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DIAGNOSTIC SOLUTIONS & HEALTHCARE CHALLENGES

AST / MIC / Resistance Testing

The global incidence of multi-drug resistance (MDR) among gram-negative and gram-positive pathogens has risen in recent years, with serious consequences for both hospital- and community-acquired infections.

AST / MIC / Resistance Testing

Detecting the potential resistance mechanisms and phenotypic resistance of organisms with high mortality rates such as Enterococcus fae­cium, Staphylococcus aureus, Klebsiella pneu­moniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter spp. and Escherichia coli is of high clinical and epidemiological importance.

Bruker offers a meaningful portfolio of MALDI-TOF based, broth microdilution and molecular assays to detect antimicrobial resistance determinants and phenotypic resistance to critically important antibiotics.

MALDI-TOF mass spectrometry has the potential to identify specific resistance markers. When using the IVD MALDI Biotyper® the dedicated MBT Subtyping® IVD Module combines the identification of important pathogens with automated subsequent detection of specific resistance markers in one automated workflow, providing a warning about a potential resistance.

With the subsequent MBT-STAR® IVD assays, the IVD MALDI Biotyper® combines microbial identification with phenotypic detection of carbapenemase and cephalosporinase activity.

With the negative ion mode available on Bruker’s high-end MALDI Biotyper® sirius Systems, analysis of lipids has become accessible for microbial research, enabling exploration of lipidomics for resistance detection. The MBT Lipid XtractTM Kit (RUO) allows sample preparation of the Lipid A molecule and all its modifications within less than 15 minutes and therefore delivering rapid colistin resistance detection.

The MICRONAUT and UMIC® broth microdilution (BMD) assays provide specialty and routine antimicrobial and antifungal susceptibility testing solutions as well as convenient and flexible MIC determination of highest accuracy for single antibiotics (UMIC®) like colistin, cefiderocol, and piperacillin-tazobactam.

Bruker further supports resistance management by offering the Carbaplex® real-time PCR kit to detect presence of the big 5 carbapenemase genes from a rectal swab, for patients who are at risk of colonization from Carbapenamase Producing Enterobacteriaceae (CPE).



 

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Beta-Lactamase Activity Detection

Extending the capabilities of your MALDI Biotyper® beyond the identification of microorganisms, these assays provide rapid assessment of β-lactamase activity in bacterial isolates, with dedicated MBT STAR® reagent kits and software modules.
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subtyping-keyvisual-bruker-md-web

Instant and Automated Typing

Dive into deeper microorganism characterization, enabling the automated detection of specific marker peaks or peak profiles, for elevated differentiation of hard to distinguish species or for instant detection of resistance markers.
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MALDI Biotyper® sirius System 

The MALDI Biotyper® sirius System is a must-have for rapid and accurate microbial identification, developed in the scope of broadening research capabilities, including resistance detection applications based on the lipid analysis in the negative ion mode. 
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Antimicrobial susceptibility testing

The MICRONAUT and UMIC® broth microdilution (BMD) product portfolios offer a broad range of antibiotic resistance and specialty antimicrobial susceptibility testing.
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