Exploiting the timsTOF and MALDI-2 Platforms to Assess Pharmacodynamics and Pharmacokinetics in Preclinical Models
May 17, 2022
11 am EDT, 4 pm BST, 5 pm CEST
Introduction
An integrated evaluation of the pharmacodynamic and pharmacokinetic properties of a drug is essential for successful translation to the clinic. However, cost-effective methods to measure these parameters at the systems level in pre-clinical models are lacking. Here, we introduce a timsTOF and MALDI-2 workflow to evaluate therapeutic activity. The platform combines ion mobility, mass spectrometry-based imaging, absolute drug quantitation across different biological matrices, in vivo isotope tracing, and global metabolome analysis in the adult zebrafish.
Attend this webinar to:
- Learn about innovative metabolomics workflows
- Discover how the Bruker timsTOF Pro and fleX systems can be used in metabolomics workflows
- Learn how the MALDI-2 post-ionization laser can see never before observed compounds
Speaker
Prof. Gary Patti, Ph.D., Department of Chemistry, Washington University, St. Louis, MO, USA
For Research Use Only. Not for use in clinical diagnostic procedures.