Unprecedented Resolution.
Ultra-high field, ultra-high performance.
The strength of the magnetic field is one of the most important properties of an NMR spectrometer. The dispersion (i.e. the “distance” of two peaks in an NMR spectrum) is enhanced at higher magnetic fields. For the investigation of substances with a large number of peaks, higher magnetic fields render it possible to separate different peaks from one another, making GHz-class NMR an invaluable tool for structure determination. An example is shown in Figure 1.
Another great advantage of higher magnetic fields is the improved sensitivity that can be achieved in an NMR experiment. Higher magnetic fields lead to a larger number of nuclear spins of the sample residing in the lower energy quantum state, which results in a stronger NMR signal. This is particularly beneficial for multi-dimensional NMR experiments, where the sensitivity increases additionally with the power of the number of dimensions.
For many years, high-resolution NMR was limited to a magnetic field of 23.5 Tesla, equivalent to a proton resonance frequency of 1.0 GHz. This limit was set by the physical properties of metallic, low-temperature superconductors (LTS), and it was first reached in 2009 with an Avance 1000 spectrometer at the Ultra-High Field NMR Center in Lyon, France.
High-temperature superconductors (HTS), first discovered in the 1980s, opened the door towards even higher magnetic fields at low temperatures, but considerable challenges in YBCO HTS tape manufacturing and in superconducting magnet technology made further UHF progress daunting until the early 2020ies.
Bruker's 1.0 GHz Ascend Evo, and 1.1 and 1.2 GHz Ascend magnets utilize a sophisticated hybrid design with high-temperature superconductor (HTS) in the inner sections and low-temperature superconductors (LTS) in the outer sections of the magnet, as illustrated in Figure 2. Bruker’s GHz-class NMR magnets feature a 54 mm room-temperature bore (“standard bore”) and have exquisite homogeneity and field stability compatible with the demanding requirements of high-resolution NMR.
The enhanced resolution and sensitivity make GHz-class NMR the ideal tool for many areas of research, in particular for material science and structural biology. The most important benefits are the following:
Bruker’s GHz-class spectrometers are available with a large selection of NMR probes, including CryoProbes for solution-state NMR and fast-spinning MAS solid-state NMR probes. The most popular probes for Bruker’s GHz-class NMR spectrometers are the following:
NMR research has entered a new era with the introduction of GHz-class spectrometers, which enable unprecedented resolution and sensitivity for studying complex biological systems and materials. Europe has been at the forefront of this innovation, with several 1.2 GHz NMRs already in operation across the continent. The US and Asia-Pacific are also embracing this technology, with the first 1.2 GHz NMR in the US and the first 4.2 K single-story 1.0 GHz NMR in Japan. More GHz-class NMRs are being installed or planned in these regions, reflecting the growing demand and recognition for this powerful and versatile tool for scientific discovery.
Below, you can find more information about some of the leading research institutions that have chosen GHz-class NMR for their projects.