Food Intolerance
Lactose Intolerance
Lactose intolerance is very widespread worldwide, although there are significant differences depending on the region and population. About 5 to 15 % of Europeans cannot tolerate lactose. Lactose intolerance is rarest in northern Europe. In Africa or East Asia, however, 65 to over 90 % of adults are affected.
In case of this most common form of food intolerance, the enzyme lactase can no longer be formed in the intestines and lactase deficiency results. A distinction is made between primary and secondary lactose intolerance, depending on the cause of this decrease. In case of primary lactose intolerance, the decrease is genetically based and manifests itself starting at around 10 years of age.
In case of the acquired secondary form, lactase deficiency is the consequence of another disease. Due to lack of lactase, lactose contained in the food can no longer be digested and therefore reaches the small intestine in an undigested form. As a result symptoms such as abdominal pain, vomiting, diarrhea and flatulence, occur. Therefore, the presence of lactose intolerance should be considered and investigated after clarification of other organic causes in persons with these kinds of symptoms.
Fructose intolerance
With a frequency of 1:20,000 in Europe, hereditary fructose intolerance (HFI) is rare but a quite severe form of food intolerance. Three common mutations (A149P, A174D and N334K) in the aldolase B gene account for approximately 85% of all HFI cases in Europe. Those mutations lead to an accumulation of fructose-1-phosphate due to a decreased enzymatic activity of aldolase B. The ingestion of fructose is linked with fatal consequences for the patient.
Symptoms include severe abdominal pain, hypoglycaemia, potentially fatal liver and kidney failure. However, affected individuals often develop an aversion to sweets, so the diagnosis is frequently missed until adulthood.
Products for diagnostics of food intolerance
Both forms of food intolerance can be easily detected by using molecular genetic methods directly from blood specimens. There is no need for time-consuming and uncomfortable patient testing, which can lead to life-threatening consequences in case of fructose intolerance!
Our test systems allow for fast and reliable detection of hereditary lactose and fructose intolerance.
The choice is yours: different technologies and test systems provide you with your individual results.
The test systems GenoType LCT VER 1.0 and GenoType SugarTol VER 1.0 are based on the user-friendly DNA•STRIP technology and reliably detect both forms of food intolerance.
The FluoroType® LCT VER 1.0 test is based on the innovative FluoroType® technology enabling the secure identification of primary lactose intolerance.
Product range
Your fluorescence-based test system for the reliable detection of primary lactose intolerance.
Your benefits with FluoroType® LCT VER 1.0
- Reliable result: Only genetically based lactose intolerance is detected. This makes it possible to differentiate it from acquired lactose intolerance, which is treatable in some cases.
- Rapid result: In contrast to complex function tests, the patient does not need to spend several hours under medical observation. Only a blood sample is needed for the determination.
- User-friendly: From amplification to detection, all steps are performed in the FluoroCycler®. Analysis and interpretation of results are then performed using a test-specific software. Your diagnostics therefore become even simpler and more reliable.
At a glance
Molecular genetic fluorescence-based test system for analysis of the genetically determined lactose intolerance
Starting material:
EDTA blood
DNA Isolation:
GXT Blood Extraction Kit VER 2.0 (with GenoXtract®)
Instrument for Amplification and Detection:
FluoroCycler® 12
FluoroCycler® XT
Technology:
FluoroType® technology
Downloads:
Your test system for the reliable detection of primary lactose intolerance by combined analysis of the polymorphisms C/T-13910 and G/A-22018 in the lactase gene
With GenoType LCT VER 1.0, simple and quick determination of genetically based primary lactose intolerance without any patient burden is possible. The test detects two polymorphisms in the lactase gene in positions –13910 and –22018, which are associated with primary lactose intolerance and thus makes definite detection possible.
Your benefits with GenoType® LCT VER 1.0
Reliable result: Only genetically based lactose intolerance is detected. This makes it possible to differentiate it from acquired lactose intolerance, which is treatable in some cases.
Rapid result: In contrast to complex function tests, the patient does not need to spend several hours under medical observation. Only a blood sample is needed for the determination.
Simple evaluation: Using an evaluation template, the test result can be read rapidly and easily.
At a glance
Molecular genetic assay for analysis of the genetically determined lactose intolerance
Starting material:
EDTA/Citrate blood
DNA Isolation:
GENO•CARD VER 1.0 or
GXT Blood Extraction Kit VER 2.0 (with GenoXtract®)
Technology:
DNA•STRIP technology
Downloads:
Your molecular genetic test system for the reliable detection of hereditary lactose and fructose intolerance.
GenoType SugarTol VER 1.0 enables the reliable determination of hereditary lactose and fructose intolerance. The analysis of primary lactose intolerance is possible due to detection of C/T-13910 polymorphism. In the same procedural step the three most common mutations which lead to hereditary fructose intolerance are identified.
Your benefits with GenoType SugarTol VER 1.0
- Simple detection from blood samples: The test system is based on molecular detection directly from blood samples. There is no need for time-consuming and uncomfortable patient testing, which can lead to life-threatening consequences in case of fructose intolerance.
- Relevant information at a glance: GenoType SugarTol VER 1.0 enables the detection of hereditary lactose and fructose intolerance. Thus, two important forms of food intolerance are detected with one test.
- Individual automation: DNA isolation and the detection can be performed automatically. Batch or individual automation can be performed, thus gaining maximum flexibility.
At a glance
Molecular genetic assay for analysis of the hereditary lactose and fructose intolerance
Starting material:
EDTA/Citrate blood
DNA Isolation:
GENO•CARD VER 1.0 or
GXT Blood Extraction Kit VER 2.0 (with GenoXtract®)
Technology:
DNA•STRIP technology
Downloads:
Please contact your local representative for availability in your country.
Not for sale in the USA.
Legal Manufacturer is Hain Lifescience GmbH – A Bruker Company
