Library Synthesis and Reaction Screening
with Online Benchtop NMR
synthesis and reaction screening. Unlock new chemical spaces, enhance efficiency, and achieve
reproducible results with seamless NMR integration.
Precision Meets Innovation in Every Experiment
Meeting the increasing demand for innovative medicines, FLEX ISYNTH and Fourier 80 benchtop NMR enable unique chemical exploration, enhance productivity, and deliver seamless automation to tackle your most complex challenges.
Workflow
Optimize your workflows with FLEX ISYNTH’s fully automated solutions. From inertization to gravimetric dispensing, heating, sampling, and real-time NMR integration, every step is designed to streamline and accelerate your chemical processes, ensuring precise, consistent results across diverse applications.
Synthesis and Benchtop Online NMR
Benefits
- Accelerate workflows with automated, parallel synthesis
- Enhance productivity by up to 100x compared to manual processes
- Reduce barriers to innovative chemistry with versatile configurations
- Optimize reaction screening with advanced online NMR analytics
- Improve reproducibility and consistency across experiments
Applications
- Medicinal chemistry molecule discovery
- High-throughput reaction optimization
- Parallel synthesis of libraries for drug development
- Characterization of reaction pathways and intermediates
- Screening novel routes for synthesis
Comprehensive Features and Advantages of FLEX ISYNTH
| Key Advantage / Feature | Description |
|---|---|
| Fully automated system | Integrated reaction preparation, synthesis, work-up, analysis, and output to storage vials for both solid- and liquid-phase library synthesis and reaction screening |
| High-precision glass reactor arrays | Easy-to-use, disposable, multifunctional arrays with reaction scales from μL to mL |
| Screwless, self-sealing reactor design | Supports mixing by shaking (up to 1,000 rpm), heating (up to 150°C), cooling (-20°C), refluxing, vacuum, inertization, evaporation, L/L extraction, filtration, solid-phase extraction, crystallization, and drying |
| Proprietary robotic tool exchange | Ensures flexibility in automation |
| Gravimetric solid handling | Handles solids from μg to g |
| Gravimetric liquid handling | Handles liquids from mg to g and μL to mL |
| Proven liquid handling | Includes pH adjustment, filtration, and heated needle extension |
| Hight throughput | Supports 24 / 48 / 96 / more parallel reactions per run |
| Integrated analytics | Includes benchtop online NMR, HPLC (MS), UPLC (MS), GC (MS), UV-VIS, NIR / MIR / DLS measurement cell |
| Safety and conditioning | Ventilated hood ensures safe and conditioned operation |
| AUTOSUITE Software | Drag-and-drop experimentation with integration to LIMS, ELN, data analysis, and AI/ML closed loop |
| Benchtop NMR integration | Includes NMR devices (e.g., Bruker Fourier Rxn Lite) with 80 / 90 MHz operating frequencies |
| NMR capabilities | Supports 1D and 2D spectra, sample injection, flow cell and standard 5 mm sample tube options, permanent magnet (no liquid nitrogen/helium), and a 2 Gauss line within the device housing |
Stay Ahead with Our Expert-Led Webinars
Register our webinars to gain insights from industry experts on the latest advancements in laboratory automation, analytical techniques, and scientific research. Enhance your knowledge and stay updated with cutting-edge developments and discover how integrated lab automation and digitalization solutions seamlessly integrate instruments and workflows to redefine research and testing.
