timsTOF Pro Bibliography
timsTOF Pro Bibliography
The timsTOF Pro powered by PASEF® boosts the research capability of the labs having acquired it by offering an unprecedented, uncompromised combination of speed, sensitivity, selectivity and robustness. The reproducible measurement of Collisional Cross Section (CCS) values for every peptide has allowed to develop innovative 4D proteomics™/lipidomics™/metabolomics™ approaches, making the best use of the instrument’s selectivity. New acquisition modes are rolled out on a regular basis, like dia-PASEF® introduced at HUPO 2019. The peer-reviewed communications listed below is a non-exhaustive list from the work initiated on the first instruments, and many more are to come.
Biology – timsTOF Pro - COVID-19 section
| Title | Authors | Publication | Link |
|---|---|---|---|
| Increasing the Throughput of Sensitive Proteomics by PlexDIA | Derks, J.; Leduc, A. et al. | Nat Biotechnol 2023, 41 (1), 50–59 | https://doi.org/10.1038/s41587-022-01389-w |
| Deep Visual Proteomics Defines Single-Cell Identity and Heterogeneity | Mund, A.; Coscia, F. et al. | Biotechnol 2022, 40 (8), 1231–1240 | https://doi.org/10.1038/s41587-022-01302-5 |
| AI-Driven Deep Visual Proteomics Defines Cell Identity and Heterogeneity | Mund, A.; Coscia, F. et al. | preprint; Systems Biology 2021 | https://doi.org/10.1101/2021.01.25.427969 |
| Ultra-High Sensitivity Mass Spectrometry Quantifies Single-Cell Proteome Changes upon Perturbationn | Brunner, A.-D.; Thielert, M. et al. | preprint; Systems Biology 2020 | https://doi.org/10.1101/2020.12.22.423933 |
| Hyperinflammatory environment drives dysfunctional myeloid cell effector response to bacterial challenge in COVID-19 | Mairpady Shambat, S.; Gómez-Mejia, A. et al. | PLoS Pathog 2022, 18 | https://doi.org/10.1371/journal.ppat.1010176 |
| Distinct Core Glycan and O-Glycoform Utilization of SARS-CoV-2 Omicron Variant Spike Protein RBD Revealed by Top-Down Mass Spectrometry | Roberts, D.S.; Mann, M.; Ge, Y. et al. | preprint; Biochemistry 2022 | https://doi.org/10.1101/2022.02.09.479776 |
| Immune response pattern across the asymptomatic, symptomatic and convalescent periods of COVID-19 | Chen, Y.; Zhang, N.; Wong, C.C.L. et al. | Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 2022, 1870 | https://doi.org/10.1016/j.bbapap.2021.140736 |
| Multi-level inhibition of coronavirus replication by chemical ER stress | Shaban, M.S.; Müller, C. et al. | Nat Commun 2021, 12, 5536 | https://doi.org/10.1038/s41467-021-25551-1 |
| Immunophenotyping assessment in a COVID-19 cohort (IMPACC): A prospective longitudinal study | IMPACC Manuscript Writing Team†, on behalf of the IMPACC Network Steering Committee‡ | Sci. Immunol. 2021, 6, eabf3733 | https://doi.org/10.1126/sciimmunol.abf3733 |
| DIA-Based Proteome Profiling of Nasopharyngeal Swabs from COVID-19 Patients | Mun, D.-G.; Vanderboom, P.M. et al. | J. Proteome Res. 20, 2021, 4165–4175 | https://doi.org/10.1021/acs.jproteome.1c00506 |
| Proteomic Analysis Identifies Prolonged Disturbances in Pathways Related to Cholesterol Metabolism and Myocardium Function in the COVID-19 Recovery Stage | Chen, Y.; Yao, H.; Wong, C.C.L. et al. | J. Proteome Res 2021 | https://doi.org/10.1021/acs.jproteome.1c00054 |
| SARS-CoV-2 infects human pancreatic ß cells and elicits ß cell impairment | Wu, C.-T.; Lidsky, P.V.; Jackson, P.K. et al. | Cell Metabolism 2021 | https://doi.org/10.1016/j.cmet.2021.05.013 |
| Second-Generation Antibodies Neutralize Emerging SARS-CoV-2 Variants of Concern | Kovacech, B.; Fialova, L. et al. | preprint; Microbiology 2021 | https://doi.org/10.1101/2021.06.09.447527 |
| A Blood Atlas of COVID-19 Defines Hallmarks of Disease Severity and Specificity; COvid-19 Multi-omics Blood ATlas (COMBAT) Consortium | Ahern, D. J.; Ai, Z.; Fischer, R. et al. | preprint; Infectious Diseases (except HIV/AIDS) 2021 | https://doi.org/10.1101/2021.05.11.21256877 |
| Systematic Functional Analysis of SARS-CoV-2 Proteins Uncovers Viral Innate Immune Antagonists and Remaining Vulnerabilities | Hayn, M.; Hirschenberger, M. et al. | Cell Reports 2021, 109126 | https://doi.org/10.1016/j.celrep.2021.109126 |
| Large Scale Discovery of Coronavirus-Host Factor Protein Interaction Motifs Reveals SARS-CoV-2 Specific Mechanisms and Vulnerabilities | Kruse, T.; Benz, C.; Mann, M. et al. | Biochemistry 2021 | https://doi.org/10.1101/2021.04.19.440086 |
| The COVIDome Explorer Researcher Portal | Sullivan, K. D.; Galbraith, M. D. et al. | Allergy and Immunology 2021 | https://doi.org/10.1101/2021.03.04.21252945 |
| Structural O-Glycoform Heterogeneity of the SARS-CoV-2 Spike Protein Receptor-Binding Domain Revealed by Native Top-Down Mass Spectrometry | Roberts, D. S.; Mann, M. W.; Ge, Y. et al. | preprint; Biochemistry 2021 | https://doi.org/10.1101/2021.02.28.433291 |
| Structural and Functional Characterization of SARS-CoV-2 RBD Domains Produced in Mammalian Cells | Gstöttner, C.; Zhang, T.; Wuhrer, M. et al. | preprint; Biochemistry 2021 | https://doi.org/10.1101/2021.02.23.432424 |
| High-Resolution Longitudinal Serum Proteome Trajectories in COVID-19 Reveal Patients-Specific Seroconversion | Geyer, P. E.; Arend, F. M. et al. | preprint; Infectious Diseases (except HIV/AIDS) 2021 | https://doi.org/10.1101/2021.02.22.21252236 |
| The Host Interactome of Spike Expands the Tropism of SARS-CoV-2 | Bamberger, C.; Pankow, S.; Yates, J. et al. | preprint; Molecular Biology 2021 | https://doi.org/10.1101/2021.02.16.431318 |
| Evidence of Structural Protein Damage and Membrane Lipid Remodeling in Red Blood Cells from COVID-19 Patients | Thomas, T.; Stefanoni, D. et al. | Proteome Res. 2020, 19 (11), 4455–4469 | https://doi.org/10.1021/acs.jproteome.0c00606 |
| Mass Spectrometric detection of SARS-CoV-2 virus in scrapings of the epithelium of the nasopharynx of infected patients via Nucleocapsid N protein (preprint). | Nikolaev, E.; Indeykina, M.; Borchers, C. et al. | Molecular Biology 2020 | https://doi.org/10.1101/2020.05.24.113043 |
| Immune Suppression in the Early Stage of COVID-19 Disease | Tian, W.; Zhang, N.; Wong, C. C. L. et al. | Nat Commun 2020, 11 (1), 5859 | https://doi.org/10.1038/s41467-020-19706-9 |
| SARS-CoV-2 Induced CYP19A1 Expression in the Lung Correlates with Increased Aromatization of Testosterone-to-Estradiol in Male Golden Hamsters | Stanelle-Bertram, S.; Schaumburg, B. et al. | preprint; In Review 2020 | https://doi.org/10.21203/rs.3.rs-107474/v1 |
| Transcriptional and Proteomic Insights into the Host Response in Fatal COVID-19 Cases | Wu, M.; Chen, Y. et al. | Proc Natl Acad Sci USA 2020, 117 (45), 28336–28343 | https://doi.org/10.1073/pnas.2018030117 |
| Serum Proteomics in COVID-19 Patients: Altered Coagulation and Complement Status as a Function of IL-6 Level | D’Alessandro, A.; Thomas, T. et al. | Proteome Res. 2020, 19 (11), 4417–4427 | https://doi.org/10.1021/acs.jproteome.0c00365 |
Biology – timsTOF Pro
| Title | Authors | Publication | Link |
|---|---|---|---|
| Oxonium Ion–Guided Optimization of Ion Mobility–Assisted Glycoproteomics on the timsTOF Pro | Mukherjee, S.; Jankevics, A. et al. | Molecular & Cellular Proteomics 2023, 22 (2), 100486 | https://doi.org/10.1016/j.mcpro.2022.100486 |
| Linkage-Specific Identification and Quantification of Sialylated Glycans by TIMS-TOF MS through Conjugation with Metal Complexes | Li, Y.; Wang, H. et al. | Talanta 2023, 253, 123995 | https://doi.org/10.1016/j.talanta.2022.123995 |
| Glycoproteomic Analyses of Influenza A Viruses Using TimsTOF Pro MS | Wong, T. L.; Mooney, B. P. et al. | Proteome Res. 2023, 22 (1), 62–77 | https://doi.org/10.1021/acs.jproteome.2c00469 |
| Benchmarking Commonly Used Software Suites and Analysis Workflows for DIA Proteomics and Phosphoproteomics | Lou, R.; Cao, Y. et al. | Nat Commun 2023, 14 (1), 94 | https://doi.org/10.1038/s41467-022-35740-1 |
| Multi-Omics Based Anti-Inflammatory Immune Signature Characterizes Long COVID-19 Syndrome | Kovarik, J. J.; Bileck, A. et al. | iScience 2023, 26 (1), 105717 | https://doi.org/10.1016/j.isci.2022.105717 |
| Increasing the Throughput of Sensitive Proteomics by PlexDIA | Derks, J.; Leduc, A. et al. | Nat Biotechnol 2023, 41 (1), 50–59 | https://doi.org/10.1038/s41587-022-01389-w |
| Induction of Amphotericin B Resistance in Susceptible Candida Auris by Extracellular Vesicles | Chan, W.; Chow, F. W.-N. et al. | Emerging Microbes & Infections 2022, 11 (1), 1900–1909. | https://doi.org/10.1080/22221751.2022.2098058 |
| Top-Down Ion Mobility Separations of Isomeric Proteoforms | Berthias, F.; Thurman, H. A. et al. | Anal. Chem. 2022, acs.analchem.2c02948 | https://doi.org/10.1021/acs.analchem.2c02948 |
| HIP1R and Vimentin Immunohistochemistry Predict 1p/19q Status in IDH-Mutant Glioma | Felix, M.; Friedel, D. et al. | Neuro-Oncology 2022, 24 (12), 2121–2132 | https://doi.org/10.1093/neuonc/noac111 |
| CPEB1 Directs Muscle Stem Cell Activation by Reprogramming the Translational Landscape | Zeng, W.; Yue, L. et al. | Nat Commun 2022, 13 (1), 947 | https://doi.org/10.1038/s41467-022-28612-1 |
| CEND1 Deficiency Induces Mitochondrial Dysfunction and Cognitive Impairment in Alzheimer’s Disease | Xie, W.; Guo, D. et al. | Cell Death Differ 2022, 29 (12), 2417–2428 | https://doi.org/10.1038/s41418-022-01027-7 |
| Proteomics Based Markers of Clinical Pain Severity in Juvenile Idiopathic Arthritis | Van Der Heijden, H.; Fatou, B. et al. | Pediatr Rheumatol 2022, 20 (1), 3 | https://doi.org/10.1186/s12969-022-00662-1 |
| A Novel Protein Encoded by ZCRB1-Induced CircHEATR5B Suppresses Aerobic Glycolysis of GBM through Phosphorylation of JMJD5 | Song, J.; Zheng, J. et al. | J Exp Clin Cancer Res 2022, 41 (1), 171 | https://doi.org/10.1186/s13046-022-02374-6 |
| Mass Spectroscopy-Based Proteomics and Metabolomics Analysis of Triple-Positive Breast Cancer Cells Treated with Tamoxifen and/or Trastuzumab | Sharaf, B. M.; Giddey, A. D. et al. | Cancer Chemother Pharmacol 2022, 90 (6), 467–488 | https://doi.org/10.1007/s00280-022-04478-4 |
| Hornerin Deposits in Neuronal Intranuclear Inclusion Disease: Direct Identification of Proteins with Compositionally Biased Regions in Inclusions | Park, H.; Yamanaka, T. et al. | acta neuropathol commun 2022, 10 (1), 28 | https://doi.org/10.1186/s40478-022-01333-8 |
| LKB1 Drives Stasis and C/EBP-Mediated Reprogramming to an Alveolar Type II Fate in Lung Cancer | Murray, C. W.; Brady, J. J. et al. | Nat Commun 2022, 13 (1), 1090 | https://doi.org/10.1038/s41467-022-28619-8 |
| Proximity Proteomics of C9orf72 Dipeptide Repeat Proteins Identifies Molecular Chaperones as Modifiers of Poly-GA Aggregation | Liu, F.; Morderer, D. et al. | acta neuropathol commun 2022, 10 (1), 22 | https://doi.org/10.1186/s40478-022-01322-x |
| Ibrutinib Reverses IL-6-Induced Osimertinib Resistance through Inhibition of Laminin Α5/FAK Signaling | Li, L.; Li, Z. et al. | Commun Biol 2022, 5 (1), 155 | https://doi.org/10.1038/s42003-022-03111-7 |
| Proteomic Profiling of End-Stage COVID-19 Lung Biopsies | Gindlhuber, J.; Tomin, T. et al. | Clin Proteom 2022, 19 (1), 46 | https://doi.org/10.1186/s12014-022-09386-6 |
| Lima1 Mediates the Pluripotency Control of Membrane Dynamics and Cellular Metabolism | Duethorn, B.; Groll, F. et al. | Nat Commun 2022, 13 (1), 610 | https://doi.org/10.1038/s41467-022-28139-5 |
| Dia-PASEF Data Analysis Using FragPipe and DIA-NN for Deep Proteomics of Low Sample Amounts | Demichev, V.; Szyrwiel, L. et al. | Nat Commun 2022, 13 (1), 3944 | https://doi.org/10.1038/s41467-022-31492-0 |
| Reconstruction and Analysis of a Large-Scale Binary Ras-Effector Signaling Network | Catozzi, S.; Ternet, C. et al. | Cell Commun Signal 2022, 20 (1), 24 | https://doi.org/10.1186/s12964-022-00823-5 |
| Deep Proteome Profiling Reveals Signatures of Age and Sex Differences in Paw Skin and Sciatic Nerve of Naïve Mice | Xian, F.; Sondermann, J. R. et al | eLife 2022, 11, e81431 | https://doi.org/10.7554/eLife.81431 |
| A de Novo MS1 Feature Detector for the Bruker TimsTOF Pro | Wilding-McBride, D.; Webb, A. I. | PLoS ONE 2022, 17 (11), e0277122 | https://doi.org/10.1371/journal.pone.0277122 |
| Subcellular Redox Responses Reveal Different Cu-Dependent Antioxidant Defenses between Mitochondria and Cytosol | Zhang, Y.; Wen, M.-H. et al. | Metallomics 2022, 14 (11), mfac087 | https://doi.org/10.1093/mtomcs/mfac087 |
| Ion Mobility‐resolved Phosphoproteomics with Dia‐PASEF and Short Gradients | Oliinyk, D.; Meier, F. | Proteomics 2022, 2200032 | https://doi.org/10.1002/pmic.202200032 |
| Rapid Proteomic Characterization of Bacteriocin-Producing Enterococcus Faecium Strains from Foodstuffs | Quintela-Baluja, M.; Jobling, K. et al. | IJMS 2022, 23 (22), 13830 | https://doi.org/10.3390/ijms232213830 |
| Phenazopyridine Promotes RPS23RG1/Rps23rg1 Transcription and Ameliorates Alzheimer-Associated Phenotypes in Mice | Wang, C.; Zhang, Y. et al. | Neuropsychopharmacol. 2022, 47 (12), 2042–2050 | https://doi.org/10.1038/s41386-022-01373-7 |
| Micro‐pillar Array Columns (ΜPAC): An Efficient Tool for Comparing Tissue and Cultured Cells of Glioblastoma | Berg, H. E.; Halldórsson, S. et al. | Journal of Chromatography Open 2022, 2, 100047 | https://doi.org/10.1016/j.jcoa.2022.100047 |
| Slice-PASEF: Fragmenting All Ions for Maximum Sensitivity in Proteomics | Szyrwiel, L.; Sinn, L. et al. | preprint; Biochemistry, 2022 | https://doi.org/10.1101/2022.10.31.514544 |
| A Comprehensive Study of Gradient Conditions for Deep Proteome Discovery in a Complex Protein Matrix | Wei, X.; Liu, P. N. et al. | IJMS 2022, 23 (19), 11714 | https://doi.org/10.3390/ijms231911714 |
| Proteome-Wide Analysis of the Hippocampus in Adolescent Male Mice with Learning and Memory Impairment Caused by Chronic Ethanol Exposure | Liu, D.; Liu, S. et al. | Neurobiology of Learning and Memory 2022, 194, 107661 | https://doi.org/10.1016/j.nlm.2022.107661 |
| CLE Peptides Join the Plant Longevity Club | Han, H.; Zhuang, K. et al. | Trends in Plant Science 2022, 27 (10), 961–963 | https://doi.org/10.1016/j.tplants.2022.07.001 |
| Proteomic Analysis Reveals Zinc-Finger CCHC-Type Containing Protein 3 as a Factor Inhibiting Virus Infection by Promoting Innate Signaling | Chen, X.; Li, Z. et al. | Virus Research 2022, 319, 198876 | https://doi.org/10.1016/j.virusres.2022.198876 |
| Evaluation of Quantitative Platforms for Single Target Mass Spectrometry Imaging | Bowman, A. P.; Sawicki, J. et al. | Pharmaceuticals 2022, 15 (10), 1180 | https://doi.org/10.3390/ph15101180 |
| Parallelization with Dual-Trap Single-Column Configuration Maximizes Throughput of Proteomic Analysis | Kreimer, S.; Haghani, A. et al. | Anal. Chem. 2022, 94 (36), 12452–12460 | https://doi.org/10.1021/acs.analchem.2c02609 |
| HLAII Peptide Presentation of Infliximab Increases When Complexed with TNF | Casasola-LaMacchia, A.; Seward, R. J. et al. | Front. Immunol. 2022, 13, 932252 | https://doi.org/10.3389/fimmu.2022.932252 |
| Metabolomic and Proteomic Responses of Phaeodactylum Tricornutum to Hypoxia | Zhao, P.; Wu, Q. et al. | Ocean. Limnol. 2022, 40 (5), 1963–1973 | https://doi.org/10.1007/s00343-021-1232-5 |
| Rapid and In-Depth Coverage of the (Phospho-)Proteome With Deep Libraries and Optimal Window Design for Dia-PASEF | Skowronek, P.; Thielert, M. et al. | Molecular & Cellular Proteomics 2022, 21 (9), 100279 | https://doi.org/10.1016/j.mcpro.2022.100279 |
| Toll-Like Receptor 3 Overexpression Induces Invasion of Prostate Cancer Cells, Whereas Its Activation Triggers Apoptosis | Muresan, X. M.; Slabáková, E. et al. | The American Journal of Pathology 2022, 192 (9), 1321–1335 | https://doi.org/10.1016/j.ajpath.2022.05.009 |
| Discovering the Secret of Diseases by Incorporated Tear Exosomes Analysis via Rapid-Isolation System: ITEARS | Hu, L.; Zhang, T. et al. | ACS Nano 2022, 16 (8), 11720–11732 | https://doi.org/10.1021/acsnano.2c02531 |
| Discovery of a Potent and Selective Degrader for USP7 | Pei, Y.; Fu, J. et al. | Angewandte Chemie 2022, 134 (33) | https://doi.org/10.1002/ange.202204395 |
| TIMSCONVERT: A Workflow to Convert Trapped Ion Mobility Data to Open Data Formats | Luu, G. T.; Freitas, M. A et al. | Bioinformatics 2022, 38 (16), 4046–4047 | https://doi.org/10.1093/bioinformatics/btac419 |
| The Cluster Transfer Function of AtNEET Supports the Ferredoxin–Thioredoxin Network of Plant Cells | Zandalinas, S. I.; Song, L. et al. | Antioxidants 2022, 11 (8), 1533. | https://doi.org/10.3390/antiox11081533 |
| Enhancement of Proteome Coverage by Ion Mobility Fractionation Coupled to PASEF on a TIMS–QTOF Instrument | Guergues, J.; Wohlfahrt, J. et al. | Proteome Res. 2022, 21 (8), 2036–2044 | https://doi.org/10.1021/acs.jproteome.2c00336 |
| Engineering of Succinyl-CoA Metabolism in View of Succinylation Regulation to Improve the Erythromycin Production | Ke, X.; Jiang, X. et al. | Appl Microbiol Biotechnol 2022, 106 (13), 5153–5165 | https://doi.org/10.1007/s00253-022-12060-4 |
| The Succinylome of Pinctada Fucata Martensii Implicates Lysine Succinylation in the Allograft-Induced Stress Response | Zhang, M.; Lu, J. | Fish & Shellfish Immunology 2022, 127, 585–593 | https://doi.org/10.1016/j.fsi.2022.07.009 |
| In-Depth Profiling and Quantification of the Lysine Acetylome in Hepatocellular Carcinoma with a Trapped Ion Mobility Mass Spectrometer | Xu, J.; Guan, X. et al. | Molecular & Cellular Proteomics 2022, 21 (8), 100255 | https://doi.org/10.1016/j.mcpro.2022.100255 |
| Next Generation VAMS®–Trypsin Immobilization for Instant Proteolysis in Bottom-up Protein Determination | Reubsaet, L.; Thiede, B. et al. | Advances in Sample Preparation 2022, 3, 100027 | https://doi.org/10.1016/j.sampre.2022.100027 |
| Coral and It’s Symbionts Responses to the Typical Global Marine Pollutant BaP by 4D-Proteomics Approach | Pei, Y.; Chen, S. et al. | Environmental Pollution 2022, 307, 119440 | https://doi.org/10.1016/j.envpol.2022.119440 |
| Deep Visual Proteomics defines single-cell identity and heterogeneity | Mund, A.; Coscia, F. et al. | Nat Biotechnol 2022, 40 (8), 1231–1240 | https://doi.org/10.1038/s41587-022-01302-5 |
| Targeted Proteomics on Its Way to Discovery | Mendes, M. L.; Dittmar, G. | Proteomics 2022, 22 (15–16), 2100330 | https://doi.org/10.1002/pmic.202100330 |
| Molecular Mechanism of Toxin Neutralization in the HipBST Toxin-Antitoxin System of Legionella Pneumophila | Zhen, X.; Wu, Y. et al. | Nat Commun 2022, 13 (1), 4333 | https://doi.org/10.1038/s41467-022-32049-x |
| Structural Analyses of Human Ryanodine Receptor Type 2 Channels Reveal the Mechanisms for Sudden Cardiac Death and Treatment | Miotto, M. C.; Weninger, G. et al. | Sci. Adv. 2022, 8 (29), eabo1272 | https://doi.org/10.1126/sciadv.abo1272 |
| Locality-Sensitive Hashing Enables Efficient and Scalable Signal Classification in High-Throughput Mass Spectrometry Raw Data | Bob, K.; Teschner, D. et al. | BMC Bioinformatics 2022, 23 (1), 287 | https://doi.org/10.1186/s12859-022-04833-55 |
| Proteomic Analysis Reveals Key Differences between Squamous Cell Carcinomas and Adenocarcinomas across Multiple Tissues | Song, Q.; Yang, Y. et al. | Nat Commun 2022, 13 (1), 4167 | https://doi.org/10.1038/s41467-022-31719-00 |
| Proteomic Profile of Mouse Oocytes after Vitrification: A Quantitative Analysis Based on 4D Label-Free Technique | Zhuan, Q.; Du, X.et al. | Theriogenology 2022, 187, 64–73 | https://doi.org/10.1016/j.theriogenology.2022.04.028 |
| A Designer Nanoparticle Platform for Controlled Intracellular Delivery of Bioactive Macromolecules: Inhibition of Ubiquitin-Specific Protease 7 in Breast Cancer Cells | McClary, W. D.; Catala, A. et al. | ACS Chem. Biol. 2022, 17 (7), 1853–1865 | https://doi.org/10.1021/acschembio.2c00256 |
| On-Chip Preconcentration Microchip Capillary Electrophoresis Based CE-PRM-LIVE for High-Throughput Selectivity Profiling of Deubiquitinase Inhibitors | Zhu, H.; Mellors, J. S. et al. | Anal. Chem. 2022, 94 (27), 9508–9513 | https://doi.org/10.1021/acs.analchem.2c01337 |
| Ethanolamine‐phosphate on the Second Mannose Is a Preferential Bridge for Some GPI‐anchored Proteins | Ishida, M.; Maki, Y.; Ninomiya, A. et al. | EMBO Reports 2022, 23 (7) | https://doi.org/10.15252/embr.202154352 |
| Cyclic Immonium Ion of Lactyllysine Reveals Widespread Lactylation in the Human Proteome | Wan, N.; Wang, N. et al. | Nat Methods 2022, 19 (7), 854–864 | https://doi.org/10.1038/s41592-022-01523-1 |
| Zwitter-Ionic Monolith-Based Spintip Column Coupled with Evosep One Liquid Chromatography for High-Throughput Proteomic Analysis | Su, Y.; Wang, X. et al. | Journal of Chromatography A 2022, 1675, 463122 | https://doi.org/10.1016/j.chroma.2022.463122 |
| Super-Enhancer Hypermutation Alters Oncogene Expression in B Cell Lymphoma | Bal, E.; Kumar, R. et al. | Nature 2022, 607 (7920), 808–815 | https://doi.org/10.1038/s41586-022-04906-8 |
| Microanalysis of Brain Angiotensin Peptides Using Ultrasensitive Capillary Electrophoresis Trapped Ion Mobility Mass Spectrometry | DeLaney, K.; Jia, D. et al. | Anal. Chem. 2022, 94 (25), 9018–9025 | https://doi.org/10.1021/acs.analchem.2c01062 |
| Sucrose Nonfermenting-1-Related Protein Kinase 1 Regulates Sheath-to-Panicle Transport of Nonstructural Carbohydrates during Rice Grain Filling | Hu, Y.; Liu, J. et al. | Plant Physiology 2022, 189 (3), 1694–1714 | https://doi.org/10.1093/plphys/kiac124 |
| Comparative Analysis of Extracellular Vesicles (EVs) from Human and Feline Plasma | Howard, J.; Wynne, K. et al. | Sci Rep 2022, 12 (1), 10851 | https://doi.org/10.1038/s41598-022-14211-z |
| Impact of in Vitro Hormone Treatments on the Bibenzyl Production of Radula Complanata | Blatt-Janmaat, K.; Neumann, S. et al. | Botany 2022, cjb-2022-0048 | https://doi.org/10.1139/cjb-2022-0048 |
| Human RIPK3 C-Lobe Phosphorylation Is Essential for Necroptotic Signaling | Meng, Y.; Horne, C. R. et al. | Cell Death Dis 2022, 13 (6), 1–12 | https://doi.org/10.1038/s41419-022-05009-y |
| Molecular Evidence of Chemical Disguise by the Socially Parasitic Spiny Ant Polyrhachis Lamellidens (Hymenoptera: Formicidae) When Invading a Host Colony | Iwai, H.; Mori, M. et al. | Front. Ecol. Evol. 2022, 10, 915517 | https://doi.org/10.3389/fevo.2022.915517 |
| Targeted Protein Quantitation in Human Body Fluids by Mass Spectrometry | Chen, Y.; Liao, W. et al. | Mass Spectrometry Reviews 2022 | https://doi.org/10.1002/mas.21788 |
| Innate Variability in Physiological and Omics Aspects of the Beta Thalassemia Trait-Specific Donor Variation Effects | Anastasiadi, A. T.; Tzounakas, V. L. et al. | Front. Physiol. 2022, 13, 907444 | https://doi.org/10.3389/fphys.2022.907444 |
| Zinc Is a Master-Regulator of Sperm Function Associated with Binding, Motility, and Metabolic Modulation during Porcine Sperm Capacitation | Zigo, M.; Kerns, K. et al. | Commun Biol 2022, 5 (1), 1–12 | https://doi.org/10.1038/s42003-022-03485-8 |
| Different Oligomeric States of the Tumor Suppressor P53 Show Identical Binding Behavior towards the S100β Homodimer | Wei, A. A. J.; Iacobucci, C. et al. | ChemBioChem 2022, 23 (11) | https://doi.org/10.1002/cbic.202100665 |
| Cryo-EM Structures of Gid12-Bound GID E3 Reveal Steric Blockade as a Mechanism Inhibiting Substrate Ubiquitylation | Qiao, S.; Lee, C.-W. et al. | Nat Commun 2022, 13 (1), 3041 | https://doi.org/10.1038/s41467-022-30803-9 |
| Multimodal Imaging Mass Spectrometry of Murine Gastrointestinal Tract with Retained Luminal Content | Guiberson, E. R.; Good, C. J. et al. | J. Am. Soc. Mass Spectrom. 2022, 33 (6), 1073–1076 | https://doi.org/10.1021/jasms.1c00360 |
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| Combination of intact, middle-up and bottom-up levels to characterize 7 therapeutic monoclonal antibodies by capillary electrophoresis | Giorgetti, J., Beck, A. et al. | Mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis, 2020, 182, 113107 | https://doi.org/10.1016/j.jpba.2020.113107 |
| Differential Post-Translational Amino Acid Isomerization Found among Neuropeptides in Aplysia californica | Mast, D.H., Checco, J.W. et al. | ACS Chem. Biol. 2020 | https://doi.org/10.1021/acschembio.9b00910 |
| Identification of 56 Proteins Involved in Embryo–Maternal Interactions in the Bovine Oviduct | Banliat, C., Tsikis, G. et al. | IJMS 2020, 21, 466 | https://doi.org/10.3390/ijms21020466 |
| Parallel accumulation – serial fragmentation combined with data-independent acquisition (diaPASEF): Bottom-up proteomics with near optimal ion usage | Meier, F.; Brunner A. et al. | bioRxiv 656207 | https://doi.org/10.1101/656207 |
| Simplified high-throughput methods for deep proteome analysis on the timsTOF Pro | Sandow, J. J, Infusini, G. et al. | Biochemistry, 2019, doi:10.1101/657908 | |
| Cathepsin B/ SAPC inhibition deregulates apoptosis-related proteins in neuronal cells exposed to supernatants from HIV-infected macrophages | Melendez L, PhD , Zenon-Melendez C, et al. | J Biomol Tech. 2020, 31(Suppl):S19 | |
| Trapped ion mobility spectrometry (TIMS) and parallel accumulation - serial fragmentation (PASEF) enable in-depth lipidomics from minimal sample amounts | Vasilopoulou, C. G. et al. | Systems Biology, 2019, doi:10.1101/654491 | |
| Regulation of macrophage activity by surface receptors contained within Borrelia burgdorferi-enriched phagosomal fractions | Carreras-González, A., Barriales, D. et al. | PLoS Pathog 2019, 15, e1008163 | https://doi.org/10.1371/journal.ppat.1008163 |
| The MPK8-TCP14 pathway promotes seed germination in Arabidopsis | Zhang, W.; Cochet, F. et al. | The Plant Journal, 2019 | https://doi.org/10.1111/tpj.14461 |
| Expression of a dominant‐negative AtNEET‐H89C protein disrupts iron‐sulfur metabolism and iron homeostasis in Arabidopsis | Zandalinas. S.; Song, L. et al. | The Plant Journal, 2019 | https://doi.org/10.1111/tpj.14581 |
| Chronic Elevation of Endothelin-1 Alone May Not Be Sufficient to Impair Endothelium-Dependent Relaxation | Grunewald, Z. I.; Jurrissen, T. J. et al. | Hypertension, 2019 | https://doi.org/10.1161/HYPERTENSIONAHA.119.13676 |
| Characterization of an evolutionarily conserved calcitonin signalling system in a lophotrochozoan, the Pacific oyster (Crassostrea gigas) | Schwartz, J.; Réalis-Doyelle, E. et al. | Journal of Experimental Biology, 2019 | https://doi:10.1242/jeb.201319 |
| Metal–peptide rings form highly entangled topologically inequivalent frameworks with the same ring- and crossing-numbers | Sawada, T. et al. | Nat Commun 2019, 10, 921 | |
| Recent advances in biological separations using trapped ion mobility spectrometry – mass spectrometry | Jeanne Dit Fouque, K.; Fernandez-Lima, F | TrAC Trends in Analytical Chemistry 2019, 116, 308–315 | https://doi.org/10.1016/j.trac.2019.04.010 |
| Mass spectrometry analysis of mouse hematopoietic stem cells and their progenitors reveals differential expression within and between proteome and transcriptome throughout adult and aged hematopoiesis (preprint) | Zaro, B.W.; Noh, J.J. et al. | Cell Biology, 2019 | https://doi.org/10.1101/836692 |
| A Thermogenic-Like Brown Adipose Tissue Phenotype Is Dispensable for Enhanced Glucose Tolerance in Female Mice | Winn, N. C. et al. | Diabetes 68, 1717–1729 (2019). doi:10.1002/cbic.201900276 | |
| Modulation and Visualization of EF‐G Power Stroke During Ribosomal Translocation | Yin, H.; Gavriliuc, M. et al. | ChemBioChem cbic.201900276 (2019) | |
| Positional effects of premature termination codons on the biochemical and biophysical properties of CFTR | Yeh, J.; Hwang, T. | J Physiol JP278418 (2019). doi:10.1113/JP278418 | |
| timsTOF (Native ESI): Imidazole-modified G-quadruplex DNA as metal-triggered peroxidase | Punt PM; Clever GH | Chem Sci. 2019 Jan 7;10(8):2513-2518. doi: 10.1039/c8sc05020a. eCollection 2019 Feb 28 | |
| Protein 18 Is Involved in Chloroplast Function and Thylakoid Formation | Espinoza-Corral, R.; Heinz, S. et al. | Plastoglobular Journal of Experimental Botany 2019, 70 (15), 3981–3993 | https://doi.org/10.1093/jxb/erz177 |
| SUMO-Binding Entities (SUBEs) as Tools for the Enrichment, Isolation, Identification, and Characterization of the SUMO Proteome in Liver Cancer | Lopitz-Otsoa, F.; Delgado, T. C. et al. | JoVE 2019, No. 153, 60098 | https://doi.org/10.3791/60098 |
| Methods and Guidelines for Measurement of Glucagon in Plasma | Holst, J. J.; Wewer Albrechtsen, N. J. | IJMS 2019, 20 (21), 5416 | https://doi.org/10.3390/ijms20215416 |
| Sclerotinia Sclerotiorum Circumvents Flavonoid Defenses by Catabolizing Flavonol Glycosides and Aglycones | Chen, J.; Ullah, C. et al. | Plant Physiol. 2019, 180 (4), 1975–1987 | https://doi.org/10.1104/pp.19.00461 |
| A. Linear and Differential Ion Mobility Separations of Middle-Down Proteoforms | Garabedian, A.; Baird, M. A. et al. | Anal. Chem. 2018, 90 (4), 2918–2925 | https://doi.org/10.1021/acs.analchem.7b05224 |
| Online Parallel Accumulation-Serial Fragmentation (PASEF) with a Novel Trapped Ion Mobility Mass Spectrometer | Meier, F.; Brunner, A.D. et al. | Mol Cell Proteomics. 2018 Dec;17(12):2534-2545 | |
| Parallel accumulation – serial fragmentation (PASEF): Multiplying sequencing speed and sensitivity by synchronized scans in a trapped ion mobility device | Meier, F.; Beck, S. et al. | J Proteome Res. 2015 Dec 4;14(12):5378-87 |
Chemistry (timsTOF Pro / timsTOF)
| Title | Authors | Publication | Link |
|---|---|---|---|
| Development of Approach for Flavonoid Profiling of Biotechnological Raw Materials IRIS SIBIRICA L. by HPLC with High‐resolution Tandem Mass Spectrometry | Karpitskiy, D. A.; Bessonova, E. A. et al. | Phytochemical Analysis 2022, 33 (6), 869–878 | https://doi.org/10.1002/pca.3135 |
| Ordered Micropattern Arrays Fabricated by Lung-Derived DECM Hydrogels for Chemotherapeutic Drug Screening | Zhu, X.; Li, Y. et al. | Materials Today Bio 2022, 15, 100274 | https://doi.org/10.1016/j.mtbio.2022.100274 |
| Dual-Resolving of Positional and Geometric Isomers of C=C Bonds via Bifunctional Photocycloaddition-Photoisomerization Reaction System | Feng, G.; Gao, M.; et al. | Nat Commun 2022, 13 (1), 2652 | https://doi.org/10.1038/s41467-022-30249-z |
| Development of Disulfide-Functionalized Peptides Covalently Binding G Protein-Coupled Receptors | Einsiedel, J.; Schmidt, M. F. et al. | Bioorganic & Medicinal Chemistry 2022, 61, 116720 | https://doi.org/10.1016/j.bmc.2022.116720 |
| Isoindolines and phthalides from the rhizomes of Ligusticum chuanxiong and their relaxant effects on the uterine smooth muscle | Liu, J., Feng, R. et al. | Phytochemistry 2022, 198, 113159 | https://doi.org/10.1016/j.phytochem.2022.113159 |
| Noncovalently Tagged Gas Phase Complex Ions for Screening Unknown Contaminant Metabolites in Plants | Shen, M., Gong. X. et al. | Anal. Chem. 2021, 93, 45, 14929–14933 | https://doi.org/10.1021/acs.analchem.1c03145 |
| Trapped Ion Mobility Incorporated in LC–HRMS Workflows as an Integral Analytical Platform of High Sensitivity: Targeted and Untargeted 4D-Metabolomics in Extra Virgin Olive Oil | Drakopoulou, S.K.; Damalas, D.E. et al. | J. Agric. Food Chem. 2021, 69, 15728–15737 | https://doi.org/10.1021/acs.jafc.1c04789 |
| Feature-based molecular networking in the GNPS analysis environment | Nothias, L.-F.; Petras, D. et al. | Nat Methods 2020, 17, 905–908 | https://doi.org/10.1038/s41592-020-0933-6 |
| Facile synthesis of Ti4+-immobilized magnetic covalent organic frameworks for enhanced phosphopeptide enrichment | He, Y.; Zhang, S. et al. | Talanta 2021, 235, 122789 | https://doi.org/10.1016/j.talanta.2021.122789 |
| Thiol and Disulfide Containing Vancomycin Derivatives Against Bacterial Resistance and Biofilm Formation | Shchelik, I.S.; Gademann, K. | preprint; Microbiology 2021 | https://doi.org/10.1101/2021.08.23.457343 |
| Automated Chiral Analysis of Amino Acids Based on Chiral Derivatization and Trapped Ion Mobility–Mass Spectrometry | Will, J. M.; Behrens, A. et al. | Anal. Chem. 2020, acs.analchem.0c03481 | https://doi.org/10.1021/acs.analchem.0c03481 |
| Evaluation of Trapped Ion Mobility Spectrometry Source Conditions Using Benzylammonium Thermometer Ions | Naylor, C.N.; Ridgeway, M.E. et al. | J. Am. Soc. Mass Spectrom. 2021, 31, 1593–1602 | https://doi.org/10.1021/jasms.0c00151 |
| Fast Online Separation and Identification of Electrochemically Generated Isomeric Oxidation Products by Trapped Ion Mobility-Mass Spectrometry | Fangmeyer, J.; Scheeren, S. et al. | Anal. Chem. 2019, acs.analchem.9b04337 | https://doi.org/10.1021/acs.analchem.9b04337 |
| Solvent Adducts in Ion Mobility Spectrometry: Toward an Alternative Reaction Probe for Thermometer Ions | Morsa, D.; Hanozin, E. et al. | J. Am. Soc. Mass Spectrom. 2020, jasms.0c00108 | https://doi.org/10.1021/jasms.0c00108 |
| Integration of •SO4−-based AOP mediated by reusable iron particles and a sulfidogenic process to degrade and detoxify Orange II | Yu, X.; Sun, J. et al. | Water Research 2020, 174, 115622 | https://doi.org/10.1016/j.watres.2020.115622 |
| Trends in trapped ion mobility – Mass spectrometry instrumentation | Ridgeway, M.E.; Bleiholder, C. et al. | TrAC Trends in Analytical Chemistry 2019, 116, 324–331 | https://doi.org/10.1016/j.trac.2019.03.030 |
| Integration of •SO4−-Based AOP Mediated by Reusable Iron Particles and a Sulfidogenic Process to Degrade and Detoxify Orange II | Yu, X.; Sun, J. et al. | Water Research 2020, 174, 115622 | https://doi.org/10.1016/j.watres.2020.115622 |
| Metal–Peptide Rings Form Highly Entangled Topologically Inequivalent Frameworks with the Same Ring- and Crossing-Numbers | Sawada, T.; Saito, A. et al. | Nat Commun 2019, 10 (1), 921 | https://doi.org/10.1038/s41467-019-08879-7 |
| Comparing Empty and Filled Fullerene Cages with High-Resolution Trapped Ion Mobility Spectrometry | Hennrich, F.; Schneider, E. et al. | J. Am. Soc. Mass Spectrom. 2019, 30 (10), 1973–1980 | https://doi.org/10.1007/s13361-019-02250-2 |
| Nanogymnastics: Visualization of Intercluster Reactions by High-Resolution Trapped Ion Mobility Mass Spectrometry | Baksi, A.; Schneider, E. K. et al. | J. Phys. Chem. C 2019, 123 (46), 28477–28485 | https://doi.org/10.1021/acs.jpcc.9b08686 |
| Imidazole-Modified G-Quadruplex DNA as Metal-Triggered Peroxidase | Punt, P. M.; Clever, G. | Chem. Sci. 2019, 10 (8), 2513–2518 | https://doi.org/10.1039/C8SC05020A |
| Effective Liquid Chromatography–Trapped Ion Mobility Spectrometry–Mass Spectrometry Separation of Isomeric Lipid Species | Jeanne Dit Fouque, K.; Ramirez, C. E. et al. | Anal. Chem. 2019, 91 (8), 5021–5027 | https://doi.org/10.1021/acs.analchem.8b04979 |
| Visible-Light-Driven [2 + 2] Photocycloadditions between Benzophenone and C═C Bonds in Unsaturated Lipids | Li, H.-F.; Cao, W. et al. | J. Am. Chem. Soc. 2020, 142 (7), 3499–3505 | https://doi.org/10.1021/jacs.9b12120 |
| Helicenes Fused with Hexafluorocyclopentene (HFCP): Synthesis, Structure, and Properties: Helicenes Fused with Hexafluorocyclopentene (HFCP): Synthesis, Structure, and Properties | Agou, T.; Kohara, M. et al. | Eur. J. Org. Chem. 2020, 2020 (12), 1871–1880 | https://doi.org/10.1002/ejoc.202000152 |
| Visible-Transparent Aromatic Polymers Obtained by the Polycondensation of a Bis(Trifluorovinyl)Benzene with Bisphenols | Agou, T.; Yoshinari, K. et al. | Macromolecules 2020, 53 (8), 2942–2949 | https://doi.org/10.1021/acs.macromol.0c00157 |
| Tacticity, Molecular Weight, and Temporal Control by Lanthanide Triflate-Catalyzed Stereoselective Radical Polymerization of Acrylamides with an Organotellurium Chain Transfer Agent | Imamura, Y.; Fujita, T. et al. | Polym. Chem. 2020, 11 (44), 7042–7049 | https://doi.org/10.1039/D0PY01280G |
| Flavonoids and Other Phenolics in Herbs Commonly Used in Norwegian Commercial Kitchens | Slimestad, R.; Fossen, T. et al. | Food Chemistry 2020, 309, 125678 | https://doi.org/10.1016/j.foodchem.2019.125678 |
| “Conformation Pinning” by Anion Attachment Enabling Separation of Isomeric Steroid Monomers by Ion Mobility Spectrometry | Cole, R. B.; Bayat, P. et al. | J Mass Spectrom 2020, 55 (12) | https://doi.org/10.1002/jms.4657 |
| Synthesis of Trialkylamines with Extreme Steric Hindrance and Their Decay by a Hofmann-like Elimination Reaction | Banert, K.; Hagedorn, M. et al. | J. Org. Chem. 2020, 85 (21), 13630–13643 | https://doi.org/10.1021/acs.joc.0c01790 |
| Oxidative Formation of Disulfide Bonds by a Chemiluminescent 1,2-Dioxetane under Mild Conditions | Sauer, C. S.; Köckenberger, J. et al. | J. Org. Chem. 2020, 85 (14), 9331–9338 | https://doi.org/10.1021/acs.joc.0c00569 |
| Linear Size Contraction of Ligand Protected Ag 29 Clusters by Substituting Ag with Cu | Baksi, A.; Schneider, E. K. et al. | ACS Nano 2020, 14 (11), 15064–15070 | https://doi.org/10.1021/acsnano.0c05082 |
| A Recyclable Photocatalytic Tea-Bag-like Device Model Based on Ultrathin Bi/C/BiOX (X = Cl, Br) Nanosheets | Li, H.; Long, B. et al. | Applied Surface Science 2020, 515, 145967 | https://doi.org/10.1016/j.apsusc.2020.145967 |
| Hydroperoxylated vs Dihydroxylated Lipids: Differentiation of Isomeric Cardiolipin Oxidation Products by Multidimensional Separation Techniques | Helmer, P. O.; Behrens, A. et al. | Anal. Chem. 2020, 92 (17), 12010–12016 | https://doi.org/10.1021/acs.analchem.0c02605 |
| Hydrophilic Spacer-Arm Containing Magnetic Nanoparticles for Immobilization of Proteinase K: Employment for Speciation of Proteins for Mass Spectrometry-Based Analysis | Bayramoglu, G.; Kayili, H. M. et al. | Talanta 2020, 206, 120218 | https://doi.org/10.1016/j.talanta.2019.120218 |
| Effective Temperature and Structural Rearrangement in Trapped Ion Mobility Spectrometry | Morsa, D.; Hanozin, E. et al. | Anal. Chem. 2020, 92 (6), 4573–4582 | https://doi.org/10.1021/acs.analchem.9b05850 |
| LC-Trapped Ion Mobility Spectrometry-TOF MS Differentiation of 2- and 3-Disulfide-Bonded Isomers of the μ-Conotoxin PIIIA | Schmitz, T.; Pengelley, S. et al. | Anal. Chem. 2020, 92 (16), 10920–10924 | https://doi.org/10.1021/acs.analchem.0c02151 |
For Research Use Only. Not for use in clinical diagnostic procedures.