SCiLS™ Lab Bibliography

SCiLS™ Lab Bibliography 2024

Title Author Publication Link
Metabolic heterogeneity affects trastuzumab response and survival in HER2-positive advanced gastric cancer Wang J.; Sun N. et al. British Journal of Cancer https://doi.org/10.2139/ssrn.4176351
Spatial N-glycomics with MALDI-MSI for human lung tissue Velickovic D.; Anderton C. https://doi.org/10.17504/protocols.io.5jyl8p876g2w/v2
Differential Distribution of Characteristic Constituents in Peel and Pulp of Aurantii Fructus Immaturus Using Maldi Mass Spectrometry Imaging Cai W.; Zhang S. et al. Available at SSRN 4698864 https://doi.org/10.2139/ssrn.4698864
Nitro Indole Derivatives as Novel Dual-Polarity Matrices for MALDI Mass Spectrometry and Imaging with Broad Applications Liang Q.; Mondal P. et al. Analytical Chemistry https://doi.org/10.1021/acs.analchem.3c04684.s001
Sodium doping and trapped ion mobility spectrometry improve lipid detection for novel MALDI-MSI analysis of oats Lau W.C.; Donnellan L. et al. Food Chemistry https://doi.org/10.2139/ssrn.4474290
An N-glycome tissue atlas of 15 human normal and cancer tissue types determined by MALDI-imaging mass spectrometry Wallace E.N.; West C.A. et al. Scientific Reports https://doi.org/10.1038/s41598-023-50957-w
Spatiotemporal Visualization of Paraquat Distribution, Toxicokinetics, and Its Detoxification in Zebrafish Using Matrix-Assisted Laser Desorption Ionization Mass Spectrometry Imaging Qin L.; Huang J. et al. Chemical Research in Toxicology https://doi.org/10.1021/acs.chemrestox.3c00338
Thin‐section‐and matrix‐free mass spectrometry imaging: Reproducible sample transfer using novel platinum‐coated porous plate formed of glass beads Ikeda T.; Kotani M. Rapid Communications in Mass Spectrometry https://doi.org/10.1002/rcm.9697
Spatial Omics Reveals that Cancer-Associated Glycan Changes Occur Early in Liver Disease Development in a Western Diet Mouse Model of MASLD Ochoa-Rios S.; Grauzam S.E. et al. Journal of Proteome Research https://doi.org/10.1021/acs.jproteome.3c00672.s001
Efficacy and pharmacodynamic effect of anti-CD73 and anti-PD-L1 monoclonal antibodies in combination with cytotoxic therapy: observations from mouse tumor models Kaistha B.P.; Kar G. et al. Cancer Biology & Therapy https://doi.org/10.1080/15384047.2023.2296048
Spatial Lipidomics of Coronary Atherosclerotic Plaque Development in a Familial Hypercholesterolemia Swine Model Slijkhuis N.; Razzi F. et al. Journal of Lipid Research https://doi.org/10.1016/j.jlr.2024.100504
Ultrasonic elastography for the prevention of breast implant rupture: Detection of an increase with stiffness over implantation time Ruffenach L.; Heintz D. et al. Journal of Biomechanics https://doi.org/10.1016/j.jbiomech.2024.111955
Fasting mimicking diet in diabetic mice partially preserves glomerular endothelial glycocalyx coverage, without changing the diabetic metabolic environment van der Velden A.I.; Koudijs A. et al. American Journal of Physiology-Renal Physiology https://doi.org/10.1152/ajprenal.00333.2023
Mass Spectrometry Imaging of Organoids to Improve Pre‐Clinical Research Zivko C.; Hahm T. et al. Advanced Healthcare Materials https://doi.org/10.1002/adhm.202302499
Structural and functional characterisation of Tst2, a novel TRPV1 inhibitory peptide from the Australian sea anemone Telmatactis stephensoni Elnahriry K.A.; Wai D.C. et al. Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics https://doi.org/10.2210/pdb8sem/pdb
Visualization of Differential Cardiolipin Profiles in Murine Retinal Cell Layers by High-Resolution MALDI Mass Spectrometry Imaging Bessler S.; Soltwisch J. et al. Analytical Chemistry https://doi.org/10.1021/acs.analchem.3c01465.s001

SCiLS™ Lab Bibliography 2023

Title Author Publication Link
Impact of spatial metabolomics on immune-microenvironment in oral cancer prognosis: a clinical report. Bag S, Oetjen J et al. Mol Cell Biochem 2023 https://doi.org/10.1007/s11010-023-04713-3
Spatial resolution of renal amyloid deposits through MALDI-MSI: a combined digital and molecular approach to monoclonal gammopathies. Bindi G, Smith A et al. J Clin Pathol 2023 https://doi.org/10.1136/jcp-2023-208790
Rewiring of the N-Glycome with prostate cancer progression and therapy resistance. Butler W, McDowell C et al. NPJ Precis Oncol 2023;7(1):22 https://doi.org/10.1038/s41698-023-00363-2
3D bioprinted colorectal cancer models based on hyaluronic acid and signalling glycans. Cadamuro F, Marongiu L et al. Carbohydr Polym 2023;302:120395 https://doi.org/10.1016/j.carbpol.2022.120395
A Comparison of Different Sample Processing Protocols for MALDI Imaging Mass Spectrometry Analysis of Formalin-Fixed Multiple Myeloma Cells. Casadonte R, Kriegsmann J et al. Cancers (Basel) 2023;15(3) https://doi.org/10.3390/cancers15030974
Imaging Mass Spectrometry for the Classification of Melanoma Based on BRAF/NRAS Mutational Status. Casadonte R, Kriegsmann M et al. Int J Mol Sci 2023;24(6) https://doi.org/10.3390/ijms24065110
MALDI-IHC-Guided In-Depth Spatial Proteomics: Targeted and Untargeted MSI Combined. Claes BSR, Krestensen KK et al. Anal Chem 2023;95(4):2329-2338 https://doi.org/10.1021/acs.analchem.2c04220
In Situ Imaging of O-Linked β-N-Acetylglucosamine Using On-Tissue Hydrolysis and MALDI Mass Spectrometry. Escobar EE, Seeley EH et al. Cancers (Basel) 2023;15(4) https://doi.org/10.3390/cancers15041224
Longitudinal spatial mapping of lipid metabolites reveals pre-symptomatic changes in the hippocampi of Huntington's disease transgenic mice. Farzana F, McConville MJ et al. Neurobiol Dis 2023;176:105933 https://doi.org/10.1016/j.nbd.2022.105933
MALDI mass spectrometry imaging shows a gradual change in the proteome landscape during mouse ovarian folliculogenesis. Fiorentino G, Smith A et al. Mol Hum Reprod 2023;29(4) https://doi.org/10.1093/molehr/gaad006
Titania Nanosheet as a Matrix for Surface-Assisted Laser Desorption/Ionization Mass Spectrometry Analysis and Imaging. Gao C, Wang Y et al. Anal Chem 2023;95(2):650-658 https://doi.org/10.1021/acs.analchem.2c01878
MALDI Imaging, a Powerful Multiplex Approach to Decipher Intratumoral Heterogeneity: Combined Hepato-Cholangiocarcinomas as Proof of Concept. Gigante E, Cazier H et al. Cancers (Basel) 2023;15(7) https://doi.org/10.3390/cancers15072143
Characterization of Hormone Receptor and HER2 Status in Breast Cancer Using Mass Spectrometry Imaging. Gonçalves JPL, Bollwein C et al. Int J Mol Sci 2023;24(3) https://doi.org/10.3390/ijms24032860
Optimized protocol for MALDI MSI of N-glycans using an on-tissue digestion in fresh frozen tissue sections. Grgic A ,Krestensen KK ,Heeren RMA Sci Rep 2023;13(1):2776 https://doi.org/10.1038/s41598-023-29560-6
Divide and Conquer: A Flexible Deep Learning Strategy for Exploring Metabolic Heterogeneity from Mass Spectrometry Imaging Data. Guo L, Dong J et al. Anal Chem 2023;95(3):1924-32 https://doi.org/10.1021/acs.analchem.2c04045
Sample preparation for lipid analysis of intra-articular adipose tissue by using matrix-assisted laser desorption/ionization imaging. Haartmans MJJ, Claes BSR et al. Anal Biochem 2023;662:115018 https://doi.org/10.1016/j.ab.2022.115018
Tumor ratio of unsaturated to saturated sulfatide species is associated with disease-free survival in intrahepatic cholangiocarcinoma. Huizing L, Chen L et al. Cell Oncol (Dordr) 2023 https://doi.org/10.1007/s13402-022-00766-6
Investigation of Phospholipid Differences in Valproic Acid-Induced Autistic Mouse Model Brain Using Mass Spectrometry Imaging. Jang HJ, Kwon KJ et al. Metabolites 2023;13(2) https://doi.org/10.3390/metabo13020178
Effect of Micro-Patterned Mucin on Quinolone and Rhamnolipid Profiles of Mucoid Pseudomonas aeruginosa under Antibiotic Stress. Jia J, Parmar D et al. ACS Infect Dis 2023;9(1):150-161 https://doi.org/10.1021/acsinfecdis.2c00519
Classification of Pancreatic Ductal Adenocarcinoma Using MALDI Mass Spectrometry Imaging Combined with Neural Networks. Kanter F, Lellmann J et al. Cancers (Basel) 2023;15(3) https://doi.org/10.3390/cancers15030686
In Situ Self-Assembled Formation of Nitrogen-Rich Ag@Ti3C2 Film for Sensitive Detection and Spatial Imaging of Pesticides with Laser Desorption/Ionization Mass Spectrometry (LDI-MS). Li W, He Q et al. ACS Appl Mater Interfaces 2023;15(14):18402-18413 https://doi.org/10.1021/acsami.2c22347
Spatial metabolomics reveals skeletal myofiber subtypes. Luo L, Ma W et al. Sci Adv 2023;9(5):eadd0455 https://doi.org/10.1126/sciadv.add0455
Applications and continued evolution of glycan imaging mass spectrometry. McDowell CT, Lu X et al. Mass Spectrom Rev 2023;42(2):674-705 https://doi.org/10.1002/mas.21725
Targeting succinate metabolism to decrease brain injury upon mechanical thrombectomy treatment of ischemic stroke. Mottahedin A, Prag HA et al. Redox Biol 2023;59:102600 https://doi.org/10.1016/j.redox.2023.102600
Lipidized PrRP Analog Exhibits Strong Anti-Obesity and Antidiabetic Properties in Old WKY Rats with Obesity and Glucose Intolerance. Mráziková L, Hojná S et al. Nutrients 2023;15(2) https://doi.org/10.3390/nu15020280
Monoisotopic silver nanoparticles-based mass spectrometry imaging of human bladder cancer tissue: Biomarker discovery. Ossoliński K, Ruman T et al. Adv Med Sci 2023;68(1):38-45 https://doi.org/10.1016/j.advms.2022.12.002
Spatially Resolved Molecular Approaches for the Characterisation of Non-Invasive Follicular Tumours with Papillary-like Features (NIFTPs). Piga I, L'Imperio V et al. Int J Mol Sci 2023;24(3) https://doi.org/10.3390/ijms24032567
Fast and Reproducible Matrix Deposition for MALDI Mass Spectrometry Imaging with Improved Glass Sublimation Setup. Shanmugaraj N, Rutten T et al. J Am Soc Mass Spectrom 2023;34(3):513-517 https://doi.org/10.1021/jasms.2c00301
Development of Spheroid-FPOP: An In-Cell Protein Footprinting Method for 3D Tumor Spheroids. Shortt RL, Wang Y et al. J Am Soc Mass Spectrom 2023;34(3):417-425 https://doi.org/10.1021/jasms.2c00307
A multimodal pipeline using NMR spectroscopy and MALDI-TOF mass spectrometry imaging from the same tissue sample. Tressler CM, Ayyappan V et al. NMR Biomed 2023;36(4):e4770 https://doi.org/10.1002/nbm.4770
Detection of early proteomic alterations in 5xFAD Alzheimer's disease neonatal mouse model via MALDI-MSI. Uras I, Karayel-Basar M et al. Alzheimers Dement 2023 https://doi.org/10.1002/alz.13008
Hepatic glutamine synthetase controls N5-methylglutamine in homeostasis and cancer. Villar VH, Allega MF et al. Nat Chem Biol 2023;19(3):292-300 https://doi.org/10.1038/s41589-022-01154-9
Commensal microbiome promotes hair follicle regeneration by inducing keratinocyte HIF-1α signaling and glutamine metabolism. Wang G, Sweren E et al. Sci Adv 2023;9(1):eabo7555 https://doi.org/10.1126/sciadv.abo7555
Mobility-resolved broadband dissociation and parallel reaction monitoring for laser desorption/ionization-mass spectrometry - Tattoo pigment identification supported by trapped ion mobility spectrometry. Wolf C, Behrens A et al. Anal Chim Acta 2023;1242:340796 https://doi.org/10.1016/j.aca.2023.340796
Region-resolved multi-omics of the mouse eye. Xiang H, Zhang B et al. Cell Rep 2023;42(2):112121 https://doi.org/10.1016/j.celrep.2023.112121
Exposure to isocyanates predicts atopic dermatitis prevalence and disrupts therapeutic pathways in commensal bacteria. Zeldin J, Chaudhary PP et al. Sci Adv 2023;9(1):eade8898 https://doi.org/10.1126/sciadv.ade8898
Tandemly duplicated CYP82Ds catalyze 14-hydroxylation in triptolide biosynthesis and precursor production in Saccharomyces cerevisiae. Zhang Y, Gao J et al. Nat Commun 2023;14(1):875 https://doi.org/10.1038/s41467-023-36353-y
Impact of spatial metabolomics on immune-microenvironment in oral cancer prognosis: a clinical report Bag S.; Oetjen J. et al. Molecular and Cellular Biochemistry https://doi.org/10.1007/s11010-023-04713-3
Tumor ratio of unsaturated to saturated sulfatide species is associated with disease-free survival in intrahepatic cholangiocarcinoma Huizing L.; Chen L. et al. Cellular Oncology https://doi.org/10.1007/s13402-022-00766-6
MALDI mass spectrometry imaging shows a gradual change in the proteome landscape during mouse ovarian folliculogenesis Fiorentino G.; Smith A. et al. Molecular Human Reproduction https://doi.org/10.1093/molehr/gaad006
A Caged In‐Source Laser‐Cleavable MALDI Matrix with High Vacuum Stability for Extended MALDI‐MS Imaging Zhou Q.; Rizzo S. et al. Angewandte Chemie International Edition https://doi.org/10.1002/ange.202304188
Expanded coverage of phytocompounds by mass spectrometry imaging using on-tissue chemical derivatization by 4-APEBA Zemaitis K.J.; Lin V.S. et al. Analytical Chemistry https://doi.org/10.1021/acs.analchem.3c01345
Spatial resolution of renal amyloid deposits through MALDI-MSI: a combined digital and molecular approach to monoclonal gammopathies Bindi G.; Smith A. et al. Journal of Clinical Pathology https://doi.org/10.1136/jcp-2023-208790
Optimized protocol for MALDI MSI of N-glycans using an on-tissue digestion in fresh frozen tissue sections Grgic A.; Krestensen K.K. et al. Scientific Reports https://doi.org/10.1038/s41598-023-29560-6
Classification of Pancreatic Ductal Adenocarcinoma Using MALDI Mass Spectrometry Imaging Combined with Neural Networks Kanter F.; Lellmann J. et al. Cancers https://doi.org/10.3390/cancers15030686
Spatial metabolomics reveals skeletal myofiber subtypes Luo L.; Ma W. et al. Science Advances https://doi.org/10.1126/sciadv.add0455
Divide and Conquer: A Flexible Deep Learning Strategy for Exploring Metabolic Heterogeneity from Mass Spectrometry Imaging Data Guo L.; Dong J. et al. Analytical Chemistry https://doi.org/10.1021/acs.analchem.2c04045.s001
Characterization of Hormone Receptor and HER2 Status in Breast Cancer Using Mass Spectrometry Imaging Gonçalves J.P.L.; Bollwein C. et al. International Journal of Molecular Sciences https://doi.org/10.3390/ijms24032860
Detection of early proteomic alterations in 5xFAD Alzheimer's disease neonatal mouse model via MALDI‐MSI Uras I.; Karayel‐Basar M. et al. Alzheimer's & Dementia https://doi.org/10.1002/alz.13008
Spatially Resolved Molecular Approaches for the Characterisation of Non-Invasive Follicular Tumours with Papillary-like Features (NIFTPs) Piga I.; L’Imperio V. et al. International Journal of Molecular Sciences https://doi.org/10.3390/ijms24032567
Longitudinal spatial mapping of lipid metabolites reveals pre-symptomatic changes in the hippocampi of Huntington's disease transgenic mice Farzana F.; McConville M.J. et al. Neurobiology of Disease https://doi.org/10.1016/j.nbd.2022.105933
Adipose transplantation improves olfactory function and neurogenesis via PKCα-involved lipid metabolism in Seipin Knockout mice Yang J.; Yang N. et al. Stem Cell Research & Therapy https://doi.org/10.21203/rs.3.rs-1948538/v1
MALDI Imaging, a Powerful Multiplex Approach to Decipher Intratumoral Heterogeneity: Combined Hepato-Cholangiocarcinomas as Proof of Concept Gigante E.; Cazier H. et al. Cancers https://doi.org/10.3390/cancers15072143
A sensitive on-tissue chemical derivatization-mass spectrometry imaging method for the quantitative visualization of helicid in mice Liu Y.; Cai Y. et al. International Journal of Mass Spectrometry https://doi.org/10.1016/j.ijms.2023.117038
Monoisotopic silver nanoparticles-based mass spectrometry imaging of human bladder cancer tissue: Biomarker discovery Ossoliński K.; Ruman T. et al. Advances in Medical Sciences https://doi.org/10.1016/j.advms.2022.12.002
Investigation of Phospholipid Differences in Valproic Acid-Induced Autistic Mouse Model Brain Using Mass Spectrometry Imaging Jang H.J.; Kwon K.J. et al. Metabolites https://doi.org/10.3390/metabo13020178
Exposure to isocyanates predicts atopic dermatitis prevalence and disrupts therapeutic pathways in commensal bacteria Zeldin J.; Chaudhary P.P. et al. Science Advances https://doi.org/10.1126/sciadv.ade8898
Spatial Analysis of Phospholipids in Insect Models by Positive Ionization Mode Matrix-Assisted Laser Desorption Ionization Mass Spectrometric Imaging Bhandari S.; Marwah H. et al. Journal ISSN https://doi.org/10.37871/jbres1684
Multicellular tumor spheroids bridge the gap between two-dimensional cancer cells and solid tumors: The role of lipid metabolism and distribution Xie P.; Zhang J. et al. Chinese Chemical Letters https://doi.org/10.1016/j.cclet.2022.03.072
Plasmonic polydopamine-modified TiO2 nanotube substrates for surface-assisted laser desorption/ionization mass spectrometry imaging Chen D.; Du M. et al. Nano Research https://doi.org/10.1007/s12274-022-4924-z
Development of Spheroid-FPOP: An In-Cell Protein Footprinting Method for 3D Tumor Spheroids Shortt R.L.; Wang Y. et al. Journal of the American Society for Mass Spectrometry https://doi.org/10.1021/jasms.2c00307.s001
Exposure to solar ultraviolet radiation establishes a novel immune suppressive lipidome in skin-draining lymph nodes Tse B.C.; Ferguson A.L. et al. Frontiers in Immunology https://doi.org/10.3389/fimmu.2022.1045731
Lipidized PrRP Analog Exhibits Strong Anti-Obesity and Antidiabetic Properties in Old WKY Rats with Obesity and Glucose Intolerance Mráziková L.; Hojná S. et al. Nutrients https://doi.org/10.3390/nu15020280
Correlative radioimaging and mass spectrometry imaging: a powerful combination to study 14 C-graphene oxide in vivo biodistribution Cazier H.; Malgorn C. et al. Nanoscale https://doi.org/10.1039/d2nr06753f
Rewiring of the N-Glycome with prostate cancer progression and therapy resistance Butler W.; McDowell C. et al. NPJ Precision Oncology https://doi.org/10.1038/s41698-023-00363-2
MALDI-IHC-Guided in-depth spatial proteomics: Targeted and untargeted MSI combined Claes B.S.; Krestensen K.K. et al. Analytical Chemistry https://doi.org/10.1021/acs.analchem.2c04220.s001
Systematic study of tissue section thickness for MALDI MS profiling and imaging Wang X.; Zhang L. et al. Analyst https://doi.org/10.1039/d2an01739c
Sample preparation for lipid analysis of intra-articular adipose tissue by using matrix-assisted laser desorption/ionization imaging Haartmans M.J.; Claes B.S. et al. Analytical biochemistry https://doi.org/10.1016/j.ab.2022.115018
A multimodal pipeline using NMR spectroscopy and MALDI‐TOF mass spectrometry imaging from the same tissue sample Tressler C.M.; Ayyappan V. et al. NMR in Biomedicine https://doi.org/10.1002/nbm.4770
Mobility-resolved broadband dissociation and parallel reaction monitoring for laser desorption/ionization-mass spectrometry-Tattoo pigment identification supported by trapped ion mobility spectrometry Wolf C.; Behrens A. et al. Analytica Chimica Acta https://doi.org/10.1016/j.aca.2023.340796
In Situ Self-Assembled Formation of Nitrogen-Rich Ag@ Ti3C2 Film for Sensitive Detection and Spatial Imaging of Pesticides with Laser Desorption/Ionization Mass Spectrometry (LDI-MS) Li W.; He Q. et al. ACS Applied Materials & Interfaces https://doi.org/10.1021/acsami.2c22347.s001
3D bioprinted colorectal cancer models based on hyaluronic acid and signalling glycans Cadamuro F.; Marongiu L. et al. Carbohydrate Polymers https://doi.org/10.1016/j.carbpol.2022.120395
Spatial Omics Imaging of Fresh-Frozen Tissue and Routine FFPE Histopathology of a Single Cancer Needle Core Biopsy: A Freezing Device and Multimodal Workflow Rittel M.F.; Schmidt S. et al. Cancers https://doi.org/10.1101/2023.02.11.528125
Integrated mass spectrometry imaging and metabolomics reveals sublethal effects of indoxacarb on the red fire ant Solenopsis invicta Du M.; Yin Z. et al. Pest Management Science https://doi.org/10.1002/ps.7489
The acquisition of thin sections of açaí (Euterpe oleracea Mart.) seed with elevated potassium content for molecular mapping by mass spectrometry imaging Brum F.L.; Martins G.R. et al. Rapid Communications in Mass Spectrometry https://doi.org/10.1002/rcm.9474/v1/review2
Defining the spatial distribution of extracellular adenosine revealed a myeloid-dependent immunosuppressive microenvironment in pancreatic ductal adenocarcinoma Graziano V.; Dannhorn A. et al. Journal for Immunotherapy of Cancer https://doi.org/10.1101/2022.05.24.493238
Defining the spatial distribution of extracellular adenosine revealed a myeloid-dependent immunosuppressive microenvironment in pancreatic ductal adenocarcinoma Graziano V.; Dannhorn A. et al. Journal for Immunotherapy of Cancer https://doi.org/10.1101/2022.05.24.493238
Robust phenotyping of highly multiplexed tissue imaging data using pixel-level clustering Liu C.C.; Greenwald N.F. et al. Nature Communications https://doi.org/10.1101/2022.08.16.504171
Fast and Reproducible Matrix Deposition for MALDI Mass Spectrometry Imaging with Improved Glass Sublimation Setup Shanmugaraj N.; Rutten T. et al. Journal of the American Society for Mass Spectrometry https://doi.org/10.1021/jasms.2c00301.s001
Imaging Mass Spectrometry for the Classification of Melanoma Based on BRAF/NRAS Mutational Status Casadonte R.; Kriegsmann M. et al. International Journal of Molecular Sciences https://doi.org/10.3390/ijms24065110
A Comparison of Different Sample Processing Protocols for MALDI Imaging Mass Spectrometry Analysis of Formalin-Fixed Multiple Myeloma Cells Casadonte R.; Kriegsmann J. et al. Cancers https://doi.org/10.3390/cancers15030974
Targeting succinate metabolism to decrease brain injury upon mechanical thrombectomy treatment of ischemic stroke Mottahedin A.; Prag H.A. et al. Redox Biology https://doi.org/10.2139/ssrn.4273833
Supervised topological data analysis for MALDI imaging applications Klaila G.; Vutov V. et al. arXiv preprint arXiv:2302.13948 https://doi.org/10.1186/s12859-023-05402-0
Tandemly duplicated CYP82Ds catalyze 14-hydroxylation in triptolide biosynthesis and precursor production in Saccharomyces cerevisiae Zhang Y.; Gao J. et al. Nature Communications https://doi.org/10.1038/s41467-023-36353-y
Fungal organic acid uptake of mineral derived K is dependent on distance from carbon hotspot Bhattacharjee A.; Velickovic D. et al. bioRxiv https://doi.org/10.1101/2023.03.17.533228
In Situ Imaging of O-Linked β-N-Acetylglucosamine Using On-Tissue Hydrolysis and MALDI Mass Spectrometry Escobar E.E.; Seeley E.H. et al. Cancers https://doi.org/10.3390/cancers15041224
Hepatic glutamine synthetase controls N 5-methylglutamine in homeostasis and cancer Villar V.H.; Allega M.F. et al. Nature Chemical Biology https://doi.org/10.1038/s41589-022-01154-9
Dissecting the brain with spatially resolved multi-omics Fangma Y.; Liu M. et al. Journal of Pharmaceutical Analysis https://doi.org/10.46936/ltds.proj.2022.60285/60008460
Commensal microbiome promotes hair follicle regeneration by inducing keratinocyte HIF-1α signaling and glutamine metabolism Wang G.; Sweren E. et al. Science Advances https://doi.org/10.1016/j.jid.2022.05.775
Correlative Chemical Imaging and Spatial Chemometrics Delineate Alzheimer Plaque Heterogeneity at High Spatial Resolution Wehrli P.M.; Ge J. et al. JACS Au https://doi.org/10.1021/jacsau.2c00492.s002
Applications and continued evolution of glycan imaging mass spectrometry McDowell C.T.; Lu X. et al. Mass Spectrometry Reviews https://doi.org/10.1002/mas.21725
Region-resolved multi-omics of the mouse eye Xiang H.; Zhang B. et al. Cell Reports https://doi.org/10.1016/j.celrep.2023.112121
Sample Preparation Method for MALDI Mass Spectrometry Imaging of Fresh-Frozen Spines Bender K.J.; Wang Y. et al. Analytical Chemistry https://doi.org/10.1021/acs.analchem.3c03672.s001
Deep MALDI-MS Spatial Omics guided by Quantum Cascade Laser Mid-infrared Imaging Microscopy Gruber L.; Schmidt S. et al. bioRxiv https://doi.org/10.1101/2023.12.14.571637
Bioorthogonal Chemical Labeling Probes Targeting Sialic Acid Isomers for N-Glycan MALDI Imaging Mass Spectrometry of Tissues, Cells, and Biofluids Lu X.; McDowell C.T. et al. Analytical Chemistry https://doi.org/10.1021/acs.analchem.2c04882.s001
Visualization of metabolites and microbes at high spatial resolution using MALDI mass spectrometry imaging and in situ fluorescence labeling Bourceau P.; Geier B. et al. Nature Protocols https://doi.org/10.1038/s41596-023-00864-1
MALDI-2 Mass Spectrometry for Synthetic Polymer Analysis Molina-Millán L.; Körber A. et al. Macromolecules https://doi.org/10.1002/9780470567234
Chemical QuantArray: A quantitative tool for mass spectrometry imaging Stopka S.A.; Ruiz D. et al. Analytical chemistry https://doi.org/10.1021/acs.analchem.3c00803.s001
Quantification of Irinotecan in Single Spheroids Using Internal Standards by MALDI Mass Spectrometry Imaging Wang Y.; Hummon A.B. Analytical Chemistry https://doi.org/10.1021/acs.analchem.3c00699.s001
Spatial lipidomics and metabolomics of multicellular tumor spheroids using MALDI-2 and trapped ion mobility imaging Chen J.; Xie P. et al. Talanta https://doi.org/10.1016/j.talanta.2023.124795
On-Tissue Chemical Derivatization for Comprehensive Mapping of Brain Carboxyl and Aldehyde Metabolites by MALDI–MS Imaging Kaya I.; Schembri L.S. et al. Journal of the American Society for Mass Spectrometry https://doi.org/10.1021/jasms.2c00336.s001
Evaluation of antibody-based single cell type imaging techniques coupled to multiplexed imaging of N-glycans and collagen peptides by matrix-assisted laser desorption/ionization mass spectrometry imaging Dunne J.; Griner J. et al. Analytical and Bioanalytical Chemistry https://doi.org/10.1007/s00216-023-04983-2
Cytological Cytospin Preparation for the Spatial Proteomics Analysis of Thyroid Nodules Using MALDI-MSI Piga I.; Pagni F. et al. Imaging Mass Spectrometry: Methods and Protocols https://doi.org/10.1007/978-1-0716-3319-9_9
Advanced Method for High-Resolution Spatial Proteomics: Bruker Scientific describes how the MALDI-HiPLEX-IHC workflow can generate high-resolution images and spatially determine analytes in tissues Stumpo K. Genetic Engineering & Biotechnology News https://doi.org/10.1089/gen.43.12.17
Single‐filament imaging mass spectrometry lipidomics in Arthrospira platensis Lesco K.C.; Rowland S.M. et al. Rapid Communications in Mass Spectrometry https://doi.org/10.1002/rcm.9525/v1/review2
Toward Omics-Scale Quantitative Mass Spectrometry Imaging of Lipids in Brain Tissue Using a Multiclass Internal Standard Mixture Vandenbosch M.; Mutuku S.M. et al. Analytical Chemistry https://doi.org/10.1021/acs.analchem.3c02724.s002
OR19-06 State-of-the-art MALDI Mass Spectrometry Imaging Reveals Unique Spatial Lipid Signatures in Human and Mouse Ovarian Compartments Pascuali N.; Tobias F. et al. Journal of the Endocrine Society https://doi.org/10.1210/jendso/bvad114.1652
Detection of proteomic alterations at different stages in a Huntington's disease mouse model via matrix‐assisted laser desorption/ionization mass spectrometry (MALDI‐MS) imaging Karayel‐Basar M.; Uras I. et al. European Journal of Neuroscience https://doi.org/10.1111/ejn.16103/v2/review1
Spatially-Resolved Lipidomic Analysis of Normal and Idiopathic Pulmonary Fibrosis (IPF) Human Lungs Using Matrix-Assisted Laser Desorption Ionization Mass Spectrometry Imaging (MALDI-MSI) Khaliullin T.; Sekera E. et al. A68. MITOCHONDRIAL AND METABOLOMIC ALTERATIONS IN THE PATHOGENESIS OF ILDs https://doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2284
High-Resolution N-Glycan MALDI Mass Spectrometry Imaging of Subchondral Bone Tissue Microarrays in Patients with Knee Osteoarthritis Lee Y.; Briggs M.T. et al. Analytical Chemistry https://doi.org/10.1021/acs.analchem.3c00348.s001
MALDI and Trace Metal Analysis in Age-Related Macular Degeneration Millar J.; Campbell S. et al. Imaging Mass Spectrometry: Methods and Protocols https://doi.org/10.1007/978-1-0716-3319-9_1
Spatial Analysis of Nucleotide Metabolism: From CRISPR Knockout Cancer Cells to MALDI Imaging of Tumors Hyrossova P.; Milosevic M. et al. Metabolic Reprogramming: Methods and Protocols https://doi.org/10.1007/978-1-0716-3247-5_22
Complex-Type N-Glycans Are Associated with Cartilage Degeneration within Different Loading Sites of the Tibial Plateau for Knee Osteoarthritis Patients Lee Y.; Briggs M.T. et al. Journal of Proteome Research https://doi.org/10.1021/acs.jproteome.3c00251.s001
Single-cell lipidomics enabled by dual-polarity ionization and ion mobility-mass spectrometry imaging Zhang H.; Liu Y. et al. Nature Communications https://doi.org/10.1038/s41467-023-40512-6
Mass spectrometry imaging reveals early metabolic priming of cell lineage in differentiating human-induced pluripotent stem cells Nikitina A.A.; Van Grouw A. et al. Analytical Chemistry https://doi.org/10.1021/acs.analchem.2c04416.s001
Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) reveals potential lipid markers between infrapatellar fat pad biopsies of osteoarthritis and cartilage defect patients Haartmans M.J.; Claes B.S. et al. Analytical and bioanalytical chemistry https://doi.org/10.1007/s00216-023-04871-9
Mass spectrometry imaging for biosolids characterization to assess ecological or health risks before reuse Villette C.; Maurer L. et al. Nature Communications https://doi.org/10.1038/s41467-023-40051-0
Visualization of the Distribution of PFOS and PFHxS in Concrete by DESI MSI Vo P.H.; Hamilton B.R. et al. Environmental Science & Technology Letters https://doi.org/10.1021/acs.estlett.3c00211.s001
Mass spectrometry imaging reveals flavor distribution in edible mushrooms Vats M.; Cillero-Pastor B. et al. Journal of Food Science and Technology https://doi.org/10.1007/s13197-023-05883-0
Spatially resolved visualization of reprogrammed metabolism in hepatocellular carcinoma by mass spectrometry imaging Ma B.; Zhang Y. et al. Cancer Cell International https://doi.org/10.1186/s12935-023-03027-0
Spatial Proteomics of Cartilage and Bone in Osteoarthritic Knees via Mass Spectrometry Imaging Reveals Molecular Details of Disease Severity and Progression Schurman C.A.; Woo J.J. et al. Musculoskeletal Biology Workshop, July 22–27, 2023, Midway, Utah https://doi.org/10.3920/978-90-8686-776-9_22
Integrated Spatial Metabolomics and Transcriptomics Decipher the Hepatoprotection Mechanisms of Wedelolactone and Demethylwedelolactone on Non-alcoholic Fatty Liver Disease Chen P.; Zhu Z. et al. Journal of Pharmaceutical Analysis https://doi.org/10.1016/j.jpha.2023.11.017
Multimodal Mass Spectrometry Imaging of an Aggregated 3D Cell Culture Model Flint L. Imaging Mass Spectrometry: Methods and Protocols https://doi.org/10.1007/978-1-0716-3319-9_13
MALDImID: Spatialomics R package and Shiny app for more specific identification of MALDI imaging proteolytic peaks using LC‐MS/MS‐based proteomic biomarker discovery data Oliveira C.; Longuespée R. Proteomics https://doi.org/10.1002/pmic.202300005
Direct mass spectrometric imaging of document handwriting with laser desorption ionization and post ultraviolet photodissociation Jia S.; Zhou X. et al. Analytica Chimica Acta https://doi.org/10.1016/j.aca.2023.341267
Advancing multi-day ex vivo kidney perfusion using spatially resolved metabolomics de Haan M.J.; Witjas F.M. et al. bioRxiv https://doi.org/10.1101/2023.05.10.540143
Mass spectrometry imaging of natural carbonyl products directly from agar-based microbial interactions using 4-APEBA derivatization Veličković D.; Zemaitis K.J. et al. Msystems https://doi.org/10.1101/2023.05.15.540794
Imaging the metabolic reprograming of fatty acid synthesis pathway enables new diagnostic and therapeutic opportunity for breast cancer Wang F.; Ma S. et al. Cancer Cell International https://doi.org/10.1186/s12935-023-02908-8
Spatially resolved multi-omics highlights cell-specific metabolic remodeling and interactions in gastric cancer Sun C.; Wang A. et al. Nature Communications https://doi.org/10.3410/f.742641480.793599708
Multiplexed neuropeptide mapping in ant brains integrating microtomography and three-dimensional mass spectrometry imaging Geier B.; Gil-Mansilla E. et al. PNAS nexus https://doi.org/10.1101/2022.11.02.514707
Multilevel human secondary lymphoid immune system compartmentalization revealed by complementary imaging approaches Oyler B.L.; Valencia-Dávila J.A. et al. Iscience https://doi.org/10.1101/2022.11.01.514691
Laser desorption/ionization-mass spectrometry for the analysis of interphases in lithium ion batteries Göldner V.; Quach L. et al. Iscience https://doi.org/10.1016/j.isci.2023.107517
WSD-0922, a novel brain-penetrant inhibitor of epidermal growth factor receptor, promotes survival in glioblastoma mouse models Conage-Pough J.E.; Stopka S.A. et al. Neuro-Oncology Advances https://doi.org/10.1093/noajnl/vdad066
Cardinal v3-a versatile open source software for mass spectrometry imaging analysis Bemis K.A.; Foell M.C. et al. bioRxiv https://doi.org/10.1101/2023.02.20.529280
Functional mass spectrometry imaging maps phospholipase-A2 enzyme activity during osteoarthritis progression Fan X.; Young R.S. et al. Theranostics https://doi.org/10.7150/thno.86623
Preparation of Hard Palm Seeds for Matrix-Assisted Laser Desorption/Ionization-Imaging Mass Spectrometry Analysis Martins G.R.; Brum F.L. et al. JoVE (Journal of Visualized Experiments) https://doi.org/10.3791/65650
Optimization of Mass Spectrometry Imaging for Drug Metabolism and Distribution Studies in the Zebrafish Larvae Model: A Case Study with the Opioid Antagonist Naloxone Park Y.M.; Meyer M.R. et al. International Journal of Molecular Sciences https://doi.org/10.3390/ijms241210076
Mass spectrometry imaging as an emerging tool for studying metabolism in human brain organoids Cappuccio G.; Khalil S.M. et al. Frontiers in Molecular Biosciences https://doi.org/10.3389/fmolb.2023.1181965
Spatial lipidomics reveals brain region-specific changes of sulfatides in an experimental MPTP Parkinson’s disease primate model Kaya I.; Nilsson A. et al. npj Parkinson's Disease https://doi.org/10.1038/s41531-023-00558-1
Characterization of spatial lipidomic signatures in tick-bitten guinea pig skin as a model for host-vector-pathogen interaction profiling Scott A.J.; Smith A.A. et al. Msystems https://doi.org/10.1128/msystems.00927-23
Metabolic heterogeneity in adrenocortical carcinoma impacts patient outcomes Wang Q.; Sun N. et al. JCI insight https://doi.org/10.1172/jci.insight.167007
Profiling and Localization of Stilbene Phytoalexins Revealed by MALDI-MSI during the Grapevine–Botrytis cinerea Interaction Maia M.; Aziz A. et al. Journal of Agricultural and Food Chemistry https://doi.org/10.1021/acs.jafc.3c03620.s001
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Visualization of Small Intact Proteins in Breast Cancer FFPE Tissue Giampà M.; Andersen M.K. et al. Imaging Mass Spectrometry: Methods and Protocols https://doi.org/10.1007/978-1-0716-3319-9_14
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ST6GAL1‐mediated aberrant sialylation promotes prostate cancer progression Scott E.; Archer Goode E. et al. The Journal of pathology https://doi.org/10.3390/cancers14174248
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Identification of raffinose family oligosaccharides in processed Rehmannia glutinosa Libosch using matrix‐assisted laser desorption/ionization mass spectrometry image combined with machine learning Li H.; Zhang S. et al. Rapid Communications in Mass Spectrometry https://doi.org/10.1002/rcm.9635
Chemical Mapping of the Degradation of Geranium Lake in Paint Cross Sections by MALDI-MSI Alvarez-Martin A.; Quanico J. et al. Analytical Chemistry https://doi.org/10.1021/acs.analchem.3c03992.s001
Evaluating the Pharmacokinetics and Pharmacodynamics of Chemotherapeutics within a Spatial SILAC-Labeled Spheroid Model System Beller N.C.; Wang Y. et al. Analytical Chemistry https://doi.org/10.1021/acs.analchem.3c00905.s002
Lipidomic Phenotyping Of Human Small Intestinal Organoids Using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging Duivenvoorden A.A.; Claes B.S. et al. Analytical Chemistry https://doi.org/10.1021/acs.analchem.3c03543.s001
Biological injection therapy with leukocyte-poor platelet-rich plasma induces cellular alterations, enhancement of lubricin, and inflammatory downregulation in vivo in human knees: A controlled, prospective human clinical trial based on mass spectrometry imaging analysis Baltzer A.W.; Casadonte R. et al. Frontiers in Surgery https://doi.org/10.3389/fsurg.2023.1169112
Spatial metabolomics principles and application to cancer research Planque M.; Igelmann S. et al. Current Opinion in Chemical Biology https://doi.org/10.1016/j.cbpa.2023.102362
RespectM revealed metabolic heterogeneity powers deep learning for reshaping the DBTL cycle Meng X.; Xu P. et al. iScience https://doi.org/10.1016/j.isci.2023.107069
Muscle Injuries Induce a Prostacyclin‐PPARγ/PGC1a‐FAO Spike That Boosts Regeneration Luo L.; Chua Y.B. et al. Advanced Science https://doi.org/10.1002/advs.202301519
Mass spectrometry imaging and single-cell transcriptional profiling reveal the tissue-specific regulation of bioactive ingredient biosynthesis in Taxus leaves Zhan X.; Qiu T. et al. Plant Communications https://doi.org/10.1016/j.xplc.2023.100630
In-depth profiling of carbohydrate isomers in biological tissues by chemical derivatization-assisted mass spectrometry imaging Wang L.; Han Y. et al. Analytica Chimica Acta https://doi.org/10.1016/j.aca.2023.341741
Isotope-Coded On-Tissue Derivatization for Quantitative Mass Spectrometry Imaging of Short-Chain Fatty Acids in Biological Tissues Han Y.; Qu X. et al. Analytical Chemistry https://doi.org/10.1021/acs.analchem.3c03308.s001
Phosphatidylinositol metabolism of the renal proximal tubule S3 segment is disturbed in response to diabetes Rietjens R.G.; Wang G. et al. Scientific Reports https://doi.org/10.1038/s41598-023-33442-2
Reduced sulfatide content in deferoxamine-induced senescent HepG2 cells Ghislanzoni S.; Sarcinelli G.M. et al. The International Journal of Biochemistry & Cell Biology https://doi.org/10.1016/j.biocel.2023.106419
Ambient Mass Spectrometry Imaging by Water-Assisted Laser Desorption/Ionization for Ex Vivo and in Vivo Applications Ogrinc N.; Chaillou P. et al. Imaging Mass Spectrometry: Methods and Protocols https://doi.org/10.1007/978-1-0716-3319-9_8
Ultrahigh resolution lipid mass spectrometry imaging of high-grade serous ovarian cancer mouse models Ma X.; Botros A. et al. Frontiers in Chemistry https://doi.org/10.1101/2023.10.30.564760
Shotgun proteomics identification of proteins expressed in the Descemet’s membrane of patients with Fuchs endothelial corneal dystrophy Nakagawa T.; Okumura N. et al. Scientific Reports https://doi.org/10.1038/s41598-023-37104-1
Spatial distribution and biochemical characterization of serine peptidase inhibitors in the venom of the brazilian sea anemone anthopleura cascaia using mass spectrometry imaging da Silva D.L.; Valladão R. et al. Marine Drugs https://doi.org/10.3390/md21090481
Development of an Antibody-Based Platform for the Analysis of Immune Cell-Specific N-linked Glycosylation Dressman J.W.; McDowell C.T. et al. Analytical Chemistry https://doi.org/10.1021/acs.analchem.3c00838.s001
Rapid Metabolic Profiling of 1 μL Crude Cerebrospinal Fluid by Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging Can Differentiate De Novo Parkinson’s Disease Vallianatou T.; Nilsson A. et al. Analytical Chemistry https://doi.org/10.1021/acs.analchem.3c02900.s002
Nanoliter Scale Parallel Liquid–Liquid Extraction for High‐Throughput Purification on a Droplet Microarray Wiedmann J.J.; Demirdögen Y.N. et al. Small https://doi.org/10.1002/smll.202204512
Targeted Energy Metabolomics Combined with Spatial Metabolomics Study on the Efficacy of Guhong Injection Against Cerebral Ischemia Reperfusion Wang H.; Li Z. et al. Molecular Neurobiology https://doi.org/10.1007/s12035-023-03403-x
Spatial metabolomics and lipidomics reveal the mechanisms of the enhanced growth of breast cancer cell spheroids exposed to triclosan Chen J.; Xie P. et al. Environmental Science & Technology https://doi.org/10.1021/acs.est.3c01746.s001
A novel visualization method for the composition analysis of processed garlic by MALDI-TOF imaging mass spectrometry (MSI) and Q-TOF LC-MS/MS Li N.; Li S. et al. Food Research International https://doi.org/10.1016/j.foodres.2023.112746
Long chain acyl‐CoA synthetase 6 facilitates the local distribution of di‐docosahexaenoic acid‐and ultra‐long‐chain‐PUFA‐containing phospholipids in the retina to support normal visual function in mice Kuroha S.; Katada Y. et al. The FASEB Journal https://doi.org/10.1096/fj.202300976r
Multi-omics data reveals aberrant gut microbiota-host glycerophospholipid metabolism in association with neuroinflammation in APP/PS1 mice Qian X.; Hai W. et al. Gut Microbes https://doi.org/10.1080/19490976.2023.2282790
Spatial metabolomics identifies distinct tumor-specific and stroma-specific subtypes in patients with lung squamous cell carcinoma Wang J.; Sun N. et al. NPJ precision oncology https://doi.org/10.1038/s41698-023-00434-4
Spatially Resolved Proteomics Reveals Lens Suture-Related Cell–Cell Junctional Protein Distributions Wang Z.; Gletten R.B. et al. Investigative Ophthalmology & Visual Science https://doi.org/10.1167/iovs.64.11.28
Visualizing the Distribution of Jujube Metabolites at Different Maturity Stages Using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging Lu D.; Wu Y. et al. Foods https://doi.org/10.1021/acs.jafc.2c06995.s001
Utilizing multimodal mass spectrometry imaging for profiling immune cell composition and N-glycosylation across colorectal carcinoma disease progression Young L.E.; Nietert P.J. et al. Frontiers in Pharmacology https://doi.org/10.3389/fphar.2023.1337319
A pilot radiometabolomics integration study for the characterization of renal oncocytic neoplasia Klontzas M.E.; Koltsakis E. et al. Scientific Reports https://doi.org/10.1038/s41598-023-39809-9
Molecular-level degradation pathways of black phosphorus revealed by mass spectrometry fingerprinting Huang X.; Li Y. et al. Chemical Science https://doi.org/10.1039/d2sc06297f
Spatially resolved metabolites in stable and unstable human atherosclerotic plaques identified by mass spectrometry imaging Seeley E.H.; Liu Z. et al. Arteriosclerosis, thrombosis, and vascular biology https://doi.org/10.1161/atvb.42.suppl_1.441
Desorption electrospray ionization and matrix-assisted laser desorption/ionization as imaging approaches for biological samples analysis Maciel L.Í.L.; Bernardo R.A. et al. Analytical and Bioanalytical Chemistry https://doi.org/10.46936/genr.proj.2002.3171/60003925
Spatial Lipidomics Reveals Lipid Changes in the Cotyledon and Plumule of Mung Bean Seeds during Germination Xie P.; Chen J. et al. Journal of Agricultural and Food Chemistry https://doi.org/10.1021/acs.jafc.3c06029.s001
Recent Contributions of Mass Spectrometry-Based “Omics” in the Studies of Breast Cancer Banerjee S.; Hatimuria M. et al. Chemical Research in Toxicology https://doi.org/10.1021/acs.chemrestox.3c00223
How the Oviduct Lipidomic Profile Changes over Time after the Start of an Obesogenic Diet in an Outbred Mouse Model Moorkens K.; Leroy J.L. et al. Biology https://doi.org/10.3390/biology12071016
Extracellular Vesicles Contribute to the Difference in Lipid Composition between Ovarian Follicles of Different Size Revealed by Mass Spectrometry Imaging Maugrion E.; Shedova E.N. et al. Metabolites https://doi.org/10.3390/metabo13091001
Multilayered regulation of developmentally programmed pre-anthesis tip degeneration of the barley inflorescence Shanmugaraj N.; Rajaraman J. et al. The Plant Cell https://doi.org/10.1093/plcell/koad164
SETD2 deficiency accelerates sphingomyelin accumulation and promotes the development of renal cancer Rao H.; Liu C. et al. Nature Communications https://doi.org/10.1038/s41467-023-43378-w
Translating genomic tools to Raman spectroscopy analysis enables high-dimensional tissue characterization on molecular resolution Sigle M.; Rohlfing A. et al. Nature Communications https://doi.org/10.1038/s41467-023-41417-0
Diverse organ-specific localisation of a chemical defence, cyanogenic glycosides, in flowers of eleven species of Proteaceae Ritmejerytė E.; Boughton B.A. et al. Plos one https://doi.org/10.1371/journal.pone.0285007
High spatial resolution mass spectrometry imaging for spatial metabolomics: Advances, challenges, and future perspectives Ma S.; Leng Y. et al. TrAC Trends in Analytical Chemistry https://doi.org/10.1016/j.trac.2022.116902
Lysolipids are prominent in subretinal drusenoid deposits, a high-risk phenotype in age-related macular degeneration Anderson D.M.; Kotnala A. et al. Frontiers in ophthalmology https://doi.org/10.3389/fopht.2023.1258734
Patterns of carbon-bound exogenous compounds impact disease pathophysiology in lung cancer subtypes in different ways Shen J.; Sun N. et al. ACS nano https://doi.org/10.1021/acsnano.2c11161.s001
Unveiling a CAAX Protease‐Like Protein Involved in Didemnin Drug Maturation and Secretion Zou X.; Hui Z. et al. Advanced Science https://doi.org/10.1002/advs.202306044
Identifying lipid traces of atherogenic mechanisms in human carotid plaque Slijkhuis N.; Towers M. et al. Atherosclerosis https://doi.org/10.1016/j.atherosclerosis.2023.117340
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Spatially resolved metabolomics and isotope tracing reveal dynamic metabolic responses of dentate granule neurons with acute stimulation Miller A.; York E.M. et al. Nature Metabolism https://doi.org/10.1038/s42255-023-00890-z
Analysis of n-linked glycan alterations in tissue and serum reveals promising biomarkers for intrahepatic cholangiocarcinoma Ochoa-Rios S.; Blaschke C.R. et al. Cancer Research Communications https://doi.org/10.1158/2767-9764.crc-22-0422
Deletion of Cardiac Fgf23 Impairs Myocardial Energy Metabolism and Ameliorates Fibrosis in a Pressure Overload Model in Mice Erben R.; Latic N. et al. https://doi.org/10.21203/rs.3.rs-3705542/v1
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Liberation of host heme by Clostridioides difficile-mediated damage enhances Enterococcus faecalis fitness during infection Smith A.B.; Specker J.T. et al. Mbio https://doi.org/10.1128/mbio.01656-23
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Strigolactones repress nodule development and senescence in pea Van Dingenen J.; De Keyser A. et al. The Plant Journal https://doi.org/10.1111/tpj.16421
Interpretable dimensionality reduction and classification of mass spectrometry imaging data in a visceral pain model via non-negative matrix factorization Pathirage K.; Virmani A. et al. bioRxiv https://doi.org/10.1101/2023.04.24.538180
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SCiLS™ Lab Bibliography 2022

Title Author Publication Link
The fatal trajectory of pulmonary COVID-19 is driven by lobular ischemia and fibrotic remodelling. Ackermann M, Kamp JC et al. EBioMedicine 2022;85:104296 https://doi.org/10.1016/j.ebiom.2022.104296
A Protocol for the Acquisition of Comprehensive Proteomics Data from Single Cases Using Formalin-Fixed Paraffin Embedded Sections. Acland M, Mittal P et al. Methods Protoc 2022;5(4) https://doi.org/10.3390/mps5040057
Venoms for all occasions: The functional toxin profiles of different anatomical regions in sea anemones are related to their ecological function. Ashwood LM, Undheim EAB et al. Mol Ecol 2022;31(3):866-883 https://doi.org/10.1111/mec.16286
An overview of image registration for aligning mass spectrometry imaging with clinically relevant imaging modalities. Balluff B ,Heeren RMA ,Race AM J Mass Spectrom Adv Clin Lab 2022;23:26-38 https://doi.org/10.1016/j.jmsacl.2021.12.006
Mass spectrometry-based metabolomics in microbiome investigations. Bauermeister A, Mannochio-Russo H et al. Nat Rev Microbiol 2022;20(3):143-160 https://doi.org/10.1038/s41579-021-00621-9
Fallopian tube secreted protein affects ovarian metabolites in high grade serous ovarian cancer. Bergsten TM, Levy SE et al. Front Cell Dev Biol 2022;10:1042734 https://doi.org/10.3389/fcell.2022.1042734
Mass spectrometry imaging to explore molecular heterogeneity in cell culture. Bien T, Koerfer K et al. Proc Natl Acad Sci U S A 2022;119(29):e2114365119 https://doi.org/10.1073/pnas.2114365119
Integrating age, BMI, and serum N-glycans detected by MALDI mass spectrometry to classify suspicious mammogram findings as benign lesions or breast cancer. Blaschke CRK, Hill EG et al. Sci Rep 2022;12(1):20801 https://doi.org/10.1038/s41598-022-25401-0
Neuroinflammation in neuronopathic Gaucher disease: Role of microglia and NK cells, biomarkers, and response to substrate reduction therapy. Boddupalli CS, Nair S et al. Elife 2022;11 https://doi.org/10.7554/eLife.79830
MALDI Mass Spectrometry Imaging for the Distinction of Adenocarcinomas of the Pancreas and Biliary Tree. Bollwein C, Gonҫalves JPL et al. Molecules 2022;27(11) https://doi.org/10.3390/molecules27113464
Evaluation of Quantitative Platforms for Single Target Mass Spectrometry Imaging. Bowman AP, Sawicki J et al. Pharmaceuticals (Basel) 2022;15(10) https://doi.org/10.3390/ph15101180
High-Mannose N-Glycans as Malignant Progression Markers in Early-Stage Colorectal Cancer. Boyaval F, Dalebout H et al. Cancers (Basel) 2022;14(6) https://doi.org/10.3390/cancers14061552
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Visualizing the Distribution of Lipids in Peanut Seeds by MALDI Mass Spectrometric Imaging. Wang X, Chen Y et al. Foods 2022;11(23) https://doi.org/10.3390/foods11233888
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Mapping Glucose Uptake, Transport and Metabolism in the Bovine Lens Cortex. Zahraei A, Guo G et al. Front Physiol 2022;13:901407 https://doi.org/10.3389/fphys.2022.901407
Enhanced Spatial Mapping of Histone Proteoforms in Human Kidney Through MALDI-MSI by High-Field UHMR-Orbitrap Detection. Zemaitis KJ, Veličković D et al. Anal Chem 2022;94(37):12604-12613 https://doi.org/10.1021/acs.analchem.2c01034
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MALDI Mass Spectrometry Imaging highlights specific metabolome and lipidome profiles in salivary gland tumor tissues Sommella E.; Salviati E. et al. Metabolites https://doi.org/10.3390/metabo12060530
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On-tissue derivatization for isomer-specific mass spectrometry imaging and relative quantification of monosaccharides in biological tissues Han Y.; Zhao Y. et al. Analytica Chimica Acta https://doi.org/10.1016/j.aca.2022.340241
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Path to clonal theranostics in luminal breast cancers Hajjaji N.; Aboulouard S. et al. Frontiers in Oncology https://doi.org/10.2139/ssrn.3907620
Spatial dynamic metabolomics identifies metabolic cell fate trajectories in human kidney differentiation Wang G.; Heijs B. et al. Cell Stem Cell https://doi.org/10.1016/j.stem.2022.10.008
iMS2Net: a multiscale networking methodology to decipher metabolic synergy of organism Dong J.; Peng Q. et al. Iscience https://doi.org/10.2139/ssrn.4113511
‘On the spot’digital pathology of breast cancer based on single-cell mass spectrometry imaging Cuypers E.; Claes B.S. et al. Analytical Chemistry https://doi.org/10.1021/acs.analchem.1c05238.s001
Venoms for all occasions: the functional toxin profiles of different anatomical regions in sea anemones are related to their ecological function Ashwood L.M.; Undheim E.A. et al. Molecular Ecology https://doi.org/10.1111/mec.16286
Mass Spectrometry Imaging of Lipids Using MALDI Coupled with Plasma-Based Post-Ionization on a Trapped Ion Mobility Mass Spectrometer Michael J.A.; Mutuku S.M. et al. Analytical Chemistry https://doi.org/10.1021/acs.analchem.2c03745.s001
Multilevel human secondary lymphoid immune system compartmentalization revealed by complementary multiplexing and mass spectrometry imaging approaches Oyler B.L.; Valencia-Davila J.A. et al. bioRxiv https://doi.org/10.1101/2022.11.01.514691
Analyzing cell-type-specific dynamics of metabolism in kidney repair Wang G.; Heijs B. et al. Nature Metabolism https://doi.org/10.21203/rs.3.pex-1912/v1
Correlating Mass Spectrometry Imaging and Liquid Chromatography-Tandem Mass Spectrometry for Tissue-Based Pharmacokinetic Studies Dannhorn A.; Kazanc E. et al. Metabolites https://doi.org/10.3390/metabo12030261
MALDI Mass Spectrometry Imaging of Lipids on Free-Floating Brain Sections and Immunohistochemically Colocalized Markers of Neurodegeneration Strnad Š.; Strnadová V. et al. Mass Spectrometry Imaging of Small Molecules: Methods and Protocols https://doi.org/10.1007/978-1-0716-2030-4_16
Method to visualize the intratumor distribution and impact of gemcitabine in pancreatic ductal adenocarcinoma by multimodal imaging Strittmatter N.; Richards F.M. et al. Analytical Chemistry https://doi.org/10.1021/acs.analchem.1c04579.s001
Application of artificial intelligence in the diagnosis and prognostic prediction of ovarian cancer Zhou J.; Cao W. et al. Computers in Biology and Medicine https://doi.org/10.1016/j.compbiomed.2022.105608
Acquiring thin histological sections of açaí (Euterpe oleracea Mart.) seeds for molecular mapping by mass spectrometry imaging Brum F.L.; Martins G.R. et al. bioRxiv https://doi.org/10.1101/2022.08.20.504526
Integration of imaging modalities with lipidomic characterization to investigate MSCs potency metrics Priyadarshani P.; Van Grouw A. et al. bioRxiv https://doi.org/10.1101/2022.05.25.493259
Multimodal Imaging Mass Spectrometry of Murine Gastrointestinal Tract with Retained Luminal Content Guiberson E.R.; Good C.J. et al. Journal of the American Society for Mass Spectrometry https://doi.org/10.1021/jasms.1c00360
Master thesis: New Cytomine modules for multimodal studies and mass spectrometry imaging Amodei M. https://doi.org/10.1039/9781839165191-00457
MALDI-MSI: A Powerful Approach to Understand Primary Pancreatic Ductal Adenocarcinoma and Metastases Gonçalves J.P.L.; Bollwein C. et al. Molecules https://doi.org/10.3390/molecules27154811
KineticMSI, an R-based framework for relative quantification of spatial isotopic incorporation in mass spectrometry imaging experiments Farzana F.; Martinez-Seidel F. et al. bioRxiv https://doi.org/10.1101/2022.08.31.505954
Physiological constraints dictate toxin spatial heterogeneity in snake venom glands Kazandjian T.D.; Hamilton B.R. et al. BMC biology https://doi.org/10.1186/s12915-022-01350-y
Spatially Resolved Metabolites in Stable and Vulnerable Human Atherosclerotic Plaques Identified by Mass Spectrometry Imaging Seeley E.H.; Liu Z. et al. bioRxiv https://doi.org/10.1161/atvb.42.suppl_1.441
Mass spectrometry-based metabolomics in microbiome investigations Bauermeister A.; Mannochio-Russo H. et al. Nature Reviews Microbiology https://doi.org/10.1038/s41579-021-00621-9
Spatial N-glycomics with MALDI-MSI for human kidney tissue Velickovic D.; Sharma K. et al. https://doi.org/10.17504/protocols.io.8epv5j1m4l1b/v2
The metabolic landscape in chronic rotator cuff tear reveals tissue‐region‐specific signatures Olie C.S.; van Zeijl R. et al. Journal of cachexia, sarcopenia and muscle https://doi.org/10.1002/jcsm.12873
iSegMSI: an interactive strategy to improve spatial segmentation of mass spectrometry imaging data Guo L.; Liu X. et al. Analytical Chemistry https://doi.org/10.1021/acs.analchem.2c01456.s001
High-mannose N-glycans as malignant progression markers in early-stage colorectal cancer Boyaval F.; Dalebout H. et al. Cancers https://doi.org/10.3390/cancers14061552
Enhanced spatial mapping of histone proteoforms in human kidney through MALDI-MSI by high-field UHMR-orbitrap detection Zemaitis K.J.; Veličković D. et al. Analytical chemistry https://doi.org/10.1021/acs.analchem.2c01034
Evaluation of formalin-fixed and FFPE tissues for spatially resolved metabolomics and drug distribution studies Dannhorn A.; Swales J.G. et al. Pharmaceuticals https://doi.org/10.3390/ph15111307
Three-dimensional mass spectrometry imaging reveals distributions of lipids and the drug metabolite associated with the enhanced growth of colon cancer cell spheroids treated with triclosan Xie P.; Zhang H. et al. Analytical Chemistry https://doi.org/10.1021/acs.analchem.2c00768
Multicenter Evaluation of Tissue Classification by Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging Deininger S.; Bollwein C. et al. Analytical Chemistry https://doi.org/10.5772/32133
A simple preparation step to remove excess liquid lipids in white adipose tissue enabling improved detection of metabolites via MALDI-FTICR imaging MS Wang Q.; Sun N. et al. Histochemistry and Cell Biology https://doi.org/10.1007/s00418-022-02088-y
Mass spectrometry imaging revealed sulfatides depletion in brain tissues of rats exposed in real air with high fine particulate matter Diao X.; Xie C. et al. Environmental Science & Technology Letters https://doi.org/10.1021/acs.estlett.2c00615
Utilizing imaging mass spectrometry to analyze microbial biofilm chemical responses to exogenous compounds McCaughey C.S.; Trebino M.A. et al. Methods in Enzymology https://doi.org/10.1016/bs.mie.2021.11.014
Spatially revealed perfluorooctane sulfonate-induced nephrotoxicity in mouse kidney using atmospheric pressure MALDI mass spectrometry imaging Chen Y.; Jiang L. et al. Science of The Total Environment https://doi.org/10.1016/j.scitotenv.2022.156380
GlycoFibroTyper: A novel method for the glycan analysis of IgG and the development of a biomarker signature of liver fibrosis Scott D.A.; Wang M. et al. Frontiers in Immunology https://doi.org/10.3389/fimmu.2022.797460
Multiomic Mass Spectrometry Imaging to Advance Future Pathological Understanding of Ocular Disease Millar J.; Ozaki E. et al. Metabolites https://doi.org/10.3390/metabo12121239
Imaging mass spectrometry reveals complex lipid distributions across Staphylococcus aureus biofilm layers Rivera E.S.; Weiss A. et al. Journal of Mass Spectrometry and Advances in the Clinical lab https://doi.org/10.1016/j.jmsacl.2022.09.003
Spatial Multiomics of Lipids, N-Glycans, and Tryptic Peptides on a Single FFPE Tissue Section Denti V.; Capitoli G. et al. Journal of Proteome Research https://doi.org/10.1021/acs.jproteome.2c00601.s001
Visualizing the spatial distribution of functional metabolites in Forsythia suspensa at different harvest stages by MALDI mass spectrometry imaging Jing F.; Wang L. et al. Fitoterapia https://doi.org/10.1016/j.fitote.2022.105285
Resolving the developmental distribution patterns of polyphenols and related primary metabolites in bilberry (Vaccinium myrtillus) fruit Dare A.P.; Günther C.S. et al. Food Chemistry https://doi.org/10.1016/j.foodchem.2021.131703
Structural amyloid plaque polymorphism is associated with distinct lipid accumulations revealed by trapped ion mobility mass spectrometry imaging Michno W.; Wehrli P.M. et al. Journal of Neurochemistry https://doi.org/10.26434/chemrxiv-2021-w1470
High spatial resolution MALDI imaging mass spectrometry of fresh-frozen bone Good C.J.; Neumann E.K. et al. Analytical chemistry https://doi.org/10.1021/acs.analchem.1c04604.s001
Multiplexed neuropeptide mapping in ant brains integrating microtomography and 3D mass spectrometry imaging Geier B.; Gil-Mansilla E. et al. bioRxiv https://doi.org/10.1101/2022.11.02.514707
In situ metabolic profile and spatial distribution of ocular tissues: New insights into dry eye disease Chen X.; Zhang C. et al. The Ocular Surface https://doi.org/10.1016/j.jtos.2021.12.013
FT-ICR mass spectrometry imaging at extreme mass resolving power using a dynamically harmonized ICR cell with 1ω or 2ω detection Tiquet M.; La Rocca R. et al. Analytical Chemistry https://doi.org/10.26434/chemrxiv-2022-5w90f-v3
Visual authentication of steroidal saponins in Allium macrostemon Bge. and Allium chinense G. Don using MALDI-TOF imaging mass spectrometry and their structure activity relationship Duan S.; Li X. et al. Arabian Journal of Chemistry https://doi.org/10.1016/j.arabjc.2022.104138
Mass spectrometry imaging discriminates glioblastoma tumor cell subpopulations and different microvascular formations based on their lipid profiles O’Neill K.C.; Liapis E. et al. Scientific Reports https://doi.org/10.1038/s41598-022-22093-4
Spatial metabolomics shows contrasting phosphonolipid distributions in tissues of marine bivalves Bourceau P.; Michellod D. et al. PeerJ Analytical Chemistry https://doi.org/10.7287/peerj-achem.21v0.1/reviews/2
Quaternized Acridine Maleimide MALDI Probe Enables Mass Spectrometry Imaging of Thiols Ma Z.; Yuan J. et al. Analytical Chemistry https://doi.org/10.1021/acs.analchem.2c02292.s001
Matrix-assisted laser desorption/ionization mass spectrometry imaging reveals “Spatial-Temporal-Content” changes of parishins in Gastrodiae Rhizoma during the steaming process Ma T.; Sun C. et al. Food Research International https://doi.org/10.1016/j.foodres.2022.112092
Acute lyme disease IgG N-linked glycans contrast the canonical inflammatory signature Haslund-Gourley B.S.; Grauzam S. et al. Frontiers in Immunology https://doi.org/10.1101/2022.05.09.491121
Deep multilayer brain omics identifies the potential involvement of menopause molecular networks in Gliomas’ disease progression Liu C.; Zhang W. et al. The FASEB Journal https://doi.org/10.1096/fj.202200427rr
Chiral derivatization-enabled discrimination and on-tissue detection of proteinogenic amino acids by ion mobility mass spectrometry Xie C.; Chen Y. et al. Chemical Science https://doi.org/10.1101/2022.07.04.498692
Cryo-ultramicrotomy and mass spectrometry imaging analysis of nudibranch microstructures Hamilton B.R.; Chan W. et al. Journal of the American Society for Mass Spectrometry https://doi.org/10.1021/jasms.1c00254.s001
Spatial metabolomics reveals upregulation of several pyrophosphate-producing pathways in cortical bone of Hyp mice Buck A.; Prade V.M. et al. JCI insight https://doi.org/10.1172/jci.insight.162138
Spatial quantitation of antibiotics in bone tissue compartments by laser-capture microdissection coupled with UHPLC-tandem mass spectrometry Kaya F.; Zimmerman M.D. et al. Analytical and Bioanalytical Chemistry https://doi.org/10.1007/s00216-022-04257-3
Impact of Skin Tissue Collection Method on Downstream MALDI-Imaging Yadav M.; Chaudhary P.P. et al. Metabolites https://doi.org/10.3390/metabo12060497
A Protocol for the Acquisition of Comprehensive Proteomics Data from Single Cases Using Formalin-Fixed Paraffin Embedded Sections Acland M.; Mittal P. et al. Methods and Protocols https://doi.org/10.3390/mps5040057
Sphingomyelinases in retinas and optic nerve heads: Effects of ocular hypertension and ischemia Fan J.; Liu J. et al. Experimental Eye Research https://doi.org/10.1016/j.exer.2022.109250
High-throughput screening and spatial profiling of low-mass pesticides using a novel Ti3C2 MXene nanowire (TMN) as MALDI MS matrix Ma C.; Wang X. et al. Chemosphere https://doi.org/10.1016/j.chemosphere.2021.131826
Pro-inflammatory IgG1 N-glycan signature correlates with primary graft dysfunction onset in COPD patients McQuiston A.; Scott D. et al. Transplant Immunology https://doi.org/10.1016/j.trim.2021.101491
FTICR Mass spectrometry imaging at extreme mass resolving power using 1 a dynamically harmonized ICR cell with 1ω or 2ω detection Tiquet M.; La Rocca R. et al. https://doi.org/10.26434/chemrxiv-2022-5w90f-v3
Advances in mass spectrometry imaging for spatial cancer metabolomics Ma X.; Fernández F.M. Mass Spectrometry Reviews https://doi.org/10.1002/mas.21804
On-tissue spatially resolved glycoproteomics guided by N-glycan imaging reveal global dysregulation of canine glioma glycoproteomic landscape Malaker S.A.; Quanico J. et al. Cell chemical biology https://doi.org/10.1016/j.chembiol.2021.05.007
Metabolic tumor constitution is superior to tumor regression grading for evaluating response to neoadjuvant therapy of esophageal adenocarcinoma patients Buck A.; Prade V.M. et al. The journal of pathology https://doi.org/10.1002/path.5828
On-tissue amidation of sialic acid with aniline for sensitive imaging of sialylated N-glycans from FFPE tissue sections via MALDI mass spectrometry Zhang H.; Shi X. et al. Analytical and bioanalytical chemistry https://doi.org/10.1007/s00216-022-03894-y
Spatial analysis of the glioblastoma proteome reveals specific molecular signatures and markers of survival Duhamel M.; Drelich L. et al. Nature Communications https://doi.org/10.1038/s41467-022-34208-6
Novel Combined Enzymatic Approach to Analyze Nonsialylated N-Linked Glycans through MALDI Imaging Mass Spectrometry DelaCourt A.T.; Liang H. et al. Journal of Proteome Research https://doi.org/10.1021/acs.jproteome.2c00193
MALDI imaging mass spectrometry: An emerging tool in neurology Schnackenberg L.K.; Thorn D.A. et al. Metabolic Brain Disease https://doi.org/10.1007/s11011-021-00797-2
Targeting keratin 17-mediated reprogramming of de novo pyrimidine biosynthesis to overcome chemoresistance in pancreatic cancer Pan C.; Chaika N.V. et al. bioRxiv https://doi.org/10.1158/1538-7445.panca22-b006
Pharmacological inhibition of MERTK induces in vivo retinal degeneration: a multimodal imaging ocular safety assessment Hamm G.; Maglennon G. et al. Archives of Toxicology https://doi.org/10.1007/s00204-021-03197-8
Multi-omics profiling of collagen-induced arthritis mouse model reveals early metabolic dysregulation via SIRT1 axis Li L.; Freitag J. et al. Scientific Reports https://doi.org/10.1038/s41598-022-16005-9
Plasmonic gold nanoshell-assisted laser desorption/ionization mass spectrometry for small-biomolecule analysis and tissue imaging Du M.; Chen D. et al. ACS Applied Nano Materials https://doi.org/10.1021/acs.analchem.6b01141.s001
Mass spectrometry imaging to explore molecular heterogeneity in cell culture Bien T.; Koerfer K. et al. Proceedings of the National Academy of Sciences https://doi.org/10.1007/978-1-0716-3319-9_13
Chemical traits of cerebral amyloid angiopathy in familial British‐, Danish‐, and non‐Alzheimer ʼs dementias Michno W.; Koutarapu S. et al. Journal of Neurochemistry https://doi.org/10.1111/jnc.15694
A non-dividing cell population with high pyruvate dehydrogenase kinase activity regulates metabolic heterogeneity and tumorigenesis in the intestine Sebastian C.; Ferrer C. et al. Nature Communications https://doi.org/10.1038/s41467-022-29085-y
Lipidomic analysis reveals the protection mechanism of GLP-1 analogue dulaglutide on high-fat diet-induced chronic kidney disease in mice Yeung M.H.Y.; Leung K.L. et al. Frontiers in Pharmacology https://doi.org/10.3389/fphar.2021.777395
Neuroinflammation in neuronopathic Gaucher disease: Role of microglia and NK cells, biomarkers, and response to substrate reduction therapy Boddupalli C.S.; Nair S. et al. Elife https://doi.org/10.7554/elife.79830.sa0
Dissecting the Kinetic Mechanism of Human Lysine Methyltransferase 2D and Its Interactions with the WRAD2 Complex Edwardes L.V.; Caswell S.J. et al. Biochemistry https://doi.org/10.1021/acs.biochem.2c00385
Sample preparation optimization of insects and zebrafish for whole-body mass spectrometry imaging Ma L.; Xie Q. et al. Analytical and Bioanalytical Chemistry https://doi.org/10.1021/jasms.9b00097.s001
Evaluation of quantitative platforms for single target mass spectrometry imaging Bowman A.P.; Sawicki J. et al. Pharmaceuticals https://doi.org/10.3390/ph15101180
Mass spectrometry imaging spatial tissue analysis toward personalized medicine Gonçalves J.P.; Bollwein C. et al. Life https://doi.org/10.3390/life12071037
Orthotopic Glioblastoma Models for Evaluation of the Clinical Target Volume Concept Bütof R.; Hönscheid P. et al. Cancers https://doi.org/10.3390/cancers14194559
3D-Mass Spectrometry Imaging of Micro-scale 3D Cell Culture Models in Cancer Research Iakab S.; Keller F. et al. bioRxiv https://doi.org/10.1101/2022.12.05.519157
Protein Alterations in Cardiac Ischemia/Reperfusion Revealed by Spatial-Omics Mezger S.T.; Mingels A.M. et al. International journal of molecular sciences https://doi.org/10.3390/ijms232213847
Device-Controlled Microcondensation for Spatially Confined On-Tissue Digests in MALDI Imaging of N-Glycans Fülöp A.; Marsching C. et al. Pharmaceuticals https://doi.org/10.3390/ph15111356
Structural Characterization and Spatial Mapping of Tetrodotoxins in Australian Polyclads McNab J.M.; Briggs M.T. et al. Marine Drugs https://doi.org/10.3390/md20120788
Boosting phototherapy efficacy of NIR-absorbing ruthenium (II) complex via supramolecular engineering Wang Z.; Li C. et al. Materials Today Nano https://doi.org/10.1016/j.mtnano.2022.100220
Optimization of Zebrafish Larvae Sectioning for Mass Spectrometry Imaging Yang J.; Rendino L. et al. Pharmaceuticals https://doi.org/10.3390/ph15101230
Titania Nanosheet as a Matrix for Surface-Assisted Laser Desorption/Ionization Mass Spectrometry Analysis and Imaging Gao C.; Wang Y. et al. Analytical Chemistry https://doi.org/10.1021/acs.analchem.2c01878.s001
Unravelling prostate cancer heterogeneity using spatial approaches to lipidomics and transcriptomics Mutuku S.M.; Spotbeen X. et al. Cancers https://doi.org/10.3390/cancers14071702
Reduced hemoglobin signal and improved detection of endogenous proteins in blood-rich tissues for MALDI mass spectrometry imaging Lin M.; Eberlin L.S. et al. Journal of the American Society for Mass Spectrometry https://doi.org/10.1021/jasms.1c00300.s001
Imaging mass spectrometry reveals alterations in N-linked glycosylation that are associated with histopathological changes in nonalcoholic steatohepatitis in mouse and human Ochoa-Rios S.; O'Connor I.P. et al. Molecular & Cellular Proteomics https://doi.org/10.1016/j.mcpro.2022.100225
CD138 Is Expressed in Different Entities of Salivary Gland Cancer and Their Lymph Node Metastases and Therefore Represents a Potential Therapeutic Target Mayer M.; Nachtsheim L. et al. International Journal of Molecular Sciences https://doi.org/10.3390/ijms23169037
Integrating age, BMI, and serum N-glycans detected by MALDI mass spectrometry to classify suspicious mammogram findings as benign lesions or breast cancer Blaschke C.R.; Hill E.G. et al. Scientific Reports https://doi.org/10.1038/s41598-022-25401-0
Imaging Mass Spectrometry (IMS) for drug discovery and development survey: Results on methods, applications and regulatory compliance Solon E.; Groseclose M.R. et al. Drug Metabolism and Pharmacokinetics https://doi.org/10.1016/j.dmpk.2021.100438
Spatial mapping of plant N-glycosylation cellular heterogeneity inside soybean root nodules provided insights into legume-rhizobia symbiosis Veličković D.; Liao Y. et al. Frontiers in Plant Science https://doi.org/10.3389/fpls.2022.869281
Quantifying individual responses to microbial plaque Joshi V.M. https://doi.org/10.22541/au.159225329.91452334
Unraveling metabolic alterations in transgenic mouse model of Alzheimer's disease using MALDI MS imaging with 4-aminocinnoline-3-carboxamide matrix Chen Y.; Hu D. et al. Analytica Chimica Acta https://doi.org/10.1016/j.aca.2021.339337
PALP: A rapid imaging technique for stratifying ferroptosis sensitivity in normal and tumor tissues in situ Wang F.; Graham E.T. et al. Cell Chemical Biology https://doi.org/10.1016/j.chembiol.2021.11.001
MALDI Mass Spectrometry Imaging for the Distinction of Adenocarcinomas of the Pancreas and Biliary Tree Bollwein C.; Gonҫalves J.P.L. et al. Molecules https://doi.org/10.3390/molecules27113464
Metabolic links to socioeconomic stresses uniquely affecting ancestry in normal breast tissue at risk for breast cancer Rujchanarong D.; Scott D. et al. Frontiers in Oncology https://doi.org/10.3389/fonc.2022.876651
Induction of liver size reduction in zebrafish larvae by the emerging synthetic cannabinoid 4F-MDMB-BINACA and its impact on drug metabolism Park Y.M.; Dahlem C. et al. Molecules https://doi.org/10.3390/molecules27041290
Mapping glucose uptake, transport and metabolism in the bovine lens cortex Zahraei A.; Guo G. et al. Frontiers in Physiology https://doi.org/10.3389/fphys.2022.901407
Fallopian tube secreted protein affects ovarian metabolites in high grade serous ovarian cancer Bergsten T.M.; Levy S.E. et al. Frontiers in Cell and Developmental Biology https://doi.org/10.3389/fcell.2022.1042734
An overview of image registration for aligning mass spectrometry imaging with clinically relevant imaging modalities Balluff B.; Heeren R.M. et al. Journal of Mass Spectrometry and Advances in the Clinical lab https://doi.org/10.1016/j.jmsacl.2021.12.006
In situ N-glycosylation signatures of epithelial ovarian cancer tissue as defined by MALDI mass spectrometry imaging Grzeski M.; Taube E.T. et al. Cancers https://doi.org/10.3390/cancers14041021
Effect of Micro-Patterned Mucin on Quinolone and Rhamnolipid Profiles of Mucoid Pseudomonas aeruginosa under Antibiotic Stress Jia J.; Parmar D. et al. ACS infectious diseases https://doi.org/10.1021/acsinfecdis.2c00519.s001
Lipid analysis of fracture hematoma with MALDI-MSI: Specific lipids are associated to bone fracture healing over time Groven R.V.; Nauta S.P. et al. Frontiers in Chemistry https://doi.org/10.3389/fchem.2021.780626
PARP-inhibition reprograms macrophages toward an anti-tumor phenotype Wang L.; Wang D. et al. Cell reports https://doi.org/10.1016/j.celrep.2022.111462
Spatially resolved multi-omics deciphers bidirectional tumor-host interdependence in glioblastoma Ravi V.M.; Will P. et al. Cancer Cell https://doi.org/10.2139/ssrn.3865275
Bioactive lipid screening during respiratory tract infections with bacterial and viral pathogens in mice Schultz D.; Cuypers F. et al. Metabolomics https://doi.org/10.1007/s11306-022-01898-4
The fatal trajectory of pulmonary COVID-19 is driven by lobular ischemia and fibrotic remodelling Ackermann M.; Kamp J.C. et al. EBioMedicine https://doi.org/10.1016/j.ebiom.2022.104296
Hornerin deposits in neuronal intranuclear inclusion disease: direct identification of proteins with compositionally biased regions in inclusions Park H.; Yamanaka T. et al. Acta Neuropathologica Communications https://doi.org/10.1186/s40478-022-01333-8
Generation and multiomic profiling of a TP53/CDKN2A double-knockout gastroesophageal junction organoid model Zhao H.; Cheng Y. et al. Science translational medicine https://doi.org/10.1126/scitranslmed.abq6146
Klebsiella pneumoniae induces host metabolic stress that promotes tolerance to pulmonary infection Lung T.W.F.; Charytonowicz D. et al. Cell Metabolism https://doi.org/10.1016/j.cmet.2022.03.009
Novel tumorigenic FOXM1-PTAFR-PTAF axis revealed by multi-omic profiling in TP53/CDKN2A-double knockout human gastroesophageal junction organoid model Zhao H.; Cheng Y. et al. bioRxiv https://doi.org/10.1101/2022.05.10.491356
S100A4 exerts robust mucosal adjuvant activity for co-administered antigens in mice Sen Chaudhuri A.; Yeh Y. et al. Mucosal Immunology https://doi.org/10.1038/s41385-022-00535-6
SETD2 deficiency promotes the transition from PKD to ccRCC by dysregulation of sphingomyelin metabolism Zhang Y.; Liu C. et al. bioRxiv https://doi.org/10.1101/2022.11.10.515911
Spatial reference and alternative proteome analysis of glioblastoma reveals molecular signatures and associates survival with specific markers Duhamel M.; Drelich L. et al. https://doi.org/10.1038/s41467-022-34208-6
Multiplatform metabolomics studies of human cancers with NMR and mass spectrometry imaging Zhong A.B.; Muti I.H. et al. Frontiers in Molecular Biosciences https://doi.org/10.1158/1538-7445.am2022-2322
Collection of embryos and fluid from the bovine oviduct Havlicek V.; Autz A. et al. Anim Reprod https://doi.org/10.1071/rd05048
Tetrodotoxin identified in polyclad flatworms of temperate Eastern Australia McNab J.M. https://doi.org/10.5479/si.00963801.108-3410.543
Multi-modal mass spectrometry imaging reveals single-cell metabolic states in mammalian liver Tian H.; Rajbhandari P. et al. bioRxiv https://doi.org/10.1101/2022.09.26.508878
Protective Mechanism of Polygonum perfoliatum L. Extract on Chronic Alcoholic Liver Injury Based on UHPLC-QExactive Plus Mass Spectrometry Lipidomics and MALDI-TOF/TOF Mass Spectrometry Imaging Chen H.; Peng L. et al. Foods https://doi.org/10.3390/foods11111583
In situ mass spectrometry imaging reveals heterogeneous glycogen stores in human normal and cancerous tissues Young L.E.; Conroy L.R. et al. EMBO Molecular Medicine https://doi.org/10.15252/emmm.202216029
Mass spectrometry-based differentiation of oral tongue squamous cell carcinoma and nontumor regions with the SpiderMass technology Ogrinc N.; Attencourt C. et al. Frontiers in Oral Health https://doi.org/10.3389/froh.2022.827360
Spatial metabolomics for evaluating response to neoadjuvant therapy in non‐small cell lung cancer patients Shen J.; Sun N. et al. Cancer communications https://doi.org/10.1002/cac2.12310
Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis Sato S.; Dyar K.A. et al. Cell metabolism https://doi.org/10.3410/f.741452768.793591178
Caffeine intake exerts dual genome-wide effects on hippocampal metabolism and learning-dependent transcription Paiva I.; Cellai L. et al. The Journal of clinical investigation https://doi.org/10.1172/jci149371
Glycosphingolipids are mediators of cancer plasticity through independent signaling pathways Cumin C.; Huang Y. et al. Cell Reports https://doi.org/10.1016/j.celrep.2022.111181

SCiLS™ Lab Bibliography 2021

Title Author Publication Link
Peak learning of mass spectrometry imaging data using artificial neural networks. Abdelmoula WM, Lopez BG et al. Nat Commun 2021;12(1):5544 https://doi.org/10.1038/s41467-021-25744-8
GD3 synthase deletion alters retinal structure and impairs visual function in mice. Abreu CA, Teixeira-Pinheiro LC et al. J Neurochem 2021;158:694-709 https://doi.org/10.1111/jnc.15443
Spatial differentiation of metabolism in prostate cancer tissue by MALDI-TOF MSI. Andersen MK, Høiem TS et al. Cancer Metab 2021;9(1):9 https://doi.org/10.1186/s40170-021-00242-z
Electroblotting through Enzymatic Membranes to Enhance Molecular Tissue Imaging. Andrews WT, Bickner AN et al. J Am Soc Mass Spectrom 2021;32:1689-1699 https://doi.org/10.1021/jasms.1c00046
Visualizing Cholesterol in the Brain by On-Tissue Derivatization and Quantitative Mass Spectrometry Imaging. Angelini R, Yutuc E et al. Anal Chem 2021;93(11):4932-4943 https://doi.org/10.1021/acs.analchem.0c05399
Machine learning for grading and prognosis of esophageal dysplasia using mass spectrometry and histological imaging. Beuque M, Martin-Lorenzo M et al. Comput Biol Med 2021;138:104918 https://doi.org/10.1016/j.compbiomed.2021.104918
Molecular insights into symbiosis-mapping sterols in a marine flatworm-algae-system using high spatial resolution MALDI-2-MS imaging with ion mobility separation. Bien T, Hambleton EA et al. Anal Bioanal Chem 2021;413:2767-2777 https://doi.org/10.1007/s00216-020-03070-0
Direct N-Glycosylation Profiling of Urine and Prostatic Fluid Glycoproteins and Extracellular Vesicles. Blaschke CRK, Hartig JP et al. Front Chem 2021;9:734280 https://doi.org/10.3389/fchem.2021.734280
Cross-Normalization of MALDI Mass Spectrometry Imaging Data Improves Site-to-Site Reproducibility. Boskamp T, Casadonte R et al. Anal Chem 2021;93(30):10584-10592 https://doi.org/10.1021/acs.analchem.1c01792
N-Glycomic Signature of Stage II Colorectal Cancer and Its Association With the Tumor Microenvironment. Boyaval F, van Zeijl R et al. Mol Cell Proteomics 2021;20:100057 https://doi.org/10.1074/mcp.RA120.002215
GSK-3 Inhibition Is Cytotoxic in Glioma Stem Cells through Centrosome Destabilization and Enhances the Effect of Radiotherapy in Orthotopic Models. Brüning-Richardson A, Shaw GC et al. Cancers (Basel) 2021;13(23) https://doi.org/10.3390/cancers13235939
Use of MALDI Mass Spectrometry Imaging to Identify Proteomic Signatures in Aortic Aneurysms after Endovascular Repair. Buerger M, Klein O et al. Biomedicines 2021;9(9) https://doi.org/10.3390/biomedicines9091088
Lipidomic Profiling of Clinical Prostate Cancer Reveals Targetable Alterations in Membrane Lipid Composition. Butler LM, Mah CY et al. Cancer Res 2021;81(19):4981-4993 https://doi.org/10.1158/0008-5472.CAN-20-3863
Mass spectrometry imaging of L-[ring-13C6]-labeled phenylalanine and tyrosine kinetics in non-small cell lung carcinoma. Cao J, Balluff B et al. Cancer Metab 2021;9(1):26 https://doi.org/10.1186/s40170-021-00262-9
Imaging Mass Spectrometry-Based Proteomic Analysis to Differentiate Melanocytic Nevi and Malignant Melanoma. Casadonte R, Kriegsmann M et al. Cancers (Basel) 2021;13(13) https://doi.org/10.3390/cancers13133197
Visualization of HIV-1 reservoir: an imaging perspective. Chapon C, Moysi E et al. Curr Opin HIV AIDS 2021;16(4):232-239 https://doi.org/10.1097/COH.0000000000000691
Trends in oligomannosylation and α1,2-mannosidase expression in human cancers. Chatterjee S, Ugonotti J et al. Oncotarget 2021;12(21):2188-2205 https://doi.org/10.18632/oncotarget.28064
Mass spectrometry imaging revealed alterations of lipid metabolites in multicellular tumor spheroids in response to hydroxychloroquine. Chen Y, Wang T et al. Anal Chim Acta 2021;1184:339011 https://doi.org/10.1016/j.aca.2021.339011
Multiplexed imaging mass spectrometry of the extracellular matrix using serial enzyme digests from formalin-fixed paraffin-embedded tissue sections. Clift CL, Drake RR et al. Anal Bioanal Chem 2021;413:2709-2719 https://doi.org/10.1007/s00216-020-03047-z
Proteomic Analysis Identifies FNDC1, A1BG, and Antigen Processing Proteins Associated with Tumor Heterogeneity and Malignancy in a Canine Model of Breast Cancer. Cordeiro YG, Mulder LM et al. Cancers (Basel) 2021;13(23) https://doi.org/10.3390/cancers13235901
Muscle metabolic remodelling patterns in Duchenne muscular dystrophy revealed by ultra-high-resolution mass spectrometry imaging. Dabaj I, Ferey J et al. Sci Rep 2021;11(1):1906 https://doi.org/10.1038/s41598-021-81090-1
N-Glycosylation Patterns Correlate with Hepatocellular Carcinoma Genetic Subtypes. DelaCourt A, Black A et al. Mol Cancer Res 2021;19(11):1868-1877 https://doi.org/10.1158/1541-7786.MCR-21-0348
Reproducible Lipid Alterations in Patient-Derived Breast Cancer Xenograft FFPE Tissue Identified with MALDI MSI for Pre-Clinical and Clinical Application. Denti V, Andersen MK et al. Metabolites 2021;11(9) https://doi.org/10.3390/metabo11090577
Lipidomic Typing of Colorectal Cancer Tissue Containing Tumour-Infiltrating Lymphocytes by MALDI Mass Spectrometry Imaging. Denti V, Mahajneh A et al. Metabolites 2021;11(9) https://doi.org/10.3390/metabo11090599
Lesion Penetration and Activity Limit the Utility of Second-Line Injectable Agents in Pulmonary Tuberculosis. Ernest JP, Sarathy J et al. Antimicrob Agents Chemother 2021;65(10):e0050621 https://doi.org/10.1128/AAC.00506-21
Heterogeneity of Lipid and Protein Cartilage Profiles Associated with Human Osteoarthritis with or without Type 2 Diabetes Mellitus. Eveque-Mourroux MR, Emans PJ et al. J Proteome Res 2021;20(5):2973-2982 https://doi.org/10.1021/acs.jproteome.1c00186
Molecular Mapping of Neutral Lipids Using Silicon Nanopost Arrays and TIMS Imaging Mass Spectrometry. Fincher JA, Djambazova KV et al. J Am Soc Mass Spectrom 2021;32(10):2519-2527 https://doi.org/10.1021/jasms.1c00159
Comparison of Osteosarcoma Aggregated Tumour Models with Human Tissue by Multimodal Mass Spectrometry Imaging. Flint LE, Hamm G et al. Metabolites 2021;11(8) https://doi.org/10.3390/metabo11080506
Mass spectrometry imaging identifies abnormally elevated brain l-DOPA levels and extrastriatal monoaminergic dysregulation in l-DOPA-induced dyskinesia. Fridjonsdottir E, Shariatgorji R et al. Sci Adv 2021;7(2) https://doi.org/10.1126/sciadv.abe5948
Connecting structure and function from organisms to molecules in small-animal symbioses through chemo-histo-tomography. Geier B, Oetjen J et al. Proc Natl Acad Sci U S A 2021;118(27) https://doi.org/10.1073/pnas.2023773118
Integrative Metabolomics Reveals Deep Tissue and Systemic Metabolic Remodeling in Glioblastoma. Gilard V, Ferey J et al. Cancers (Basel) 2021;13(20) https://doi.org/10.3390/cancers13205157
The Impact of Histological Annotations for Accurate Tissue Classification Using Mass Spectrometry Imaging. Gonçalves JPL, Bollwein C et al. Metabolites 2021;11(11) https://doi.org/10.3390/metabo11110752
Lipid Analysis of Fracture Hematoma With MALDI-MSI: Specific Lipids are Associated to Bone Fracture Healing Over Time. Groven RVM, Nauta SP et al. Front Chem 2021;9:780626 https://doi.org/10.3389/fchem.2021.780626
Data Filtering and Its Prioritization in Pipelines for Spatial Segmentation of Mass Spectrometry Imaging. Guo L, Hu Z et al. Anal Chem 2021;93(11):4788-4793 https://doi.org/10.1021/acs.analchem.0c05242
Transcriptomic, peptidomic, and mass spectrometry imaging analysis of the brain in the ant Cataglyphis nodus. Habenstein J, Schmitt F et al. J Neurochem 2021;158:391-412 https://doi.org/10.1111/jnc.15346
Path to Clonal Theranostics in Luminal Breast Cancers. Hajjaji N, Aboulouard S et al. Front Oncol 2021;11:802177 https://doi.org/10.3389/fonc.2021.802177
Complementing Matrix-Assisted Laser Desorption Ionization-Mass Spectrometry Imaging with Chromatography Data for Improved Assignment of Isobaric and Isomeric Phospholipids Utilizing Trapped Ion Mobility-Mass Spectrometry. Helmer PO, Nordhorn ID et al. Anal Chem 2021;93:2135-2143 https://doi.org/10.1021/acs.analchem.0c03942
Registration of Image Modalities for Analyses of Tissue Samples Using 3D Image Modelling. Hermann J, Brehmer K et al. Proteomics Clin Appl 2021;15(1):e1900143 https://doi.org/10.1002/prca.201900143
An imaging mass spectrometry atlas of lipids in the human neurologically normal and Huntington's disease caudate nucleus. Hunter M, Demarais NJ et al. J Neurochem 2021;157:2158-2172 https://doi.org/10.1111/jnc.15325
Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging of Phospholipid Changes in a Drosophila Model of Early Amyotrophic Lateral Sclerosis. Jang HJ, Le MUT et al. J Am Soc Mass Spectrom 2021;32(10):2536-2545 https://doi.org/10.1021/jasms.1c00167
Biopolymer Patterning-Directed Secretion in Mucoid and Nonmucoid Strains of Pseudomonas aeruginosa Revealed by Multimodal Chemical Imaging. Jia J, Ellis JF et al. ACS Infect Dis 2021;7(3):598-607 https://doi.org/10.1021/acsinfecdis.0c00765
Classification of Molecular Subtypes of High-Grade Serous Ovarian Cancer by MALDI-Imaging. Kassuhn W, Klein O et al. Cancers (Basel) 2021;13(7) https://doi.org/10.3390/cancers13071512
Protease-dependent defects in N-cadherin processing drive PMM2-CDG pathogenesis. Klaver EJ, Dukes-Rimsky L et al. JCI Insight 2021;6(24) https://doi.org/10.1172/jci.insight.153474
Toward Revealing Microcystin Distribution in Mouse Liver Tissue Using MALDI-MS Imaging. Kucheriavaia D, Veličković D et al. Toxins (Basel) 2021;13(10) https://doi.org/10.3390/toxins13100709
Patterns of Carbon-Bound Exogenous Compounds in Patients with Lung Cancer and Association with Disease Pathophysiology. Kunzke T, Prade VM et al. Cancer Res 2021;81(23):5862-5875 https://doi.org/10.1158/0008-5472.CAN-21-1175
MALDI-IMS combined with shotgun proteomics identify and localize new factors in male infertility. Lahiri S, Aftab W et al. Life Sci Alliance 2021;4(3) https://doi.org/10.26508/lsa.202000672
Absolute quantification of 2-hydroxyglutarate on tissue by matrix-assisted laser desorption/ionization mass spectrometry imaging for rapid and precise identification of isocitrate dehydrogenase mutations in human glioma. Lan C, Li H et al. Int J Cancer 2021;149(12):2091-2098 https://doi.org/10.1002/ijc.33729
Mitochondrial Ndufa4l2 Enhances Deposition of Lipids and Expression of Ca9 in the TRACK Model of Early Clear Cell Renal Cell Carcinoma. Laursen KB, Chen Q et al. Front Oncol 2021;11:783856 https://doi.org/10.3389/fonc.2021.783856
Therapeutic Potential of Fosmanogepix (APX001) for Intra-abdominal Candidiasis: from Lesion Penetration to Efficacy in a Mouse Model. Lee A, Wang N et al. Antimicrob Agents Chemother 2021;65 https://doi.org/10.1128/AAC.02476-20
A digital single-molecule nanopillar SERS platform for predicting and monitoring immune toxicities in immunotherapy. Li J, Wuethrich A et al. Nat Commun 2021;12(1):1087 https://doi.org/10.1038/s41467-021-21431-w
Three-Dimensional Imaging of Whole-Body Zebrafish Revealed Lipid Disorders Associated with Niemann-Pick Disease Type C1. Liang X, Cao S et al. Anal Chem 2021;93:8178-8187 https://doi.org/10.1021/acs.analchem.1c00196
Spatially Resolved Metabolomics and Lipidomics Reveal Salinity and Drought-Tolerant Mechanisms of Cottonseeds. Liu B, Wang X et al. J Agric Food Chem 2021;69(28):8028-8037 https://doi.org/10.1021/acs.jafc.1c01598
Examination of lipid profiles in abdominal fascial healing using MALDI-TOF to identify potential therapeutic targets. Liu H, Cao J et al. J Mass Spectrom Adv Clin Lab 2021;20:35-41 https://doi.org/10.1016/j.jmsacl.2021.06.002
Peptide Signatures for Prognostic Markers of Pancreatic Cancer by MALDI Mass Spectrometry Imaging. Loch FN, Klein O et al. Biology (Basel) 2021;10(10) https://doi.org/10.3390/biology10101033
Tumor resistance to ferroptosis driven by Stearoyl-CoA Desaturase-1 (SCD1) in cancer cells and Fatty Acid Biding Protein-4 (FABP4) in tumor microenvironment promote tumor recurrence. Luis G, Godfroid A et al. Redox Biol 2021;43:102006 https://doi.org/10.1016/j.redox.2021.102006
A Mass Spectrometry Imaging Based Approach for Prognosis Prediction in UICC Stage I/II Colon Cancer. Martin B, Gonçalves JPL et al. Cancers (Basel) 2021;13(21) https://doi.org/10.3390/cancers13215371
Rapid visualization of lipopeptides and potential bioactive groups of compounds by combining ion mobility and MALDI imaging mass spectrometry. McCann A, Kune C et al. Drug Discov Today Technol 2021;39:81-88 https://doi.org/10.1016/j.ddtec.2021.08.003
Imaging Mass Spectrometry and Lectin Analysis of N-Linked Glycans in Carbohydrate Antigen-Defined Pancreatic Cancer Tissues. McDowell CT, Klamer Z et al. Mol Cell Proteomics 2021;20:100012 https://doi.org/10.1074/mcp.RA120.002256
Study of the Distribution of Acetaminophen and Its Metabolites in Rats, from the Whole-Body to Isolated Organ Levels, by Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging after On-Tissue Chemical Derivatization. Merdas M, Lagarrigue M et al. Anal Chem 2021;93(39):13242-13250 https://doi.org/10.1021/acs.analchem.1c02487
Mass Spectrometry Spatial-Omics on a Single Conductive Slide. Mezger STP, Mingels AMA et al. Anal Chem 2021;93:2527-2533 https://doi.org/10.1021/acs.analchem.0c04572
Cancer Tissue Classification Using Supervised Machine Learning Applied to MALDI Mass Spectrometry Imaging. Mittal P, Condina MR et al. Cancers (Basel) 2021;13(21) https://doi.org/10.3390/cancers13215388
Lipid signature of advanced human carotid atherosclerosis assessed by mass spectrometry imaging. Moerman AM, Visscher M et al. J Lipid Res 2021;62:100020 https://doi.org/10.1194/jlr.RA120000974
Complementary Lipidomic, Proteomic, and Mass Spectrometry Imaging Approach to the Characterization of the Acute Effects of Radiation in the Non-human Primate Mesenteric Lymph Node after Partial-body Irradiation with Minimal Bone Marrow Sparing. Muller L, Huang W et al. Health Phys 2021;121(4):372-383 https://doi.org/10.1097/HP.0000000000001470
Imaging lipids in biological samples with surface-assisted laser desorption/ionization mass spectrometry: A concise review of the last decade. Müller WH, De Pauw E et al. Prog Lipid Res 2021;83:101114 https://doi.org/10.1016/j.plipres.2021.101114
Spatial metabolomics using imaging mass spectrometry to identify the localization of asparaptine A in Asparagus officinalis. Nakabayashi R, Hashimoto K et al. Plant Biotechnol (Tokyo) 2021;38(3):311-315 https://doi.org/10.5511/plantbiotechnology.21.0504b
A new technological approach in diagnostic pathology: mass spectrometry imaging-based metabolomics for biomarker detection in urachal cancer. Neumann JM, Niehaus K et al. Lab Invest 2021;101:1281-1288 https://doi.org/10.1038/s41374-021-00612-7
A new technological approach in diagnostic pathology: mass spectrometry imaging-based metabolomics for biomarker detection in urachal cancer. Neumann JM, Niehaus K et al. Lab Invest 2021;101(9):1281-1288 https://doi.org/10.1038/s41374-021-00612-7
Mass spectrometry-based protein identification in proteomics-a review. Noor Z, Ahn SB et al. Brief Bioinform 2021;22(2):1620-1638 https://doi.org/10.1093/bib/bbz163
Tryptophan metabolism is inversely regulated in the tumor and blood of patients with glioblastoma. Panitz V, Končarević S et al. Theranostics 2021;11(19):9217-9233 https://doi.org/10.7150/thno.60679
MALDI-IMS as a Tool to Determine the Myocardial Response to Syndecan-2-Selected Mesenchymal Stromal Cell Application in an Experimental Model of Diabetic Cardiomyopathy. Pappritz K, Klein O et al. Proteomics Clin Appl 2021;15(1):e2000050 https://doi.org/10.1002/prca.202000050
Fast Nanoliter-Scale Cell Assays Using Droplet Microarray-Mass Spectrometry Imaging. RamalloGuevara C, Paulssen D et al. Adv Biol (Weinh) 2021;5(3):e2000279 https://doi.org/10.1002/adbi.202000279
Mineralization of 3D Osteogenic Model Based on Gelatin-Dextran Hybrid Hydrogel Scaffold Bioengineered with Mesenchymal Stromal Cells: A Multiparametric Evaluation. Re F, Sartore L et al. Materials (Basel) 2021;14(14) https://doi.org/10.3390/ma14143852
Complete spatial characterisation of N-glycosylation upon striatal neuroinflammation in the rodent brain. Rebelo AL, Gubinelli F et al. J Neuroinflammation 2021;18(1):116 https://doi.org/10.1186/s12974-021-02163-6
Safety, Tissue Distribution, and Metabolism of LNA-Containing Antisense Oligonucleotides in Rats. Romero-Palomo F, Festag M et al. Toxicol Pathol 2021;49:1174-1192 https://doi.org/10.1177/01926233211011615
Defining the Tumor Microenvironment by Integration of Immunohistochemistry and Extracellular Matrix Targeted Imaging Mass Spectrometry. Rujchanarong D, Lefler J et al. Cancers (Basel) 2021;13(17) https://doi.org/10.3390/cancers13174419
Clinical importance of high-mannose, fucosylated, and complex N-glycans in breast cancer metastasis. Ščupáková K, Adelaja OT et al. JCI Insight 2021;6(24) https://doi.org/10.1172/jci.insight.146945
CRL4AMBRA1 is a master regulator of D-type cyclins. Simoneschi D, Rona G et al. Nature 2021;592(7856):789-793 https://doi.org/10.1038/s41586-021-03445-y
Elaboration Pipeline for the Management of MALDI-MS Imaging Datasets. Smith A, Piga I et al. Methods Mol Biol 2021;2361:129-142 https://doi.org/10.1007/978-1-0716-1641-3_8
Traumatic brain injury induces region-specific glutamate metabolism changes as measured by multiple mass spectrometry methods. Sowers JL, Sowers ML et al. iScience 2021;24(10):103108 https://doi.org/10.1016/j.isci.2021.103108
Inhibition of Ganglioside Synthesis Suppressed Liver Cancer Cell Proliferation through Targeting Kinetochore Metaphase Signaling. Su T, Qin XY et al. Metabolites 2021;11(3) https://doi.org/10.3390/metabo11030167
Visualizing the distributions and spatiotemporal changes of metabolites in Panax notoginseng by MALDI mass spectrometry imaging. Sun C, Ma S et al. J Ginseng Res 2021;45(6):726-733 https://doi.org/10.1016/j.jgr.2021.04.001
Integration of Mass Spectrometry Imaging and Machine Learning Visualizes Region-Specific Age-Induced and Drug-Target Metabolic Perturbations in the Brain. Vallianatou T, Shariatgorji R et al. ACS Chem Neurosci 2021;12(10):1811-1823 https://doi.org/10.1021/acschemneuro.1c00103
Rapid Automated Annotation and Analysis of N-Glycan Mass Spectrometry Imaging Data Sets Using NGlycDB in METASPACE. Veličković D, Bečejac T et al. Anal Chem 2021;93(40):13421-13425 https://doi.org/10.1021/acs.analchem.1c02347
Activation of the integrated stress response confers vulnerability to mitoribosome-targeting antibiotics in melanoma. Vendramin R, Katopodi V et al. J Exp Med 2021;218(9) https://doi.org/10.1084/jem.20210571
Experimental and Data Analysis Considerations for Three-Dimensional Mass Spectrometry Imaging in Biomedical Research. Vos DRN, Ellis SR et al. Mol Imaging Biol 2021;23:149-159 https://doi.org/10.1007/s11307-020-01541-5
On-Slide Heat Sterilization Enables Mass Spectrometry Imaging of Tissue Infected with High-Threat Pathogens Outside of Biocontainment: A Study Directed at Mycobacterium tuberculosis. Wang N, Sarathy JP et al. J Am Soc Mass Spectrom 2021;32(11):2664-2674 https://doi.org/10.1021/jasms.1c00205
Spatial-resolved metabolomics reveals tissue-specific metabolic reprogramming in diabetic nephropathy by using mass spectrometry imaging. Wang Z, Fu W et al. Acta Pharm Sin B 2021;11(11):3665-3677 https://doi.org/10.1016/j.apsb.2021.05.013
Clostridioides difficile infection induces a rapid influx of bile acids into the gut during colonization of the host. Wexler AG, Guiberson ER et al. Cell Rep 2021;36(10):109683 https://doi.org/10.1016/j.celrep.2021.109683
Trophoblast Cell Surface Antigen 2 (Trop-2) Protein is Highly Expressed in Salivary Gland Carcinomas and Represents a Potential Therapeutic Target. Wolber P, Nachtsheim L et al. Head Neck Pathol 2021;15:1147-1155 https://doi.org/10.1007/s12105-021-01325-5
Icaritin Provides Neuroprotection in Parkinson's Disease by Attenuating Neuroinflammation, Oxidative Stress, and Energy Deficiency. Wu H, Liu X et al. Antioxidants (Basel) 2021;10(4) https://doi.org/10.3390/antiox10040529
Discovery of Spatial Peptide Signatures for Neuroblastoma Risk Assessment by MALDI Mass Spectrometry Imaging. Wu Z, Hundsdoerfer P et al. Cancers (Basel) 2021;13(13) https://doi.org/10.3390/cancers13133184
Lipidomic Analysis Reveals the Protection Mechanism of GLP-1 Analogue Dulaglutide on High-Fat Diet-Induced Chronic Kidney Disease in Mice. Yeung MHY, Leung KL et al. Front Pharmacol 2021;12:777395 https://doi.org/10.3389/fphar.2021.777395
Integration of omics analysis and atmospheric pressure MALDI mass spectrometry imaging reveals the cadmium toxicity on female ICR mouse. Zeng T, Guo W et al. Sci Total Environ 2021;801:149803 https://doi.org/10.1016/j.scitotenv.2021.149803
Airborne fine particulate matter induces cognitive and emotional disorders in offspring mice exposed during pregnancy. Zhao C, Xie P et al. Sci Bull (Beijing) 2021;66(6):578-591 https://doi.org/10.1016/j.scib.2020.08.036
A Small Molecule Coordinates Symbiotic Behaviors in a Host Organ. Zink KE, Ludvik DA et al. mBio 2021;12(2) https://doi.org/10.1128/mBio.03637-20
MALDI mass Spectrometry based proteomics for drug discovery & development. Zubair F Drug Discov Today Technol 2021;40:29-35 https://doi.org/10.1016/j.ddtec.2021.09.002

SCiLS™ Lab Bibliography 2020

Title Author Publication Link
Simultaneous Detection of Zinc and Its Pathway Metabolites Using MALDI MS Imaging of Prostate Tissue. Andersen MK, Krossa S et al. Anal Chem 2020;92:3171-3179 https://doi.org/10.1021/acs.analchem.9b04903
In situ metabolite and lipid analysis of GluN2D-/- and wild-type mice after ischemic stroke using MALDI MSI. Andrews WT, Donahue D et al. Anal Bioanal Chem 2020;412(24):6275-6285 https://doi.org/10.1007/s00216-020-02477-z
Extracellular matrix alterations in low-grade lung adenocarcinoma compared with normal lung tissue by imaging mass spectrometry. Angel PM, Bruner E et al. J Mass Spectrom 2020;55:e4450 https://doi.org/10.1002/jms.4450
Zonal regulation of collagen-type proteins and posttranslational modifications in prostatic benign and cancer tissues by imaging mass spectrometry. Angel PM, Spruill L et al. Prostate 2020;80(13):1071-1086 https://doi.org/10.1002/pros.24031
Imaging Study by Mass Spectrometry of the Spatial Variation of Cellulose and Hemicellulose Structures in Corn Stalks. Arnaud B, Durand S et al. J Agric Food Chem 2020;68(13):4042-4050 https://doi.org/10.1021/acs.jafc.9b07579
MALDI-TOF Mass Spectrometry Revealed Significant Lipid Variations in Follicular Fluid and Somatic Follicular Cells but Not in Enclosed Oocytes between the Large Dominant and Small Subordinate Follicles in Bovine Ovary. Bertevello PS, Teixeira-Gomes AP et al. Int J Mol Sci 2020;21(18) https://doi.org/10.3390/ijms21186661
µ Opioid Receptor Agonism for L-DOPA-Induced Dyskinesia in Parkinson's Disease. Bezard E, Li Q et al. J Neurosci 2020;40(35):6812-6819 https://doi.org/10.1523/JNEUROSCI.0610-20.2020
Visualizing Microbial Community Dynamics via a Controllable Soil Environment. Bhattacharjee A, Velickovic D et al. mSystems 2020;5(1) https://doi.org/10.1128/mSystems.00645-19
Detection of small molecule concentration gradients in ocular tissues and humours. Boughton BA, Thomas ORB et al. J Mass Spectrom 2020;55:e4460 https://doi.org/10.1002/jms.4460
N-glycomic signature of stage II colorectal cancer and its association with the tumor microenvironment. Boyaval F, Van Zeijl R et al. Mol Cell Proteomics 2020 https://doi.org/10.1074/mcp.RA120.002215
Welding fume inhalation exposure and high-fat diet change lipid homeostasis in rat liver. Boyce GR, Shoeb M et al. Toxicol Rep 2020;7:1350-1355 https://doi.org/10.1016/j.toxrep.2020.10.008
A Simple and Effective Sample Preparation Strategy for MALDI-MS Imaging of Neuropeptide Changes in the Crustacean Brain Due to Hypoxia and Hypercapnia Stress. Buchberger AR, Vu NQ et al. J Am Soc Mass Spectrom 2020;31(5):1058-1065 https://doi.org/10.1021/jasms.9b00107
MALDI-MSI spatially maps N-glycan alterations to histologically distinct pulmonary pathologies following irradiation. Carter CL, Parker GA et al. Sci Rep 2020;10(1):11559 https://doi.org/10.1038/s41598-020-68508-y
Antigen Retrieval and Its Effect on the MALDI-MSI of Lipids in Formalin-Fixed Paraffin-Embedded Tissue. Denti V, Piga I et al. J Am Soc Mass Spectrom 2020;31:1619-1624 https://doi.org/10.1021/jasms.0c00208
MS Imaging-Guided Microproteomics for Spatial Omics on a Single Instrument. Dewez F, Oejten J et al. Proteomics 2020;20:e1900369 https://doi.org/10.1002/pmic.201900369
MALDI MSI Reveals the Spatial Distribution of Protein Markers in Tracheobronchial Lymph Nodes and Lung of Pigs after Respiratory Infection. Do T, Guran R et al. Molecules 2020;25(23) https://doi.org/10.3390/molecules25235723
Defining the human kidney N-glycome in normal and cancer tissues using MALDI imaging mass spectrometry. Drake RR, McDowell C et al. J Mass Spectrom 2020;55:e4490 https://doi.org/10.1002/jms.4490
Validation of MALDI-MS imaging data of selected membrane lipids in murine brain with and without laser postionization by quantitative nano-HPLC-MS using laser microdissection. Eiersbrock FB ,Orthen JM ,Soltwisch J Anal Bioanal Chem 2020;412(25):6875-6886 https://doi.org/10.1007/s00216-020-02818-y
Spatial metabolomics of in situ host-microbe interactions at the micrometre scale. Geier B, Sogin EM et al. Nat Microbiol 2020;5(3):498-510 https://doi.org/10.1038/s41564-019-0664-6
Revealing the Regional Localization and Differential Lung Retention of Inhaled Compounds by Mass Spectrometry Imaging. Hamm GR, Bäckström E et al. J Aerosol Med Pulm Drug Deliv 2020;33:43-53 https://doi.org/10.1089/jamp.2019.1536
MALDI-2 for the Enhanced Analysis of N-Linked Glycans by Mass Spectrometry Imaging. Heijs B, Potthoff A et al. Anal Chem 2020;92(20):13904-13911 https://doi.org/10.1021/acs.analchem.0c02732
Simultaneous mass spectrometry imaging of multiple neuropeptides in the brain and alterations induced by experimental parkinsonism and L-DOPA therapy. Hulme H, Fridjonsdottir E et al. Neurobiol Dis 2020;137:104738 https://doi.org/10.1016/j.nbd.2020.104738
Sample preparation strategies for high-throughput mass spectrometry imaging of primary tumor organoids. Johnson J, Sharick JT et al. J Mass Spectrom 2020;55:e4452 https://doi.org/10.1002/jms.4452
Glioblastoma multiforme: Metabolic differences to peritumoral tissue and IDH-mutated gliomas revealed by mass spectrometry imaging. Kampa JM, Kellner U et al. Neuropathology 2020;40(6):546-558 https://doi.org/10.1111/neup.12671
Mass spectrometry imaging reveals lipid upregulation and bile acid changes indicating amitriptyline induced steatosis in a rat model. Kampa JM, Sahin M et al. Toxicol Lett 2020;325:43-50 https://doi.org/10.1016/j.toxlet.2020.02.007
Multiplex enzyme activity imaging by MALDI-IMS of substrate library conversions. Klein O, Haeckel A et al. Sci Rep 2020;10(1):15522 https://doi.org/10.1038/s41598-020-72436-2
Comparison of Dietary Oils with Different Polyunsaturated Fatty Acid n-3 and n-6 Content in the Rat Model of Cutaneous Wound Healing. Komprda T, Sladek Z et al. Int J Mol Sci 2020;21(21) https://doi.org/10.3390/ijms21217911
Discovery of Prognostic Markers for Early-Stage High-Grade Serous Ovarian Cancer by Maldi-Imaging. Kulbe H, Klein O et al. Cancers (Basel) 2020;12(8) https://doi.org/10.3390/cancers12082000
Derangements of amino acids in cachectic skeletal muscle are caused by mitochondrial dysfunction. Kunzke T, Buck A et al. J Cachexia Sarcopenia Muscle 2020;11(1):226-240 https://doi.org/10.1002/jcsm.12498
Hepatotoxic effects of inhalation exposure to polycyclic aromatic hydrocarbons on lipid metabolism of C57BL/6 mice. Li F, Xiang B et al. Environ Int 2020;134:105000 https://doi.org/10.1016/j.envint.2019.105000
Peak detection for MALDI mass spectrometry imaging data using sparse frame multipliers. Lieb F ,Boskamp T ,Stark HG J Proteomics 2020;225:103852 https://doi.org/10.1016/j.jprot.2020.103852
Storage Conditions of Human Kidney Tissue Sections Affect Spatial Lipidomics Analysis Reproducibility. Lukowski JK, Pamreddy A et al. J Am Soc Mass Spectrom 2020;31:2538-2546 https://doi.org/10.1021/jasms.0c00256
Evaluation of Data Analysis Platforms and Compatibility with MALDI-TOF Imaging Mass Spectrometry Data Sets. Luu GT, Condren AR et al. J Am Soc Mass Spectrom 2020;31(6):1313-1320 https://doi.org/10.1021/jasms.0c00039
Imaging Mass Spectrometry and Lectin Analysis of N-linked Glycans in Carbohydrate Antigen Defined Pancreatic Cancer Tissues. McDowell CT, Klamer Z et al. Mol Cell Proteomics 2020 https://doi.org/10.1074/mcp.RA120.002256
Chemical imaging of evolving amyloid plaque pathology and associated Aβ peptide aggregation in a transgenic mouse model of Alzheimer's disease. Michno W, Wehrli P et al. J Neurochem 2020;152:602-616 https://doi.org/10.1111/jnc.14888
Lipid signature of advanced human carotid atherosclerosis assessed by mass spectrometry imaging. Moerman AM, Visscher M et al. J Lipid Res 2020 https://doi.org/10.1194/jlr.RA120000974
A Co-registration Pipeline for Multimodal MALDI and Confocal Imaging Analysis of Stem Cell Colonies. Nikitina A, Huang D et al. J Am Soc Mass Spectrom 2020;31(4):986-989 https://doi.org/10.1021/jasms.9b00094
Localized Metabolomic Gradients in Patient-Derived Xenograft Models of Glioblastoma. Randall EC, Lopez BGC et al. Cancer Res 2020;80:1258-1267 https://doi.org/10.1158/0008-5472.CAN-19-0638
Unique and highly specific cyanogenic glycoside localization in stigmatic cells and pollen in the genus Lomatia (Proteaceae). Ritmejerytė E, Boughton BA et al. Ann Bot 2020;126(3):387-400 https://doi.org/10.1093/aob/mcaa038
Dual Mass Spectrometric Tissue Imaging of Nanocarrier Distributions and Their Biochemical Effects. Sikora KN, Hardie JM et al. Anal Chem 2020;92:2011-2018 https://doi.org/10.1021/acs.analchem.9b04398
Detecting Proteomic Indicators to Distinguish Diabetic Nephropathy from Hypertensive Nephrosclerosis by Integrating Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging with High-Mass Accuracy Mass Spectrometry. Smith A, Iablokov V et al. Kidney Blood Press Res 2020;45(2):233-248 https://doi.org/10.1159/000505187
On-Tissue Derivatization Strategy for Mass Spectrometry Imaging of Carboxyl-Containing Metabolites in Biological Tissues. Sun C, Liu W et al. Anal Chem 2020;92(18):12126-12131 https://doi.org/10.1021/acs.analchem.0c02303
Development of a high-coverage matrix-assisted laser desorption/ionization mass spectrometry imaging method for visualizing the spatial dynamics of functional metabolites in Salvia miltiorrhiza Bge. Sun C, Liu W et al. J Chromatogr A 2020;1614:460704 https://doi.org/10.1016/j.chroma.2019.460704
1,1'-binaphthyl-2,2'-diamine as a novel MALDI matrix to enhance the in situ imaging of metabolic heterogeneity in lung cancer. Sun C, Liu W et al. Talanta 2020;209:120557 https://doi.org/10.1016/j.talanta.2019.120557
The choice of tissue fixative is a key determinant for mass spectrometry imaging based tumor metabolic reprogramming characterization. Sun C, Wang F et al. Anal Bioanal Chem 2020;412(13):3123-3134 https://doi.org/10.1007/s00216-020-02562-3
A spatially-resolved approach to visualize the distribution and biosynthesis of flavones in Scutellaria baicalensis Georgi. Sun C, Zhang M et al. J Pharm Biomed Anal 2020;179:113014 https://doi.org/10.1016/j.jpba.2019.113014
Mass Spectrometry Imaging Establishes 2 Distinct Metabolic Phenotypes of Aldosterone-Producing Cell Clusters in Primary Aldosteronism. Sun N, Meyer LS et al. Hypertension 2020;75:634-644 https://doi.org/10.1161/HYPERTENSIONAHA.119.14041
Effects of Thymoquinone on Small-Molecule Metabolites in a Rat Model of Cerebral Ischemia Reperfusion Injury Assessed using MALDI-MSI. Tian F, Liu R et al. Metabolites 2020;10(1) https://doi.org/10.3390/metabo10010027
Considerations for MALDI-Based Quantitative Mass Spectrometry Imaging Studies. Tobias F ,Hummon AB J Proteome Res 2020;19(9):3620-3630 https://doi.org/10.1021/acs.jproteome.0c00443
Sample Preparation for Metabolic Profiling using MALDI Mass Spectrometry Imaging. Veerasammy K, Chen YX et al. J Vis Exp 2020 https://doi.org/10.3791/62008
Response Surface Methodology As a New Approach for Finding Optimal MALDI Matrix Spraying Parameters for Mass Spectrometry Imaging. Veličković D, Zhang G et al. J Am Soc Mass Spectrom 2020;31(3):508-516 https://doi.org/10.1021/jasms.9b00074
Investigation of Xenobiotics Metabolism In Salix alba Leaves via Mass Spectrometry Imaging. Villette C ,Maurer L ,Heintz D J Vis Exp 2020 https://doi.org/10.3791/61011
Localization of the lens intermediate filament switch by imaging mass spectrometry. Wang Z ,Ryan DJ ,Schey KL Exp Eye Res 2020;198:108134 https://doi.org/10.1016/j.exer.2020.108134
Opisthobranch grazing results in mobilisation of spherulous cells and re-allocation of secondary metabolites in the sponge Aplysina aerophoba. Wu YC, García-Altares M et al. Sci Rep 2020;10(1):21934 https://doi.org/10.1038/s41598-020-78667-7
Spatial Lipidomics Reveals Anticancer Mechanisms of Bufalin in Combination with Cinobufagin in Tumor-Bearing Mice. Zhang J, Hong Y et al. Front Pharmacol 2020;11:593815 https://doi.org/10.3389/fphar.2020.593815
Evaluation of the splenic injury following exposure of mice to bisphenol S: A mass spectrometry-based lipidomics and imaging analysis. Zhao C, Yong T et al. Environ Int 2020;135:105378 https://doi.org/10.1016/j.envint.2019.105378

SCiLS™ Lab Bibliography 2019

Title Author Publication Link
Extracellular Matrix Alterations in Low Grade Lung Adenocarcinoma Compared to Normal Lung Tissue by Imaging Mass Spectrometry Angel PM, Bruner E et al. Journal of Mass Spectrometry. 2019 https://doi.org/10.1002/jms.4450
Extracellular Matrix Imaging of Breast Tissue Pathologies by MALDI–Imaging Mass Spectrometry Angel PM, Schwamborn K et al. PROTEOMICS–Clinical Applications. 2019;13(1):1700152 https://doi.org/10.1002/prca.201700152
Neratinib protects pancreatic beta cells in diabetes Ardestani A, Li S et al. Nature communications. 2019;10(1):1-17 https://doi.org/10.1038/s41467-019-12880-5
Integrative Clustering in Mass Spectrometry Imaging for Enhanced Patient Stratification Balluff B, Buck A et al. PROTEOMICS–Clinical Applications. 2019;13(1):1800137 https://doi.org/10.1002/prca.201800137
Dual strategy for reduced signal-suppression effects in matrix-assisted laser desorption/ionization mass spectrometry imaging Bastrup J, Birkelund S et al. Rapid Communications in Mass Spectrometry. 2019;33(22):1711-21 https://doi.org/10.1002/rcm.8521
Metal Oxide Laser Ionization Mass Spectrometry Imaging (MOLI MSI) Using Cerium (IV) Oxide Basu SS, McMinn MH et al. Analytical chemistry. 2019;91(10):6800-7 https://doi.org/10.1021/acs.analchem.9b00894
Rapid MALDI mass spectrometry imaging for surgical pathology Basu SS, Regan MS et al. NPJ precision oncology. 2019;3(1):1-5 https://doi.org/10.1038/s41698-019-0089-y
MALDI Mass Spectrometry Imaging Linked with Top-Down Proteomics as a Tool to Study the Non-Small-Cell Lung Cancer Tumor Microenvironment Berghmans E, Van Raemdonck G et al. Methods and protocols. 2019;2(2):44 https://doi.org/10.3390/mps2020044
Antibody Panel Based N-Glycan Imaging for N-Glycoprotein Biomarker Discovery Black AP, Angel PM et al. Current protocols in protein science. 2019;98(1):e99 https://doi.org/10.1002/cpps.99
A novel mass spectrometry platform for multiplexed N-Glycoprotein biomarker discovery from patient biofluids by antibody panel based N-Glycan imaging Black AP, Liang H et al. Analytical chemistry. 2019;91(13):8429-35 https://doi.org/10.1021/acs.analchem.9b01445
Using the chemical noise background in MALDI mass spectrometry imaging for mass alignment and calibration Boskamp T, Lachmund D et al. Analytical Chemistry. 2019 https://doi.org/10.1021/acs.analchem.9b04473
Detection of small molecule concentration gradients in ocular tissues and humours Boughton BA, Thomas OR et al. Journal of Mass Spectrometry. 2019 https://doi.org/10.1002/jms.4460
MALDI Mass Spectrometry Imaging of Early- and Late-Stage Serous Ovarian Cancer Tissue Reveals Stage-Specific N-Glycans Briggs MT, Condina MR et al. Proteomics. 2019;19(21-22):1800482 https://doi.org/10.1002/pmic.201800482
Translating N-glycan analytical applications into clinical strategies for ovarian cancer Briggs MT, Condina MR et al. PROTEOMICS–Clinical Applications. 2019;13(3):1800099 https://doi.org/10.1002/prca.201800099
Mass spectrometry-based integration and expansion of the chemical diversity harbored within a marine sponge Cantrell TP, Freeman CJ et al. Journal of The American Society for Mass Spectrometry. 2019;30(8):1373-84 https://doi.org/10.1021/jasms.8b06062
Development of a class prediction model to discriminate pancreatic ductal adenocarcinoma from pancreatic neuroendocrine tumor by MALDI mass spectrometry imaging Casadonte R, Kriegsmann M et al. PROTEOMICS–Clinical Applications. 2019;13(1):1800046 https://doi.org/10.1002/prca.201800046
Biofilm inhibitor taurolithocholic acid alters colony morphology, specialized metabolism, and virulence of Pseudomonas aeruginosa Condren AR, Kahl LJ et al. ACS Infectious Diseases. 2019 https://doi.org/10.1021/acsinfecdis.9b00424
Targeted feature extraction in MALDI mass spectrometry imaging to discriminate proteomic profiles of breast and ovarian cancer Cordero Hernandez Y, Boskamp T et al. PROTEOMICS–Clinical Applications. 2019;13(1):1700168 https://doi.org/10.1002/prca.201700168
Assessing the effect of nitisinone induced hypertyrosinaemia on monoamine neurotransmitters in brain tissue from a murine model of alkaptonuria using mass spectrometry imaging Davison AS, Strittmatter N et al. Metabolomics. 2019;15(5):68 https://doi.org/10.1007/s11306-019-1531-4
Age-related spatial differences of human lens UV filters revealed by negative ion mode MALDI imaging mass spectrometry Demarais NJ, Donaldson PJ, Grey AC Experimental eye research. 2019;184:146-51 https://doi.org/10.1016/j.exer.2019.04.016
Defining the Human Kidney N-Glycome in Normal and Cancer Tissues Using MALDI Imaging Mass Spectrometry Drake RR, McDowell C et al. Journal of Mass Spectrometry. 2019:e4490 https://doi.org/10.1002/jms.4490
Spatially resolved endogenous improved metabolite detection in human osteoarthritis cartilage by matrix assisted laser desorption ionization mass spectrometry imaging Eveque-Mourroux M, Emans P et al. Analyst. 2019;144(20):5953-8 https://doi.org/10.1039/C9AN00944B
Pre-and Postoperative Neratinib for HER2-Positive Breast Cancer Brain Metastases: Translational Breast Cancer Research Consortium 022 Freedman RA, Gelman RS et al. Clinical breast cancer. 2019 https://doi.org/10.1016/j.clbc.2019.07.011
Spatial UBE2N protein expression indicates genomic instability in colorectal cancers Gemoll T, Miroll E et al. BMC cancer. 2019;19(1):710 https://doi.org/10.1186/s12885-019-5856-1
MALDI-Mass Spectrometry Imaging to Investigate Lipid and Bile Acid Modifications Caused by Lentil Extract Used as a Potential Hypocholesterolemic Treatment Genangeli M, Heijens AM et al. Journal of the American Society for Mass Spectrometry. 2019;30(10):2041-50 https://doi.org/10.1021/jasms.8b06217
Spatio-Temporal Metabolite and Elemental Profiling of Salt Stressed Barley Seeds During Initial Stages of Germination by MALDI-MSI and μ-XRF Spectrometry Gupta SVK, Rupasinghe TWT et al. Frontiers in plant science. 2019;10:1139 https://doi.org/10.3389/fpls.2019.01139
Revealing the Regional Localization and Differential Lung Retention of Inhaled Compounds by Mass Spectrometry Imaging Hamm GR, Bäckström E et al. Journal of aerosol medicine and pulmonary drug delivery. 2019 https://doi.org/10.1089/jamp.2019.1536
Polydopamine-capped AgNPs as a novel matrix overcoming the ion suppression of phosphatidylcholine for MALDI MS comprehensive imaging of glycerophospholipids and sphingolipids in impact-induced injured brain Han C, Li S et al. Analyst. 2019;144(21):6304-12 https://doi.org/10.1039/C9AN01361J
MALDI Imaging Mass Spectrometry: Neurochemical Imaging of Proteins and Peptides Hanrieder J, Zetterberg H, Blennow K. Neuroproteomics: Springer; 2019. p. 179-97 https://doi.org/10.1007/978-1-4939-9662-9_15
Identification of Proteomic Markers in Head and Neck Cancer Using MALDI–MS Imaging, LC–MS/MS, and Immunohistochemistry Hoffmann F, Umbreit C et al. PROTEOMICS – Clinical Applications. 2019;13(1):1700173. doi: 10.1002/prca.201700173 https://doi.org/10.1002/prca.201700173
Matrix-assisted laser desorption/ionization mass spectrometry imaging to uncover protein alterations associated with the progression of IgA nephropathy Ivanova M, Dyadyk O et al. Virchows Archiv. 2019:1-12 https://doi.org/10.1007/s00428-019-02705-7
Sample Preparation Strategies for High-Throughput Mass Spectrometry Imaging of Primary Tumor Organoids Johnson J, Sharick JT et al. Journal of Mass Spectrometry. 2019 https://doi.org/10.1002/jms.4452
MALDI-Imaging for Classification of Epithelial Ovarian Cancer Histotypes from a Tissue Microarray Using Machine Learning Methods Klein O, Kanter F et al. PROTEOMICS–Clinical Applications. 2019;13(1):1700181 https://doi.org/10.1002/prca.201700181
The Emerging Role of Cytoskeletal Proteins as Reliable Biomarkers Klingler-Hoffmann M, Mittal P, Hoffmann P Proteomics. 2019;19(21-22):1800483 https://doi.org/10.1002/pmic.201800483
Mapping natural dyes in archeological textiles by imaging mass spectrometry Kramell AE, García-Altares M et al. Scientific reports. 2019;9(1):1-9 https://doi.org/10.1038/s41598-019-38706-4
MALDI imaging for proteomic painting of heterogeneous tissue structures Kriegsmann J, Kriegsmann M et al. PROTEOMICS–Clinical Applications. 2019;13(1):1800045 https://doi.org/10.1002/prca.201800045
Combined Immunohistochemistry after Mass Spectrometry Imaging for superior spatial information Kriegsmann K, Longuespée R et al. PROTEOMICS–Clinical Applications. 2019;13(1):1800035 https://doi.org/10.1002/prca.201800035
Derangements of amino acids in cachectic skeletal muscle are caused by mitochondrial dysfunction Kunzke T, Buck A et al. Journal of Cachexia, Sarcopenia and Muscle. 2019 https://doi.org/10.1002/jcsm.12498
MALDI imaging in Fabry nephropathy: a multicenter study L’Imperio V, Smith A et al. Journal of nephrology. 2019:1-8 https://doi.org/10.1007/s40620-019-00627-w
Histopathology-guided mass spectrometry differentiates benign nevi from malignant melanoma Lazova R, Smoot K et al. Journal of cutaneous pathology. 2019 https://doi.org/10.1111/cup.13610
MALDI–MSI Pilot Study Highlights Glomerular Deposits of Macrophage Migration Inhibitory Factor as a Possible Indicator of Response to Therapy in Membranous Nephropathy L’Imperio V, Smith A et al. PROTEOMICS–Clinical Applications. 2019;13(3):1800019 https://doi.org/10.1002/prca.201800019
Metabolomics profiling of methamphetamine addicted human serum and three rat brain areas Lin M, Xu J et al. RSC Advances. 2019;9(70):41107-19 https://doi.org/10.1039/C9RA08096A
Effect of Shenfu injection on lipopolysaccharide (LPS)-induced septic shock in rabbits Liu X, Liu R et al. Journal of ethnopharmacology. 2019;234:36-43 https://doi.org/10.1016/j.jep.2019.01.008
In MALDI–Mass Spectrometry Imaging on Formalin-Fixed Paraffin-Embedded Tissue Specimen Section Thickness Significantly Influences m/z Peak Intensity Longuespée R, Kriegsmann K et al. PROTEOMICS–Clinical Applications. 2019;13(1):1800074 https://doi.org/10.1002/prca.201800074
Site-to-Site Reproducibility and Spatial Resolution in MALDI–MSI of Peptides from Formalin-Fixed Paraffin-Embedded Samples Ly A, Longuespée R et al. PROTEOMICS–Clinical Applications. 2019;13(1):1800029 https://doi.org/10.1002/prca.201800180
Enhanced Coverage of Insect Neuropeptides in Tissue Sections by an Optimized Mass-Spectrometry-Imaging Protocol Ly A, Ragionieri L et al. Analytical chemistry. 2019;91(3):1980-8 https://doi.org/10.1021/acs.analchem.8b04304
Maldi msi of lipids in experimental model of traumatic brain injury detects acylcarnitines as injury related markers lah K, Quanico J et al. 2019 https://doi.org/10.1021/acs.analchem.9b02633
Distinguishing core from penumbra by lipid profiles using Mass Spectrometry Imaging in a transgenic mouse model of ischemic stroke Mulder I, Potočnik NO et al. Scientific reports. 2019;9(1):1-10 https://doi.org/10.1038/s41598-018-37612-5
Intratumoral immunotherapy with TLR7/8 agonist MEDI9197 modulates the tumor microenvironment leading to enhanced activity when combined with other immunotherapies Mullins SR, Vasilakos JP et al. Journal for immunotherapy of cancer. 2019;7(1):1-18 https://doi.org/10.1186/s40425-019-0724-8
Evaluation of Small Molecule Drug Uptake in patient-Derived prostate cancer explants by Mass Spectrometry Mutuku SM, Trim PJ et al. Scientific reports. 2019;9(1):1-11 https://doi.org/10.1038/s41598-019-51549-3
Keeping the shape of plant tissue for visualizing metabolite features in segmentation and correlation analysis of imaging mass spectrometry in Asparagus officinalis Nakabayashi R, Hashimoto K et al. Metabolomics. 2019;15(2):24 https://doi.org/10.1007/s11306-019-1486-5
Unsupervised machine learning using an imaging mass spectrometry dataset automatically reassembles grey and white matter Nampei M, Horikawa M et al. Scientific reports. 2019;9(1):1-11 https://doi.org/10.1038/s41598-019-49819-1
MALDI-imaging mass spectrometry screening of lipid profile changes in the rat model for tauopathies Olesova D, Majerova P, Kovac A 4th Meeting of Middle European Societies for Immunology and Allergology; 2019: Wiley Online Library https://doi.org/10.1002/eji.201970500
Higher mass accuracy MALDI-TOF/TOF lipid imaging of human brain tissue in Alzheimer’s disease O’Rourke MB, Smith CC et al. Current protocols in molecular biology. 2019;126(1):e86 https://doi.org/10.1002/cpmb.86
‘What did I do wrong?’ An empirical evaluation of sample preparation methodologies in matrix-assisted laser desorption/ionization-mass spectrometry imaging O’Rourke MB, Smith CC et al. Future Science OA. 2019;5(4):FSO362 https://doi.org/10.4155/fsoa-2018-0095
Three-dimensional mass spectrometry imaging identifies lipid markers of medulloblastoma metastasis Paine MR, Liu J et al. Scientific reports. 2019;9(1):1-10 https://doi.org/10.1038/s41598-018-38257-0
Lipidomic changes in the rat hippocampus following cocaine conditioning, extinction, and reinstatement of drug-seeking Pati S, Angel P et al. Brain and behavior. 2019;9(12):e01451 https://doi.org/10.1002/brb3.1451
Uncovering Matrix Effects on Lipid Analyses in MALDI Imaging Mass Spectrometry Experiments Perry WJ, Patterson NH et al. Journal of Mass Spectrometry. 2019:e4491 https://doi.org/10.1002/jms.4491
Novel prognostic markers in triple-negative breast cancer discovered by MALDI-mass spectrometry imaging Phillips L, Gill AJ, Baxter RC Frontiers in oncology. 2019;9:379 https://doi.org/10.3389/fonc.2019.00379
Molecular characterization of prostate cancer with associated Gleason score using mass spectrometry imaging Randall EC, Zadra G et al. Molecular Cancer Research. 2019;17(5):1155-65 https://doi.org/10.1158/1541-7786.MCR-18-1057
Mapping insoluble indole metabolites in the gastrointestinal environment of a murine colorectal cancer model using desorption/ionisation on porous silicon imaging Rudd DA, Benkendorff K et al. Scientific reports. 2019;9(1):1-13 https://doi.org/10.1038/s41598-019-48533-2
Comparative spatial lipidomics analysis reveals cellular lipid remodelling in different developmental zones of barley roots in response to salinity Sarabia LD, Boughton BA et al. Plant, cell & environment. 2019 https://doi.org/10.1111/pce.13653
In plaque-mass spectrometry imaging of a bloom-forming alga during viral infection reveals a metabolic shift towards odd-chain fatty acid lipids Schleyer G, Shahaf N et al. Nature microbiology. 2019;4(3):527-38 https://doi.org/10.1038/s41564-018-0336-y
Maintenance of Deep Lung Architecture and Automated Airway Segmentation for 3D Mass Spectrometry Imaging Scott AJ, Chandler CE et al. Scientific Reports. 2019;9(1):1-12 https://doi.org/10.1038/s41598-019-56364-4
Microscopy and Mass Spectrometry Imaging Reveals the Distributions of Curcumin Species in Dried Turmeric Root Shimma S, Sagawa T Journal of Agricultural and Food Chemistry. 2019;67(34):9652-7. doi: 10.1021/acs.jafc.9b02768 https://doi.org/10.1021/acs.jafc.9b02768
Molecular signatures of medullary thyroid carcinoma by matrix-assisted laser desorption/ionisation mass spectrometry imaging Smith A, Galli M et al. Journal of proteomics. 2019;191:114-23 https://doi.org/10.1016/j.jprot.2018.03.021
High Spatial Resolution MALDI-MS Imaging in the Study of Membranous Nephropathy Smith A, L’Imperio V et al. PROTEOMICS–Clinical Applications. 2019;13(1):1800016 https://doi.org/10.1002/prca.201800016
High-Performance Molecular Imaging with MALDI Trapped Ion-Mobility Time-of-Flight (timsTOF) Mass Spectrometry Spraggins JM, Djambazova KV et al. Analytical chemistry. 2019;91(22):14552-60 https://doi.org/10.1021/acs.analchem.9b03612
Ambient metabolic profiling and imaging of biological samples with ultrahigh molecular resolution using laser ablation electrospray ionization 21 tesla FTICR mass spectrometry Stopka SA, Samarah LZ et al. Analytical chemistry. 2019;91(8):5028-35 https://doi.org/10.1021/acs.analchem.8b05084
Sarcosine is a prostate epigenetic modifier that elicits aberrant methylation patterns through the SAM e-Dnmts axis Strmiska V, Michalek P et al. Molecular oncology. 2019;13(5):1002-17 https://doi.org/10.1002/1878-0261.12439
The use of 1, 5-diaminonaphthalene for matrix-assisted laser desorption/ionization mass spectrometry imaging of brain in neurodegenerative disorders Strnad Š, Pražienková V et al. Talanta. 2019;201:364-72 https://doi.org/10.1016/j.talanta.2019.03.117
Acetone immersion enhanced MALDI-MS imaging of small molecule metabolites in biological tissues Sun C, Li Z et al. Journal of pharmaceutical and biomedical analysis. 2019;176:112797 https://doi.org/10.1016/j.jpba.2019.112797
A process of convergent amplification and tissue-specific expression dominates the evolution of toxin and toxin-like genes in sea anemones Surm JM, Smith HL et al. Molecular ecology. 2019;28(9):2272-89 https://doi.org/10.1111/mec.15084
Quantitative MALDI imaging of spatial distributions and dynamic changes of tetrandrine in multiple organs of rats Tang W, Chen J et al. Theranostics. 2019;9(4):932 https://dx.doi.org/10.7150%2Fthno.30408
Deciphering PSE-like muscle defect in cooked hams: A signature from the tissue to the molecular scale Théron L, Sayd T et al. Food chemistry. 2019;270:359-66 https://doi.org/10.1016/j.foodchem.2018.07.081
Developing a Drug Screening Platform: MALDI-Mass Spectrometry Imaging of Paper-Based Cultures Tobias F, McIntosh JC et al. Analytical chemistry. 2019;91(24):15370-6 https://doi.org/10.1021/acs.analchem.9b03536
Peptide Profile Differences of Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features, Encapsulated Follicular Variant, and Classical Papillary Thyroid Carcinoma: An Application of Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging Ucal Y, Tokat F et al. Thyroid. 2019;29(8):1125-37 https://doi.org/10.1089/thy.2018.0392
Molecular imaging identifies age-related attenuation of acetylcholine in retrosplenial cortex in response to acetylcholinesterase inhibition Vallianatou T, Shariatgorji M et al. Neuropsychopharmacology. 2019;44(12):2091-8 https://doi.org/10.1038/s41386-019-0397-5
Rapid Identification of Ischemic Injury in Renal Tissue by Mass-Spectrometry Imaging van Smaalen T, Ellis S et al. Analytical chemistry. 2019;91(5):3575-81 https://doi.org/10.1021/acs.analchem.8b05521
Mass spectrometric imaging of cysteine rich proteins in human skin Vanickova L, Guran R et al. International journal of biological macromolecules. 2019;125:270-7 https://doi.org/10.1016/j.ijbiomac.2018.11.272
An approach for visualizing the spatial metabolome of an entire plant root system inspired by the Swiss-rolling technique Veličković D, Chu RK et al. Journal of Mass Spectrometry. 2019 https://doi.org/10.1002/jms.4363
Spatiotemporal Transformation in the Alkaloid Profile of Pinus Roots in Response to Mycorrhization Veličković D, Liao H-L et al. Journal of natural products. 2019;82(5):1382-6 https://doi.org/10.1021/acs.jnatprod.8b01050
In situ localization of micropollutants and associated stress response in Populus nigra leaves Villette C, Maurer L et al. Environment international. 2019;126:523-32 https://doi.org/10.1016/j.envint.2019.02.066
Strategies for managing multi-patient 3D mass spectrometry imaging data Vos D, Jansen I et al. Journal of proteomics. 2019;193:184-91 https://doi.org/10.1016/j.jprot.2018.10.008
Software solutions for evaluation and visualization of laser ablation inductively coupled plasma mass spectrometry imaging (LA-ICP-MSI) data: a short overview Weiskirchen R, Weiskirchen S et al. Journal of cheminformatics. 2019;11(1):16 https://doi.org/10.1186/s13321-019-0338-7
Pharmacodynamic Evaluation of Shenfu Injection in Rats With Ischemic Heart Failure and Its Effect on Small Molecules Using Matrix-Assisted Laser Desorption/Ionization–Mass Spectrometry Imaging Wu H, Dai Z et al. Frontiers in Pharmacology. 2019;10(1424). doi: 10.3389/fphar.2019.01424 https://doi.org/10.3389/fphar.2019.01424

 

For Research Use Only. Not for use in clinical diagnostic procedures.