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NMR Software

TopSpin

Get the most out of your Bruker NMR instrument with TopSpin software for both routine and advanced NMR acquisition and analysis.

TopSpin 4.4.1 release includes bug fixes and new features.

  • New deep learning 2D peak picking algorithm expands family of AI-based tools
  • Data Browser bug fixes and enhancements - improved performance, index can be disabled for large data collections on network drives
  • Updated documentation for TopSpin commands and parameters. HTML help is available from the command line or from the command and parameter index. A full PDF description is also available.
  • A detailed list of all enhancements and bug fixes is available in the release notes.

TopSpin 4.4.1 for Spectrometer Control has been tested and validated on Windows 11 and Alma Linux 9.4.

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Smart Acquisition
Get high quality data in short time due to effective workflows.
Advanced Processing
Profit from fast and flexible algorithms for processing and analysis of NMR data/spectra.
Modular Application Platform

Leverage a wide range of add-ons.

 

TopSpin® is Bruker's standard NMR software used in a wide range of workflows. Starting with the control of the spectrometer up to the processing and analysis of multidimensional NMR spectra. The acquisition interface provides easy access to vast NMR experiment libraries including standard Bruker pulse sequences and user generated experiment libraries, for both routine and advanced NMR users. TopSpin provides numerous options for setting up and optimizing NMR experiments, making the setup of sophisticated experiments simple and efficient. For users who must be compliant with the GxP regulations, the software supports the various principles of data integrity. 

TopSpin® offers a fully workflow-oriented user interface and leverages the latest 64-bit features of modern Windows / CentOS / macOS operating systems for optimal performance. The software is designed to accelerate the operation and throughput of sample analysis for increased cost efficiency.


Get an Industrial / Pharma processing license:

Get a License

 

Get a free academic processing license:

Get free license

TopSpin Features

  • Assisted acquisition including experiment selector, advanced non-uniform sampling methods (NUS), bioTop, and TopSolids Method development environment
  • Flexible task automation (scripting)
  • GxP ready: supports compliance with audit trails, electronic signatures, auto-archiving
  • Unlimited offline processing capabilities
  • Comprehensive analysis tools available (structure elucidation of small molecules with CMC-seTM, small molecule characterization, solid-state NMR, including dynamic NMR)
  • Educational package to train future NMR users

Benefits

  • TopSpin provides full control of your spectrometer.
  • Extensive functionality for processing, displaying and analyses in one tool – time saving and without loss of accuracy.
  • The ideal tool for NMR experts as well as for NMR novices
  • Higher sample throughput and therefore higher cost efficiency

Applications

TopSpin Python Interface

Python is the most popular programming language in the scientific community. The Python Package Index (PyPI), the official repository for third-party Python software, contains more than 290,000 packages with a wide range of features.
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Non-Uniform Sampling (NUS) with TopSpin

Non-Uniform Sampling (NUS) is an acquisition method for NMR experiments with two or more dimensions
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TopSpin Educational Package

This free academia license includes several tools supporting the understanding of NMR experiments and the analysis of the acquired data.
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Advanced Chemical Profiling

Data processing, interpretation, and automatic report generation are crucial steps in recurring tasks such as formulation screening within the chemical manufacturing industry.
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Experiment Selector - Intuitive acquisition setup: The parameter available in TopSpin sets have been categorized and displayed as a tree. Only one mouse click is required to prepare an experiment based on the selected parameter set. The spectrometer user can create their own personal selector that matches their preferences.
Topspin includes rich set of tools supporting the setup and design of experiments using shaped pulses. The detailed behavior of such pulses can be visualized, for example, as magnetization motion or excitation profile.
TopSpin includes many advanced visualization features like common cursor correlating the signals in all spectra shown.
Topspin for processing is available for Windows, Linux and macOS. The user interface is highly customizable. You may add your own flow bars or toolbar buttons. The spectra display may be also adapted according to your preferences.

Specifications

Supported Operating Systems

  • 64-bit operating system required for TopSpin
  • Windows 10, 11 or AlmaLinux 9.2 required for spectrometer control. CentOS 7 is also supported, however it reaches its end of live at June 30 2024.
  • Processing version of TopSpin are available for Windows 10, 11, AlmaLinux 9.2, CentOS 7, and macOS
  • Detailed list of supported operating systems is available here (requires login)


Detailed information about licences and more can be found in the TopSpin FAQ

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Accessories

IconNMR

IconNMR

Integrated into TopSpin, IconNMR™ allows fully automated acquisition and processing and is the ideal solutions for labs with large numbers of samples or many user accessing the spectrometer.
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BioTop

bioTop

Designed to simplify biomolecular NMR, BioTop automates tasks based on user experience level. The software optimizes and maintains consistency for commonly used and shared parameters
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TopSolids

TopSolids

Automated spectrometer adjustment together with a comprehensive range of pre-defined protocols guarantees optimum spectral quality and high productivity for both expert and novice users
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Webinars

topspin
On-Demand

Deep Learning Based Phase and Baseline Correction on NMR Spectra

Bruker's commitment in developing artificial intelligence based NMR applications has led to a new function available in TopSpin: the automatic simultaneous phase and baseline correction of 1H NMR spectra.
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On-Demand

TopSpin News: Python 3 Interface, User Experience and Acquisition Improvements

In this webinar, we would like to present the latest developments in TopSpin. The main focus will be on the new Python 3 interface, including a preview of the upcoming TopSpin 4.2 release.

More Information about TopSpin

LabScape

Service & Life Cycle Support for Magnetic Resonance and Preclinical Imaging

Bruker’s commitment to provide customers with unparalleled help throughout the buying cycle, from initial inquiry to evaluation, installation, and the lifetime of the instrument is now characterized by the LabScape service concept.

LabScape Maintenance Agreements, On-Site On-Demand and Enhance Your Lab are designed to offer a new approach to maintenance and service for the modern laboratory

Connexus – Connecting Labs

Connexus® brings clients in need of advanced analytical techniques together with labs that have available capacity on their high-tech scientific NMR instruments*.

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*The new Bruker BioSpin online platform Connexus is available in selected European countries

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