Ultra-Sensitive 3 mm MNI CryoProbe

The state-of-the-art 3 mm Multi-Nuclear Inverse CryoProbe (CP-MNI) offers unprecedented sensitivity and versatility in the characterization of unlabelled biological molecules. This advanced two-channel probe features a newly designed ultra-sensitive inner coil tuneable to ¹H or ¹⁹F, while the outer coil is tuneable between ¹³C, ¹⁵N, and ³¹P nuclei.

Compared to the 5 mm CP-TCI or CP-QCIF probes, the 3 mm CP-MNI provides almost twice the proton sensitivity and at least 30 % higher fluorine mass-sensitivity. Although the CP-MNI X-coil lacks full broadband capability, it is tuneable to the most relevant biological nuclei. Due to this selectivity, the CP-MNI probe is a close rival in terms of carbon, nitrogen, and phosphorus mass-sensitivity to the 5 mm CP-BBO probe.

With its high sensitivity and versatility, the CP-MNI probe is an invaluable tool for researchers working on the structural characterization of peptides, oligonucleotides, and natural products. It offers fast, reliable, and accurate results for a wide range of applications in the fields of biology and pharmaceutical studies.

Therapeutic Oligonucleotides Characterization and Quality Control

There is an increasing demand from the pharmaceutical industry and regulatory agencies for analytical methods capable of accurately characterizing therapeutic oligonucleotides, which often contain chemically modified nucleotides to increase their biostability and bioavailability. The CP-MNI probe allows time-efficient assignment of the ¹H, ¹³C, ³¹P, and ¹⁹F signals of such oligonucleotides, the confirmation of their primary structure, as well as the identification and quantification of all the diastereomers.

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Peptides Characterization

Pharmaceutical peptides and peptides from natural sources are often available in very limited amounts and may contain chemically modified or non-natural amino acids, necessitating detailed structural characterization. The ultra-sensitive CP-MNI probe enables rapid assignment of the ¹H, ¹³C, and ¹⁵N signals, allowing for the verification of their primary structure. Additionally, it facilitates the detection and quantification of any modifications or impurities, ensuring the accuracy and reliability of peptide characterization.

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Small Pharmaceutical Molecules

The vast majority of pharmaceutical drugs on the market contain nitrogen, fluorine, or phosphorus in their scaffold. The CP-MNI probe excels in this regard, enabling rapid and accurate assignment of ¹H, ¹³C, ³¹P, ¹⁹F, and ¹⁵N signals. Even with limited sample amounts, the acquisition of direct ¹³C-¹³C correlation experiments at natural abundance (ADEQUATE) in a relatively short time is feasible due to the probe's unprecedented sensitivity. This ensures effortless signal assignment, making the CP-MNI an invaluable tool for efficient and precise structural characterization in the pharmaceutical industry.

• Twice higher ¹H mass-sensitivity compared to 5 mm CP-TCI
• Optimized for inverse double resonance experiments with ³¹P, ¹³C or ¹⁵N decoupling.
• Excellent ³¹P, ¹³C and ¹⁵N direct detection capabilities with ¹H or ¹⁹F decoupling
• Cold preamplifiers for all channels
• Available at 500, 600 MHz
• Z-gradient
• ATM compatible
• -40 °C – +120 °C