Dissolution of a tablets
The dissolution process of a tablet can be characterized using magnetic resonance techniques, which enables to acquire in-vivo images, localized quantitative and qualitative spectra, and track the molecular diffusion of pharmaceutical compounds.
A tablet is a drug delivery system which ensures that the pharmaceutical ingredients are available at the targeted location with the right concentration and timing. The dissolution process of a tablet can be characterized using magnetic resonance techniques, which enables to acquire in-vivo images, localized quantitative and qualitative spectra, and track the molecular diffusion of pharmaceutical compounds.
Orthogonal gradient Echo images (axial, sagittal, coronal) of a tablet. Tablet was Tablet submerged in silicon oil under vacuum for 2h prior to acquisition.
Timeseries of the dissolution of a tablet in a 0.3% hydrochloric acid solution (gastric acid HCL 0.5 - 1 %). The time span between the acquired images was 30 min. Image: SpinEcho 3D (FOV 14 x 14 x 14 mm3, resolution 109 x 109 x 109 um3, Micro5 1H 10 mm saddle coil)
3D SpinEcho? image of two tablets. The images show a difference in homogeneity and porosity.