MR Diffusion

MR Diffusion is a powerful and widespread method to investigate molecular motion, such as Brownian motion, translational motion, and flow.

Dedicated diffusion probes are the ultimate tools to deliver increased resolution in DOSY and in q-space experiments. High gradient strength and fast switching times enable diffusion investigation of samples with diffusion coefficients as low as 5 x 10^-15 m²/s, thus allowing the detection of various diffusion times over a wide range and investigation of X-Nuclei which requires a high gradient strength.

The MR Diffusion accessory and  MR Microscopy accessory share the same hardware platform, allowing to drive the diffusion gradient coils with the imaging accessory’s gradient amplifiers.   

Bruker offers a complete hardware and software accessory package for MR Diffusion which can be easily added to existing AVANCE spectrometers with standard bore (52 mm), wide bore (89 mm), or super wide bore (154 mm) magnets.

This accessory provides state of the art MR Diffusion capabilities, very strong gradients together with high resolution MR probe technology together allowing to extend the high-resolution spectroscopy seemlessly into the range of big, slow diffusion molecules.  On the other hand it also allows investigating more exotic systems, e.g. porous media.

The MR Diffusion accessory is a user-friendly routine diffusion package which contains both state-of-the art hardware and software which enables non-expert and expert user to take full control of their MR experiment - whether running routine diffusion investigation or developing highly sophisticated diffusion sequences. 

MR Diffusion Probes

MR Diffusion probes are available for SB, WB, and SWB system. The SB probe also fits into larger bore magnets and offer 1H-19F/XBB and lock in BBI or BBO configurations as well as automatic tuning and matching and a wide temperature range. The WB probe features exchangeable rf coils in various diameters for 1H and X-nucleus available as single or double tuned.

Hardware

Bruker MR Microscopy / MR Diffusion hardware is flexible and powerful, whether performing routine measurements, creating new demanding methods or investigating new types of objects. Bruker Great60 gradient amplifier combines strong gradient pulses with up to 60 A and fast switching times with stability over a large bandwidth, low distortion, linearity and low noise.

The MR Diffusion cabinet is required for all Bruker wide bore or standard bore diffusion gradient coils, requiring one gradient amplifiers. To enable high performance applications with large current amplitudes, fast switching and high duty cycles all MR Diffusion gradient coils are water cooled by a close looped water chiller with built-in temperature, cooling fluid level and flow rate remote monitoring. 

1 x Great 60 amplifiers

• Linear current amplifier 100 V 60 A
• Digital preemphasis and B0 compensation
• Current blanking
• Digital signal distribution to eliminate interference from ground connections
• 1 µs timing resolution
• 20 bit amplitude resolution
• Gradient coil supervision (power / temperature)

Cooling unit low maintenance water chiller

MR Diffusion accessory: 1 Great 60 amplifiers and safety controller mounted in the rack. 

TopSpin® sets the industry standard for NMR data analysis and the acquisition and processing of NMR spectra. The latest release of TopSpin® software, 4.0, features a new, user-friendly GUI which provides easy access to vast experiment libraries including standard Bruker pulse sequences and user generated experiment libraries for both industrial and academic users.

The diff package is a comprehensive software to simplify the set-up of diffusion experiments. To focus on physically relevant diffusion parameters, machine level settings  are replaced by experiment level parameters. For example, rather than setting the gradient strength in percent, the gradient strength is given in physical units. The user can select between Gauss/cm, mT/m, T/m and Hz/cm (1H). For experimentally relevant parameters, like the diffusion time, the diff program calculates all relevant delays building the diffusion time and provides a lower limit given by the unavoidable delays in the sequence. In other words, the users do not need to know, which delays form the diffusion time, they only need to specify the diffusion time and the program will automatically set the other parameters. Most of the parameters will be checked for reasonable upper and lower limits. 

The diff program covers the standard diffusion/DOSY experiments. It also offers a couple of “2D” methods, where “2D” stands for 2 non-FT or dynamic dimensions, for example like DDCOSY having 2 orthogonal diffusion dimensions, or DRCOSY having a diffusion and a relaxation dimension. The number of available methods will continue to grow in the future.

There are also new setup experiments and pure T1 and T2 experiments.

The diff program prepares the data analysis in Dynamics Center and triggers the automatic analysis in Dynamics Center.

Dynamic Center is an easy-to-use and integrated platform featuring general dynamics and protein dynamics. It offers intuitive, method-oriented workflows for the analysis of a wide range of experiments. 

The diffusion accessory is compatible with the MNOVA software suite.