Fluorescence Microscopy Webinars

Transforming depression with an innovative neurobehavioral assay to assess potentially novel antidepressants

Learn about Inscopix's latest contract research services (CRO) for pharmaceutical companies and biotech.

Advancing Pharmaceutical Research with Miniscope Imaging

During this webinar, Dr. Jonathan Nassi showcases Inscopix's latest contract research services (CRO) for pharmaceutical and biotech companies, highlighting the advanced capabilities of the Inscopix Discovery Lab with in vivo miniscope imaging and behavioral analysis. Additionally, Dr. Benjamin Siemsen from Supernus Pharmaceuticals, Inc. presents findings from a recent project, focusing on the unique neurobehavioral signature of NV-5138 compared to ketamine and rapastinel.

Webinar Summary

Learn about Inscopix's latest contract research services (CRO) for pharmaceutical companies and biotech. Dr. Jonathan Nassi demonstrates the cutting-edge capabilities of the Inscopix Discovery Lab, using advanced in vivo miniscope imaging integrated with behavioral analysis. This innovative method supports pharmaceutical preclinical programs by providing a unique way to evaluate new compounds and understand the effects of drugs on brain function during active behavior. Additionally, he highlights an antidepressant profiling and reference library developed in collaboration with pharma. One such collaboration, and the resulting data, is presented in this webinar.

Dr. Benjamin Siemsen of Supernus Pharmaceuticals, Inc. unveils the newest findings from a project conducted through the Inscopix Discovery Lab, in a presentation titled,


NV-5138 screening through Inscopix neurobehavioral assay: Comparison with ketamine and rapastinel

The need for rapid onset time coupled with improved efficacy has ushered in a wave of innovations in antidepressant pharmacotherapeutics. These so-called rapid-acting antidepressants (RAADs) are thought to engage the brain’s neuroplasticity mechanisms in key brain regions implicated in depression etiology, such as the prefrontal cortex (PFC). NV-5138 is a Phase 2 drug candidate with potential RAAD effects that was recently screened through the Inscopix neurobehavioral assay. Relative to ketamine and rapastinel, NV-5138 displayed a unique neurobehavioral signature that will be discussed in detail during this webinar.

Find out more about the technology featured in this webinar or our other solutions for Miniscope Imaging:

Speakers

Jonathan Nassi, Ph.D., Senior Director, Translational Science, Inscopix, A Bruker Company

Jonathan Nassi is the Senior Director of Translational Science at Inscopix. Prior to joining Inscopix, he received his PhD in Neuroscience from UCSD and conducted postdoctoral research at Harvard Medical School and the Salk Institute. He has over 14 years of research experience utilizing advanced methods in neuroanatomy, in-vivo imaging and electrophysiology, optogenetics and behavioral measurement to study neural circuit function in rodents and non-human primates. Jonathan is committed to the advancement of innovative technologies that will enable tomorrow’s breakthrough neuroscience discoveries and next-generation therapies for neurodegenerative and neuropsychiatric disease.

Benjamin Siemsen, Ph.D., Senior Manager, Preclinical Pharmacology, Supernus Pharmaceuticals

Benjamin (Ben) Siemsen, PhD is a Senior Manager in the preclinical pharmacology and DMPK team at Supernus Pharmaceuticals, Inc.. This US-based company focuses on developing innovative treatments for CNS disorders with particularly high unmet needs.