AvanceCore

400 MHz

The AvanceCore is a full-fledged, two-channel 400 MHz NMR spectrometer.

Cost-effective

Additional features can be flexibly enabled and disabled with software subscriptions. You only pay for what you need, when you need it.

Quality & Performance

The AvanceCore offers the quality and high performance Bruker is known for, at a lower price.

More Information on the AvanceCore NMR Spectrometer

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How affordable is NMR? Calculate the bottom line!

This calculator is intended for customers with greater than 5 samples per day. Taking into account the costs of investing in an AvanceCore NMR spectrometer, the associated running costs, and the number of samples you work with, we provide you with an estimate for your average cost per measurement.

AvanceCore Calculators

What is my ideal AvanceCore configuration and when will my investment pay off?

This calculator is especially suited for customers with less than 5 NMR samples per day. The amortization calculator compares the costs of investing in an AvanceCore NMR spectrometer to using an external NMR service provider. We calculate the time from which you will see a return on your investment.

AvanceCore Calculators

Features

NMR is an extremely powerful analytical method. In combination with the affordability of the AvanceCore, this makes NMR the ideal tool to address a large range of analytical questions, including structure elucidation and verification, molecular interactions, and quantitation. The AvanceCore solution offers NMR at a price similar to a standard liquid chromatography mass spec instrument.

Benefits

NMR offers many advantages over other analytical techniques. The AvanceCore provides better value for money than other methods:

With NMR, what you see is what is present. Chromatographic analysis requires process steps such as liquid injection or sample evaporation. Potential sample degradation or unwanted reactions complicate the assignment of signals.
NMR selectively detects nuclei such as ¹H, ¹³C, ¹⁹F and ³¹P which are present in organic molecules. This is not apparent with other analytical techniques. For example, UV detectors for chromatography miss many substances without a chromophore. IR and mass detectors have similar limitations.
With NMR, substances can be identified and quantified against any reference standard. Other analytical methods rely on a reference standard of the same material.
1D NMR experiments can be run with standard parameters for most samples. Several compounds are identified and quantified from a single spectrum. HPLC, for instance, can also deliver good separation and signal-to-noise — provided that the method was optimized for the particular application. NMR helps you to save time and money.

Applications

Direct Assignment of the Carbon Backbone with Room Temperature Probes at Medium Fields: The INAD NMR experiment

The INADEQUATE NMR experiment facilitates the direct structural assignment of organic molecules via the carbon backbone. This poses advantages over other, indirect methods. Learn how to record the experiment at 400 MHz with a room temperature probe in 24h - even with a limited amount of sample substance.

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Decoupling: The Key to High Resolution and Sensitivity in
One-Dimensional NMR Spectra

Two important factors in one-dimensional NMR spectroscopy are high resolution and sensitivity. Both can be more than doubled when using heteronuclear decoupling, which allows for the separation of overlapping signals as demonstrated for the analysis of diluted components in reaction mixtures.

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10-fold Signal-to-Noise Improvement with
Weak Lock Coupling

In NMR, small signals - e.g. from trace impurities - can easily get buried in noise. Weak lock coupling can reduce the noise!

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Mixture Analysis with NMR: Benefiting from Multi-Signal Suppression

¹H NMR spectroscopy is great for detecting impurities and trace compounds. There is no “hiding” as most organic molecules contain the highly sensitive ¹H nucleus! Lift the lid to discover what selectively suppressing large signals can uncover.

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Radiation Damping: What It Is and What To Do

One of the strengths of NMR spectroscopy over other methods is that the sample amount can be chosen relatively freely, from the sub-milligram-range to several grams. Provided that radiation damping is correctly accounted for, measurements of trace compounds, undiluted products, and the mixture of both can be performed very straightforwardly.

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¹³C Satellites in Proton NMR Spectroscopy

Analyzing the ¹³C satellites in proton spectra enables interesting experimental strategies. In this application note, we give examples which illustrate the vast amount of information that can be obtained from ¹³C satellites.

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Determining Relaxation with the Inversion-Recovery Experiment

NMR experiments typically consist of RF pulses followed by a period of recording the resulting NMR signal. Very often, several such sequences are executed after another - for instance to increase the signal to noise ratio by averaging. It is important to wait with the application of a new pulse until the RF signal from the previous pulse has decayed.

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The AvanceCore is highly cost effective and facilitates uncompromized performance in high-resolution NMR. Outstanding dispersion and signal-to-noise ratio enable mixture analysis down to ppm concentrations. The AvanceCore supports state-of-the-art 2D NMR methods to elucidate molecular structure at the atomic level.

Identification and quantitation: The above 1H spectrum was acquired with the AvanceCore Foundation from a 20 mg sample in less than 5 minutes. The sample contains 100 ppm (0.002 mg) of the following impurities: acetonitrile, acetone, ethyl acetate and acetic acid in DMSO-d6.

The AvanceCore Foundation also supports state-of-the-art 1H-1H 2D experiments such as TOCSY, COSY, ROESY and NOESY. The above spectrum shows TOCSY-correlations of the anti-inflammatory drug Ibuprofen.The TOCSY can be used for structure assignment.

With the AvanceCore Foundation, the 1H DOSY NMR experiment for mixture analysis can be performed. DOSY is often referred to as “chromatographic NMR”. Just like LC-MS, it resolves the different mass and diffusion properties of indivual mixture components.

The AvanceCore Select supports heteronuclear experiments (HSQC, HMBC...) which are essential for molecular structure elucidation. The above spectrum shows a 2D 1H/13C HSQC-TOCSY experiment recorded from a 20 mg Ibuprofen sample.

Configurations

In order to keep costs low, Bruker has streamlined the AvanceCore into three pre-configured packages.

Foundation: In the most fundamental version, the AvanceCore provides high-resolution ¹H NMR spectroscopy. The bundle includes a 400 MHz NMR magnet, a console and a 5 mm probe.

Select: The AvanceCore Select includes all the hardware and software for ¹H and heteronuclear (¹³C, ³¹P...) state-of-the-art experiments.

Convenience: The AvanceCore Convenience includes a 24-position sample changer. The IconNMR software enables open access use and automated routine measurements.

Your instrument can grow with your needs: An existing AvanceCore can easily be upgraded from Foundation to Select and from Select to Convenience.

Specifications

The AvanceCore is a complete, full-fledged 400 MHz NMR-spectrometer. The AvanceCore spectrometer has the following key characteristics:

AvanceCore Magnet	NMR-frequency (¹H)	400 MHz
	Typical helium hold time	300 days
	Typical nitrogen hold time	16 days
AvanceCore Console	Number of RF channels	2
	Timing Resolution	12.5 ns
	Frequency Resolution	< 0.005Hz
	Digital Lock	Included
	RF amplifier frequency range	⁵⁷Fe-¹⁹F/¹H
AvanceCore Probe	NMR Tube Diameter	5 mm
	Channels	¹H, BB & ²H Lock
	Z-Gradient	50 G/cm
Available Accessories	Sample Temperature Control Unit, 24-position Sample Changer