SLAS Europe

Location: Room 304

Accelerating the drug development process with Bruker high-throughput mass spec solutions powered by timsTOF technology

This tutorial will highlight the unique capabilities of Bruker's high-throughput pharma and biopharma mass spec solutions based on innovative timsTOF technology. The presentation will address various critically important drug discovery/development workflows and illustrate how Bruker's customized timsTOF solutions stand out to accelerate and enhance these, e.g.

• Label-free (ultra)high-throughput screening and high-throughput experimentation monitoring in early drug discovery enabled by timsTOF MALDI PharmaPulse^®
• Molecular imaging in tissues with MALDI guided SpatialOMx^®
• High-throughput protein degradation studies, HCP analysis and immunopeptidomics facilitated by 4D-Proteomics™ Ecosystem
• Complete characterization of DNA, RNA and beyond provided by OligoQuest™

Bruker SPR Pro: Multiple ways of kinetic profiling with High Throughput Surface Plasmon Resonance

Surface Plasmon Resonance is an established and widely used biophysical technology in screening and lead development campaigns for novel drug candidates. The real-time, label-free analysis of interactions offers additional insights into kinetics as well as binding profiles. Besides the usage of a common multi injection kinetic, the titration cycle kinetic offers a quick insight into the kinetics behavior of a full screening campaign. We herewith present an automated and high-throughput optimized approach for kinetic profile determination using SPR. Especially the high comparability between the shown approaches will increase the flexibility for the user to determine the typical parameters from a SPR experiment.