books
books

MRMS Bibliography

MRMS Metabolomics and Imaging Bibliography

The MRMS technology is used in Metabolomics to study metabolites in plants, body fluids as well as in bacteria and yeast. MALDI Imaging is a technology that can be perfectly perform with high mass accuracy using the MRMS system. Imaging can be applied to human and animal tissue samples as well as plant samples. An overview of the literature of both technologies is shown here.

Metabolomics - Plants and Food

Title Authors Publication Link
Untargeted metabolomic analysis by ultra-high-resolution mass spectrometry for the profiling of new Italian wine varieties A. Onzo et al. Analytical and Bioanalytical Chemistry 2022, 414(27), 7805-7812 https://doi.org/10.1007/s00216-022-04314-x
Grapevine leaf MALDI-MS imaging reveals the localisation of a putatively identified sucrose metabolite associated to Plasmopara viticola development M. Maia et al. bioRxiv 2022, Preprint https://doi.org/10.1101/2022.08.01.502001
FTICR/MS Analysis of Micromeria Fruticosa and Teucrium Polium Growing in Lebanon M. Al-Hamawi et al. Pharmacognosy Journal 2022, 14(1), 112-127 https://doi.org/10.5530/pj.2022.14.16
Chemical fingerprinting of phenolic compounds in Finnish berry wines using Fourier transform ion cyclotron resonance mass spectrometry Y. Dou et al. Food Chemistry 2022, 383, 132303 https://doi.org/10.1016/j.foodchem.2022.132303
Analysis of coffee bean with laser desorption ionization high‐resolution mass spectrometry E. Cho et al. Bulletin of the Korean Chemical Society 2022, 43(3), 438-443 https://doi.org/10.1002/bkcs.12477
Olive Oil Quality and Authenticity Assessment Aspects Employing FIA-MRMS and LC-Orbitrap MS Metabolomic Approaches T. Nikou et al. Frontiers in Public Health 2020, Volume 8, Article 558226 https://www.frontiersin.org/articles/10.3389/fpubh.2020.558226/full
Expanding the Scope of Detectable Microbial Natural Products by Complementary Analytical Methods and Cultivation Systems C. Bader et al. J. Nat. Prod. 2021, 84, 2, 268–277 https://pubs.acs.org/doi/10.1021/acs.jnatprod.0c00942
Chemical Fingerprinting of Conifer Needle Essential Oils and Solvent Extracts by Ultrahigh-Resolution Fourier Transform Ion Cyclotron Resonance Mass Spectrometry O. O. Mofikoya et al. ACS Omega 2020 5 (18), 10543-10552 https://pubs.acs.org/doi/10.1021/acsomega.0c00901
Wine aging: a bottleneck story T. Karbowiak et al. npj Science of Food 3, 14 (2019) https://www.nature.com/articles/s41538-019-0045-9
Wine microbiology is driven by vineyard and winery anthropogenic factors C. Grangeteau et al. Microbial Biotechnology (2017) 10(2), 354–370 https://sfamjournals.onlinelibrary.wiley.com/doi/10.1111/1751-7915.12428
The chemodiversity of wines can reveal a metabologeography expression of cooperage oak wood R. D. Gougeon et al. PNAS 2009 106 (23) 9174-9179 https://www.pnas.org/content/106/23/9174
A grape and wine chemodiversity comparison of different appellations in Burgundy: Vintage vs terroir effects C. Roullier-Gall et al. Food Chem. 2014, 152, 100-107 https://www.sciencedirect.com/science/article/abs/pii/S0308814613016907
A Multilevel Study of Melon Fruit Reticulation Provides Insight into Skin Ligno-Suberization Hallmarks H. Cohen et. al. Plant Physiology, 179, 4, 2019, 1486–1501 https://academic.oup.com/plphys/article/179/4/1486/6116732
Revisiting anabasine biosynthesis in tobacco hairy roots expressing plant lysine decarboxylase gene by using 15N-labeled lysine S. Bunsupa et al. Plant Biotechnol. 31(5): 511-518 (2014) https://www.jstage.jst.go.jp/article/plantbiotechnology/31/5/31_14.1008a/_article

Metabolomics - Plants

Title Authors Publication Link
Direct introduction MALDI FTICR MS based on dried droplet deposition applied to non-targeted metabolomics on Pisum Sativum root exudates. V. Calabrese et al. Talanta 2022, 253, 123901 https://doi.org/10.1016/j.talanta.2022.123901
Discrimination of Wine Attributes by Metabolome Analysis A. Cuadros-Inostroza et al. Anal. Chem. 2010, 82, 9, 3573–3580 https://pubs.acs.org/doi/10.1021/ac902678t
Unraveling different chemical fingerprints between a champagne wine and its aerosols G. Liger-Belair et al. PNAS, 2009, 106, 16545–16549 https://www.pnas.org/content/106/39/16545
The chemodiversity of wines can reveal a metabologeography expression of cooperage oak wood R. D. Gougeon et al. PNAS, 2009, 106, 9174–9179 https://www.pnas.org/content/106/23/9174
Exploring the chemical space of white wine antioxidant capacity: A combined DPPH, EPR and FT-ICR-MS study R. Romanet et. al. Food Chem. 355:129566 (2021) https://www.sciencedirect.com/science/article/abs/pii/S0308814621005720
Hidden in its color: A molecular-level analysis of the beer’s Maillard reaction network S. Pieczonka et. al. Food Chem. 361:130112 (2021) https://www.sciencedirect.com/science/article/abs/pii/S0308814621011183
On the Trail of the German Purity Law: Distinguishing the Metabolic Signatures of Wheat, Corn and Rice in Beer S. Pieczonka et. al. Front. Chem. 9:715372 (2021) https://www.frontiersin.org/articles/10.3389/fchem.2021.715372/full
Decomposing the molecular complexity of brewing S. Pieczonka et. al. npj Science of Food (2020) 4, 11 https://www.nature.com/articles/s41538-020-00070-3
Determination of soyasaponins in Fagioli di Sarconi beans (Phaseolus vulgaris L.) by LC-ESI-FTICR-MS and evaluation of their hypoglycemic activity G. Bianco et al. Anal. Bioanal. Chem. 410, 1561–1569 (2018) https://link.springer.com/article/10.1007/s00216-017-0806-8
In situ localization of micropollutants and associated stress response in Populus nigra leaves C. Vilette et. al. Environment International 126 (2019) 523–532 https://www.sciencedirect.com/science/article/pii/S0160412018324917

Metabolomics - Body Fluids

Title Authors Publication Link
Matrix‐assisted laser desorption/ionization‐Fourier‐transform ion cyclotron resonance‐mass spectrometry analysis of exosomal lipids from human serum I. Jalaludin et al. Rapid Communications in Mass Spectrometry 2022, 37(2), e9427 https://doi.org/10.1002/rcm.9427
Differential Kendrick’s Plots as an Innovative Tool for Lipidomics in Complex Samples: Comparison of Liquid Chromatography and Infusion-Based Methods to Sample Differential Study J. Hustin et al. Journal of The American Society for Mass Spectrometry 2022, 33(12), 2273-2282 - https://doi.org/10.1021/jasms.2c00232
MALDI(+) FT-ICR Mass Spectrometry (MS) Combined with Machine Learning toward Saliva-Based Diagnostic Screening for COVID-19 C.M de Almeida et al. Journal of Proteome Research 2022, 21(8), 1868-1875 https://doi.org/10.1021/acs.jproteome.2c00148
Prenatal and Early Postnatal Cerebral d-Aspartate Depletion Influences l-Amino Acid Pathways, Bioenergetic processes, and Developmental Brain Metabolism M. Grimaldi et al. J. Proteome Res. 2021, 20, 1, 727–739 https://pubs.acs.org/doi/10.1021/acs.jproteome.0c00622
Ultrahigh-Resolution Mass Spectrometry-Based Platform for Plasma Metabolomics Applied to Type 2 Diabetes Research Y. Zhu et al. J. Proteome Res. 2021 20, 1, 463-473 https://pubs.acs.org/doi/10.1021/acs.jproteome.0c00510
Metabolomics Reveals Metabolic Biomarkers of Crohn's Disease J. Jansson et al. PLOS ONE 2009, 4, e6386 https://journals.plos.org/plosone/article/metrics?id=10.1371/journal.pone.0006386
The compositional space of exhaled breath condensate and its link to the human breath volatilome F. Moritz et al. J. Breath Res. 9 027105 (2015) https://iopscience.iop.org/article/10.1088/1752-7155/9/2/027105
Oral versus intravenous iron replacement therapy distinctly alters the gut microbiota and metabolome in patients with IBD T. Lee et al. Gut 2017;66:863–871 https://gut.bmj.com/content/66/5/863
Dietary fat and gut microbiota interactions determine diet-induced obesity in mice R. Kübeck et al. Mol Metab. 2016 Oct 13;5(12):1162-1174 https://www.sciencedirect.com/science/article/pii/S2212877816301892
Insulin Sensitivity Is Reflected by Characteristic Metabolic Fingerprints - A Fourier Transform Mass Spectrometric Non-Targeted Metabolomics Approach M. Lucio et al. PLOS ONE 2010, 5(10): e13317 https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0013317

Metabolomics – Animals, Yeast and Bacteria

Title Authors Publication Link
Understanding the biodegradation pathways of azo dyes by immobilized white-rot fungus, Trametes hirsuta D7, using UPLC-PDA-FTICR MS supported by in silico simulations and toxicity assessment R. Alam et al. Chemosphere 2023, 313, 137505 https://doi.org/10.1016/j.chemosphere.2022.137505
Direct injection Fourier transform ion cyclotron resonance mass spectrometric method for high throughput quantification of quinolones in poultry L. E. Ikkere, et al. Journal of Pharmaceutical and Biomedical Analysis 188 (2020) 113389 https://www.sciencedirect.com/science/article/abs/pii/S0731708520312759
Combination of UHPLC-MS/MS-molecular networking approach and FTICR-MS for the metabolic profiling of Saccharomyces cerevisiae O. Perruchon et al. Journal of Pharmaceutical and Biomedical Analysis 195 (2021) 113857 https://www.sciencedirect.com/science/article/abs/pii/S0731708520317441
Exploring yeast interactions through metabolic profiling C. Roullier-Gall et al. Sci Rep 10, 6073 (2020) https://www.nature.com/articles/s41598-020-63182-6
DI-ICR-FT-MS-based high-throughput deep metabotyping: a case study of the Caenorhabditis elegans–Pseudomonas aeruginosa infection model M. Witting et al. Analytical and Bioanalytical Chemistry 407, 1059–1073 (2015) https://link.springer.com/article/10.1007/s00216-014-8331-5
Marine sequestration of carbon in bacterial metabolites O. J. Lechtenfeld et al. Nature Communications 6, 6711 (2015) https://www.nature.com/articles/ncomms7711
Comprehensive Analysis of the Alternaria Mycobolome Using Mass Spectrometry Based Metabolomics M. Gotthardt et. al. Mol. Nutr. Food Res. 2020, 64, 1900558 https://onlinelibrary.wiley.com/doi/10.1002/mnfr.201900558

Metabolomics – Methods

Title Authors Publication Link
PM2.5-mediated photochemical reaction of typical toluene in real air matrix with identification of products by isotopic tracing and FT-ICR MS Li, Q. et al. Environmental Pollution 2022, 313, 120181 https://doi.org/10.1016/j.envpol.2022.120181
13C Isotope-Labeled Metabolomes Allowing for Improved Compound Annotation and Relative Quantification in Liquid Chromatography-Mass Spectrometry-based Metabolomic Research P. Giavalisco et. al. Anal. Chem. 2009, 81, 15, 6546–6551 https://pubs.acs.org/doi/10.1021/ac900979e
High-Resolution Direct Infusion-Based Mass Spectrometry in Combination with Whole 13C Metabolome Isotope Labeling Allows Unambiguous Assignment of Chemical Sum Formulas P. Giavalisco et. al. Anal. Chem. 2008, 80, 24, 9417–9425 https://pubs.acs.org/doi/10.1021/ac8014627
Potential of dynamically harmonized Fourier transform ion cyclotron resonance cell for high-throughput metabolomics fingerprinting: control of data quality B. Habchi et al. Analytical and Bioanalytical Chemistry, 410, 483–490 (2018) https://link.springer.com/article/10.1007%2Fs00216-017-0738-3
Ultrahigh resolution metabolomics for S-containing metabolites R. Nakabayashi et. al. Current Opinion in Biotechnology 2017, 43, 8–16 https://www.sciencedirect.com/science/article/pii/S0958166916301604
An Enhanced Isotopic Fine Structure Method for Exact Mass Analysis in Discovery Metabolomics: FIA-CASI-FTMS C. J. Thompson et al. J. Am. Soc. Mass Spectrom. 2020, 31, 10, 2025–2034 https://pubs.acs.org/doi/10.1021/jasms.0c00047

Imaging – General Biology

Title Authors Publication Link
MALDI Mass Spectrometry Imaging Highlights Specific Metabolome and Lipidome Profiles in Salivary Gland Tumor Tissues E. Sommella et al. Metabolites - Article Metabolites, 12(6), 530 - June 2022 https://doi.org/10.3390/metabo12060530
Lipid Dynamics due to Muscle Atrophy Induced by Immobilization K. Kimura et al. Journal of Oleo Science 2021, 70, 7, 937-946 https://www.jstage.jst.go.jp/article/jos/70/7/70_ess21045/_article
Integration of Mass Spectrometry Imaging and Machine Learning Visualizes Region-Specific Age-Induced and Drug-Target Metabolic Perturbations in the Brain T. Vallianatou et al. ACS Chemical Neuroscience 2021, 12, 10, 1811-1823 https://pubs.acs.org/doi/10.1021/acschemneuro.1c00103
Ocular phenotypes in a mouse model of impaired glucocerebrosidase activity M. Weber et al. Scientific Reports 2021, 11, 1, 6079 https://www.nature.com/articles/s41598-021-85528-4
GD3 synthase deletion alters retinal structure and impairs visual function in mice C. A. Abreu et al. Journal of Neurochemistry 2021, 158, 3, 694-709 https://onlinelibrary.wiley.com/doi/10.1111/jnc.15443
Brain glycogen serves as a critical glucosamine cache required for protein glycosylation R. C. Sun et al. Cell Metabolism 2021, 33, 7, 1404-1417.e9 https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00220-5
Multimodal Imaging Mass Spectrometry of Murine Gastrointestinal Tract with Retained Luminal Content Shows Molecular Localization Patterns E. R. Guiberson et al. bioRxiv 2021, preprint https://www.biorxiv.org/content/10.1101/2021.10.03.462819v1
Chelator sensing and lipopeptide interplay mediates molecular interspecies interactions between soil bacilli and pseudomonads S. Andric et al. bioRxiv 2021, pre-print https://www.biorxiv.org/content/10.1101/2021.02.22.432387v2
Mass spectrometry imaging reveals glycine distribution in the developing and adult mouse brain F. Eto et al. Journal of Chemical Neuroanatomy 2020, 110, 101869 https://www.sciencedirect.com/science/article/abs/pii/S0891061820301381
In situ metabolite and lipid analysis of GluN2D−/− and wild-type mice after ischemic stroke using MALDI MSI W. T. Andrews et al. Analytical and Bioanalytical Chemistry 2020, 412, 24, 6275-6285 https://link.springer.com/article/10.1007%2Fs00216-020-02477-z
In situ detection and imaging of lysophospholipids in zebrafish using matrix‐assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometry K. He et al. Journal of Mass Spectrometry 2021, 56, 4, e4637 https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/jms.4637
Spatial Localization of Vitamin D Metabolites in Mouse Kidney by Mass Spectrometry Imaging K. W. Smith et al. ACS Omega 2020, 5, 22, 13430-13437 https://pubs.acs.org/doi/10.1021/acsomega.0c01697
Mass spectrometry imaging reveals differential localization of natural sunscreens in the mantle of the giant clam Tridacna crocea M. Goto-Inoue et al. Scientific Reports 2020, 10, 1, 656 https://www.nature.com/articles/s41598-019-57296-9
Localization of the lens intermediate filament switch by imaging mass spectrometry Z. Wang et al. Experimental Eye Research 2020, 198, 108134 https://www.sciencedirect.com/science/article/abs/pii/S0014483520303924
Region-specific effects of Scrapper on the abundance of glutamate and gamma-aminobutyric acid in the mouse brain F. Eto et al. Scientific Reports 2020, 10, 1, 7435 https://www.nature.com/articles/s41598-020-64277-w
Mapping glucose metabolites in the normal bovine lens: Evaluation and optimisation of a matrix‐assisted laser desorption/ionisation imaging mass spectrometry method A. Zahraei et al. Journal of Mass Spectrometry 2021, 56, 4, e4666 https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/jms.4666
Spatial segmentation and metabolite annotation involved in sperm maturation in the rat epididymis by MALDI Imaging mass spectrometry M. Lagarrigue et al. Journal of Mass Spectrometry 2020, 55, 12, e4633 https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/abs/10.1002/jms.4633
Imaging mass spectrometry to visualise increased acetylcholine in lungs of asthma model mice T. Matsuda et al. Analytical and Bioanalytical Chemistry 2020, 412, 18, 4327-4341 https://link.springer.com/article/10.1007%2Fs00216-020-02670-0
A micrometer‐scale snapshot on phototroph spatial distributions: mass spectrometry imaging of microbial mats in Octopus Spring, Yellowstone National Park L. Wörmer et al. Geobiology 2020, 18, 6, 742-759 https://onlinelibrary.wiley.com/doi/10.1111/gbi.12411
PHD3 Loss Promotes Exercise Capacity and Fat Oxidation in Skeletal Muscle H. Yoon et al. Cell Metabolism 2020, 32, 2, 215-228.e7 https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30318-1
A Global Cndp1-Knock-Out Selectively Increases Renal Carnosine and Anserine Concentrations in an Age- and Gender-Specific Manner in Mice T. Weigand et al. International Journal of Molecular Sciences 2020, 21, 14, 4887 https://www.mdpi.com/1422-0067/21/14/4887
Nonclinical applications of quantitative whole-body autoradiography, and imaging mass spectrometry in drug discovery and development E. G. Solon et al. Progress in Biomedical Optics and Imaging 2020, Vol. 11219, 1121903-1121903-13 https://www.spiedigitallibrary.org/conference-proceedings-of-spie/11219/2551441/Nonclinical-applications-of-quantitative-whole-body-autoradiography-and-imaging-mass/10.1117/12.2551441.short
Epilipidomics of Senescent Dermal Fibroblasts Identify Lysophosphatidylcholines as Pleiotropic Senescence-Associated Secretory Phenotype (SASP) Factors M. Narzt et al. Journal of Investigative Dermatology 2020, 141, 4, 993-1006.e15 https://www.jidonline.org/article/S0022-202X(20)32367-8/fulltext
Mass spectrometry imaging of blast overpressure induced modulation of GABA/glutamate levels in the central auditory neuraxis of Chinchilla K. Zemaitis et al. Experimental and Molecular Pathology 2021, 119, 104605 https://www.sciencedirect.com/science/article/abs/pii/S0014480021000046

Imaging – Plant Biology

Title Authors Publication Link
Analysis of Gliricidia sepium Leaves by MALDI Mass Spectrometry Imaging A. C. Hertel Pereira Journal of The American Society for Mass Spectrometry, 33(3), 573-583 - February 2022 https://doi.org/10.1021/jasms.1c00367
Unveiling spatial metabolome of Paeonia suffruticosa and Paeonia lactiflora roots using MALDI MS imaging B. Li et al. New Phytologist 2021, 231, 2, 892-902 https://nph.onlinelibrary.wiley.com/doi/10.1111/nph.17393
Analysis of Erythroxylum coca Leaves by Imaging Mass Spectrometry (MALDI–FT–ICR IMS) N. A. dos Santos et al. Journal of The American Society for Mass Spectrometry 2021, 32, 4, 946-955 https://pubs.acs.org/doi/10.1021/jasms.0c00449
Sclareol and linalyl acetate are produced by glandular trichomes through the MEP pathway C. Chalvin et al. Horticulture Research 2021, 8, 1, 206 https://www.nature.com/articles/s41438-021-00640-w
High spatial resolution imaging of the dynamics of cuticular lipid deposition during Arabidopsis flower development L. E. Alexander Plant Direct 2021, 5, 4, e00322 https://onlinelibrary.wiley.com/doi/10.1002/pld3.322
The metabolic environment of the developing embryo: A multidisciplinary approach on oilseed rapeseed H. Rolletschek et al. Journal of Plant Physiology 2021, 265, 153505 https://www.sciencedirect.com/science/article/pii/S0176161721001449
The GORKY glycoalkaloid transporter is indispensable for preventing tomato bitterness Y. Kazachkova et al. Nature Plants 2021, 7, 4, 468-480 https://www.nature.com/articles/s41477-021-00865-6
Spatial metabolomics using imaging mass spectrometry to identify the localization of asparaptine A in Asparagus officinalis R. Nakabayashi et al. Plant Biotechnology 2021, 38, 3, 311-315 https://www.jstage.jst.go.jp/article/plantbiotechnology/38/3/38_21.0504b/_article
A multimodal metabolomics approach using imaging mass spectrometry and liquid chromatography-tandem mass spectrometry for spatially characterizing monoterpene indole alkaloids secreted from roots R. Nakabayashi et al. Plant Biotechnology 2021, 38, 3, 305-310 https://www.jstage.jst.go.jp/article/plantbiotechnology/38/3/38_21.0504a/_article
Preserved and variable spatial‐chemical changes of lipids across tomato leaves in response to central vein wounding reveals potential origin of linolenic acid in signal transduction cascade D. Veličković, et al. Plant-Environment Interactions 2021, 2, 1, 28-35 https://onlinelibrary.wiley.com/doi/10.1002/pei3.10038
Maize Zmcyp710a8 Mutant as a Tool to Decipher the Function of Stigmasterol in Plant Metabolism S. I. Aboobucker et al. Frontiers in Plant Science 2021, 12, 732216 https://www.frontiersin.org/articles/10.3389/fpls.2021.732216/full
Localization of mercury and gold in cassava (Manihot esculenta Crantz) H. J. P. Alcantara et al. Environmental Science and Pollution Research 2020, 27, 15, 18498-18509 https://link.springer.com/article/10.1007%2Fs11356-020-08285-3
Unique and highly specific cyanogenic glycoside localisation in stigmatic cells and pollen in the genus Lomatia (Proteaceae) E. Ritmejerytė et al. Annals of Botany 2020, 126, 3, 387-400 https://academic.oup.com/aob/article/126/3/387/5802779
An approach for broad molecular imaging of the root-soil interface via indirect matrix-assisted laser desorption/ionization mass spectrometry D. Veličković et al. Soil Biology and Biochemistry 2020, 146, 107804 https://www.sciencedirect.com/science/article/abs/pii/S0038071720301012
Chemical characterization, antioxidant and antimicrobial activities of açaí seed (Euterpe oleracea Mart.) extracts containing A- and B-type procyanidins G. R. Martins et al. LWT 2020, 132, 109830 https://www.sciencedirect.com/science/article/abs/pii/S0023643820308197
Differential distribution of characteristic constituents in root, stem and leaf tissues of Salvia miltiorrhiza using MALDI mass spectrometry imaging S. Li et al. Fitoterapia 2020, 146, 104679 https://www.sciencedirect.com/science/article/abs/pii/S0367326X20302616
Rhizosphere microbiome mediates systemic root metabolite exudation by root-to-root signaling E. Korenblum et al. Proceedings of the National Academy of Sciences of the United States of America 2020, 117, 7, 3874-3883 https://www.pnas.org/content/117/7/3874
Metabolomics should be deployed in the identification and characterization of gene‐edited crops P. D. Fraser et al. The Plant Journal 2020, 102, 5, 897-902 https://onlinelibrary.wiley.com/doi/10.1111/tpj.14679

Imaging – Other Applications

Title Authors Publication Link
Spatially Resolved Neuropeptide Characterization from Neuropathological Formalin-Fixed, Paraffin-Embedded Tissue Sections by a Combination of Imaging MALDI FT-ICR Mass Spectrometry Histochemistry and Liquid Extraction Surface Analysis-Trapped Ion Mobility Spectrometry-Tandem Mass Spectrometry Y. L. Cintron-Diaz et al. Journal of The American Society for Mass Spectrometry, 33(4), 681-687 - March 2022 https://doi.org/10.1021/jasms.1c00376
Secret messaging with endogenous chemistry E. Kennedy et al. Scientific Reports 2021, 11, 1, 13960 https://www.nature.com/articles/s41598-021-92987-2
Mechanistic Insights Into Molecular Proxies Through Comparison of Subannually Resolved Sedimentary Records With Instrumental Water Column Data in the Santa Barbara Basin, Southern California S. Alfken et al. Paleoceanography and Paleoclimatology 2020, 35, 10, e2020PA004076 https://agupubs.onlinelibrary.wiley.com/doi/10.1029/2020PA004076
An annually resolved record of Western European vegetation response to Younger Dryas cooling I. Obreht et al. Quaternary Science Reviews 2020, 231, 106198 https://www.sciencedirect.com/science/article/pii/S0277379119311485
Moxidectin toxicity to zebrafish embryos: Bioaccumulation and biomarker responses M. S. Muniz et al. Environmental Pollution 2021, 283, 117096 https://www.sciencedirect.com/science/article/abs/pii/S0269749121006783

Imaging – Clinical, Other Applications

Title Authors Publication Link
Multimodal Imaging Mass Spectrometry of Murine Gastrointestinal Tract with Retained Luminal Content E.R Guiberson et al. Journal of The American Society for Mass Spectrometry 2022, 33(6), 1073-1076 https://doi.org/10.1021/jasms.1c00360
LPS-induced lipid alterations in microglia revealed by MALDI mass spectrometry-based cell fingerprinting in neuroinflammation studies M. Blank et al. Scientific Reports 2022, 12(1), 2908 https://doi.org/10.1038/s41598-022-06894-1
CEST MRI and MALDI imaging reveal metabolic alterations in the cervical lymph nodes of EAE micCEST MRI and MALDI imaging reveal metabolic alterations in the cervical lymph nodes of EAE mice A. M. Thomas et al. Journal of Neuroinflammation 2022, 19(1), 130 https://doi.org/10.1186/s12974-022-02493-z
MALDI Mass Spectrometry Imaging in a Primary Demyelination Model of Murine Spinal Cord E. R. Sekera et al. Journal of The American Society for Mass Spectrometry 2020, 31, 12, 2462-2468 https://pubs.acs.org/doi/10.1021/jasms.0c00187
Diet-induced alteration of intestinal stem cell function underlies obesity and prediabetes in mice A. Aliluev et al. Nature Metabolism 2021, 3, 9, 1202-1216 https://www.nature.com/articles/s42255-021-00458-9
Targeted Expression of TGFBIp Peptides in Mouse and Human Tissue by MALDI-Mass Spectrometry Imaging V. Anandalakshmi et al. Separations 2021, 8, 7, 97 https://www.mdpi.com/2297-8739/8/7/97
Identification of a distinct lipidomic profile in the osteoarthritic synovial membrane by mass spectrometry imaging B. Rocha et al. Osteoarthritis and Cartilage 2021, 29, 5, 750-761 https://www.oarsijournal.com/article/S1063-4584(21)00038-8/fulltext
Muscle metabolic remodelling patterns in Duchenne muscular dystrophy revealed by ultra-high-resolution mass spectrometry imaging I. Dabaj et al. Scientific Reports 2021, 11, 1, 1906 https://www.nature.com/articles/s41598-021-81090-1
Integrative Metabolic Pathway Analysis Reveals Novel Therapeutic Targets in Osteoarthritis B. Rocha et al. Molecular & Cellular Proteomics 2020, 19, 4, 574-588 https://www.mcponline.org/article/S1535-9476(20)35018-0/fulltext
Maternal obesity alters placental lysophosphatidylcholines, lipid storage, and the expression of genes associated with lipid metabolism K. L. Bidne et al. Biology of Reproduction 2021, 104, 1, 197-210 https://academic.oup.com/biolreprod/article/104/1/197/5922235

Imaging – Clinical, Cancer

Title Authors Publication Link
Reproducible Lipid Alterations in Patient-Derived Breast Cancer Xenograft FFPE Tissue Identified with MALDI MSI for Pre-Clinical and Clinical Application V. Denti et al. Metabolites 2021, 11, 9, 577 https://www.mdpi.com/2218-1989/11/9/577
Mass spectrometry imaging of L-[ring-13C6]-labeled phenylalanine and tyrosine kinetics in non-small cell lung carcinoma J. Cao et al. Cancer & Metabolism 2021, 9, 1, 26 https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00262-9
Metabolic tumor constitution is superior to tumor regression grading for evaluating response to neoadjuvant therapy of esophageal adenocarcinoma patients A. Buck et al. The Journal of Pathology, in print https://onlinelibrary.wiley.com/doi/10.1002/path.5828
N-Glycosylation Patterns Correlate with Hepatocellular Carcinoma Genetic Subtypes A. DelaCourt et al. Molecular Cancer Research 2021, 19, 1868-77 https://mcr.aacrjournals.org/content/19/11/1868
Metabolomic therapy response prediction in pretherapeutic tissue biopsies for trastuzumab in patients with HER2‐positive advanced gastric cancer T. Kunzke et al. Clinical and Translational Medicine 2021, 11, 9, e547 https://onlinelibrary.wiley.com/doi/10.1002/ctm2.547
Patterns of carbon-bound exogenous compounds in lung cancer patients and association with disease pathophysiology T. Kunzke et al. Cancer Research 2021, in print https://cancerres.aacrjournals.org/content/81/23/5862
Tumor resistance to ferroptosis driven by Stearoyl-CoA Desaturase-1 (SCD1) in cancer cells and Fatty Acid Biding Protein-4 (FABP4) in tumor microenvironment promote tumor recurrence G. Luis et al. Redox Biology 2021, 43, 102006 https://www.sciencedirect.com/science/article/pii/S2213231721001646
Tryptophan metabolism is inversely regulated in the tumor and blood of patients with glioblastoma V. Panitz et al. Theranostics 2021, 11, 19, 2021, 9217-9233 https://www.thno.org/v11p9217.htm
A unique subset of glycolytic tumour-propagating cells drives squamous cell carcinoma J. Choi et al. Nature Metabolism 2021, 3, 2, 182-195 https://www.nature.com/articles/s42255-021-00350-6
Imaging Mass Spectrometry and Lectin Analysis of N-Linked Glycans in Carbohydrate Antigen–Defined Pancreatic Cancer Tissues C. T. McDowell et al. Molecular & Cell Proteomics 2021, 20, 100012 https://www.mcponline.org/article/S1535-9476(20)35126-4/fulltext
Spatiotemporal heterogeneity of glioblastoma is dictated by microenvironmental interference V. M. Ravi et al. bioRxiv 2021, pre-print https://www.biorxiv.org/content/10.1101/2021.02.16.431475v1
Slow TCA flux implies low ATP production in tumors C. R. Bartman et al. bioRxiv 2021, pre-print https://www.biorxiv.org/content/10.1101/2021.10.04.463108v1
Tryptophan metabolism drives dynamic immunosuppressive myeloid states in IDH-mutant gliomas M. Friedrich et al. Nature Cancer 2021, 2, 7, 723-740 https://www.nature.com/articles/s43018-021-00201-z
Glioblastoma multiforme: Metabolic differences to peritumoral tissue and IDH‐mutated gliomas revealed by mass spectrometry imaging J. M. Kampa et al. Neuropathology 2020, 40, 6, 546-558 https://onlinelibrary.wiley.com/doi/10.1111/neup.12671
Defining the human kidney N-glycome in normal and cancer tissues using MALDI imaging mass spectrometry R. R. Drake et al. Journal of Mass Spectrometry 2020, 55, e4490 https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/jms.4490
Extracellular matrix alterations in low‐grade lung adenocarcinoma compared with normal lung tissue by imaging mass spectrometry P. M. Angel et al. Journal of Mass Spectrometry 2020, 55, 4, e4450 https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/jms.4450
MALDI-MSI spatially maps N-glycan alterations to histologically distinct pulmonary pathologies following irradiation C. L. Carter et al. Scientific Reports 2020, 10, Article number: 11559 https://www.nature.com/articles/s41598-020-68508-y
Zonal regulation of collagen‐type proteins and posttranslational modifications in prostatic benign and cancer tissues by imaging mass spectrometry P. M. Angel et al. The Prostate 2020, 80, 13, 1071-1086 https://onlinelibrary.wiley.com/doi/10.1002/pros.24031
Accumulation of long-chain fatty acids in the tumor microenvironment drives dysfunction in intrapancreatic CD8+ T cells T. Manzo et al. Journal of Experimental Medicine 2020, 217, 8, e20191920 https://rupress.org/jem/article/217/8/e20191920/151833/Accumulation-of-long-chain-fatty-acids-in-the
Native glycan fragments detected by MALDI-FT-ICR mass spectrometry imaging impact gastric cancer biology and patient outcome T. Kunzke. et al. Oncotarget 2017, 8, 68012-68025 https://www.oncotarget.com/article/19137/text/
Evaluation of Therapeutic Collagen-Based Biomaterials in the Infarcted Mouse Heart by Extracellular Matrix Targeted MALDI Imaging Mass Spectrometry C. L. Clift et al. Journal of The American Society for Mass Spectrometry 2021, 32, 12, 2746–2754 https://pubs.acs.org/doi/10.1021/jasms.1c00189
Lipid signature of advanced human carotid atherosclerosis assessed by mass spectrometry imaging A. M. Moerman et al. The Journal of Lipid Research 2021, 62, 100020 https://www.jlr.org/article/S0022-2275(20)43743-5/fulltext
Spatial N-glycomics of the human aortic valve in development and pediatric endstage congenital aortic valve stenosis P. M. Angel et al. Journal of Molecular and Cellular Cardiology 2021, 154, 6-20 https://www.jmcc-online.com/article/S0022-2828(21)00018-3/fulltext
Imaging Mass Spectrometry Reveals the Changes in the Taurine Conjugates of Dihydroxycholanoic Acid During Hepatic Warm Ischemia and Reperfusion in a Rat Model K. Shibata et al. Transplantation Proceedings 2020, 52, 6, 1880-1883 https://www.sciencedirect.com/science/article/abs/pii/S0041134519317397
Inhibition of macrophage proliferation dominates plaque regression in response to cholesterol lowering C. Härdtner et al. Basic Research in Cardiology 2020, 115, 6, 78 https://link.springer.com/article/10.1007%2Fs00395-020-00838-4
A lipid atlas of human carotid atherosclerosis A. M. Moerman et al. bioRxiv 2020, pre-print https://www.biorxiv.org/content/10.1101/2020.03.09.976043v1

Imaging – Clinical, Cardiovascular

Title Authors Publication Link
Matrix-assisted laser desorption/ionization mass spectrometric imaging the spatial distribution of biodegradable vascular stents using a self-made semi-quantitative target plate L. Houwei et al. Journal of Pharmaceutical and Biomedical Analysis 2022, 219, 114888 https://www.sciencedirect.com/science/article/abs/pii/S0731708522003090
Evaluation of Therapeutic Collagen-Based Biomaterials in the Infarcted Mouse Heart by Extracellular Matrix Targeted MALDI Imaging Mass Spectrometry C. L. Clift et al. Journal of The American Society for Mass Spectrometry 2021, 32, 12, 2746–2754 https://pubs.acs.org/doi/10.1021/jasms.1c00189
Lipid signature of advanced human carotid atherosclerosis assessed by mass spectrometry imaging A. M. Moerman et al. The Journal of Lipid Research 2021, 62, 100020 https://www.jlr.org/article/S0022-2275(20)43743-5/fulltext
Spatial N-glycomics of the human aortic valve in development and pediatric endstage congenital aortic valve stenosis P. M. Angel et al. Journal of Molecular and Cellular Cardiology 2021, 154, 6-20 https://www.jmcc-online.com/article/S0022-2828(21)00018-3/fulltext
Imaging Mass Spectrometry Reveals the Changes in the Taurine Conjugates of Dihydroxycholanoic Acid During Hepatic Warm Ischemia and Reperfusion in a Rat Model K. Shibata et al. Transplantation Proceedings 2020, 52, 6, 1880-1883 https://www.sciencedirect.com/science/article/abs/pii/S0041134519317397
Inhibition of macrophage proliferation dominates plaque regression in response to cholesterol lowering C. Härdtner et al. Basic Research in Cardiology 2020, 115, 6, 78 https://link.springer.com/article/10.1007%2Fs00395-020-00838-4
A lipid atlas of human carotid atherosclerosis A. M. Moerman et al. bioRxiv 2020, pre-print https://www.biorxiv.org/content/10.1101/2020.03.09.976043v1

Imaging – Clinical, Neurology

Title Authors Publication Link
Simultaneous mass spectrometry imaging of multiple neuropeptides in the brain and alterations induced by experimental parkinsonism and L-DOPA therapy H. Hulme et al. Neurobiology of Disease 2020, 137, 104738 https://www.sciencedirect.com/science/article/pii/S0969996120300139
Mass spectrometry imaging identifies abnormally elevated brain l-DOPA levels and extrastriatal monoaminergic dysregulation in l-DOPA–induced dyskinesia E. Fridjonsdottir et al. Science Advances 2021, 7, 2, eabe5948 https://www.science.org/doi/10.1126/sciadv.abe5948
An imaging mass spectrometry atlas of lipids in the human neurologically normal and Huntington’s disease caudate nucleus M. Hunter et al. Journal of Neurochemistry 2021, 157, 6, 2158-2172 https://onlinelibrary.wiley.com/doi/10.1111/jnc.15325
Metabolomic analysis and mass spectrometry imaging after neonatal stroke and cell therapies in mouse brains E. Tanaka et al. Scientific Reports 2020, 10, 1, 21881 https://www.nature.com/articles/s41598-020-78930-x
µ Opioid Receptor Agonism for L-DOPA-Induced Dyskinesia in Parkinson's Disease E. Bezard et al. Journal of Neuroscience 2020, 40, 35, 6812-6819 https://www.jneurosci.org/content/40/35/6812

Imaging – Clinical, Pathogen

Title Authors Publication Link
Clostridioides difficile infection induces a rapid influx of bile acids into the gut during colonization of the host A. G. Wexler et al. Cell Reports 2021, 36, 10, 109683 https://www.cell.com/cell-reports/fulltext/S2211-1247(21)01130-X
In Vitro Miniaturized Tuberculosis Spheroid Model S. Mukundan et al. Biomedicines 2021, 9, 9, 1209 https://www.mdpi.com/2227-9059/9/9/1209
Identification of Metabolically Quiescent Leishmania mexicana Parasites in Peripheral and Cured Dermal Granulomas Using Stable Isotope Tracing Imaging Mass Spectrometry J. Kloehn et al. mBio 2021, 12, 2, e00129-21 https://journals.asm.org/doi/10.1128/mBio.00129-21
The ascorbate-deficient guinea pig model of shigellosis allows the study of the entire Shigella life cycle A. C. André et al. bioRxiv 2020, pre-print https://www.biorxiv.org/content/10.1101/2020.08.28.270074v1

Imaging – Method Development

Title Authors Publication Link
FT-ICR Mass Spectrometry Imaging at Extreme Mass Resolving Power Using a Dynamically Harmonized ICR Cell with 1ω or 2ω Detection M. Tiquet et al. Analytical Chemistry 2022 94(26), 9316-9326 https://doi.org/10.1021/acs.analchem.2c00754
A simple preparation step to remove excess liquid lipids in white adipose tissue enabling improved detection of metabolites via MALDI-FTICR imaging MS Q. Wang et al. Histochemistry and Cell Biology 2022, 157(5), 595-605 https://doi.org/10.1007/s00418-022-02088-y
Streamlined Multimodal DESI and MALDI Mass Spectrometry Imaging on a Singular Dual-Source FT-ICR Mass Spectrometer K. J. Zemaitis et al. Metabolites 2021, 11, 4, 253 https://www.mdpi.com/2218-1989/11/4/253
α‑Cyano-4-hydroxycinnamic Acid and Tri-Potassium Citrate Salt Pre-Coated Silicon Nanopost Array Provides Enhanced Lipid Detection for High Spatial Resolution MALDI Imaging Mass Spectrometry M. Dufresne et al. Analytical Chemistry 2021, 93, 36, 12243-12249 https://pubs.acs.org/doi/10.1021/acs.analchem.1c01560
Automated annotation and visualisation of high-resolution spatial proteomic mass spectrometry imaging data using HIT-MAP G. Guo et al. Nature Communications 2021, 12, 1, 3241 https://www.nature.com/articles/s41467-021-23461-w
Molecular Mapping of Neutral Lipids Using Silicon Nanopost Arrays and TIMS Imaging Mass Spectrometry J. A. Fincher, et al. Journal of The American Society for Mass Spectrometry 2021, 32, 10, 2519-2527 https://pubs.acs.org/doi/10.1021/jasms.1c00159
Adaptive Pixel Mass Recalibration for Mass Spectrometry Imaging Based on Locally Endogenous Biological Signals R. La Rocca, et al. Analytical Chemistry 2021, 93, 8, 4066-4074 https://pubs.acs.org/doi/10.1021/acs.analchem.0c05071
Determination of Abundant Metabolite Matrix Adducts Illuminates the Dark Metabolome of MALDI-Mass Spectrometry Imaging Datasets M. Janda et al. Analytical Chemistry 2021, 93, 24, 8399-8407 https://pubs.acs.org/doi/10.1021/acs.analchem.0c04720
Electroblotting through Enzymatic Membranes to Enhance Molecular Tissue Imaging W. T. Andrews et al. Journal of The American Society for Mass Spectrometry 2021, 32, 7, 1689-1699 https://pubs.acs.org/doi/10.1021/jasms.1c00046
Rapid Automated Annotation and Analysis of N‑Glycan Mass Spectrometry Imaging Data Sets Using NGlycDB in METASPACE D. Veličković et al. Analytical Chemistry 2021, 93, 40, 13421-13425 https://pubs.acs.org/doi/10.1021/acs.analchem.1c02347
Desorption ionization using through‐hole alumina membrane offers higher reproducibility than 2,5‐dihydroxybenzoic acid, a widely used matrix in Fourier transform ion cyclotron resonance mass spectrometry imaging analysis Md. Mahmudul Hasan et al. Rapid Communications in Mass Spectrometry 2021, 35, 10, e9076 https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/rcm.9076
On-Slide Heat Sterilization Enables Mass Spectrometry Imaging of Tissue Infected with High-Threat Pathogens Outside of Biocontainment: A Study Directed at Mycobacterium tuberculosis N. Wang et al. Journal of The American Society for Mass Spectrometry 2021, 32, 2664−2674 https://pubs.acs.org/doi/10.1021/jasms.1c00205
Spatial Probabilistic Mapping of Metabolite Ensembles in Mass Spectrometry Imaging D. A. Sammour et al. bioRxiv 2021, preprint https://www.biorxiv.org/content/10.1101/2021.10.27.466114v1
massNet: integrated processing and classification of spatially resolved mass spectrometry data using deep learning for rapid tumor delineation W. M. Abdelmoula et al. bioRxiv 2021, pre-print https://www.biorxiv.org/content/10.1101/2021.05.06.442938v1
High Spatial Resolution MALDI Imaging Mass Spectrometry of Fresh-Frozen Bone C. J. Good et al. bioRxiv 2021, pre-print https://www.biorxiv.org/content/10.1101/2021.10.01.462831v2
Tissue fixation effects on human retinal lipid analysis by MALDI imaging and LC-MS/MS technologies A. Kotnala et al. bioRxiv 2021, pre-print https://www.biorxiv.org/content/10.1101/2021.04.29.442044v2
Spatially aware clustering of ion images in mass spectrometry imaging data using deep learning W. Zhang et al. Analytical and Bioanalytical Chemistry 2021, 413,10, 2803-2819 https://link.springer.com/article/10.1007%2Fs00216-021-03179-w
Dual-polarity SALDI FT-ICR MS imaging and Kendrick mass defect data filtering for lipid analysis W. H. Müller et al. Analytical and Bioanalytical Chemistry 2021, 413, 10, 2821-2830 https://link.springer.com/article/10.1007%2Fs00216-020-03020-w
Identification of Phosphatidylcholine Isomers in Imaging Mass Spectrometry Using Gas-Phase Charge Inversion Ion/Ion Reactions J. T. Specker et al. Analytical Chemistry 2020, 92, 19, 13192-13201 https://pubs.acs.org/doi/10.1021/acs.analchem.0c02350
Bromopyrylium Derivatization Facilitates Identification by Mass Spectrometry Imaging of Monoamine Neurotransmitters and Small Molecule Neuroactive Compounds R. Shariatgorji et al. Journal of The American Society for Mass Spectrometry 2020, 31, 12, 2553-2557 https://pubs.acs.org/doi/10.1021/jasms.0c00166
Multilabel Per-Pixel Quantitation in Mass Spectrometry Imaging F. Dewez et al. Analytical Chemistry 2021, 93, 3, 1393-1400 https://pubs.acs.org/doi/10.1021/acs.analchem.0c03186
Mapping Lipogenic Flux: A Gold LDI–MS Approach for Imaging Neutral Lipid Kinetics D. P. Downes et al. Journal of The American Society for Mass Spectrometry 2020, 31, 12, 2421-2425 https://pubs.acs.org/doi/10.1021/jasms.0c00199
Dynamic Range Expansion by Gas-Phase Ion Fractionation and Enrichment for Imaging Mass Spectrometry B. M. Prentice et al. Analytical Chemistry 2020, 92, 19, 13092-13100 https://pubs.acs.org/doi/10.1021/acs.analchem.0c02121
Multiplexed imaging mass spectrometry of the extracellular matrix using serial enzyme digests from formalin-fixed paraffin-embedded tissue sections C. L. Clift et al. Analytical and Bioanalytical Chemistry 2021, 413, 10, 2709-2719 https://link.springer.com/article/10.1007%2Fs00216-020-03047-z
Discovering New Lipidomic Features Using Cell Type Specific Fluorophore Expression to Provide Spatial and Biological Specificity in a Multimodal Workflow with MALDI Imaging Mass Spectrometry M. A. Jones et al. Analytical Chemistry 2020, 92, 10, 7079-7086 https://pubs.acs.org/doi/10.1021/acs.analchem.0c00446
Uncovering matrix effects on lipid analyses in MALDI imaging mass spectrometry experiments W. J. Perry et al. Journal of Mass Spectrometry 2020, 55, 4, e4491 https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/jms.4491
Bringing SEM and MSI Closer Than Ever Before: Visualizing Aspergillus and Pseudomonas Infection in the Rat Lungs T. Juříková et al. Journal of Fungi 2020, 6, 4, 257 https://www.mdpi.com/2309-608X/6/4/257
New Derivatization Reagent for Detection of free Thiol-groups in Metabolites and Proteins in Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging A. Fülöp et al. Analytical Chemistry 2020, 92, 9, 6224-6228 https://pubs.acs.org/doi/10.1021/acs.analchem.9b05630
New Enzymatic Approach to Distinguish Fucosylation Isomers of N‑Linked Glycans in Tissues Using MALDI Imaging Mass Spectrometry C. A. West et al. Journal of Proteome Research 2020, 19, 8, 2989-2996 https://pubs.acs.org/doi/10.1021/acs.jproteome.0c00024
Accelerating Fourier Transform-Ion Cyclotron Resonance Mass Spectrometry Imaging Using a Subspace Approach Y. R. Xie et al. Journal of The American Society for Mass Spectrometry 2020, 31, 11, 2338-2347 https://pubs.acs.org/doi/10.1021/jasms.0c00276
De novo discovery of metabolic heterogeneity with immunophenotype-guided imaging mass spectrometry V. M. Prade et al. Molecular Metabolism 2020, 36, 100953 https://www.sciencedirect.com/science/article/pii/S2212877820300259
Metabolomics with 15N Labeling for Characterizing Missing Monoterpene Indole Alkaloids in Plants R. Nakabayashi et al. Analytical Chemistry 2020, 92, 8, 5670-5675 https://pubs.acs.org/doi/10.1021/acs.analchem.9b03860
Combining MALDI mass spectrometry imaging and droplet-base surface sampling analysis for tissue distribution, metabolite profiling, and relative quantification of cyclic peptide melanotan II B. Chen et al. Analytica Chimica Acta 2020, 1125, 279-287 https://www.sciencedirect.com/science/article/abs/pii/S0003267020306024
Cross-validated Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging Quantitation Protocol for a Pharmaceutical Drug and Its Drug-Target Effects in the Brain Using Time-of-Flight and Fourier Transform Ion Cyclotron Resonance Analyzers P. Källback et al. Analytical Chemistry 2020, 92, 21, 14676-14684 https://pubs.acs.org/doi/10.1021/acs.analchem.0c03203
Rapid N‑Glycan Profiling of Serum and Plasma by a Novel Slide-Based Imaging Mass Spectrometry Workflow C. R. K. Blaschke et al. Journal of The American Society for Mass Spectrometry 2020, 31, 12, 2511-2520 https://pubs.acs.org/doi/10.1021/jasms.0c00213
Lipid Landscape of the Human Retina and Supporting Tissues Revealed by High-Resolution Imaging Mass Spectrometry D. M. G. Anderson et al. Journal of The American Society for Mass Spectrometry 2020, 31, 12, 2426-2436 https://pubs.acs.org/doi/10.1021/jasms.0c00119
Automating a process convolution approach to account for spatial information in imaging mass spectrometry data C. Miller et al. Spatial Statistics 2020, 36, 100422 https://www.sciencedirect.com/science/article/abs/pii/S2211675320300166
MALDI-MS imaging of lipids in corn using a flexible ultrasonic spraying device as matrix deposition method X. Li et al. International Journal of Mass Spectrometry 2020, 455, 116373 https://www.sciencedirect.com/science/article/abs/pii/S1387380618303816
Structural elucidation of phosphatidylcholines from tissue using electron induced dissociation M. N. Born et al. International Journal of Mass Spectrometry 2020, 452, 116338 https://www.sciencedirect.com/science/article/abs/pii/S1387380619305111
Selective improvement of peptides imaging on tissue by supercritical fluid wash of lipids for matrix-assisted laser desorption/ionization mass spectrometr S. Matsushita et al. Analytical and Bioanalytical Chemistry 2017, 409, 6, 1475–1480 https://link.springer.com/article/10.1007%2Fs00216-016-0119-3
High mass resolution, spatial metabolite mapping enhances the current plant gene and pathway discovery toolbox Y. Dong et al. New Phytologist 2020, 228, 6, 1986-2002 https://nph.onlinelibrary.wiley.com/doi/10.1111/nph.16809

Imaging – Pharmacology/Toxicology

Title Authors Publication Link
Quantitative Mass Spectrometry Imaging to Study Drug Distribution in the Intestine Following Oral Dosing L. R. S. Huizing et al. Analytical Chemistry 2021, 93, 4, 2144-2151 https://pubs.acs.org/doi/10.1021/acs.analchem.0c03956
An optimized method for the detection and spatial distribution of aminoglycoside and vancomycin antibiotics in tissue sections by mass spectrometry imaging N. Wang et al. Journal of Mass Spectrometry 2021, 56, 3, e4708 https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/jms.4708
Distribution of perfluorooctane sulfonate in mice and its effect on liver lipidomic X. Li et al. Talanta 2021, 226, 122150 https://www.sciencedirect.com/science/article/abs/pii/S0039914021000710
An orthogonal methods assessment of topical drug concentrations in skin and the impact for risk assessment in the viable epidermis B. D. Hollingshead et al. Regulatory Toxicology and Pharmacology, 123, 2021, 104934 https://www.sciencedirect.com/science/article/abs/pii/S027323002100074X
Multiorgan Crystal Deposition of an Amphoteric Drug in Rats Due to Lysosomal Accumulation and Conversion to a Poorly Soluble Hydrochloride Salt B. Lenz et al. Toxicological Sciences, 180(2), 2021, 383-394 https://academic.oup.com/toxsci/article/180/2/383/6102740
Study of the Distribution of Acetaminophen and Its Metabolites in Rats, from the Whole-Body to Isolated Organ Levels, by Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging after On-Tissue Chemical Derivatization M. Merdas et al. Analytical Chemistry 2021, 93, 39, 13242-13250 https://pubs.acs.org/doi/10.1021/acs.analchem.1c02487
Neuropharmacokinetic visualization of regional and subregional unbound antipsychotic drug transport across the blood–brain barrier D. Luptáková et al. Molecular Psychiatry 2021, 1-14 https://www.nature.com/articles/s41380-021-01267-y
Mercapturate pathway metabolites of sotorasib, a covalent inhibitor of KRASG12C, are associated with renal toxicity in the Sprague Dawley rat J. A. Werner et al. Toxicology and Applied Pharmacology 2021, 423, 115578 https://www.sciencedirect.com/science/article/pii/S0041008X2100185X
Safety, Tissue Distribution, and Metabolism of LNA-Containing Antisense Oligonucleotides in Rats F. Romero-Palomo et al. Toxicologic Pathology 2021, 49, 6, 1174-1192 https://journals.sagepub.com/doi/10.1177/01926233211011615
Partitioning and Spatial Distribution of Drugs in Ocular Surface Tissues A. Balla et al. Pharmaceutics 2021, 13, 5, 658 https://www.mdpi.com/1999-4923/13/5/658
Lesion Penetration and Activity Limit the Utility of Second-Line Injectable Agents in Pulmonary Tuberculosis J. P. Ernest et al. Antimicrobial Agents and Chemotherapy 2021, 65, 10, e00506-21 https://journals.asm.org/doi/10.1128/AAC.00506-21
Antibacterial activity of apramycin at acidic pH warrants wide therapeutic window in the treatment of complicated urinary tract infections and acute pyelonephritis K. Becker et al. EBioMedicine 2021, 73, 103652 https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(21)00446-1/fulltext
Mass spectrometry imaging reveals lipid upregulation and bile acid changes indicating amitriptyline induced steatosis in a rat model J. M. Kampa et al. Toxicology Letters 2020, 325, 43-50 https://www.sciencedirect.com/science/article/abs/pii/S0378427420300564
Brain distribution of geissoschizine methyl ether in rats using mass spectrometry imaging analysis T. Matsumoto et al. Scientific Reports 2020, 10, 1, 7293 https://www.nature.com/articles/s41598-020-63474-x
Drug Administration Routes Impact the Metabolism of a Synthetic Cannabinoid in the Zebrafish Larvae Model Y. M. Park et al. Molecules 2020, 25, 19, 4474 https://www.mdpi.com/1420-3049/25/19/4474

Imaging – Protocols

Title Authors Publication Link
In Situ Localization of Plant Lipid Metabolites by Matrix-Assisted Laser Desorption/Ionization Mass SpectrometrySpectrometry Imaging (MALDI-MSI) D. Sturtevant et al. Methods in Molecular Biology 2021, Vol. 2295, 417-438 https://link.springer.com/protocol/10.1007%2F978-1-0716-1362-7_24
Multiplexed Imaging Mass Spectrometry of Histological Staining, N-Glycan and Extracellular Matrix from One Tissue Section: A Tool for Fibrosis Research C. L. Clift et al. Methods in Molecular Biology 2021, Vol. 2350, 313-329 https://link.springer.com/protocol/10.1007%2F978-1-0716-1593-5_20
Spatial visualization of comprehensive brain neurotransmitter systems and neuroactive substances by selective in situ chemical derivatization mass spectrometry imaging R. Shariatgorji et al. Nature Protocols 2021, 16, 7, 3298-3321 https://www.nature.com/articles/s41596-021-00538-w
Investigation of Xenobiotics Metabolism In Salix alba Leaves via Mass Spectrometry Imaging. C. Villette et al. Journal of Visualized Experiments 2020, 160, e61011 https://www.jove.com/de/t/61011/investigation-xenobiotics-metabolism-salix-alba-leaves-via-mass

Structural Biology

Title Authors Publication Link
Quantitating α-amidated peptide degradation by separative technologies and ultra-high resolution mass spectrometry E. Logerot et al. Talanta 2023, 253, 124036 https://doi.org/10.1016/j.talanta.2022.124036
Top-down mass spectrometry and assigning internal fragments for determining disulfide bond positions in proteins B. Wei et al. Analyst 2022, 148(1), 26-37 https://doi.org/10.1039/d2an01517j
Utilization of Fast Photochemical Oxidation of Proteins and Both Bottom-up and Top-down Mass Spectrometry for Structural Characterization of a Transcription Factor–dsDNA Complex M. Polák et al. Analytical Chemistry 2022, 94(7), 3203-3210 https://doi.org/10.1021/acs.analchem.1c04746
Enhancing Biomolecule Analysis and 2DMS Experiments by Implementation of (Activated Ion) 193 nm UVPD on a FT-ICR Mass Spectrometer A. Theisen et al. Analytical Chemistry 2022, 94(45), 15631-15638 https://doi.org/10.1021/acs.analchem.2c02354
Top-Down Detection of Oxidative Protein Footprinting by Collision-Induced Dissociation, Electron-Transfer Dissociation, and Electron-Capture Dissociation G. Yassaghi et al. Analytical Chemistry 2022, 94(28), 9993-10002 https://doi.org/10.1021/acs.analchem.1c05476

Instrumentation

Title Authors Publication Link
Magnitude Filter Combined with Mass Filter: A Reliable Strategy to Improve the Reproducibility of ESI-FT-ICR-MS Analysis on the Fingerprint of Dissolved Organic Matter M. Chen et al. Analytical Chemistry 2022 94(30), 10643-10650 https://doi.org/10.1021/acs.analchem.2c00879
Enhancing Biomolecule Analysis and 2DMS Experiments by Implementation of (Activated Ion) 193 nm UVPD on a FT-ICR Mass Spectrometer A. Theisen et al. Analytical Chemistry 2022 94(45), 15631-15638 https://doi.org/10.1021/acs.analchem.2c02354
Fine Structure in Isotopic Peak Distributions Measured Using Fourier Transform Ion Cyclotron Resonance Mass Spectrometry: A Comparison between an Infinity ICR Cell and a Dynamically Harmonized ICR Cell J. Xu et al. Journal of The American Society for Mass Spectrometry 2022, 33(8), 1499-1509 https://doi.org/10.1021/jasms.2c00093
Characterization of the Time-Domain Isotopic Beat Patterns of Monoclonal Antibodies in Fourier Transform Mass Spectrometry K. O. Nogornov et al. Journal of The American Society for Mass Spectrometry 2022, 33(7), 1113-1125 https://doi.org/10.1021/jasms.1c00336

Environmental

TITLE AUTHORS PUBLICATION LINK
Molecular and optical signatures of photochemical transformation of dissolved organic matter: Nonnegligible role of suspended particulate matter in urban river J. Hou et al. The Science of The Total Environment, 903, 166842 - September 2023 https://doi.org/10.1016/j.scitotenv.2023.166842
Comparative analysis of organic chemical compositions in airborne particulate matter from Ulaanbaatar, Beijing, and Seoul using UPLC-FT-ICR-MS and artificial neural network S. Son et al. The Science of The Total Environment, 901, 165917 - July 2023 https://doi.org/10.1016/j.scitotenv.2023.165917
Spatial and molecular variations in forest topsoil dissolved organic matter as revealed by FT-ICR mass spectrometry M. Sheng et al. The Science of The Total Environment, 895, 165099 - June 2023 https://doi.org/10.1016/j.scitotenv.2023.165099
Evolution of dissolved organic nitrogen (DON) during sludge reject water treatment revealed by FTICR-MS R. Yin et al. The Science of The Total Environment, 893, 164944 - June 2023 https://doi.org/10.1016/j.scitotenv.2023.164944
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Urban particulate water-soluble organic matter in winter: Size-resolved molecular characterization, role of the S-containing compounds on haze formation C. Ning et al. The Science of The Total Environment, 875, 162657 - March 2023 https://doi.org/10.1016/j.scitotenv.2023.162657
Concealed by darkness: Combination of NMR and HRMS reveal the molecular nature of dissolved organic matter in fractured-rock groundwater and connected surface waters M.C. Bridoux et al. Water Research, 243, 120392 - July 2023 https://doi.org/10.1016/j.watres.2023.120392
Investigation with ESI FT-ICR MS on sorbent selectivity and comprehensive molecular composition of landfill leachate dissolved organic matter Q. Zhang et al. Water Research, 243, 120359 - July 2023 https://doi.org/10.1016/j.watres.2023.120359
Molecular composition and chemodiversity of dissolved organic matter in wastewater sludge via Fourier transform ion cyclotron resonance mass spectrometry: Effects of extraction methods and electrospray ionization modes P. Zhao et al. Water Research, 232, 119687 - February 2023 https://doi.org/10.1016/j.watres.2023.119687
UV/chlorine and chlorination of effluent organic matter fractions: Tracing nitrogenous DBPs using FT-ICR mass spectrometry Y. Wang et al. Water Research, 231, 119646 - January 2023 https://doi.org/10.1016/j.watres.2023.119646
Characterization of Soluble and Insoluble Lignin Oligomers by Means of Ultrahigh Resolving Mass Spectrometry K. Sander et al. Energy & Fuels, 37(1), 439-449 - December 2022 https://doi.org/10.1021/acs.energyfuels.2c03538
Molecular level characterization of the biolability of rainwater dissolved organic matter H. Bao et al. The Science of The Total Environment, 862, 160709 - December 2022 https://doi.org/10.1016/j.scitotenv.2022.160709
Comprehensive understanding of DOM reactivity in anaerobic fermentation of persulfate-pretreated sewage sludge via FT-ICR mass spectrometry and reactomics analysis J. Liu et al. Water Research, 229, 119488 - December 2022 https://doi.org/10.1016/j.watres.2022.119488
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Deciphering the structural characteristics and molecular transformation of dissolved organic matter during the electrolytic oxygen aerobic composting process J. Wie et al. The Science of The Total Environment, 845, 157174 - July 2022 https://doi.org/10.1016/j.scitotenv.2022.157174
The impact of natural sunlight irradiation on the biotoxicities of different molecular sizes EfOM/SRNOM and its relationship with spectral and molecular level parameters X. Y. Ma et al. The Science of The Total Environment, 843, 156972 - June 2022 https://doi.org/10.1016/j.scitotenv.2022.156972
Molecular and spectroscopic changes of peat-derived organic matter following photo-exposure: Effects on heteroatom composition of DOM M. Harir et al. The Science of The Total Environment, 838(Pt 1), 155790 - May 2022 https://doi.org/10.1016/j.scitotenv.2022.155790
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High-Resolution Molecular-Level Characterization of a Blanket Bog Peat Profile G. Trifiró et al. Environmental Science and Technology, 56(1), 660-671 - December 2021 https://doi.org/10.1021/acs.est.1c05837
Exploring the fate of dissolved organic matter at the molecular level in the reactive electrochemical ceramic membrane system using fluorescence spectroscopy and FT-ICR MS T. Maqbool et al. Water Research, 210, 117979 - December 2021 https://doi.org/10.1016/j.watres.2021.117979
Chemical characterization of dissolved organic matter as disinfection byproduct precursors by UV/fluorescence and ESI FT-ICR MS after smoldering combustion of leaf needles and woody trunks of pine (Pinus jeffreyi) H. Chen et al. Water Research, 209, 117962 - December 2021 https://doi.org/10.1016/j.watres.2021.117962
Molecular insights into the reactivity of aquatic natural organic matter towards hydroxyl (•OH) and sulfate (SO4 •−) radicals using FT-ICR MS S. Zhang et al. Chemical Engineering Journal, 425, 130622 - December 2021 https://doi.org/10.1016/j.cej.2021.130622
Unraveling the impact of iron oxides-organic matter complexes on iodine mobilization in alluvial-lacustrine aquifers from central Yangtze River Basin J. Xue et al. The Science of The Total Environment, 814, 151930 - November 2021 https://doi.org/10.1016/j.scitotenv.2021.151930
Deciphering dissolved organic matter from freshwater aquaculture ponds in Eastern China based on optical and molecular signatures D. Wang et al. Process Safety and Environmental Protection, 155, 122-130 - November 2021 https://doi.org/10.1016/j.psep.2021.09.025
Selective Reactivity and Oxidation of Dissolved Organic Matter by Manganese Oxides E. L. Trainer et al. Environmental Science and Technology, 55(17), 12084-12094 - August 2021 https://doi.org/10.1021/acs.est.1c03972
Dissolved Organic Matter Processing in Pristine Antarctic Streams M. Kida et al. Environmental Science and Technology, 55(14), 10175-10185 - July 2021 https://doi.org/10.1021/acs.est.1c03163
Algal Organic Matter Drives Methanogen-Mediated Methylmercury Production in Water from Eutrophic Shallow Lakes P. Lei et al. Environmental Science and Technology, 55(15), 10811-10820 - July 2021 https://doi.org/10.1021/acs.est.0c08395
Interfacial Molecular Fractionation on Ferrihydrite Reduces the Photochemical Reactivity of Dissolved Organic Matter Z. Wang et al. Environmental Science and Technology, 55(3), 1769-1778 - January 2021 https://doi.org/10.1021/acs.est.0c07132
Effects of feeding a pine-based biochar to beef cattle on subsequent manure nutrients, organic matter composition and greenhouse gas emissions C. M. Romero et al. The Science of The Total Environment, 812, 152267 - December 2021 https://doi.org/10.1016/j.scitotenv.2021.152267
Molecular chemodiversity of water-soluble organic matter in atmospheric particulate matter and their associations with atmospheric conditions C. Ning et al. The Science of The Total Environment, 809, 151171 - October 2021 https://doi.org/10.1016/j.scitotenv.2021.151171
Natural organic matter composition and nanomaterial surface coating determine the nature of platinum nanomaterial-natural organic matter corona M. Baalousha et al. The Science of The Total Environment, 806(Pt 1), 150477 - September 2021 https://doi.org/10.1016/j.scitotenv.2021.150477
Determination of anthropogenic organics in dichlomethane extracts of aerosol particulate matter collected from four different locations in China and Republic of Korea by GC–MS and FTICR–MS D. Kim et al. The Science of The Total Environment, 805, 150230 - September 2021 https://doi.org/10.1016/j.scitotenv.2021.150230
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Molecular insight into the variation of dissolved organic phosphorus in a wastewater treatment plant S. Gao et al. Water Research, 203, 117529 - August 2021 https://doi.org/10.1016/j.watres.2021.117529
Unravelling molecular transformation of dissolved effluent organic matter in UV/H2O2, UV/persulfate, and UV/chlorine processes based on FT-ICR-MS analysis B. Zhang et al. Water Research, 199, 117158 - April 2021 https://doi.org/10.1016/j.watres.2021.117158
Characterization of Dissolved Organic Matter from Wildfire-induced Microcystis aeruginosa Blooms controlled by Copper Sulfate as Disinfection Byproduct Precursors Using APPI(-) and ESI(-) FT-ICR MS H. Chen et al. Water Research, 189, 116640 - November 2020 https://doi.org/10.1016/j.watres.2020.116640
Unveiling the transformation of dissolved organic matter during ozonation of municipal secondary effluent based on FT-ICR-MS and spectral analysis B. Zhang et al. Water Research, 188, 116484 - September 2020 https://doi.org/10.1016/j.watres.2020.116484
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Preferential Sorption of Tannins at Aluminum Oxide Affects the Electron Exchange Capacities of Dissolved and Sorbed Humic Acid Fractions E. Subdiaga et al. Environmental Science and Technology, 54(3), 1837-1847 - January 2020 https://doi.org/10.1021/acs.est.9b04733
Detection of organosulfates and nitrooxy-organosulfates in Arctic and Antarctic atmospheric aerosols, using ultra-high resolution FT-ICR mass spectrometry Y. Ye et al. The Science of The Total Environment, 767, 144339 - December 2020 https://doi.org/10.1016/j.scitotenv.2020.144339
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Improved Mass Accuracy and Isotope Confirmation through Alignment of Ultrahigh-Resolution Mass Spectra of Complex Natural Mixtures J.Merder et al. Analytical Chemistry, 92(3), 2558-2565 - December 2019 https://doi.org/10.1021/acs.analchem.9b04234
Spectroscopic and molecular-level characteristics of dissolved organic matter in the Pearl River Estuary, South China Y. Liu et al. The Science of The Total Environment, 710, 136307 - December 2019 https://doi.org/10.1016/j.scitotenv.2019.136307
Molecular Characterization of Water- and Methanol-Soluble Organic Compounds Emitted from Residential Coal Combustion Using Ultrahigh-Resolution Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry J. Song et al. Environmental Science and Technology, 53(23), 13607-13617 - November 2019 https://doi.org/10.1021/acs.est.9b04331
The Role of Dissolved Organic Matter Composition in Determining Photochemical Reactivity at the Molecular Level S. M. Berg et al. Environmental Science and Technology, 53(20), 11725-11734 - September 2019 https://doi.org/10.1021/acs.est.9b03007
Molecular differences between water column and sediment pore water SPE-DOM in ten Swedish boreal lakes J. Valle et al. Water Research, 170, 115320 - November 2019 https://doi.org/10.1016/j.watres.2019.115320
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Transformation of dissolved organic matter during full-scale treatment of integrated chemical wastewater: Molecular composition correlated with spectral indexes and acute toxicity B. Zhang et al. Water Research, 157, 472-482 - April 2019 https://doi.org/10.1016/j.watres.2019.04.002
Simultaneous removal of dissolved organic matter and nitrate from sewage treatment plant effluents using photocatalytic membranes H. Xu et al. Water Research, 143, 250-259 - June 2018 https://doi.org/10.1016/j.watres.2018.06.044
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Molecular Characterization of Water-Soluble Humic like Substances in Smoke Particles Emitted from Combustion of Biomass Materials and Coal Using Ultrahigh-Resolution Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry J. Song et al. Environmental Science and Technology, 52(5), 2575-2585 - January 2018 https://doi.org/10.1021/acs.est.7b06126
Compositional changes of dissolved organic carbon during its dynamic desorption from hyporheic zone sediments C. Zhou et al. The Science of The Total Environment, 658, 16-23 - December 2018 https://doi.org/10.1016/j.scitotenv.2018.12.189
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