

MRI Applications Scientist at Bruker USA

Dr. Rohan Virgincar is an MRI Applications Scientist at Bruker USA. Prior to joining Bruker, he was a graduate student at Duke University, where he gained over 7 years of experience with hyperpolarized gas imaging in the laboratory of Dr. Bastiaan Driehuys, with a focus on preclinical imaging development and applications.

Dr. Kristin Granlund

MRI Applications Scientist at Bruker USA

Dr. Kristin Granlund is an MRI Applications Scientist at Bruker USA. Prior to joining Bruker, she was a postdoctoral fellow at Memorial Sloan Kettering Cancer Center. Working with Dr. Kayvan Keshari, she developed methods for imaging in vivo cancer metabolism using hyperpolarized pyruvate.

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