Bruker Spatial Biology

CellScape

Precise Spatial Proteomics enables versatile assay design and quantitative phenotyping

CellScape

The CellScape™ Precise Spatial Proteomics platform is an optimized multiplex immunofluorescence (mIF) solution for high plex spatial protein detection and quantitative phenotyping. Combining an advanced imaging system with integrated microfluidics for walk-away automation and an open ecosystem employing simple chemistry and robust performance, the CellScape platform accelerates biological discovery and translational science across multiple disciplines.

High-Plex    
capability
Unlimited iterative staining and imaging cycles for highly multiplexed immunofluorescent biomarker detection
Fast
time to result
Large fields of view, 4-sample holder, and walk-away automation for rapid imaging of entire tissue sections
Straightforward
reliable technique
Compatible with over 6,000 commercially available antibodies and a comprehensive selection of multiplex assay kits to streamline assay validation
            

See What You've Been Missing

Using the PowerOMX™ data engine, the CellScape platform enables accurate detection of both high-and low-expressing biomarker targets on the same sample at single-cell resolution. Supported by industry-leading 182 nm/pixel digital sampling rate and two large field of view options, the CellScape instrument can image entire tissue sections and discern biologically relevant details in the tissue microenvironment.

Fast and Flexible

The CellScape platform simplifies spatial proteomics with a seamless, flexible workflow. Use off-the-shelf fluorescently labeled antibodies—no proprietary reagents needed. Powered by EpicIF™ technology, the CellScape platform  enables rapid, gentle signal removal while preserving tissue integrity and expands beyond immunofluorescence with RNA-FISH and in situ proximity ligation assay compatibility.

Highly Multiplexed

Designed for the CellScape platform, VistaPlex Assay Kits are ready-to-use antibody panels designed for essential biomarker insights—whether for phenotyping, tissue architecture, or segmentation. Pre-optimized for rapid deployment, they accelerate time to data while offering flexibility. Users can seamlessly add markers, personalizing a universally powerful tool to fit their unique research needs.

CellScape offers exceptional versatility and simplicity for spatial biology. Through a combination of top-tier optics, walkaway automation, open-source antibodies, and efficient assay validation, the CellScape represents an extremely straightforward solution for our customers. Our R&D team has deep expertise in optical imaging, multi-omic assay development, and bioinformatics, and is thus well poised to deliver transformative spatial biology tools for academic and pre-clinical research.

Oliver Braubach
Director of R&D, Canopy Biosciences

Applications

CellScape Enables Emerging Spatial and Single-Cell Applications

Spatial Profiling of Cancer Tisue
Identify spatial relationships and cell-cell interactions in tumor microenvironments

Data-Driven Assay Expansion

Seal, store, and re-explore samples later for true hypothesis-driven biology

VistaPlex Assay Kit Design and Validation
Explore a robust process for rapid assay development

Specifications

Sample Compatibility
  • Formaldehyde fixed, paraffin embedded (FFPE) tissues
  • Fresh frozen tissues
  • Cell suspensions, including blood and PBMCs
Objective, Field of View, Resolution, and Digital Sampling
Standard Mode
  • Objective: 20X | 0.80 NA
  • Field of view: 0.8 mm2
  • Resolution: 278 nm
  • Digital sampling: 182 nm/pixel
FalconFAST™ Mode
  • Objective: 10X | 0.30 NA
  • Field of view: 3.3 mm2
  • Resolution: 742 nm
  • Digital sampling: 365 nm/pixel
Components
  • CellScape automated microscope
  • PlexFlo fluidics unit
  • Degasser unit
  • Light source
  • eBox
  • Computer with image acquisition and analysis software
  • Computer monitor
  • Barcode scanner
Dimensions
  • CellScape Instrument: 57 cm x 38 cm x 32 cm
  • PlexFlo Fluidics Unit: 37 cm x 30 cm x 20 cm
  • Weight: 60 kg

More Information

CellScape Service

Getting started is simple. Partner with Canopy Multiomic Services to access contract research with the CellScape platform.

Resource Library

View posters, webinars, application notes, and more from Bruker Spatial Biology.

Data Explorer

Experience two spatial biology stories by exploring precise data collected with CellScape.

Contact Us About Your Spatial-Omics Interests

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