Multiphoton Microscopes
Leading advances in neuroscience with fast, deep and large field-of-view multiphoton imaging
See Deeper into Brain Activity
Multiphoton microscopy (MPM) is well-suited for functional imaging deeper into biological tissues than what is possible with confocal microscopy. This imaging technique is commonly used in intravital imaging of healthy and diseased tissues and cells, with or without fluorescent labeling. Recent advances in multiphoton microscopy technology support fast, in vivo imaging with single-cell resolution and a large field of view. Integration of optogenetics with multiphoton imaging has opened new avenues in studying the computational performance of the brain in live animals.
At the forefront of scientific discoveries for nearly two decades, Bruker’s Ultima multiphoton imaging technology is a direct result of close collaboration and laboratory experience with leading neuroscientists around the world. These efforts have led to a host of unique capabilities and features found only on Ultima systems, such as our modular setup, incorporated photostimulation light path, and feature-rich Prairie View software.
Multiphoton Microscopy Webinar Series
Hear from researchers and experts on best practices, new techniques and discoveries, and ideas for new applications using two-photon microscopy.
Learn More About Multiphoton Microscopy
Browse Multiphoton Microscopy Articles
| Year | Title | Author(s) | Imaging Platform | Subject(s) | Methodology |
|---|---|---|---|---|---|
| 2023 | Holographic stimulation of opposing amygdala ensembles bidirectionally modulates valence-specific behavior via mutual inhibition | Piantadosi, S.C., Zhou, Z.C., (...), Bruchas, M.R. | Ultima 2P plus | Basolateral amygdala neurons | Mouse, In-vivo, Calcium Imaging, Holographic Photostimulation |
| 2023 | A stable, distributed code for cue value in mouse cortex during reward learning | Ottenheimer, D.J., Hjort, M.M., (...), Stuber, G.D. | Ultima 2P plus | Cortex | Mouse, In-vivo, Calcium imaging, Electrophysiology |
| 2023 | Electrophysiological measurements of synaptic connectivity and plasticity in the longitudinal dentate gyrus network from mouse hippocampal slices | Kwon, Y.J., Pak, S, (...), Yang, S. | Ultima InVitro | Hippocampus, Dentate Gyrus Granule Neurons | Mouse, In-vitro, Calcium Imaging, Glutamate Uncaging |
| 2023 | Fluorescence Lifetime Imaging Microscopy (FLIM) reveals spatial-metabolic changes in 3D breast cancer spheroids | Karrobi, K., Tank, A., (...), Roblyer, D. | Ultima Investigator | Cancer Organoids, Hippocampus | Calcium Imaging, FLIM |
| 2023 | Dually innervated dendritic spines develop in the absence of excitatory activity and resist plasticity through tonic inhibitory crosstalk | Kleinjan, M.S., Buchta, W.C., (...), Kennedy, M.J. | Ultima | Hippocampus, Dendritic Spines | Rat, In-vivo, Calcium Imaging, Glutamate Uncaging |
| 2023 | Cortico-cortical feedback engages active dendrites in visual cortex | Fişek, M., Herrmann, D., (…), Häusser, M. | Ultima 2P plus | Cortical Regions | Mouse, In-vivo, Calcium Imaging, Volumetric Imaging, Holographic Stimulation |
| 2022 | Maturation and circuit integration of transplanted human cortical organoids | Revah, O., Gore, F., (…), Pașca, P.S. | Ultima 2P plus | Somatosensory Cortex | Rat, In-vivo, Calcium Imaging, Electrophysiology, Optogenetic Stimulation |
| 2021 | Reduced synchroneity of intra-islet Ca2+ oscillations in vivo in Robo-deficient β cells (eLife) | Adams, M.T., Dwulet, J.M., (…), Kravets, V. | Ultima Inverted | Pancreas | Mouse, In-vivo, Calcium Imaging |
| 2021 | Autonomous Purkinje cell activation instructs bidirectional motor learning through evoked dendritic calcium signaling (Nat Commun) | Bonnan, A., Rowan, M.M.J., (…), Christie, J.M. | Ultima | Cerebellum, Neurotransmission | Mouse, In-vitro, Calcium Imaging, Optogenetics, ChR2(H134R), Electrophysiology, Dodt |
| 2021 | Fruitless decommissions regulatory elements to implement cell-type-specific neuronal masculinization (PLoS Genet.) | Brovkina, M.V., Duffie, R., (…), Clowney, E.J. | Ultima Investigator | Sexual dimorphism | Drosophila, Deep Imaging, Fixed sample |
| 2021 | Combined tumor-directed recruitment and protection from immune suppression enable CAR T cell efficacy in solid tumors (Sci Adv.) | Cadilha, B.L., Benmebarek, M.R., (…), Kobold, S. | Ultima | Immune system | Mouse, In-vivo, Multicolor Imaging |
| 2021 | Recent innovations in fluorescence lifetime imaging microscopy for biology and medicine (J Biomed Opt.) | Datta, R., Gillete, A., Stefely, M., Skala, M.C. | Ultima Inverted | FLIM | FLIM |
| 2021 | Optogenetic strategies for high-efficiency all-optical interrogation using blue-light-sensitive opsins (eLife) | Forli, A., Pisoni, M., (…), Fellin, T. | Ultima Investigator | Somatosensory Cortex | Mouse, In-vivo, Calcium Imaging, Holographic, Optogenetics, CoChR, Electrophysiology |
| 2021 | A two-photon FRAP protocol to measure the stereociliary membrane diffusivity in rat cochlear hair cells (STAR Protocols) | George, S.S., Steeke C.R., Ricci, A.J. | Ultima | Cochlea, cilia | Mouse, In-vitro, FRAP |
| 2021 | Intercalated amygdala clusters orchestrate a switch in fear state (Nature) | Hagihara, K.M., Bukalo, O., (…), Holmes, A. | Ultima | Amygdala | Mouse, In-vivo, Calcium Imaging, GRIN lens |
| 2021 | Brain capillary pericytes exert a substantial but slow influence on blood flow (Nature Neuroscience) | Hartmann, D.A., Berthiaume, (…), Shih, A.Y. | Ultima Investigator | Neurovascular system | Mouse, In-vivo, Optogenetics |
| 2021 | Visual recognition is heralded by shifts in local field potential oscillations and inhibitory networks in primary visual cortex (J Neurosci.) | Hayden, D.J., Montgomery, D.P., Cooke, S.F., Bear, M.F. | Ultima | Visual Cortex | Mouse, In-vivo, Calcium imaging, Electrophysiology |
| 2021 | The role of intra-articular neuronal CCR2 receptors in knee joint pain associated with experimental osteoarthritis in mice (Arthritis Res Ther.) | Ishihara S, Obeidat AM, (…), Miller RE. | Ultima | Dorsal Root Ganglion, Pain | Mouse, In-vivo, Calcium Imaging, GCaMP3 or GCaMP6 |
| 2021 | Clustered functional domains for curves and corners in cortical area V4 (eLife) | Jiang, R., Andolina, M.I., Tang, S. | Ultima | Visual Cortex | Macaque, In-vivo, Calcium Imaging |
| 2021 | Chronic Cranial Windows for Long Term Multimodal Neurovascular Imaging in Mice (Front Physiol.) | Kılıç K, Desjardins M, (…), Devor A. | Ultima | Neurovascular system | Mouse, In-vivo, Protocol |
| 2021 | Photo-labeling neurons in the Drosophila brain (STAR Protocols) | Li, J., Ellis, K.E., Caron, S.J.C. | Ultima | Cellular morphology | Drosophila, Photolabelling, Protocol |
| 2021 | Presynaptic NMDA receptors facilitate short-term plasticity and BDNF release at hippocampal mossy fiber synapses (eLife) | Lituma, P.J., Kwon, H., (…), Castillo, P.E. | Ultima | Neurotransmission | Mouse, In-vitro, Calcium Imaging, Electrophysiology, Neurotransmitter Uncaging |
| 2021 | Stress induces microglia-associated synaptic circuit alterations in the dorsomedial prefrontal cortex (Neurobiology of Stress) | Liu, T., Lu, J., (…), Zuo, Y. | Ultima Investigator | Prefrontal Cortex, Glia, Spines | Mouse, In-vivo |
| 2021 | Coupling of activity, metabolism and behaviour across the Drosophila brain (Nature) | Mann, K., Deny, S., (…), Clandinin, T.R. | Ultima | Metabolism | Drosophila, In-Vivo, Calcium Imaging, GCaMP6s, jRGECO1a, Optogenetics, CsChrimson, Pyronic, iATPSnFR |
| 2021 | Expansion of tumor-associated Treg cells upon disruption of a CTLA-4-dependent feedback loop (Cell) | Marangoni, F., Zhakyp, A., (...), Mempel, T.R. | Ultima | Immune system | Mouse, In-vivo, Multicolor Imaging |
| 2021 | VasoMetrics: unbiased spatiotemporal analysis of microvascular diameter in multi-photon imaging applications (Quantitative Imaging in Medicine and Surgery) | McDowell, K.P., Berthiaume, A., (...), Shih, A.Y. | Ultima Investigator | Neurovascular system | Mouse, In-vivo, Protocol |
| 2021 | Microglial Gi-dependent dynamics regulate brain network hyperexcitability (Nature Neuroscience) | Merlini, M., Rafalski, V.A., (...), Akassoglou, K. | Ultima | Immune system, Glia, Epilepsy | Mouse, In-vivo, Calcium Imaging, Neurotransmitter Uncaging |
| 2021 | Net decrease in spine-surface GluA1-containing AMPA receptors after post-learning sleep in the adult mouse cortex (Nature Communications) | Miyamoto, D., Marshall, W., Tononi, G., Cirelli, C. | Ultima | Motor Cortex, Spines | Mouse, In-vivo, Calcium Imaging |
| 2021 | Dysregulation of the mesoprefrontal dopamine circuit mediates an early-life stress-induced synaptic imbalance in the prefrontal cortex (Cell Reports) | Oh, W.C., Rodriguez, (...), Kwon, H.B. | Ultima Investigator | Prefrontal Cortex | Mouse, In-vivo, Calcium Imaging, In-vitro, Electrophysiology |
| 2021 | Increased dopaminergic neurotransmission results in ethanol dependent sedative behaviors in Caenorhabditis elegans (PLoS Genetics) | Pandey, P., Singh, A., (...), Babu, K. | Ultima | Neurotransmission | C.elegans, In-vivo, Imaging, Ablation |
| 2021 | The physiological basis for the computation of direction selectivity in the Drosophila OFF pathway (bioRxiv) | Ramos-Traslosheros, G., Silies, M. | Ultima Investigator | Visual system | Drosophila, In-vivo, Calcium Imaging, GCaMP, jRGECO1a |
| 2021 | Long-term Transverse Imaging of the Hippocampus with Glass Microperiscopes (bioRxiv) | Redman, W.T., Wolcott, N.S. (...), Goard, M.J. | Ultima Investigator | Hippocampus, dendrites | Mouse, In-vivo, Calcium Imaging, Microperiscope, Protocol |
| 2021 | All-optical interrogation of neural circuits in behaving mice (bioRxiv) | Russell, L.E., Dalgleish, H.W.P., (...) Häusser, M. | Ultima | Barrel Cortex | Mouse, In-vivo, Calcium Imaging, Holographic, Optogenetics, C1V1, SLM |
| 2021 | Robustness and plasticity in Drosophila heat avoidance (Nature Communications) | Simões, J.M., Levy, J.I., (...), Gallio, M. | Ultima | Innate behavior | Drosophila, In-vivo, Calcium Imaging, Electrophysiology |
| 2021 | Astrocyte glutamate uptake coordinates experience-dependent, eye-specific refinement in developing visual cortex (Glia) | Sipe, G.O., Petravicz, J., (...), Sur, M. | Ultima | Visual Cortex, Glia, Spines | Mouse, In-vivo, Visual Stimulation, In-vitro, Electrophysiology, Intrinsic imaging |
| 2021 | Two-photon calcium imaging of seizures in awake, head-fixed mice (Cell Calcium) | Somarowthu, A., Goff, K.M., Goldberg, E.M. | Ultima | Cortex, Epilepsy | Mouse, In-vivo, Calcium Imaging, Protocol |
| 2021 | Sexual arousal gates visual processing during Drosophila courtship (Nature) | Sten, T.H., Rufei, L., Otopalik, A., Ruta, V. | Ultima | Innate behavior | Drosophila, In-vivo, Calcium Imaging, Visual Stimulation |
| 2021 | Inhibiting retinoic acid mitigates vision loss in a mouse model of retinal degeneration (bioRxiv) | Telias, M., Sit, K., (...), Kramer, R.H. | Ultima Investigator | Visual cortex | Mouse, In-vivo, Calcium Imaging |
| 2021 | In vivo two-photon microscopy protocol for imaging microglial responses and spine elimination at sites of fibrinogen deposition in mouse brain (STAR Protoc.) | Tognatta, R., Merlini, M., (...), Akassoglou, K. | Ultima | Glia, Immune system, Alzheimers | Mouse, In-vivo, Calcium Imaging, Neurotransmitter Uncaging, Protocol |
| 2021 | Dendritic calcium signals in rhesus macaque motor cortex drive an optical brain-computer interface (Nat Commun.) | Trautmann, E.M., O'Shea, D.J., Sun, X., (...), Shenoy, K.V. | Ultima | Motor Cortex, Dendrites | Macaque, In-vivo, Calcium Imaging |
| 2021 | The connectome predicts resting-state functional connectivity across the Drosophila brain (Current Biology) | Turner, M.H., Mann, K., Clandinin, T.R. | Ultima | Connectome | Drosophila, In-vivo, whole brain imaging |
| 2021 | Classification of T-cell activation via autofluorescence lifetime imaging (Nature Biomedical Engineering) | Walsh, A.J., Mueller, K.P., (...), Skala, M.C. | Ultima | Immune system | Mouse, In-vitro, FLIM |
| 2021 | Environmental enrichment sharpens sensory acuity by enhancing information coding in barrel cortex and premotor cortex (eNeuro) | Zheng, H.J.V., Meagher, J.P., (...), Kwon, H.B. | Ultima | Somatosensory Cortex | Mouse, In-vivo, Calcium Imaging |
| 2021 | Cortical astrocytes independently regulate sleep depth and duration via separate GPCR pathways (eLife) | Vaidyanathan, T.V., Collard, M., (...), Poskanzer, K.E. | Ultima | Visual Cortex, Layer 2/3, astrocytes | Mouse, In-vivo, In-vitro, Calcium Imaging GCaMP6f |
| 2021 | A distributed circuit for associating environmental context with motor choice in retrosplenial cortex (Science Adv) | Franco, L.M., Goard, M.J. | Ultima Investigator | Visual Cortex | Mouse, In-vivo, Calcium Imaging, GCaMP6s, Virtual reality |
| 2021 | Specialized coding patterns among dorsomedial prefrontal neuronal ensembles predict conditioned reward seeking (Elife) | Grant RI, Doncheck EM, (...), Otis JM. | Ultima | Prefrontal Cortex | Mouse, In-vivo, Calcium Imaging, GCaMP6s, GRIN lens |
| 2020 | Differential relation between neuronal and behavioral discrimination during hippocampal memory encoding (Neuron) | Allegra M., Posani L., (…), Schmidt-Hieber C. | Ultima | Cognition, memory, place cells | Mouse, In-vivo, Calcium Imaging, cannula, GRIN lens, Electrophysiology, virtual reality |
| 2020 | Motor learning promotes remyelination via new and surviving oligodendrocytes (Nature Neuroscience) | Bacmeister, C.M., Barr, H.J., (…), Hughes, E.G. | Ultima Investigator | Motor Cortex, Glia | Mouse, In-vivo |
| 2020 | Astrocytic Ca2+ signaling is reduced during sleep and is involved in the regulation of slow wave sleep (Nature Communications) | Bojarskaite, L., Bjørnstad, D.M., (…), Nagelhus, E.A. | Ultima | Neocortex, Glia | Mouse, In-vivo, calcium imaging, intrinsic imaging, electrophysiology |
| 2020 | Hippocampal neurons with stable excitatory connectivity become part of neuronal representations (PLoS Biology) | Castello-Waldow T.P., Weston G., (…), Attardo A. | Ultima | Hippocampus, Spines | Mouse, In-vivo, cannula |
| 2020 | Dysfunction of cortical GABAergic neurons leads to sensory hyper-reactivity in a Shank3 mouse model of ASD (Nature Neuroscience) | Chen Q., Deister C.A., (…), Feng G. | Ultima | Somatosensory Cortex | Mouse, In-vivo, sensory stimulation, calcium imaging |
| 2020 | How many neurons are sufficient for perception of cortical activity? (eLife) | Dalgleish, H.W.P., Russell, L.E., (…), Häusser, M. | Ultima | Barrel Cortex | Mouse, In-vivo, Prairie Link, All-optical approach |
| 2020 | Astrocytes and microglia play orchestrated roles and respect phagocytic territories during neuronal corpse removal in vivo (Science Advances) | Damisah, E.C., Hill, R.A., (…), Grutzendler, J. | Ultima Investigator | Glia | Mouse, In-vivo, 2Phatal |
| 2020 | Epithelial layer unjamming shifts energy metabolism toward glycolysis (Sci Rep) | DeCamp, S.J., Tsuda, V.M.K., (...), Fredberg, J.J. | Ultima Investigator | Wound healing | Epithelial cell culture, In-vitro, FLIM |
| 2020 | Optofluidic control of rodent learning using cloaked caged glutamate (Proc Natl Acad Sci U.S.A.) | Durand-de Cuttoli, R., Chauhan, P.S., (…), Ellis-Davies, G.C.R. | Ultima | Neurotransmission | Mouse, In-vivo, Neurotransmitter uncaging |
| 2020 | Recurrent architecture for adaptive regulation of learning in the insect brain (Nature Neuroscience) | Eschbach, C., Fushiki, A., (…), Zlatic, M. | Ultima | Connectome, Neuromodulation | Drosophila, In vivo, Calcium Imaging, Optogenetics, LED |
| 2020 | Functional dissection of basal ganglia inhibitory inputs onto substantia nigra dopaminergic neurons (Cell Reports) | Evans R.C., Twedell E.L., (…), Khaliq, Z.M. | Ultima | Striatum, Basal Ganglia | Mouse, In-vitro, Calcium Imaging, Electrophysiology, Optogenetics |
| 2020 | Rat auditory inner hair cell mechanotransduction and stereociliary membrane diffusivity are similarly modulated by calcium (iScience) | George S.S., Steele C.R., Ricci A.J. | Ultima | Cochlea, Hair Cells | Rat, In-vitro, FRAP, FLIM, Electrophysiology |
| 2020 | Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain (Nature Neuroscience) | Graves, S.M., Xie, Z., (…), Surmeier, D.J. | Ultima | Metabolism, Dopamine | Mouse, In-vitro, Electrophysiology, Dodt |
| 2020 | Circuit mechanisms underlying chromatic encoding in Drosophila photoreceptors (Current Biology) | Heath, S.L., Christenson, M.P., (…), & Behnia, R. | Ultima Investigator | Medulla | Drosophila, In-vivo, Calcium Imaging |
| 2020 | Distinct prefrontal top-down circuits differentially modulate sensorimotor behavior (Nature Communications) | Huda, R., Sipe, G.O., (…), Sur, M. | Ultima | Prefrontal cortex | Mouse, In-vivo, Calcium imaging, Visual Stimulation |
| 2020 | A role for astroglial calcium in mammalian sleep and sleep regulation (Current Biology) | Ingiosi, A.M., Hayworth, C.R., (…), Frank, M. G. | Ultima | Glia | Mouse, In-vivo, Calcium Imaging, Grin lens |
| 2020 | Nicotine Self-Administration Induces Plastic Changes to Nicotinic Receptors in Medial Habenula (eNeuro) | Jin XT, Tucker BR, Drenan RM. | Ultima | Habenula, Addiction | Mouse, In-vitro, Neurotransmitter Uncaging, Electrophysiology, Dodt |
| 2020 | Spatiotemporal functional organization of excitatory synaptic inputs onto macaque V1 neurons (Nat Commun.) | Ju N, Li Y, (...), Tang, S. | Ultima | Visual Cortex, Dendrites | Macaque, In-Vivo, Calcium Imaging, iGluSnFR |
| 2020 | A role for the locus coeruleus in hippocampal CA1 place cell reorganization during spatial reward learning (Neuron) | Kaufman, A.M., Geiller, T., Losonczy, A. | Ultima | Hippocampus, Place cells, Neuromodulation | Mouse, In-vivo, Calcium Imaging, Optogenetics, Inhibition, Piezo, LED |
| 2020 | Luminance Information Is Required for the Accurate Estimation of Contrast in Rapidly Changing Visual Contexts (Curr Biol.) | Ketkar MD, Sporar K, (...), Silies M. | Ultima Investigator | Visual System | Drosophila, Visual Stimulation |
| 2020 | Cell-type-specific outcome representation in the primary motor cortex (Neuron) | Levy, S., Lavzin, M., (…), Schiller, J. | Ultima | Motor Cortex, Layer 5 | Mouse, In-vivo, Calcium Imaging, Optogenetics |
| 2020 | Visual input into the Drosophila melanogaster mushroom body (Cell Reports) | Li, J., Mahoney, B.D., (…), Caron, S.J.C. | Ultima | Mushroom body | Drosophila, Photolabelling |
| 2020 | Three-photon imaging of synthetic dyes in deep layers of the neocortex (Scientific Reports) | Liu, C.J., Roy, A., (…), Kara, P. | Ultima Investigator | Neocortex | Mouse, In-Vivo, 3P Imaging |
| 2020 | Spatial readout of visual looming in the central brain of Drosophila (eLife) | Morimoto, M.M., Nern, A., (…), Reiser, M.B. | Ultima | Visual system, Optic glomerus | Drosophila, In-vivo, Calcium Imaging, Optogenetics |
| 2020 | Precise, 3-D optogenetic control of the diameter of single arterioles (bioRxiv) | O’Herron, P.J, Hartmann, D.A., (...), Shih A.Y. | Ultima 2P plus | Neurovascular System | Mouse, In-vivo, Optogenetics, SLM |
| 2020 | A thalamocortical top-down circuit for associative memory (Science) | Pardi, M.B., Vogenstahl, J., (…), Letzkus, J.J. | Ultima Investigator | Thalamus, Auditory Cortex | Mouse, In-vivo, Calcium Imaging, Optogenetics, Electrophysiology |
| 2020 | Young adult-born neurons improve odor coding by mitral cells (Nature Communications) | Shani-Narkiss, H., Vinograd, A., (...), Mizrahi, A. | Ultima | Olfactory bulb, Neurogenesis | Mouse, In-Vivo, Calcium Imaging |
| 2020 | Distributed and retinotopically asymmetric processing of coherent motion in mouse visual cortex (Nature Communications) | Sit, K.K., Goard, M.J. | Ultima Investigator | Visual cortex | Mouse, In-vivo, GCaMP |
| 2020 | A spike-timing-dependent plasticity rule for dendritic spines (Nature Communications) | Tazerart, S., Mitchell, D.E.,(...), Araya, R. | Ultima | Neurotransmission, Layer 5, Spines | Mouse, In-vitro, Neurotransmitter Uncaging, |
| 2020 | Imaging and optogenetic modulation of vascular mural cells in the live brain (Nature Protocols) | Tong, L., Hiil, R.A., (...), Grutzendler, J. | Ultima Investigator | Neurovascular system | Mouse, In-vivo, Calcium Imaging, Optogenetics, Protocol |
| 2020 | Transient and persistent representations of odor value in prefrontal cortex (Neuron) | Wang, P.Y., Boboila, C., (...), Axel, R. | Ultima | Olfaction, Behavior | Mouse, In-vivo, Calcium Imaging, Optogenetics |
| 2020 | Context-dependent decision making in a premotor circuit (Neuron) | Wu,Z., Litwin-Kumar, A., (...), Shadlen, M.N. | Ultima | Olfaction, Behavior | Mouse, In-Vivo, Calcium Imaging, Eletcrophysiology, Neuronexus |
| 2019 | Widespread and highly correlated smato-dendritic activity in cortical layer 5 neurons (Neuron) | Beaulieu-Laroche, L., Toloza, E.H.S., (…), Harnett, M.T. | Ultima | Visual cortex, Dendrites | Mouse, In-vitro, Calcium imaging, GCaMP6f, Alexa 594, Line scan, Electrophysiology |
| 2019 | Long-term imaging of dorsal root ganglia in awake behaving mice (Nat Commun.) | Chen C, Zhang J, (...), Yang G. | Ultima Investigator | Spinal cord | Mouse, In-vivo, Calcium Imaging, GCaMP6s |
| 2019 | A critical role for neocortical processing of threat memory (Neuron) | Dalmay T., Abs E., (…), Letzkus J.J. | Ultima Investigator | Auditory cortex | Mouse, In-vivo, Calcium imaging, GCaMP6s |
| 2019 | Awake mouse imaging: From two-photon microscopy to blood oxygen level–dependent functional magnetic resonance imaging (Biological Psychiatry: Cognitive Neuroscience and Neuroimaging) | Desjardins, M., Kılıç, K., (…), Devor, A. | Ultima | Neurovascular system | Mouse, In-vivo, Imaging |
| 2019 | Microglia are effector cells of CD47-SIRPα antiphagocytic axis disruption against glioblastoma (Proc Natl Acad Sci U.S.A.) | Hutter G., Theruvath J., (…), Cheshier S.H. | Ultima | Brain tumor, Glia, Microglia | Mouse, In-vivo, Imaging |
| 2019 | Interacting neural ensembles in orbitofrontal cortex for social and feeding behaviour (Nature) | Jennings, J.H., Kim, C.K., (…), Deisseroth, K. | Ultima | Orbitofrontal cortex | Mouse, In-vivo,Calcium imaging, Optogenetics, GCaMP6m-bReaChES, GRIN lens |
| 2019 | Diffuse and nonlinear imaging of multiscale vascular parameters for in vivo monitoring of preclinical mammary tumors (J Biophotonics) | Karrobi K, Tank A, (...), Roblyer D. | Ultima Investigator | Cancer imaging | Tumor tissue, diffuse optical imaging |
| 2019 | Live-cell imaging reveals the relative contributions of antigen-presenting cell subsets to thymic central tolerance (Nature Communications) | Lancaster, J.N., Thyagarajan, H.M., (…), Ehrlich, L.I.R. | Ultima | Thymus | Mouse, In-vitro |
| 2019 | Cortical layer-specific critical dynamics triggering perception (Science) | Marshel, J.H., Kim, Y.S., (…), Deisseroth, K. | Ultima | Visual Cortex, Layer 2/3, Layer 5 | Mouse, In-vivo, Calcium Imaging, Optogenetics, GCaMP6m-ChRmine, SLM |
| 2019 | Maladaptive downregulation of autonomous subthalamic nucleus activity following the loss of midbrain dopamine neurons (Cell Reports) | McIver, E.L., Atherton, J.F., (…), Bevan, M. D | Ultima | Globus Pallidus, Striatum | Mouse, In-vitro, Imaging |
| 2019 | Fibrinogen Induces Microglia-Mediated Spine Elimination and Cognitive Impairment in an Alzheimer's Disease Model. (Neuron) | Merlini, M., Rafalski, V.A., (…), Akassoglou, K. | Ultima | Neurovascular system, Glia, Microglia, Spines | Mouse, In-vivo, Imaging |
| 2019 | Calcium activation of cortical neurons by continuous electrical stimulation: Frequency dependence, temporal fidelity, and activation density (Journal of Neuroscience Research) | Michelson, N.J., Eles, J.R., (…), Kozai, T.D.Y. | Ultima | Somatosensory cortex | Mouse, In-vivo, Calcium imaging, Thy1-GCaMP6s |
| 2019 | Probing single synapses via the photolytic release of neurotransmitters (frontiers in Synaptic Neuroscience) | Mitchell, D.E., Martineau, É., (…), Araya, R. | Ultima | Synaptic plasticity, Dendrites, Spines | Mouse, In-vitro, Neurotransmitter uncaging, MNI-Glu, RuBi-Glu |
| 2019 | Temporary visual deprivation causes decorrelation of spatiotemporal population responses in adult mouse auditory cortex (eNeuro) | Solarana K., Liu J., (…), Kanold P.O. | Ultima | Auditory cortex, Layer 2/3, Layer 4 | Mouse, In-vivo, Thy1-GCaMP6s |
| 2019 | Intracortical neural stimulation with untethered, utrasmall carbon fiber electrodes mediated by the photoelectric effect (IEEE Transactions on Biomedical Engineering) | Stocking, K.C., Vazquez, A.L., Kozai, T.D.Y. | Ultima | Brain stimulation | Mouse, In-vivo, NIR-stimulation |
| 2019 | Noradrenergic signaling in the wakeful state inhibits microglial surveillance and synaptic plasticity in the mouse visual cortex (Nature Neuroscience) | Stowell, R.D., Sipe, G.O., (…), Majewska, A. | Ultima | Microglia | Mouse, In-vivo, Piezo, Optogenetics, hChR2(H134R) |
| 2019 | Vasoactive intestinal polypeptide-expressing interneurons in the hippocampus support goal-oriented spatial learning (Neuron) | Turi, G.F., Li, W.K., (…), Losonczy, A. | Ultima | Hippocampus | Mouse, In-vivo, Calcium Imaging, Optogenetics, GCaMP6f, bReaChES-tdTomato, 620 nm LED |
| 2019 | Longitudinal Two-Photon Imaging of Dorsal Hippocampal CA1 in Live Mice (J Vis Exp) | Ulivi, A.F., Castello-Waldow, T.P., (…), Attardo, A. | Ultima | Hippocampus | Mouse, In-vivo, Calcium Imaging, Endoscope |
| 2019 | Electrical and synaptic integration of glioma into neural circuits (Nature) | Venkatesh, H.S., Morishita, W., (…), Monje, M. | Ultima | Brain tumor, Microglia | Mouse, In-vivo, In-vitro, Calcium Imaging, GCaMP6s |
| 2019 | Accurate quantification of astrocyte and neurotransmitter fluorescence dynamics for single-cell and population-level physiology (Nat Neurosci) | Wang Y, DelRosso NV, (...), Poskanzer KE. | Ultima | Glia, Astrocytes | Mouse, In-vivo, In-vitro, Calcium Imaging, GCaMP6f, iGluSnFR, iGABASnFR, GRAB-NE, Neurotransmitter Uncaging, RuBi-glutamate |
| 2018 | Learning-related plasticity in dendrite-targeting layer 1 interneurons (Neuron) | Abs, E., Poorthuis, R.B., (…), Letzkus, J.J | Ultima Investigator | Auditory cortex, Interneurons | Mouse, In-vivo, In-vitro, Calcium Imaging, GCaMP6f, GCamP6s, Electrophysiology, Optogenetics, ChrimsonR, LED 594 nm |
| 2018 | Preferential stabilization of newly formed dendritic spines in motor cortex during manual skill learning predicts performance gains, but not memory endurance (Neurobiology of Learning and Memory) | Clark, T.A., Fu, M., (…), Jones, T.A. | Ultima | Motor Cortex, Layer 5, Spines | Mouse, In-vivo, Imaging |
| 2018 | A gut-brain neural circuit for nutrient sensory transduction (Science) | Kaelberer, M.M., Buchanan, K.L., (…), Bohórquez, D.V. | Ultima | Gut-Brain Signalling | Mouse, In-vivo, Imaging |
| 2018 | Task-dependent representations of stimulus and choice in mouse parietal cortex (Nature Communications) | Pho, G.N., Goard, M.J., (…), Sur, M. | Ultima | Visual Cortex | Mouse, In-vivo, Calcium Imaging, GCaMP6s, Piezo |
| 2018 | Nicotinic cholinergic receptors in VTA glutamate neurons modulate excitatory transmission (Cell Reports) | Yan, Y., Peng, C., (…), Drenan, R.M. | Ultima | Ventral tegmental area (VTA) | Mouse, In-vitro, Neurotransmitter Uncaging, Optogenetics, ChR2, Electrophysiology |
| 2018 | Holographic imaging and photostimulation of neural activity (Current Opinion in Neurobiology) | Yang, W., Yuste, R. | Ultima | Cortex | Holographic Optogenetics, Review |
| 2018 | Fear extinction reverses dendritic spine formation induced by fear conditioning in the mouse auditory cortex (PNAS) | Lai CSW, Adler A, Gan WB. | Ultima | Auditory cortex, Layer 5 | Mouse, In-vivo, Spine imaging |
| 2018 | Closed-loop all-optical interrogation of neural circuits in vivo (Nature Methods) | Zhang, Z., Russell, L.E., (…), Häusser, M. | Ultima | Somatosensory Cortex | Mouse, In-vivo, Optogenetics, SLM, Calcium Imaging, Protocol |
| 2017 | Molecular and Circuit-Dynamical Identification of Top-Down Neural Mechanisms for Restraint of Reward Seeking. Cell. | Kim, C.K., Ye, L., (...), Deisseroth, K. | Ultima | Prefrontal Cortex | Mouse, In-Vivo, Calcium Imaging, Grin lens |
| 2016 | Gating of hippocampal activity, plasticity, and memory by entorhinal cortex long-range inhibition (Science) | Basu, J., Zaremba, J.D., (…), Siegelbaum, S.A. | Ultima | Hippocampus | |
| 2016 | A Family of non-GPCR Chemosensors Defines an Alternative Logic for Mammalian Olfaction (Cell) | Greer, P.L., Bear, D.M., (...), Datta, S.R. | Ultima | Olfaction | |
| 2016 | De novo synaptogenesis induced by GABA in the developing mouse cortex (Science) | Oh, W.C., Lutzu, S., (…), Kwon, H.B. | Ultima | Cortex, Dendrites, Spines | Mouse, In-vitro, Neurotransmitter Uncaging, Electrophysiology |
| 2016 | Synapse-level determination of action potential duration by K(+) channel clustering in axons (Neuron) | Rowan, M.J., DelCanto, G., (…), Christie, J.M. | Ultima | Cerebellum | Mouse, In-vitro, Electrophysiology, Neurotransmitter Uncaging, VSD imaging |
| 2015 | Multimodal chemosensory circuits controlling male courtship in Drosophila (Neuron) | Clowney, E.J., Iguchi, S., (…), Ruta, V. | Ultima | Somatosensory Cortex | Drosophila, In-vivo, Calcium Imaging |
| 2015 | Simultaneous all-optical manipulation and recording of neural circuit activity with cellular resolution in vivo (Nature Methods) | Packer, A.M., Russell, L.E., (…), Häusser, M. | Ultima | Barrel Cortex | Mouse, In-vivo, Optogenetics, SLM, Calcium Imaging, Protocol |
| 2014 | Distinct Kv channel subtypes contribute to differences in spike signaling properties in the axon initial segment and presynaptic boutons of cerebellar interneurons. (J Neurosci.) | Rowan, M.J., Tranquil, E., Christie, J.M. | Ultima | Synaptic plasticity | Mouse, In-vitro, Calcium imaging, VSD, Calcium indicator, Neurotransmitter uncaging, Electrophysiology |
| 2011 | Distinct representations of olfactory information in different cortical centres (Nature) | Sosulski DL, Bloom ML, (...), Datta SR. | Ultima | Olfactory bulb | Mouse, In-vitro |
| 2003 | Functional mapping and Ca2+ regulation of nicotinic acetylcholine receptor channels in rat hippocampal CA1 neurons (J Neurosci.) | Khirouq, L., Giniatullin R., (...), Yekel, J.L. | Ultima | Hippocampus | Neurotransmitter Uncaging, Electrophysiology |
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