PET/SPECT/CT | Preclinical SPECT | System

PET/SPECT/CT

Seamless integration of PET, SPECT and CT with fully automated animal handling system which enables automatic co-registration of images

Field Upgradable

Start with one imaging modality and upgrade the system capabilities as you need adding imaging modalities or increasing the size of the PET detector coverage

90 × 220cm

Have all the power of a trimodal PET/SPECT/CT system that will take a small space in your lab with the smallest footprint for any integrated system on the market

Like you, thousands of our customers around the world rely on advanced imaging techniques to study dynamic biological process within living animals. To better understand the progression and treatment of diseases, you can use Albira's PET, SPECT and CT imaging for quantitative 3D tomographic imaging of radiotracers, bone, and soft tissue.

Features

Animal Care Monitoring And Control

Anesthesia: Fully integrated. Compatible with most common commercial gas systems
Animal Handling System: Reliable, easy to use rat and mouse beds; Fully compatible with BRUKER MR
Physiological Signals: ECG, Respiration, Temperature, And Blood Pressure
Temperature Control System: Electrically heated mats for rat And mouse
Video Monitoring: Realtime camera
Gating Acquisition: Cardiac and Respiratory For PET and SPECT; Dual Gating for PET

Software and Workstation

Fully Integrated Albira Suite: ACQUIRER: Image Acquisition, RECONSTRUCTOR: Image Reconstruction, MANAGER: Study and Protocol Management, SUPERVISOR: Quality Control
Image Analysis Software: PMOD (PBAS, PFUS, PKIN MODULES INCLUDED)
Workstation: Dedicated Server; All Functionalities on a single system (Acquisition, Storage, Reconstruction and Image Processing)
Reconstruction: GPU Based, CPU Based SPECT

⁶⁸Ga Tracer Comparison in Tumor Mice

Micro PET/CT allows comparison of [68Ga]FSC (succ-RGD)3 with [68Ga]NODAGA-RGD in a human glioblastoma model (two mice)

3D volume rendered projections of fused microPET/CT static images for [68Ga]FSC(succ-RGD)3 and [68Ga]NODAGA-RGD at 90 min p.i.

Courtesy: Institute of Molecular and Translational Medicine, Palacky University, Olomouc, Czech Republic.

Reference: Zhai C, Franssen GM, Petrik M, et al. Molecular Imaging and Biology. 2016;18(5):758-767. doi:10.1007/s11307-016-0931-3.

Dynamic ¹⁸F-FDG PET Imaging

In vivo dynamic PET imaging and kinetic modeling supports full quantification of myocardium glucose metabolism.

Courtesy: B Kundu, M Chordia, J Li and S Berr, University of Virginia, US

⁶⁸Ga Biodistribution Studies

Static microPET/CT images of [⁶⁸Ga]-AAZTA-MG in CCK+/−, tumour xenograft BALB/c nude mice. 30 (A, D), 45 (B, E) and 60 (C, F) min p.i.; coronal slices (A, B, C) and 3D volume rendered images (D, E, F)

Courtesy: Institute of Molecular and Translational Medicine, Palacky University, Olomouc, Czech Republic.

Reference: Pfister J, Summer D, Rangger C, et al. EJNMMI Research. 2015;5:74. doi:10.1186/s13550-015-0154-7.

Tumor Specific Targeting Using ⁶⁸Ga Bombesin

High sensitivity PET imaging and automatic CT co-registration allows for an accurate evaluation of drug efficacy mechanisms.
Courtesy: D. Viertl, F. Cicone & J. Prior, D. Viertl. CHUV Lausanne

Effect of Neurodegenerative Therapy

TgF344-AD rat model imaged with AMYViD-PET/CT and co-registered with brain atlas for regional measurements.

PET imaging reveals marked reduction in Aβ levels at pituitary, auditory cortex visual cortex and ventral tegmental in treated rats.

Courtesy: S Berr, University of Virginia Radiology and Biomedical Engineering and B Costa, Virginia College of Osteopathic Medicine.

PET and MR in Mouse MetastaticTumor Model

(Left) Coronal whole-body PET/MR. (Right) Focused Axial PET/MR revealing location of lung and abdominal tumors.

Courtesy of Acknowledgements. Thanks to the Katherine Tucker, Mikayla Rodger, Dr. Lixin Ma, Dr. Carolyn Anderson, and Dr. Barry Edwards, MITC – Molecular & Imaging Theranostics Center, University of Missouri.

Total body PET/MRI images of mice

Imaged at pre-injection and 1, 5, 30, 45 mins post-injection of 0.1 mmol/kg [52Mn]Mn-2CHyd or [52Mn]Mn-1CHyd.
Courtesy Yingying Ning , Iris Yuwen Zhou, Nicholas J Rotile et al. MGH – USA

Reference: J Am Chem Soc. 2022 Sep 14;144(36):16553-16558.

⁶⁴Cu Tracer Validations/Characterizations in a Mouse Glioblastoma Model

PET/CT and MR in Mouse Glioblastoma Model. (Left) Multi-Mouse PET/CT was performed for efficient tracer validations. (Right) MR brain imaging subsequently performed and registered with PET data. Courtesy of Acknowledgements. Katherine Tucker, Mikayla Rodger, Dr. Lixin Ma, Dr. Carolyn Anderson, and Dr. Barry Edwards, MITC – Molecular & Imaging Theranostics Center, University of Missouri.

AD Model in Marmosets: Awake Imaging with ¹¹C-PiB and ¹⁸F-FDG PET

PET/CT Si78

Courtesy of A. Silva, D. Schaeffer and K. Cashman. University of Pittsburgh Brain Institute, USA

Specifications

Imaging Modalities: PET, SPECT, CT
Coincidence based PET featuring Full Field of View Accuracy which means constant resolution across the entire FOV for consistent quantification
Adaptative SPECT FOV from to 25 to 120 mm (in one single bed position) and 4 different collimator types
Single compact footprint 90 × 220 cm
Fully Shielded against X-rays

Software

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LabScape

Service & Life Cycle Support for Magnetic Resonance and Preclinical Imaging

Bruker’s commitment to provide customers with unparalleled help throughout the buying cycle, from initial inquiry to evaluation, installation, and the lifetime of the instrument is now characterized by the LabScape service concept.

LabScape Maintenance Agreements, On-Site On-Demand and Enhance Your Lab are designed to offer a new approach to maintenance and service for the modern laboratory