The research field metabolomics aims at a comprehensive qualitative and quantitative analysis of all small molecules present in a cell, a tissue or even a whole organism. Responding to intrinsic or extrinsic triggers, the entirety of compounds will change. And the goal of studying these responses is to get a more holistic picture to understand e.g. the emergence and progression of diseases.
The lipidome can be considered a subset of the metabolome, covering all lipophilic compounds. Many lipids play important roles for example in cell communication and are associated with metabolic diseases. The similarity in the physical properties of lipids, despite their structural diversity demands for dedicated workflow solutions. These are different compared to classical metabolomics approaches. Both applications are supported in MetaboScape and both are facilitated by the additional dimension that is achieved using Trapped Ion Mobility Spectrometry (TIMS).
This poster hall shows a unique collection of investigations that leverage Bruker technology, e.g. showing the benefit of CCS values and the PASEF® acquisition mode. We are very thankful to everybody who contributed their research results.
And we hope you enjoy reading through this poster hall as much as we enjoyed putting it together.
Poster ASMS 2023: Trapped ion mobility separation (TIMS) of glucose-6-phosphate and fructose-6-phosphate
Poster IMSC 2022: Applying Trapped Ion Mobility Spectrometry (TIMS) for Vitamin D Epimer Differentiation
Poster IMSC 2022: Enhanced 4D workflows using TIMS for advancing small molecule research
Poster IMSC 2022: CCS-enabled timsTOF Pro PASEF® workflow for in vitro human liver microsome drug metabolites profiling and characterization
Poster IMSC 2022: High resolution ion mobility timsTOF Pro for the fast separation and characterization of isomeric bile acids
Poster 2021: CCS Predict Pro
Poster 2021: MetaboScape® 2022 for core labs
Poster 2020: 4-dimensional annotation of Metabolomics features: CCS values as an additional source for higher confidence
Poster 2020: Untargeted UHLC-HR-QTOF-MS metabolomics study to unravel metabolites contrlling wood formation in aspen trees
Poster 2020: Inlet Probe Coupled to Trapped Ion Mobility Time-of-Flight Mass Spectrometry
Poster 2019: Enabling Rapid and High-confidence Metabolite Identification using HILIC-QTOF based MS/MS-RT library
Poster 2019: Integration of metabolomic and lipidomic workflows for studying biological samples
Poster ASMS 2023: SpatialOMx® analysis allows for the specific identification of lipid species paving the way for accurate flux analysis
Poster 2023: SpatialOMx® tissue analysis couples MALDI imaging with in-depth 4D-Lipidomics™
Poster 2020: A study of drug metabolism using a zebrafish larvae model and MALDI-MS Imaging
Poster ASMS 2023: Novel real-time acquisition logic to prevent fragmentation of uninformative precursors
Poster ASMS 2023: Combining real time and post-acquisition quality control (QC) for metabolomics workflows
Poster ASMS 2023: Interactive Design and Application of MassQL Queries after Preprocessing for the Annotation of PFAS in LC-TIMS-PASEF data
Poster IMSC 2022: Deeper and higher confident annotation of complex metabolomics data by complementary large-scale spectral libraries
Poster IMSC 2022: New CCS Prediction Workflow to Extend MS/MS Spectral Libraries On The Fly with CCS Information
Poster IMSC 2022: MetaboScape® as a quality-focused software solution for exploring metabolic profiling datasets
Poster IMSC 2022: A novel data processing workflow for isotope tracing experiments in LC-MS and LC-TIMS-MS based metabolic pathway analysis and fluxomics
Poster IMSC 2022: Anti-inflammatory effects of hop bitter acids in dentritic cells revealed by MRMS metabolomic studies
Poster 2020: Metabolite identification by assignment of collisional-cross section (CCS) and isotopic fine structure (IFS)
Poster 2020: Elucidation of carotenoids in microalgae formulations by ultra-high resolution mass spectrometry combined with APCI
Poster 2020: Untargeted FTICR-MS based Plasma Metabolomic Analysis and Translation to Type 2 Diabetes
Poster 2019: Magnetic resonance mass spectrometry profiling of myxobacterial extracts – higher resolution, deeper insights?
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