HUPO 2024

4D-Proteomics™ Innovation: Multiomics in the post-genomic era

The timsTOF mass spectrometer portfolio continues to drive advancements in proteomic analysis. Leveraging cutting-edge technologies such as Trapped Ion Mobility Spectrometry (TIMS) and Parallel Accumulation Serial Fragmentation (PASEF), timsTOF instruments offer enhanced sensitivity, speed, and dynamic range for comprehensive proteomic characterization. Additionally, the integration of 4D-Proteomics™ methodologies further refines protein identification and quantification accuracy. Join us as we explore the transformative potential of timsTOF mass spectrometers in unraveling the complexities of the proteome across a variety of different applications.

10:30 - 11:00 Registration

11:00 - 11:10 What's new at Bruker
Daniel Hornburg, Ph.D., Vice President Biomarker and Precision Medicine, Bruker Scientific LLC, San Jose, CA, USA

11:10 - 11:35 Exploring the Sweet Side of Cells
Guinevere Lageveen-Kammeijer, Ph.D., Assistant Professor, Analytical Biochemistry Group of the Groningen Research Institute of Pharmacy (GRIP), University of Groningen, Groningen, Netherlands

11:35 - 12:00 Precision Proteomics in human disease
Roman Fischer, Ph.D., Associate Professor and Head of Discovery Proteomics Facility, University of Oxford, Oxford, United Kingdom

12:00 - 12:30 Lunch break

12:30 - 13:00 Comprehensive phosphoproteome analysis using midia-PASEF
Stefan Tenzer, Ph.D., Professor for Immunoproteomics, Institute for Immunology, University Medical Center Mainz, Helmholtz Institute for Translational Oncology (HI-TRON) Mainz, Germany

13:00 - 13:30 Scalable and sensitive phosphoproteomics
Florian Meier-Rosar, Ph.D., Junior Professor, Functional Proteomics, Jena University Hospital, Jena, Germany

13:30 - 14:00 Single-cell and spatial proteomics workflows – pushing mass spectrometry acquisition for in-depth tissue mapping
Claudia Ctortecka, Ph.D., Post Doctoral Associate, Broad institute of MIT and Harvard, Cambridge, MA, USA

Unlocking High Sensitivity: Advancements in Single Cell Proteomics with the timsTOF Ecosystem

Join us for a scientifically engaging lunch seminar focused on the high sensitivity achieved with timsTOF technology, particularly in single cell proteomics. Christoph Krisp, Ph.D., will present the Bruker solution portfolio, showcasing how our advancements enable significant biological discoveries from minimal sample material. We'll explore two key concepts: discover how the group of Christine Carapito, Ph.D., Research Director at the LSMBO in Strasbourg, handles larger single cell cohorts as well as immunopeptides, and secondly, how Fabian Coscia, Ph.D., combines imaging techniques to select disease-relevant regions of interest, demonstrating the potential of spatial proteomics workflows. In the context of multiomics in the post-genomic era, learn how integrating imaging and proteomics leads to more informed decisions and deeper biological insights.

12:15 - 12:25 Where sensitivity matters - Ultra-high sensitivity Single Cell mass spectrometry on the timsTOF Ultra 2
Christoph Krisp, Ph.D., Application Development Scientist, Bruker Daltonics, Bremen, Germany

12:25 - 12:50 Spatially resolved tissue proteomics with single-cell sensitivity 
Fabian Coscia, Ph.D., Group Leader, Spatial Proteomics, Max Delbrück Center for Molecular Medicine, Berlin, Germany

12:50 - 13:00 timsTOF Ultra to explore where the very small matters very much: Immunopeptidomics and single cell proteomics explorations
Pauline Perdu-Alloy, Ph.D. Student, BioOrganic Mass Spectrometry Laboratory (LSMBO-IPHC), CNRS and University of Strasbourg, Strasbourg, France

Jeewan Babu Rijal, Post-doctoral fellow, BioOrganic Mass Spectrometry Laboratory, CNRS and University of Strasbourg, France

Maximize the Potential of Your Data: Scalable Bioinformatics to Access Meaningful Results

In the modern landscape of mass spectrometry proteomics, bioinformatics has become a cornerstone for generating, managing, and interpreting data efficiently and effectively. Our lunch seminar will delve into this critical aspect, showcasing how scalable bioinformatics solutions can prevent data analysis bottlenecks and ensure rapid, versatile results. Hear from our head of research for Bruker ProteoScape™ (BPS), Jonathan Krieger Ph.D., about our strategies to provide impactful solutions, followed by an insightful talk on rescoring MS2 data to maximize its value by members of the CompOmics group run by Prof. Lennart Martens at the University of Ghent. Finally, we will join Lukas Reiter, Ph.D., CTO at Biognosys, to discover the enhanced capabilities of Spectronaut 19, specifically optimized for timsTOF data, and see how it can elevate your proteomics research. 

Don't miss this opportunity to learn how advanced bioinformatics can influence your project's success.

12:00 - 12:10 Maximize the Potential of Your Data: Scalable Bioinformatics to Access Meaningful Results
Jonathan Krieger, Ph.D., Head of Research, Bruker ProteoScape, Bruker Daltonics, Toronto, Canada

12:10 - 12:35 From raw to refined: Always get more out of your data with TIMSRescore
Robbin Bouwmeester, Ph.D. Postdoctoral Researcher, Research Foundation - Flanders (FWO), Ghent, Belgium

Robbe Devreese, MSc, VIB-UGent Center for Medical Biotechnology & Department of Biomolecular Medicine, Ghent University, Ghent, Belgium

12:35 - 13:00 Advancing DIA data processing: pushing the boundaries and tackling current field challenges
Lukas Reiter, Ph.D., Chief Technology Officer (CTO), Biognosys, Zurich, Switzerland

Come and visit us at booth No. 5 in the exhibition and get the chance to talk to our experts. Also our partners Biognosys No. 7 and PreOmics No. 6 will be with us.