timsTOF Ultra 2

We recognize the inherent duality of research investments: opportunity and risk. Embracing innovation's dynamism, we prioritize upgradable research platforms. This commitment fosters sustainability and empowers researchers to navigate the ever-evolving landscape.

Our upgradable platform seamlessly integrates the latest advancements, keeping your projects at the forefront of discovery. It grants researchers the flexibility to choose the optimal moment to leverage these advancements, maximizing the impact of their work and aligning perfectly with their research goals.

Introducing the next generation of timsTOF Ultra mass spectrometry: the timsTOF Ultra 2. Paired with the powerful CaptiveSpray Ultra 2 ion source, this dynamic duo unlocks unparalleled sensitivity, empowering you to conquer challenging samples and detect low-abundance peptides. This translates to groundbreaking discoveries in omics research.

Dive Deeper: From minute samples to unseen peptides
timsTOF Ultra 2 and CaptiveSpray Ultra 2 join forces to reveal the full potential of your samples. Analyze even the smallest amounts and uncover previously unseen peptides. PASEF^® acquisition empowers you to delve into the depths of low-abundance peptides, extracting crucial information that was once undetectable. Additionally, trapped ion mobility separation eliminates the need for chemical tagging, streamlining the identification of novel peptides. With these advancements, the timsTOF Ultra 2 with CaptiveSpray Ultra 2 redefine what's possible in your lab, propelling your research to new heights.

The timsTOF Ultra 2 transcends conventional limitations, opening doors to new scientific possibilities. Whether it's single cell proteomics, immunopeptidomics, or plasma proteomics, the timsTOF Ultra 2 with CaptiveSpray Ultra 2 delivers the speed and sensitivity researchers need to push the boundaries and achieve groundbreaking results.

Maximize your identification depth and throughput with the new capabilities of Bruker ProteoScape™, our Run & Done database search platform. TIMScore™ and TIMS DIA-NN leverages the power of the CCS for more accurate protein identification on the fly. Additionally, Bruker ProteoScape™ provides seamless integration with Spectronaut^® 19, granting access to DirectDIA+ and enabling powerful diagonal-PASEF workflows.

The second generation of timsTOFs is all about increasing sensitivity without compromising robustness. Using the CSI Ultra 2 with its optimized vortex dynamics as well as access to diagonal-PASEF^® workflows and the second generation of ion charge control (ICC 2), the timsTOF Ultra 2 pushes the boundaries of sensitivity even further.

Experience the power of timsTOF Ultra 2
With the timsTOF Ultra 2, robust and highly sensitive mass spectrometry becomes your indispensable tool for exploring phenotypes within heterogeneous cell environments. Unravel the secrets of cancers and shed light on other diseases with complementary information to single cell genomics and transcriptomics. Decipher heterogeneity to deepen your understanding of biological processes, cell-cell communication, and enhance therapeutic options.

Discover a new era of single cell proteomics
Unleash the full potential of single cell proteomics with timsTOF Ultra 2. Peer into cellular complexity like never before. Gain a comprehensive understanding of unique phenotypes within diverse cell populations, and revolutionize the perception of diseases and their underlying mechanisms.

Illuminate the path to progress
Propel your research by harnessing the power of advanced mass spectrometry, and drive transformative breakthroughs in proteomics with the timsTOF Ultra 2. Unlock cellular mysteries, transcend conventional understanding, and shape a future where improved therapies become a reality.

Witness cells in a whole new light. Revolutionize your approach to proteomics and unlock the secrets of cellular complexity for a brighter tomorrow.

Looking to elevate your single cell analysis? Take on the challenge of analyzing single cells from FFPE tissue.

Discover the power of timsTOF Ultra in the realm of translational patient treatment. With its exceptional capabilities, timsTOF Ultra enables the precise mapping of FFPE tissue proteins to specific cancer regions, even with limited sample quantities. Experience the next-level performance of dia-PASEF^® on the timsTOF Ultra, revolutionizing low-input tissue proteomics and becoming an essential solution for molecular medicine labs.

Unleash the potential of molecular medicine with timsTOF Ultra as your ally. Conquer the complexities of single cell analysis in FFPE tissue and embark on a transformative journey towards advancing patient care.

Microbial communities play a crucial role in planetary health, impacting the well-being of humans, animals, and plants, and driving interventions for acute and global issues. As microbiome research expands and influences legislation, economics, and societal behavior, it is essential to go beyond taxonomical characterization and delve into the functional dynamics and environmental interactions of these communities. Metaproteomics has emerged as a powerful approach to gaining this understanding.

Discover the advantages:

• Unparalleled peptide and protein identification: Utilize the ion mobility dimension of TIMS and PASEF^® to identify and quantify an unprecedented number of peptides and proteins in the mouse gut microbiome and host with exceptional accuracy (CV <20%).
  
• Comprehensive taxonomical and functional profiling: Achieve profiling depths that rival or surpass commonly used genomic approaches, enabling comprehensive insights into both the taxonomical and functional aspects of microbial communities.
  
• Sensitivity and efficiency: Experience remarkable sensitivity gains, allowing analysis with minimal sample amounts, while accelerated analysis using short gradients is made possible by the incredible speed of PASEF^®.
  

Plasma proteomics plays a vital role in disease diagnosis and therapy, offering a comprehensive view of the proteome. To enable reliable identification and monitoring of biomarkers in large cohort studies, it is essential to leverage population-wide screening technologies. The integration of robust µ-flow and normal flow chromatography with timsTOF Ultra 2, powered by VIP-HESI, provides an unparalleled combination of robustness, speed, reproducibility, sensitivity, and sample throughput.

Key features:

• Robust electrospray technology enables up to 5000 LC/MS runs, providing exceptional longevity.
  
• Achieve 3x signal gain at a flow rate of 50 µL/min with the 50 µm sprayer, ensuring optimal sensitivity.

• Effortlessly replace the standard VIP-HESI sprayer with a convenient drop-in replacement for seamless integration.
• Experience efficient peptide detection and quantitation in under 10 minutes per sample with our 4D-Proteomics™ approach.
• Benefit from increased column lifetime, reducing maintenance and replacement costs.

Elevate your plasma proteomics research with our advanced solution, optimized for higher flow rates. Benefit from exceptional robustness, sensitivity, and throughput, empowering you to unravel the complexities of plasma proteomes and accelerate discoveries in disease diagnosis and therapy.

The diagnostic potential of lipids and their crucial role in cellular processes have sparked a demand for next-generation sensitivity in lipidomics. Analyzing lipids at the cellular level enables detailed insights into cell heterogeneity, paving the way for breakthrough discoveries in single-cell biology, cancer pathology, and clinical research.

Experience unmatched analytical depth with the exceptional sensitivity of the timsTOF Ultra, combined with nano-flow chromatography using the Bruker nanoElute^® 2 and CaptiveSpray Ultra source. This powerful combination empowers researchers to delve into the intricate world of cellular lipidomics and unravel the complex relationships between lipids and cellular functions.

Discover:

• Comprehensive MS/MS coverage: Benefit from comprehensive MS/MS coverage from single injections using PASEF^® acquisition, ensuring thorough exploration of lipid profiles.
• Improved MS/MS spectral quality: Achieve superior MS/MS spectral quality through MOMA separation, enhancing the accuracy and reliability of lipid annotations.
• Increased confidence with accurate CCS Values: Leverage the accurate Collision Cross Section (CCS) values obtained from TIMS, enhancing confidence in lipid identification and characterization.

Unlock the potential of cellular lipidomics with our ultra-sensitive solution. Gain unprecedented insights into lipid composition and function, revolutionizing your research in diverse fields such as single-cell biology, cancer pathology, and clinical investigations. Elevate your lipidomics studies to new heights of sensitivity and precision with the timsTOF Ultra and MetaboScape^® and pave the way for transformative discoveries in lipid-related research.