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Fluorescence Microscopy Resource Library

Controlling Biological Processes with the Luxendo Photomanipulation Module

This technical note discusses using light-sheet microscopy with the Luxendo photomanipulation module for experiments in developmental biology and neuroscience.


KEYWORDS:
 Light-sheet Fluorescence Microscopy; Photomanipulation; Developmental Biology; Photoablation; Optogenetics

Luxendo's light-sheet microscopes utilize industry-leading selective plane illumination microscopy (SPIM) technology for studies in fields such as developmental biology and drug discovery. When equipped with the innovative photomanipulation module, Luxendo SPIMs enable precise and laser-based manipulations of specific regions of interest. 

In this technical note, readers will learn about the Luxendo photomanipulation module (PM) for Luxendo's light-sheet microscopes. This add-on module enables researchers to explore diverse scientific fields such as neurobiology and plant biology. Photomanipulation is a powerful experimental technique that uses lasers to precisely manipulate biological samples including cells, tissues, and organisms. This technical note will dive into how photomanipulation works and what experiments are possible with the innovative Luxendo PM.  

Readers can expect to learn more about:

  • Light-sheet fluorescence microscopy (LSFM), also known as selective plane illumination microscopy (SPIM);
  • How photomanipulation works and the technical specifications of the Luxendo PM;
  • Experiments possible with the Luxendo PM, such as photoablation and uncaging;
  • Case studies of researchers using LSFM with the PM.