Spatially Encoded Pathways for Immune Tolerance in Human Health and Disease

There is a shared ontology within disease states and the tissue remodeling that comprises immune system regulation. Therefore, a better understanding of one disease, such as cancer, may have comparative similarities with other diseases or pathologies. Spatial analysis that can interrogate cellular compartmentalization and neighborhood interactions are necessary to reveal these similarities. 

Recent advances in spatial biology techniques, such as spatial transcriptomics and spatial proteomics, help to inform the relationships and interplay between cells, and how these interactions change in disease states. Specifically, pathologic processes that are known to exist in cancer, including angiogenesis, immune suppression, extracellular matrix remodeling, and immunometabolic alterations, are also present in tuberculosis and at the maternal-fetal interface during the first 20 weeks of pregnancy. Additionally, other molecular classes such as glycans and metabolites are key to a full understanding of biological mechanisms. 

In this webinar, Michael Angelo, Ph.D., will discuss how cross-connections between pathologies are critical to understanding immune system operations, and the mass spectrometry-based techniques that are emerging as new and powerful tools. He will also discuss how these insights can be used to develop new diagnostic and therapeutic approaches for immune-related diseases.

Why should you care about spatial biology analysis?
Spatial biology using mass spectrometry is one of the newest tools for helping to understand broad biochemical knowledge within the immune system. It can help us to:

• Understand how the immune system functions in health and disease
  
• Identify new targets for diagnostic and therapeutic interventions
• Develop personalized treatments for immune-related diseases
• Better understand the role of the immune system in other diseases, such as cancer 

If you are interested in learning more about the latest advances in spatial biology and their applications in the field of immunology, then this webinar is for you.

In this webinar, you will learn how:

• Normative pathways for immune tolerance can be hijacked in disease
  
• Various spatial techniques, including spatial transcriptomics and MALDI Imaging can be used to map the distribution of transcripts, lipids, and glycans
• These insights can be used to discover regulatory pathways that can be targeted for diagnostic and therapeutic purposes

This webinar is for scientists and researchers who are interested in learning more about the latest advances in spatial biology and their applications in the field of immunology.