Insertion pet

Hybrid Imaging

Total body PET - Total body MRI

Molecular Sensitivity

By total correlation PET and MRI

Full MRI Compatibility

No compromises in PET or MRI Easy upgrades of existing scanner

Simultaneous PET/MR - Brochure

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The PET inserts are designed for simultaneous PET and MR imaging of mice and rats using BioSpec MR imaging products. It allows researchers to gain unique insight on molecular and functional processes as well as a multitude of macroscopic and chemical information within a living system at the same time.

PET/MR exceeds the growing demands on preclinical imaging methods, which are required in all areas of molecular and medical research, such as oncology, neuroscience, cardiology, theranostics, immunology and development of new nuclear molecular tracers.

All PET Inserts are based on the Bruker Si PET imaging platform that is designed for highest sensitivity, high spatial resolution and quantification accuracy across the entire FOV, highest count rates and full MRI compatibility without interferences between the hybrid modalities.

General

Lightweight instruments
Easy and safe daily insertion/removal
fully integrated solutions for BioSpec Systems
PET optimized total body RF coils
PET optimized animal cradles
Paravision 360 for hybrid scanning, image fusion, visualization and data analysis
MR based attenuation correction for accurate PET quantification
PMOD for advanced molecular PET data analysis and modelling
Moveable on electronic cart with clean and safe operation
PET stand-alone operation with multi-modal compatible animal cradles and independent PET imaging workplaces

PET Insert Si 198

Designed for total body PET of mice and rats
- Inner diameter 112 mm
- up to 0.7 mm spatial resolution
- 12 % sensitivity
- 150 x 80 mm FOV
- multi-mouse and rats up to 600grams
Compatible with: BioSpec 70/30 and 94/30 USR

PET Insert Si 103

Designed for total body PET of mice and rat head applications
- Inner diameter 60 mm
- up to 0.7 mm spatial resolution
- 11 % sensitivity
- 101 x 55 mm FOV
Compatible with BioSpec 20 cm and 30 cm USR
Compatible with BioSpec Maxwell 30/17, 70/17 and 94/17

The PET Insert is operated by Paravision 360 with the trusted Paravision appearance and workflow allowing MRI users to followfamiliar MR imaging workflows and therefore start obtaining valuable PET/MR data almost immediately. The first system was installed in August 2016 in a 7 Tesla system atthe Katholieke Universiteit in Leuven, Belgium under the guidance of Christophe Deroose, Ph.D., Professor of Nuclear Medicine. Their initial imaging highlights the value of simultaneous PET/MR in studies involving structure/function in both tumor gross anatomy and tumor micro-environment. The potential of multi-parametric analysis, as well as simultaneous brain and cardiac imaging are also demonstrated.

Dynamic Brain Imaging in Rats using ¹¹C-Flumazenil

Curtesy: KU Leuven

Simultaneous Multi-Mouse PET/MR for Tracer Validation

Courtesy: I. Y Zhou et al. Peter Caravan Laboratory. High-Throughput Total Body Dynamic Imaging in a Preclinical PET/MRI 4.7T System. The Athinoula A. Martinos Center for Biomedical Imaging, MGH and Harvard Medical School. SNMMI 2020 Poster

IntraGate PET/MR® for
self-gated Cardiac PET/MR

Courtesy: Dr. W. Gsell, Prof. C. Deroose, Prof. U. Himmelreich, KU Leuven

High resolution mouse brain imaging using ¹⁸F-FDG PET/MR at 9.4T and registration to PMOD brain atlases

Curtesy: Dep. Of radiology and Imaging Sciences Indiana University

PET and MR in Mouse MetastaticTumor Model

(Left) Coronal whole-body PET/MR. (Right) Focused Axial PET/MR revealing location of lung and abdominal tumors.

Courtesy of Acknowledgements. Thanks to the Katherine Tucker, Mikayla Rodger, Dr. Lixin Ma, Dr. Carolyn Anderson, and Dr. Barry Edwards, MITC – Molecular & Imaging Theranostics Center, University of Missouri.

Total body PET/MRI images of mice

Imaged at pre-injection and 1, 5, 30, 45 mins post-injection of 0.1 mmol/kg [52Mn]Mn-2CHyd or [52Mn]Mn-1CHyd.
Courtesy Yingying Ning , Iris Yuwen Zhou, Nicholas J Rotile et al. MGH – USA

Reference: J Am Chem Soc. 2022 Sep 14;144(36):16553-16558.

⁶⁴Cu Tracer Validations/Characterizations in a Mouse Glioblastoma Model

PET/CT and MR in Mouse Glioblastoma Model. (Left) Multi-Mouse PET/CT was performed for efficient tracer validations. (Right) MR brain imaging subsequently performed and registered with PET data. Courtesy of Acknowledgements. Katherine Tucker, Mikayla Rodger, Dr. Lixin Ma, Dr. Carolyn Anderson, and Dr. Barry Edwards, MITC – Molecular & Imaging Theranostics Center, University of Missouri.

AD Model in Marmosets: Awake Imaging with ¹¹C-PiB and ¹⁸F-FDG PET

PET/CT Si78

Courtesy of A. Silva, D. Schaeffer and K. Cashman. University of Pittsburgh Brain Institute, USA

Webinars

From Anatomical Imaging to the Mapping of Molecular Events - Neuroimaging with the BioSpec Maxwell PET - MRI

We will present recent advances in preclinical MRI and PET technology that are combined in Bruker`s BioSpec Maxwell series and showcase examples of neuroimaging applications from the imaging of anatomy to the mapping of molecular events.

From Anatomical Imaging to the Mapping of Molecular Events - Neuroimaging with the BioSpec Maxwell PET - MRI

We will present recent advances in preclinical MRI and PET technology that are combined in Bruker`s BioSpec Maxwell series and showcase examples of neuroimaging applications from the imaging of anatomy to the mapping of molecular events.

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Brochures

Application Notes

LabScape

Service & Life Cycle Support for Magnetic Resonance and Preclinical Imaging

Bruker’s commitment to provide customers with unparalleled help throughout the buying cycle, from initial inquiry to evaluation, installation, and the lifetime of the instrument is now characterized by the LabScape service concept.

LabScape Maintenance Agreements, On-Site On-Demand and Enhance Your Lab are designed to offer a new approach to maintenance and service for the modern laboratory