PET/MR | Preclinical PET | Detector Technology

Highlights

150 mm FOV

Total body PET for dynamic imaging and biodistribution studies

Hybrid Imaging

With no compromises between the technologies

Low to High Field

Superior morphological insights with Biospec Maxwell technology at 3T, 7T and 9.4T

PET/MR - Brochure

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Combining PET with MRI enhances the capabilities to study detailed morphological changes in different organs and tumours, adding more precise information of the distribution and behaviour of the PET tracer.

Bruker’s sequential PET/MR instruments are offered at 3T for translational research and at 7T and 9.4T for high-field applications in mice and rats using Bruker’s BioSpec Maxwell MRI technology. This is combined with Bruker’s SiPM PET technology, providing the highest sensitivity, high spatial resolution and precise quantification across the entire FOV. A touch screen controlled motorized animal transport system simplifies the workflow and supports a broad spectrum of application fields, such as oncology, functional and anatomical neuroimaging, cardiac imaging and stroke models. All of this powered by the Paravision 360 software, allowing MRI users to follow familiar MR imaging workflows to obtain valuable PET/MR data immediately.

Features

General

Designed for total body PET/MR of mice, multi-mice and rats
Accurate animal positioning with the motorized animal transport system, including touchscreen operation for a simplified, precise workflow
Intuitive ParaVision software with over 100 validated and ready to use in vivo protocols and scan programs for mice and rats
Streamlined workflows including automatic image stitching, MR based attenuation correction and PET/MR image fusion
Optimized animal cradles for dynamic PET studies
PMOD for nuclear molecular data analysis and advanced kinetic modelling
Lightweight and compact footprint fits in any laboratory
Rat up to 600 grams

PET Imaging Modality

Inner diameter 112 mm
Up to 0.7 mm spatial resolution
12 % sensitivity
150 x 80 mm FOV

MRI Imaging Modality

Compact and easy-to-site BioSpec Maxwell
3T, 7T or 9.4T
PET optimized RF coils
Up to 900 mT/m, Gradient strength, 4200 T/m/s Slew rate
No liquid helium or nitrogen filling needed
No quench pipe required
Automatic magnet control

Applications

Tracking Stem Cells using Dual Labeled PET/MR Nano particles

Courtesy: Willy Gsell, Uwe Himmelreich,Molecular Small Animal Imaging Center (MoSAIC), KU Leuven, Leuven (Belgium)

PET metabolic information combined with the superior soft tissue contrast of MRI reveals small details

Courtesy: Dorde Komljenovic, Mark Ladd, Medizinische Physik in der Radiologie, DKFZ, Heidelberg, Germany

Total Body Dynamic PET Imaging in 3 Mice

Bruker BioSpin MRI GmbH, Ettlingen/Germany

18F-FDG Brain Imaging

Bruker BioSpin MRI GmbH, Ettlingen/Germany

PET and MR in Mouse MetastaticTumor Model

(Left) Coronal whole-body PET/MR. (Right) Focused Axial PET/MR revealing location of lung and abdominal tumors.

Courtesy of Acknowledgements. Thanks to the Katherine Tucker, Mikayla Rodger, Dr. Lixin Ma, Dr. Carolyn Anderson, and Dr. Barry Edwards, MITC – Molecular & Imaging Theranostics Center, University of Missouri.

Total body PET/MRI images of mice

Imaged at pre-injection and 1, 5, 30, 45 mins post-injection of 0.1 mmol/kg [52Mn]Mn-2CHyd or [52Mn]Mn-1CHyd.
Courtesy Yingying Ning , Iris Yuwen Zhou, Nicholas J Rotile et al. MGH – USA

Reference: J Am Chem Soc. 2022 Sep 14;144(36):16553-16558.

⁶⁴Cu Tracer Validations/Characterizations in a Mouse Glioblastoma Model

PET/CT and MR in Mouse Glioblastoma Model. (Left) Multi-Mouse PET/CT was performed for efficient tracer validations. (Right) MR brain imaging subsequently performed and registered with PET data. Courtesy of Acknowledgements. Katherine Tucker, Mikayla Rodger, Dr. Lixin Ma, Dr. Carolyn Anderson, and Dr. Barry Edwards, MITC – Molecular & Imaging Theranostics Center, University of Missouri.

AD Model in Marmosets: Awake Imaging with ¹¹C-PiB and ¹⁸F-FDG PET

PET/CT Si78

Courtesy of A. Silva, D. Schaeffer and K. Cashman. University of Pittsburgh Brain Institute, USA

Webinars

June 25, 2020

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Brochures

Application Notes

LabScape

Service & Life Cycle Support for Magnetic Resonance and Preclinical Imaging

Bruker’s commitment to provide customers with unparalleled help throughout the buying cycle, from initial inquiry to evaluation, installation, and the lifetime of the instrument is now characterized by the LabScape service concept.

LabScape Maintenance Agreements, On-Site On-Demand and Enhance Your Lab are designed to offer a new approach to maintenance and service for the modern laboratory