timsTOF fleX Bibliography
timsTOF fleX Bibliography
The timsTOF fleX is a high performance UHR-OTOF system with integrated dual ESI/MALDI source, exhibiting high speed and robust MALDI Imaging. The additional trapped ion mobility feature adds another separation dimension to unravel complex data and make annotations in MALDI Images more reliable through CCS-matching. Since ASMS 2020 we switched to the next level to gain higher sensitivity for a broad range of compounds and equipped the instrument with a second laser allowing for postionization (MALDI-2).
MALDI-2 uses laser based postionization to enhance and enrich the MALDI experiment, providing access to chemical classes typically opaque to MALDI, at unprecedented sensitivity (2-3 orders of magnitude compared to traditional MALDI) Postionization significantly boosts ion yields for many different analytes and reduces the ever-challenging ion suppression effects in MALDI imaging.
The peer-reviewed and in-peer-reviewing communications listed below is a non-exhaustive list from the work initiated on the first timsTOF fleX (MALDI-2) instruments in the field in the years 2019-2023 and many more are to come.
timsTOF fleX
| TITLE | AUTHOR | PUBLICATION | LINK | YEAR | APPLICATION |
|---|---|---|---|---|---|
| Advances in cellular and tissue-based imaging techniques for sarcoid granulomas | Kim, J.; Dwivedi, G.; Boughton, B. A. et al. | American Journal of Physiology-Cell Physiology, 326, 2024, 1, C10-C26 | https://doi.org/10.1152/ajpcell.00507.2023 | 2024 | |
| Sodium doping and trapped ion mobility spectrometry improve lipid detection for novel MALDI-MSI analysis of oats | Lau, W. C. D.; Donnellan, L.; Briggs, M. et al. | Food Chemistry, 433, 2024, 137275 | https://doi.org/10.1016/j.foodchem.2023.137275 | 2024 | |
| Use of tryptic peptide MALDI mass spectrometry imaging to identify the spatial proteomic landscape of colorectal cancer liver metastases. | Li, C. M. Y.; Briggs, M.; Lee, Y. R. et al. | medRxiv, 2024, preprint | https://doi.org/10.1101/2024.01.24.24301748 | 2024 | |
| Competition for iron shapes metabolic antagonism between Bacillus subtilis and Pseudomonas marginalis | Lyng, M.; Jørgensen, J. P. B.; Schostag, M. D. et al. | The ISME Journal, 18, 2024, 1, wrad001 | https://doi.org/10.1093/ismejo/wrad001 | 2024 | |
| Multimodal analytical tools for the molecular and elemental characterisation of lesions in brain tissue of multiple sclerosis patients | Niehaus, P.; de Vega, R. G.; Haindl, M. T. et al. | Talanta, 270, 2024, 125518 | https://doi.org/10.1016/j.talanta.2023.125518 | 2024 | |
| Spatial Omics Reveals that Cancer-Associated Glycan Changes Occur Early in Liver Disease Development in a Western Diet Mouse Model of MASLD | Ochoa-Rios, S.; Grauzam, S. E.; Gregory, R. et al. | Journal of Proteome Research, 2024, 23, 2, 786–796 | https://doi.org/10.1021/acs.jproteome.3c00672 | 2024 | |
| An N-glycome tissue atlas of 15 human normal and cancer tissue types determined by MALDI-imaging mass spectrometry | Wallace, E. N.; West, C. A.; McDowell, C. T. et al. | Scientific Reports, 14, 2024, 489 | https://doi.org/10.1038/s41598-023-50957-w | 2024 | |
| Spatial probabilistic mapping of metabolite ensembles in mass spectrometry imaging | Abu Sammour, D.; Cairns, J. L.; Boskamp, T. et al. | Nature Communications, 14, 2023, 1823 | https://doi.org/10.1038/s41467-023-37394-z | 2023 | |
| Unlocking the Hidden Depths: Multi-Modal Integration of Imaging Mass Spectrometry-Based and Molecular Imaging Techniques | Akbari, B.; Huber, B. R.; Sherman, J. H. et al. | Critical Reviews in Analytical Chemistry, 2023, 1-30 | https://doi.org/10.1080/10408347.2023.2266838 | 2023 | |
| Sample Preparation Method for MALDI Mass Spectrometry Imaging of Fresh-Frozen Spines | Bender, K. J; Wang, Y.; Zhai, C. Y. et al. | Analytical Chemistry, 2023, 95, 47, 17337–17346 | https://doi.org/10.1021/acs.analchem.3c03672 | 2023 | |
| Visualization of metabolites and microbes at high spatial resolution using MALDI mass spectrometry imaging and in situ fluorescence labeling | Bourceau, P.; Geier, B.; Suerdieck, V. et al. | Nature Protocols, 18, 2023, 3050–3079 | https://doi.org/10.1038/s41596-023-00864-1 | 2023 | |
| Rewiring of the N-Glycome with prostate cancer progression and therapy resistance | Butler, W.; McDowell, C.; Yang, Q. et al. | NPJ Precision Oncology, 7, 2023, 22 | https://doi.org/10.1038/s41698-023-00363-2 | 2023 | |
| MALDI TIMS IMS Reveals Ganglioside Molecular Diversity within Murine S. aureus Soft Tissue Abscesses. | Djambazova, K. V.; Gibson-Corley, K. N.; Freiberg, J. A. et al. | ChemRxiv, 2023, preprint | https://doi:10.26434/chemrxiv-2023-whtvz | 2023 | |
| Evaluation of antibody-based single cell type imaging techniques coupled to multiplexed imaging of N-glycans and collagen peptides by matrix-assisted laser desorption/ionization mass spectrometry imaging | Dunne, J.; Griner, J.; Romeo, M. et al. | Analytical and Bioanalytical Chemistry, 2023, 415, 7011–7024 | https://doi.org/10.1007/s00216-023-04983-2 | 2023 | |
| A multiplexed single cell proteomic workflow applicable to drug treatment studies | Eberhard, C. D.; Orsburn, B. C. | OSF Preprints, 2023 | https://doi.org/10.31219/osf.io/9nv5w | 2023 | |
| Functional mass spectrometry imaging maps phospholipase-A2 enzyme activity during osteoarthritis progression | Fan, X.; Young, R. S. E.; Sun, A. R. et al. | Theranostics, 2023, 13(13): 4636–4649 | https://doi.org/10.7150/thno.86623 | 2023 | |
| In situ lipidomics of Staphylococcus aureus osteomyelitis using imaging mass spectrometry | Good, C. J.; Butrico, C. E.; Colley, M. E. et al. | Biorxiv, 2023, 569690 | https://doi.org/10.1101/2023.12.01.569690 | 2023 | |
| Deep MALDI-MS Spatial Omics guided by Quantum Cascade Laser Mid-infrared Imaging Microscopy | Gruber, L.; Schmidt, S.; Enzlein, T. et al. | bioRxiv, 2023, 571637 | https://doi.org/10.1101/2023.12.14.571637 | 2023 | |
| On-tissue dataset-dependent MALDI-TIMS-MS2 bioimaging | Heuckeroth, S.; Behrens, A.; Wolf, C. et al. | Nature Communications, 14, 2023, 7495 | https://doi.org/10.1038/s41467-023-43298-9 | 2023 | |
| Imaging mass spectrometry of isotopically-resolved intact proteins on a trapped ion-mobility quadrupole time-of-flight mass spectrometer | Klein, D.; Rivera, E.; Caprioli, R. et al. | ChemRxiv, 2023, preprint | https://doi:10.26434/chemrxiv-2023-85m7b | 2023 | |
| Ion Mobility Mass Spectrometry for the Separation and Characterization of Small Molecules | Liu, L.; Wang, Z.; Zhang, Q. et al. | Analytical Chemistry, 2023, 95, 1, 134–151 | https://doi.org/10.1021/acs.analchem.2c02866 | 2023 | |
| Visualizing the Distribution of Jujube Metabolites at Different Maturity Stages Using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging | Lu, D.; Wu, Y.; Zhang, J. et al. | Foods, 12, 2023, 20, 3795 | https://doi.org/10.3390/foods12203795 | 2023 | |
| Amino acid catabolite markers for early prognostication of pneumonia in patients with COVID-19 | Maeda, R.; Seki, N.; Uwamino, Y. et al. | Nature Communications, 14, 2023, 1, 8469 | https://doi.org/10.1038/s41467-023-44266-z | 2023 | |
| A label-free approach for relative spatial quantitation of c-di-GMP in microbial biofilms | McCaughey, C. S.; Trebino, M. A.; McAtamney, A. et al. | bioRxiv, 2023, preprint | https://doi.org/10.1101/2023.10.10.561783 | 2023 | |
| Spatial metabolomics principles and application to cancer research | Planque, M.; Igelmann, S.; Campos, A. M. F. et al. | Current Opinion in Chemical Biology, 76, 2023, 102362 | https://doi.org/10.1016/j.cbpa.2023.102362 | 2023 | |
| Multi-omics data reveals aberrant gut microbiota-host glycerophospholipid metabolism in association with neuroinflammation in APP/PS1 mice | Qian, X.; Hai, W.; Chen, S. et al. | Gut Microbes, 15, 2023, 2, 2282790 | https://doi.org/10.1080/19490976.2023.2282790 | 2023 | |
| SETD2 deficiency accelerates sphingomyelin accumulation and promotes the development of renal cancer | Rao, H.; Liu, C.; Wang, A. et al. | Nature Communications, 14, 2023, 7572 | https://doi.org/10.1038/s41467-023-43378-w | 2023 | |
| Rewiring of cortical glucose metabolism fuels human brain cancer growth | Scott, A. J.; Mittal, A.; Meghdadi, B. et al. | medRxiv, 2023, preprint | https://doi.org/10.1101/2023.10.24.23297489 | 2023 | |
| A multimodal pipeline for image correction and registration of mass spectrometry imaging with microscopy | Tang, W.; Li, Z.; Zou, Y, et al. | Analytica Chimica Acta, 1283, 2023, 341969 | https://doi.org/10.1016/j.aca.2023.341969 | 2023 | |
| Toward Omics-Scale Quantitative Mass Spectrometry Imaging of Lipids in Brain Tissue Using a Multiclass Internal Standard Mixture | Vandenbosch, M.; Mutuku, S. M.; Mantas, M. J. Q. et al. | Analytical Chemistry, 2023, 95, 51, 18719–18730 | https://doi.org/10.1021/acs.analchem.3c02724 | 2023 | |
| Hepatic glutamine synthetase controls N 5-methylglutamine in homeostasis and cancer | Villar, V. H.; Allega, M. F.; Deshmukh, R.; Ackermann, T. et al. | Nature Chemical Biology, 19, 2023, 292–300 | https://doi.org/10.1038/s41589-022-01154-9 | 2023 | |
| Metabolic Markers and Association of Biological Sex in Lupus Nephritis | Wolf, B.; Blaschke, C. R. K; Mungaray, S. et al. | International Journal of Molecular Sciences, 24, 2023, 22, 16490 | https://doi.org/10.3390/ijms242216490 | 2023 | |
| Spatial Lipidomics Reveals Lipid Changes in the Cotyledon and Plumule of Mung Bean Seeds during Germination | Xie, P.; Chen, J.; Wu, P. et al. | Journal of Agricultural and Food Chemistry, 2023, 71, 49, 19879–19887 | https://doi.org/10.1021/acs.jafc.3c06029 | 2023 | |
| Untargeted and spatial-resolved metabolomics characterize serum and tissue-specific metabolic reprogramming in acute kidney injury | Xu, B.; Li, W.; Zhang, Y. et al. | Heliyon, 9, 2023, 11 | https://doi.org/10.1016/j.heliyon.2023.e21171 | 2023 | |
| The dentate gyrus differentially metabolizes glucose and alternative fuels during rest and stimulation | York, E. M.; Miller, A.; Stopka, S. A. et al. | Journal of Neurochemistry, 00, 2023, 1-22 | https://doi.org/10.1111/jnc.16004 | 2023 | |
| Single-cell lipidomics enabled by dual-polarity ionization and ion mobility-mass spectrometry imaging | Zhang, H.; Liu, Y.; Fields, L. et al. | Nature Communications, 14, 2023, 5185 | https://doi.org/10.1038/s41467-023-40512-6 | 2023 | |
| Tandemly duplicated CYP82Ds catalyze 14-hydroxylation in triptolide biosynthesis and precursor production in Saccharomyces cerevisiae | Zhang, Y.; Gao, J.; Ma, L. et al. | Nature Communications, 14, 2023, 875 | https://doi.org/10.1038/s41467-023-36353-y | 2023 | |
| Unveiling targeted spatial metabolome of rice seed at the dough stage using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry imaging | Zhao, Y.; Hu, J.; Zhang, Y. et al. | Food Research International, 174, 2023, 113578 | https://doi.org/10.1016/j.foodres.2023.113578 | 2023 | |
| Pulmonary maternal immune activation does not extend through the placenta but leads to fetal metabolic adaptation | Hansen, S. S. K.; Krautz, R.; Rago, D. et al. | bioRxiv 14, 2023, 8, 492 | https://doi.org/10.1101/2023.03.17.532052 | 2023 | Biology - Clinical |
| The microenvironment dictates glycocalyx construction and immune surveillance | Tharp, K.; Park, S.; Timblin, G. et al. | Research Square 4, 2023, 08-04, 2023.07.28.551042 | https://doi.org/10.21203/rs.3.rs-3164966/v1 | 2023 | Biology - Clinical |
| GolpHCat (TMEM87A): a unique voltage-gated and pH-sensitive cation channel in the Golgi | Kang, H.; Jeong, H.; Han, A. et al. | bioRxiv, 2023, e2300680 | https://doi.org/10.1101/2023.01.03.522543 | 2023 | Biology |
| A super-resolution strategy for mass spectrometry imaging via transfer learning | Liao, T.; Ren, Z.; Chai, Z. et al. | Nature Machine Intelligence, 2023 | https://doi.org/10.1038/s42256-023-00677-7 | 2023 | Method Development |
| Enhanced niche colonisation and competition during bacterial adaptation to a fungus | Richter, A.; Blei, F.; Hu, G. et al. | bioRxiv, 2023 | https://doi.org/10.1101/2023.03.27.534400 | 2023 | Biology |
| Interpretable dimensionality reduction and classification of mass spectrometry imaging data in a visceral pain model via non-negative matrix factorization | Pathirage, K.; Virmani, A.; Scott, A. J. et al. | bioRxiv 22, 2023, 8, 2694-2702 | https://doi.org/10.1101/2023.04.24.538180 | 2023 | Method Development |
| Resistance towards and biotransformation of Pseudomonas-produced secondary metabolites during community invasion | Hansen, M. L.; Dénes, Z.; Jarmusch, S. A. et al. | bioRxiv 95, 2023, 28, 10603-10609 | https://doi.org/10.1101/2023.06.20.545698 | 2023 | Biology - Clinical |
| Investigating post-traumatic syringomyelia and local fluid osmoregulation via a rat model | Pukale, D. D.; Adkins-Travis, K.; Aryal, S. R. et al. | Research Square 76, 2023, 102362 | https://doi.org/10.21203/rs.3.rs-3243600/v1 | 2023 | Biology - Clinical |
| Fatty acids abrogate the growth-suppressive effects induced by inhibition of cholesterol flux in pancreatic cancer cells | Li, Y.; Amrutkar, M.; Finstadsveen, A. V. et al. | Research Square 43, 2023, 9, 1626-1635 | https://doi.org/10.21203/rs.3.rs-3149861/v1 | 2023 | Biology - Clinical |
| Unveiling the spatial metabolome and anti-atherosclerosis effects of Allium macrostemon Bunge and Allium chinense G. Don | Li, S.; Lin, P.; Xing, H. et al. | Arabian Journal of Chemistry 148, 2023, 13, 3002-3018 | https://doi.org/10.1016/j.arabjc.2023.104772 | 2023 | Biology - Clinical |
| ChIP-MS reveals the local chromatin composition by label-free quantitative proteomics | Yong, W. K.; Rane, G.; Anuar, N. Z. et al. | bioRxiv, 2023, 2023.06.23.546317 | https://doi.org/10.1101/2023.01.27.525999 | 2023 | Method Development |
| FluoMALDI microscopy: matrix co-crystallization simultaneously enhances fluorescence and MALDI imaging | Yang, E.; Shen, X. E.; West-Foyle, H. et al. | bioRxiv, 2023, 2023.06.20.545698 | https://doi.org/10.1101/2023.05.27.542340 | 2023 | Method Development |
| Omics Scale Quantitative Mass Spectrometry Imaging of Lipids in Brain Tissue using a Multi-Class Internal Standard Mixture | Vandenbosch, M.; Mutuku, S. M.; Mantas, M. J. Q. et al. | bioRxiv 14, 2023, 1, 3287 | https://doi.org/10.1101/2023.06.21.546027 | 2023 | Method Development |
| Cocaine Regulates Antiretroviral Therapy CNS Access Through Pregnane-X Receptor-Mediated Drug Transporter and Metabolizing Enzyme Modulation at the Blood Brain Barrier | Fridman, L. B.; Knerler, S.; Price, A. et al. | bioRxiv 24, 2023, 8, e56439 | https://doi.org/10.1101/2023.07.28.551042 | 2023 | Biology - Clinical |
| Sleep deprivation exacerbates microglial reactivity and Aβ deposition in a TREM2-dependent manner in mice | Parhizkar, S.; Gent, G.; Chen, Y. et al. | Science Translational Medicine, 2023 | https://doi.org/10.1126/scitranslmed.ade6285 | 2023 | |
| 3-Phosphoinositide-dependent kinase 1 drives acquired resistance to osimertinib | Meraz, I. M.; Majidi, M.; Fang, B. et al. | Communications Biology 5, 2023, 6, 656-668 | https://doi.org/10.1038/s42003-023-04889-w | 2023 | Biology - Clinical |
| Coordinated adaptations define the ontogenetic shift from worm- to fish-hunting in a venomous cone snail | Rogalski, A.; Himaya, S. W. A.; Lewis, R. J. et al. | Nature Communications, 2023 | https://doi.org/10.1038/s41467-023-38924-5 | 2023 | Biology |
| Reducing oxidative protein folding alleviates senescence by minimizing ER‐to‐nucleus H2O2 release | Cheng, F.; Ji, Q.; Wang, L. et al. | EMBO Reports 16, 2023, 6, 104772 | https://doi.org/10.15252/embr.202256439 | 2023 | |
| Colitis ameliorates cholestatic liver disease via suppression of bile acid synthesis | Gui, W.; Hole, M. J.; Molinaro, A. et al. | Nature Communications, 2023, 100630 | https://doi.org/10.1038/s41467-023-38840-8 | 2023 | Biology - Clinical |
| Using mass spectrometry imaging to map fluxes quantitatively in the tumor ecosystem | Schwaiger-Haber, M.; Stancliffe, E.; Anbukumar, D. S. et al. | Nature Communications 14, 2023, 2876 | https://doi.org/10.1038/s41467-023-38403-x | 2023 | |
| Incorporating Anticoagulant and Antiplatelet Dual Functional Groups into Thermosetting Polymer Chain for Enhancing Antithrombogenicity | Wang, W.; Liu, S.; Zhang, S. et al. | Advanced Healthcare Materials, 2023 | https://doi.org/10.1002/adhm.202300680 | 2023 | |
| Strategic self-limiting production of infectious HIV particles by CRISPR in permissive cells | Liu, H.; Chen, C.; Liao, S. et al. | Molecular Therapy - Nucleic Acids 14, 2023, 1, 2876 | https://doi.org/10.1016/j.omtn.2023.04.027 | 2023 | Biology |
| Strigolactones repress nodule development and senescence in pea | Van Dingenen, J.; De Keyser, A.; Desmet, S. et al. | The Plant Journal 32, 2023, 1010-1025 | https://doi.org/10.1111/tpj.16421 | 2023 | Biology |
| Photoreduction of Anthracenes Catalyzed by peri‐Xanthenoxanthene: a Scalable and Sustainable Birch‐type Alternative | De Luca, C.; Zanetti, D.; Battisti, T. et al. | Chemistry - A European Journal 12, 2023, Suppl 1, e12329 | https://doi.org/10.1002/chem.202302129 | 2023 | Chemistry – Basic Research |
| Integrated mass spectrometry imaging and single‐cell transcriptome atlas strategies provide novel insights into taxoid biosynthesis and transport in Taxus mairei stems | Yu, C.; Hou, K.; Zhang, H. et al. | The Plant Journal, 2023, 2023.05.13.540426 | https://doi.org/10.1111/tpj.16315 | 2023 | Biology |
| Spatial metabolomics reveals glycogen as an actionable target for pulmonary fibrosis | Conroy, L. R.; Clarke, H. A.; Allison, D. B. et. al. | Nature Communications 14, 2023, 1, 2759 | https://doi.org/10.1038/s41467-023-38437-1 | 2023 | Biology - Clinical |
| WSD-0922, a novel brain-penetrant inhibitor of epidermal growth factor receptor, promotes survival in glioblastoma mouse models | Conage-Pough, J. E.; Stopka, S. A.; Oh, J. et al. | Neuro-Oncology Advances 1265, 2023, 341267 | https://doi.org/10.1093/noajnl/vdad066 | 2023 | Biology - Clinical |
| Exposure to isocyanates predicts atopic dermatitis prevalence and disrupts therapeutic pathways in commensal bacteria | Zeldin, J.; Chaudhary, P. P.; Spathies, J. et al. | Science Advances 380, 2023, 6644, 520-526 | https://doi.org/10.1126/sciadv.ade8898 | 2023 | Biology - Clinical |
| Analysis of N-linked glycan alterations in tissue and serum reveals promising biomarkers for intrahepatic Cholangiocarcinoma | Ochoa-Rios, S.; Blaschke, C. R. K.; Wang, M. et al. | Cancer Research Communications 11, 2023, 1182404 | https://doi.org/10.1158/2767-9764.crc-22-0422 | 2023 | Biology - Clinical |
| Laser desorption/ionization-mass spectrometry for the analysis of interphases in lithium ion batteries | Göldner, V.; Quach, L.; Adhitama, E. et al. | iScience 95, 2023, 19, 7475-7486 | https://doi.org/10.1016/j.isci.2023.107517 | 2023 | Chemistry – Basic Research |
| Elucidation of the environmental reductive metabolism of the herbicide tritosulfuron assisted by electrochemistry and mass spectrometry | Göldner, V.; Speitling, M.; Karst, U. | Chemosphere 15, 2023, 693, eade6285 | https://doi.org/10.1016/j.chemosphere.2023.138687 | 2023 | Chemistry – Basic Research, Environmental, pollution |
| Macromolecular Engineering: From Precise Macromolecular Inks to 3D Printed Microstructures | Catt, S. O.; Hackner, M.; Spatz, J. P. et al. | Small, 2023, e2300844 | https://doi.org/10.1002/smll.202300844 | 2023 | Chemistry – Basic Research |
| Metabolomics of bacterial–fungal pairwise interactions reveal conserved molecular mechanisms | Luu, G. T.; Little, J. C.; Pierce, E. C. et al. | Analyst, 2023, 333-357 | https://doi.org/10.1039/d3an00408b | 2023 | Biology |
| Direct mass spectrometric imaging of document handwriting with laser desorption ionization and post ultraviolet photodissociation | Jia, S.; Zhou, X.; Hu, X. et al. | Analytica Chimica Acta, 2023, 2023.03.27.534400 | https://doi.org/10.1016/j.aca.2023.341267 | 2023 | Chemistry – Basic Research, Forensic |
| A palmitate-rich metastatic niche enables metastasis growth via p65 acetylation resulting in pro-metastatic NF-κB signaling | Altea-Manzano, P.; Doglioni, G.; Liu, Y. et al. | Nature Cancer 4, 2023, 03-29, 2023.03.23.533981 | https://doi.org/10.1038/s43018-023-00513-2 | 2023 | |
| Bioorthogonal Chemical Labeling Probes Targeting Sialic Acid Isomers for N‑Glycan MALDI Imaging Mass Spectrometry of Tissues, Cells, and Biofluids | Lu, X.; McDowell, C. T.; Blaschke, C. R. K. et al. | Analytical Chemistry, 2023, 2023.03.17.532052 | https://doi.org/10.1021/acs.analchem.2c04882 | 2023 | Method Development |
| In vitro and ex vivo proteomics of Mycobacterium marinum biofilms and the development of biofilm-binding synthetic nanobodies | Hammarén, M. M.; Luukinen, H.; Sillanpää, A. et al. | mSystems, 2023 | https://doi.org/10.1128/msystems.01073-22 | 2023 | Biology - Clinical |
| Expression of transglutaminase 2 in human gut epithelial cells: Implications for coeliac disease | Amundsen, S. F.; Stamnaes, J.; Lundin, K. E. A. et al. | PLOS ONE 30, 2023, Suppl 1, 1-324 | https://doi.org/10.1371/journal.pone.0287662 | 2023 | Biology - Clinical |
| Towards optimised extracellular vesicle proteomics from cerebrospinal fluid | Kangas, P.; Nyman, T. A.; Metsähonkala, L. et al. | Scientific Reports 4, 2023, 03-29, 2023.03.13.532449 | https://doi.org/10.1038/s41598-023-36706-z | 2023 | Biology, Method Development |
| Mobility-resolved broadband dissociation and parallel reaction monitoring for laser desorption/ionization-mass spectrometry - Tattoo pigment identification supported by trapped ion mobility spectrometry | Wolf, C.; Behrens, A.; Brungs, C. et al. | Analytica Chimica Acta 34, 2023, 4, 720-727 | https://doi.org/10.1016/j.aca.2023.340796 | 2023 | Method Development |
| Evaluating the Pharmacokinetics and Pharmacodynamics of Chemotherapeutics within a Spatial SILAC-Labeled Spheroid Model System | Beller, N. C.; Wang, Y.; Hummon, A. B. | Analytical Chemistry 3, 2023, 3, 383-394 | https://doi.org/10.1021/acs.analchem.3c00905 | 2023 | Biology - Clinical, Method Development |
| De novo phytosterol synthesis in animals | Michellod, D.; Bien, T.; Birgel, D. et al. | Science 7, 2023, 1, 22 | https://doi.org/10.1126/science.add7830 | 2023 | |
| Microscopy-Directed Imaging Mass Spectrometry for Rapid High Spatial Resolution Molecular Imaging of Glomeruli | Esselman, A. B.; Patterson, N. H.; Migas, L. G. et al. | Journal of The American Society for Mass Spectrometry 42, 2023, 5, 1984-2206 | https://doi.org/10.1021/jasms.3c00033 | 2023 | Method Development |
| Analysis of single cells treated with the KRASG12D inhibitor MRTX 1133 reveals new challenges for the emerging field of single cell proteomics | Orsburn, B. C. | bioRxiv, 2023, 2023.02.20.529255 | https://doi.org/10.1101/2023.03.23.533981 | 2023 | Biology |
| High-Resolution N‑Glycan MALDI Mass Spectrometry Imaging of Subchondral Bone Tissue Microarrays in Patients with Knee Osteoarthritis | Lee, Y.; Briggs, M. T.; Kuliwaba, J. S. et al. | Analytical Chemistry 13, 2023, 1, 2776 | https://doi.org/10.1021/acs.analchem.3c00348 | 2023 | Biology - Clinical |
| Inosine enhances tumor mitochondrial respiration by inducing Rag GTPases and nascent protein synthesis under nutrient starvation | Li, M.; Wu, X.; Jing, W. et al. | Cell Death & Disease 4, 2023, 3, 344-364 | https://doi.org/10.1038/s41419-023-06017-2 | 2023 | Biology - Clinical |
| Spatially resolved metabolomics and isotope tracing reveal dynamic metabolic responses of dentate granule neurons with acute stimulation | Miller, A.; York, E.; Stopka, S. et al. | Research Square, 2023, 2023.01.27.525999 | https://doi.org/10.21203/rs.3.rs-2276903/v1 | 2023 | Biology - Clinical |
| Spatially Resolved Metabolites in Stable and Unstable Human Atherosclerotic Plaques Identified by Mass Spectrometry Imaging | Seeley, E. H.; Liu, Z.; Yuan, S. et al. | Arteriosclerosis Thrombosis and Vascular Biology 95, 2023, 4, 2329-2338 | https://doi.org/10.1161/atvbaha.122.318684 | 2023 | Biology - Clinical |
| Optimized protocol for MALDI MSI of N-glycans using an on-tissue digestion in fresh frozen tissue sections | Grgic, A.; Krestensen, K. K.; Heeren, R. M. A. | Scientific Reports 95, 2023, 1, 134-151 | https://doi.org/10.1038/s41598-023-29560-6 | 2023 | Protocol |
| Development of an Antibody-Based Platform for the Analysis of Immune Cell-Specific N‑linked Glycosylation | Dressman, J. W.; McDowell, C. T.; Lu, X. et al. | Analytical Chemistry 51, 2023, 3, dmd-mr-2022-001043 | https://doi.org/10.1021/acs.analchem.3c00838 | 2023 | Method Development |
| Complex-Type N‑Glycans Are Associated with Cartilage Degeneration within Different Loading Sites of the Tibial Plateau for Knee Osteoarthritis Patients | Lee, Y.; Briggs, M. T.; Kuliwaba, J. S. et al. | Journal of Proteome Research 1242, 2023, 340796 | https://doi.org/10.1021/acs.jproteome.3c00251 | 2023 | Biology - Clinical |
| MALDI HiPLEX-IHC: multiomic and multimodal imaging of targeted intact proteins in tissues | Lim, M. J.; Yagnik, G.; Henkel, C. et al. | Frontiers in Chemistry 43, 2023, 1, 28-29 | https://doi.org/10.3389/fchem.2023.1182404 | 2023 | Method Development |
| MALDI-IHC-Guided In-Depth Spatial Proteomics: Targeted and Untargeted MSI Combined | Claes, B. S. R.; Krestensen, K. K.; Yagnik, G. et al. | Analytical Chemistry 5, 2023, 1, vdad066 | https://doi.org/10.1021/acs.analchem.2c04220 | 2023 | Biology, Method Development |
| Visualization of Differential Cardiolipin Profiles in Murine Retinal Cell Layers by High-Resolution MALDI Mass Spectrometry Imaging | Bessler, S.; Soltwisch, J.; Dreisewerd, K. | Analytical Chemistry 2670, 2023 | https://doi.org/10.1021/acs.analchem.3c01465 | 2023 | Biology |
| Enhancement of Lipid Signals in Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry with Ammonium Fluoride as a Matrix Additive | Holbrook, J. H.; Sekera, E. R.; Lopez, A. et al. | Analytical Chemistry 119, 2023 | https://doi.org/10.1021/acs.analchem.3c00753 | 2023 | Method Development |
| A Multimodal SIMS/MALDI Mass Spectrometry Imaging Source with Secondary Electron Imaging Capabilities for Use with timsTOF Instruments | Krijnen, K.; Keelor, J. D.; Böhm, S. et al. | Journal of The American Society for Mass Spectrometry 2688, 2023 | https://doi.org/10.1021/jasms.2c00381 | 2023 | Method Development |
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| Applying imaging mass spectrometry to define the N-glycan profiles of co-localized virus and immune cell infiltrates in post-COVID-19 infected lung autopsy tissues | Jones,E. E.; Drake, R. R.; Dressman, J. W. et al. | Frontiers in Analytical Science, 2, 1021008 | https://doi.org/10.3389/frans.2022.1021008 | 2022 | Biology - Clinical |
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| Single Cell Proteomics Using a Trapped Ion Mobility Time-of-Flight Mass Spectrometer Provides Insight into the Post-translational Modification Landscape of Individual Human Cells | Orsburn, B. C.; Yuan, Y.; Bumpus, N. | bioRxiv | https://doi.org/10.1101/2022.02.12.480144 | 2022 | Biology |
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| A chromosome-level genome of Isodon rubescens reveals that tandem-duplicated CYP706V oxidase genes control oridonin biosynthesis in shoot apex | Sun, Y.; Shao, J.; Liu, H. et al. | Molecular Plant | https://doi.org/10.1016/j.molp.2022.12.007 | 2022 | Biology |
| Analogous comparison unravels heightened antiviral defense and boosted viral infection upon immunosuppression in bat organoids | Liu, X.; Li, C.; Wan, Z. et al. | Signal Transduction and Targeted Therapy, 7(1), 392 | https://doi.org/10.1038/s41392-022-01247-w | 2022 | Biology |
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| Label-free quantitative proteomics and immunoblotting identifies immunoreactive and other excretory-secretory (E/S) proteins of Anoplocephala perfoliata | Hautala, K.; Pursiainen, J.; Näreaho, A. et al. | Frontiers in Immunology, 13, 1045468 | https://doi.org/10.3389/fimmu.2022.1045468 | 2022 | Biology |
| Utilizing PET and MALDI Imaging for Discovery of a Targeted Probe for Brain Endocannabinoid α/β‑Hydrolase Domain 6 (ABHD6) | Mardon, K.; Patel, J. Z.; Savinainen, J. R. et al. | Journal of Medicinal Chemistry | https://doi.org/10.1021/acs.jmedchem.2c01485 | 2022 | Biology |
| Fallopian tube secreted protein affects ovarian metabolites in high grade serous ovarian cancer | Bergsten, T. M.; Levy, S. E.; Zink, K. E. et al. | Frontiers in Cell and Developmental Biology, 10, 1042734 | https://doi.org/10.3389/fcell.2022.1042734 | 2022 | Biology - Clinical |
| Isolation of a cytolytic subpopulation of extracellular vesicles derived from NK cells containing NKG7 and cytolytic proteins | Aarsund, M.; Nyman, T. A.; Stensland, M. E. et al. | Frontiers in Immunology, 13, 977353 | https://doi.org/10.3389/fimmu.2022.977353 | 2022 | Biology - Clinical |
| Optimization of Zebrafish Larvae Sectioning for Mass Spectrometry Imaging | Yang, J.; Rendino, L.; Cassar, S. et al. | Pharmaceuticals, 15(10), 1230 | https://doi.org/10.3390/ph15101230 | 2022 | Method Development |
| Integrating age, BMI, and serum N-glycans detected by MALDI mass spectrometry to classify suspicious mammogram findings as benign lesions or breast cancer | Blaschke, C. R. K.; Hill, E. G.; Mehta, A. S. et al. | Scientific Reports, 12(1), 20801 | https://doi.org/10.1038/s41598-022-25401-0 | 2022 | Biology - Clinical |
| PARP-inhibition reprograms macrophages toward an anti-tumor phenotype | Wang, L.; Wang, D.; Sonzogni, O. et al. | Cell Reports, 41(2), 111462 | https://doi.org/10.1016/j.celrep.2022.111462 | 2022 | Biology - Clinical |
| Chiral‐at‐Metal Silver‐Mediated Base Pairs: Metal‐Centred Chirality versus DNA Helical Chirality | Lefringhausen, N.; Seiffert, V.; Erbacher, C. et al. | Chemistry - A European Journal, e202202630 | https://doi.org/10.1002/chem.202202630 | 2022 | Chemistry – Basic Research |
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| Device-Controlled Microcondensation for Spatially Confined On-Tissue Digests in MALDI Imaging of N-Glycans | Fülöp, A.; Marsching, C.; Barka, F. et al. | Pharmaceuticals, 15(11), 1356 | https://doi.org/10.3390/ph15111356 | 2022 | Method Development |
| Insights into protein post-translational modification landscapes of individual human cells by trapped ion mobility time-of-flight mass spectrometry | Orsburn, B. C.; Yuan, Y.; Bumpus, N. et al. | Nature Communications, 13(1), 7246 | https://doi.org/10.1038/s41467-022-34919-w | 2022 | Biology |
| Visualizing the Distribution of Lipids in Peanut Seeds by MALDI Mass Spectrometric Imaging | Wang, X., Chen, Y., Liu, Y. et al. | Foods, 11(23), 3888 | https://doi.org/10.3390/foods11233888 | 2022 | Biology |
| Mass Spectrometry Imaging of Lipids Using MALDI Coupled with Plasma-Based Post-Ionization on a Trapped Ion Mobility Mass Spectrometer | Michael, J. A.; Mutuku, S. M.; Ucur, B. et al | Anal. Chem. 94, 50 | https://doi.org/10.1021/acs.analchem.2c03745 | 2022 | Method Development |
| Chiral derivatization-enabled discrimination and on-tissue detection of proteinogenic amino acids by ion mobility mass spectrometry | Chengyi, X.; Yanyan, C.; Xiaoxiao, W. et al. Xin Diao, Lin Zhu, Jianing Wang and Zongwei Cai | November 2022. Chemical Science | https://doi.org/10.1039/d2sc03604e | 2022 | Method Development |
| 3‑Acetylpyridine On-Tissue Paternò−Büchi Derivatization Enabling High Coverage Lipid C=C Location-Resolved MS Imaging in Biological Tissues | Yanyan, C.; Chengyi, X.; Xiaoxiao, W. et al. Min Li, Jianing Wang,* and Zongwei Cai* | Anal. Chem. 2022, 94, 15367−15376 | https://doi.org/10.1021/acs.analchem.2c03089 | 2022 | Method Development |
| Visual authentication of steroidal saponins in Allium macrostemon Bge. and Allium chinense G. Don using MALDI-TOF imaging mass spectrometry and their structure activity relationship | Duan, S.; Li, X.; Yao, Z. et al. | Arabian Journal of Chemistry, 15(10), 104138 | https://doi.org/10.1016/j.arabjc.2022.104138 | 2022 | Biology |
| Variation in blood microbial lipopolysaccharide (LPS) contributes to immune reconstitution in response to suppressive antiretroviral therapy in HIV | Luo, Z.; Health, S. L.; Li, M. et al. | EBioMedicine, 80, 104037 | https://doi.org/10.1016/j.ebiom.2022.104037 | 2022 | Biology - Clinical |
| Unraveling metabolic alterations in transgenic mouse model of Alzheimer's disease using MALDI MS imaging with 4-aminocinnoline-3-carboxamide matrix | Chen, Y.; Hu, D.; Zhao, L.; Tang, W.; Li, B. | Analytica Chimica Acta, 1192, 2021, 339337 | https://www.sciencedirect.com/science/article/abs/pii/S0003267021011636 | 2022 | Biology - Clinical |
| TIMSCONVERT: A workflow to convert trapped ion mobility data to open data formats | Luu, G. T.; Lizama-Chamu, I.; McCaughey, C. S. et al. | Bioinformatics, 38(16), 2022, 4046–4047, | https://doi.org/10.1093/bioinformatics/btac419 | 2022 | Protocol |
| Tattoo Pigment Identification in Inks and Skin Biopsies of Adverse Reactions by Complementary Elemental and Molecular Bioimaging with Mass Spectral Library Matching | Brungs, C.; Schmid, R.; Wolf, C. et al. | Analytical Chemistry, 94(8), 2022, 3581-3589 | https://doi.org/10.1021/acs.analchem.1c04922 | 2022 | Chemistry – Basic Research |
| Targeting keratin 17-mediated reprogramming of de novo pyrimidine biosynthesis to overcome chemoresistance in pancreatic cancer | Pan, C.; Chaika, N. V.; Tseng, R. et al. | bioRxiv | https://doi.org/10.1101/2022.08.24.504873 | 2022 | Biology - Clinical |
| Synthesis and Functionalization of Challenging meso-Substituted Aryl Bis-pocket Porphyrins Accessed via Suzuki–Miyaura Cross-Coupling | Droege, D. G.; Parker, A. L.; Milligan, G. M. et al. | The Journal of Organic Chemistry, 87(17), 11783-11795 | https://doi.org/10.1021/acs.joc.2c01538 | 2022 | Chemistry – Basic Research |
| Structural characterization and analysis of different epimers of neutral glycosphingolipid LcGg4 by ion mobility spectrometry-mass spectrometry | Gao, T.; Aneirin A Lott, A. A.; Huang, F. et al. | Analyst, 147(13), 2022, 3101-3108 | https://doi.org/10.1039/d2an00224h | 2022 | Chemistry – Basic Research |
| Spatially resolved characterization of tissue metabolic compartments in fasted and high-fat diet livers | Stopka, S. A.; van der Reest, J.; Abdelmoula, W. M. et al. | PLOS ONE, 17(9), e0261803 | https://doi.org/10.1371/journal.pone.0261803 | 2022 | Biology - Clinical |
| Single‐Cell Proteomic Profiling of Hepatocytes Reveals Heterogeneous Responses to Hepatotoxic Drugs Nevirapine, Efavirenz, and Acetaminophen | Yuan, Y.; Orsburn, B. C.; Bumpus, N. | The FASEB Journal, 36(S1) | https://doi.org/10.1096/fasebj.2022.36.S1.R4856 | 2022 | Biology - Clinical |
| Single cell spatial analysis reveals the topology of immunomodulatory purinergic signaling in glioblastoma | Coy, S.; Wang, S.; Stopka, S. A. et al. | Nature Communications, 13(1), 4814 | https://doi.org/10.1038/s41467-022-32430-w | 2022 | Biology - Clinical |
| Shielding the oil reserves: the scutellum as a source of chemical defenses | Murphy, K. M.; Poretsky, E.; Liu, H. et al. | Plant Physiology, 188(4), 1944-1949 | https://doi.org/10.1093/plphys/kiac038 | 2022 | Biology |
| Proteomic analysis of Mycobacterial Biofilm Matrix and Development of Biofilm-binding Synthetic Nanobodies | Hammarén, M.; Luukinen, H.; Sillanpää, A. et al. | Research Square | https://doi.org/10.21203/rs.3.rs-1588905/v1 | 2022 | Biology - Clinical |
| Optimizing data‐independent acquisition (DIA) spectral library workflows for plasma proteomics studies | Rice, S. J.; Belani, C. P. | Proteomics, 22(17), 2022, 2200125 | https://doi.org/10.1002/pmic.202200125 | 2022 | Protocol |
| One-Pot Chemoenzymatic Synthesis of Microviridin Analogs Containing Functional Tags | Scholz, S.; Kerestetzopoulou, S.; Wiebach, V. et al. | ChemBioChem, 2022 | https://doi.org/10.1002/cbic.202200345 | 2022 | Method Development |
| N-Succinyltransferase Encoded by a Cryptic Siderophore Biosynthesis Gene Cluster in Streptomyces Modifies Structurally Distinct Antibiotics | Schneider, O.; Zehl, M.; Ueoka, R. et al. | mBio, e01789-22 | https://doi.org/10.1128/mbio.01789-22 | 2022 | Biology - Clinical |
| Novel Combined Enzymatic Approach to Analyze Nonsialylated N-Linked Glycans through MALDI Imaging Mass Spectrometry | Andrew, T. D.; Hongyan, L.; Richard, R. D. et al. | J Proteome Res. 21(8), 2022, 1930-1938 | https://doi.org/10.1021/acs.jproteome.2c00193 | 2022 | Biology - Clinical |
| Neurotoxic and cytotoxic peptides underlie the painful stings of the tree nettle Urtica ferox | Xie, J.; Robinson, S. D.; Gilding, E. K. et al. | Journal of Biological Chemistry, 298(8), 102218 - | https://doi.org/10.1016/j.jbc.2022.102218 | 2022 | Biology |
| Neuroinflammation in neuronopathic Gaucher disease: Role of microglia and NK cells, biomarkers, and response to substrate reduction therapy | Boddupalli, C. S.; Nair, S.; Belinsky, G. et al. | eLife, 11, e79830 | https://doi.org/10.7554/elife.79830 | 2022 | Biology - Clinical |
| Neglected Very Long-Chain Hydrocarbons and the Incorporation of Body Surface Area Metrics Reveal Novel Perspectives for Cuticular Profile Analysis in Insects | Golian, M.; Bien, T.; Schmelzle, S. et al. | Insects, 13, 2022, 83 | https://doi.org/10.3390/insects13010083 | 2022 | Biology |
| Monosialotetrahexosylganglioside Promotes Early Aβ42 Oligomer Formation and Maintenance | Zhang, D. Y.; Wang, J.; Fleeman, R. M. et al. | ACS Chemical Neuroscience, 13(13), 1979-1991 | https://doi.org/10.1021/acschemneuro.2c00221 | 2022 | Biology - Clinical |
| Mass spectrometry imaging to explore molecular heterogeneity in cell culture | Bien, T.; Koerfer, K.; Schwenzfeier, J. et al. | Proceedings of the National Academy of Sciences of the United States of America, 119(29), e2114365119 | https://doi.org/10.1073/pnas.2114365119 | 2022 | Biology |
| MALDI Mass Spectrometry Imaging for the Distinction of Adenocarcinomas of the Pancreas and Biliary Tree | Bollwein, C.; Gonҫalves, J. P. L.; Utpatel, K. et al. | Molecules, 27(11), 3464 | https://doi.org/10.3390/molecules27113464 | 2022 | Biology - Clinical |
| LPS-induced lipid alterations in microglia revealed by MALDI mass spectrometry-based cell fingerprinting in neuroinflammation studies | Blank, M.; Enzlein, T.; Hopf, C. et al. | Scientific Reports, 12(1), 2022, 2908 | https://doi.org/10.1038/s41598-022-06894-1 | 2022 | Biology - Clinical |
| Lactate is an epigenetic metabolite that drives survival in model systems of glioblastoma | Torrini, C.; Nguyen, T. T. T.; Shu, C. et al. | Molecular Cell, 82(16), 3061-3076.e6 | https://doi.org/10.1016/j.molcel.2022.06.030 | 2022 | Biology - Clinical |
| Integrating multiplex immunofluorescent and mass spectrometry imaging to map myeloid heterogeneity in its metabolic and cellular context | Goossens, P.; Lu, C.; Cao, J. et al. | Cell Metabolism, 34(8), 1214-1225.e6 | https://doi.org/10.1016/j.cmet.2022.06.012 | 2022 | Biology - Clinical |
| Insight Into the Metabolic Adaptations of Electrically Pulse-Stimulated Human Myotubes Using Global Analysis of the Transcriptome and Proteome | Mengeste, A. M.; Nikolić, N.; Fernandez, A. D. et al. | Frontiers in Physiology, 13, 928195 | https://doi.org/10.3389/fphys.2022.928195 | 2022 | Biology |
| In situ mass spectrometry imaging reveals heterogeneous glycogen stores in human normal and cancerous tissues | Young, L. E. A.; Conroy, L. R.; Clarke, H. A. et al. | EMBO Molecular Medicine, e16029 | https://doi.org/10.15252/emmm.202216029 | 2022 | Biology |
| Imaging Mass Spectrometry Reveals Complex Lipid Distributions Across Staphylococcus aureus Biofilm Layers | Rivera, E. S.; Weiss, A.; Migas, L. G. et al. | Journal of Mass Spectrometry and Advances in the Clinical Lab, in press | https://doi.org/10.1016/j.jmsacl.2022.09.003 | 2022 | Biology |
| Imaging Mass Spectrometry Reveals Alterations in N-Linked Glycosylation That Are Associated With Histopathological Changes in Nonalcoholic Steatohepatitis in Mouse and Human | Ochoa-Rios, S.; O'Connor, I. P.; Kent, L. N. et al. | Molecular & Cellular Proteomics, 21(5), 100225 | https://doi.org/10.1016/j.mcpro.2022.100225 | 2022 | Biology - Clinical |
| Home-Built Spinning Apparatus for Drying Agarose-Based Imaging Mass Spectrometry Samples | Lusk, H. J.; Levy, S. E.; Bergsten, T. M. et al. | Journal of The American Society for Mass Spectrometry, 33(7), 1325-1328 | https://doi.org/10.1021/jasms.2c00044 | 2022 | Protocol |
| Forensic Discrimination of Differentially Sourced Animal Blood Using a Bottom-Up Proteomics Based MALDI MS Approach | Kennedy, K.; Cole, L.; Witt, M. et al. | Molecules, 27(7), 2022, 2039 | https://doi.org/10.3390/molecules27072039 | 2022 | Forensic |
| Establishment of a transparent soil system to study Bacillus subtilis chemical ecology | Lozano-Andrade, C. N.; Nogueira, C. G.; Wibowo, M. et al. | bioRxiv | https://doi.org/10.1101/2022.01.10.475645 | 2022 | Biology |
| Development of an Automatic Ultrasonic Matrix Sprayer for Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging | Meng, L.; Han, J.; Chen, J. et al. | Analytical Chemistry, 94(17), 2022, 6457-6462 | https://doi.org/10.1021/acs.analchem.2c00403 | 2022 | Method Development |
| Development of a cell‐free strategy to recover aged skeletal muscle after disuse | Wu, Y.; De La Toba, E. A.; Dvoretskiy, S. et al. | The Journal of Physiology, 600(13), 3029-3030 | https://doi.org/10.1113/JP282867 | 2022 | Biology - Clinical |
| De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma | Shi, D. D.; Savani, M. R.; Levitt, M. M. et al. | Cancer Cell, 40(9), 939-956.e16 | https://doi.org/10.1016/j.ccell.2022.07.011 | 2022 | Biology - Clinical |
| Composition and abundance of midgut surface proteins in the Asian citrus psyllid, Diaphorina citri | Tavares, C. S.; Mishra, R.; Ghobrial, P. N. et al. | Journal of Proteomics, 261, 2022, 104580 | https://doi.org/10.1016/j.jprot.2022.104580 | 2022 | Biology |
| Co-culture with Acinetobacter johnsonii enhances benzalkonium chloride resistance in Salmonella enterica via triggering lipid A modifications | Wilson, A.; Fegan, N.; Turner, M. S. et al. | International Journal of Food Microbiology, 381, 109905 | https://doi.org/10.1016/j.ijfoodmicro.2022.109905 | 2022 | Biology |
| A non-dividing cell population with high pyruvate dehydrogenase kinase activity regulates metabolic heterogeneity and tumorigenesis in the intestine | Sebastian, C.; Ferrer, C.; Serra, M. et al. | Nature Communications, 13(1), 2022, 1503 | https://doi.org/10.1038/s41467-022-29085-y | 2022 | Biology - Clinical |
| A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma | Pal, S.; Kaplan, J. P.; Nguyen, H. et al. | Cancer Cell, 40(9), 957-972.e10 | https://doi.org/10.1016/j.ccell.2022.07.012 | 2022 | Biology - Clinical |
| ‘On the Spot’ Digital Pathology of Breast Cancer Based on Single-Cell Mass Spectrometry Imaging | Cuypers, E.; Claes, B. S. R.; Biemans, R. et al. | Analytical Chemistry, 94(16), 2022, 6180-6190 | https://doi.org/10.1021/acs.analchem.1c05238 | 2022 | Biology - Clinical |
| High Spatial Resolution MALDI Imaging Mass Spectrometry of Fresh-Frozen Bone | Good, C. J.; Neumann, E. K.; Butrico, C. E. et al. | Analytical Chemistry, 94(7), 3165-3172 | https://doi.org/10.1021/acs.analchem.1c04604 | 2022 | Biology |
| Simulation of the oxidative metabolization pattern of netupitant, a NK1 receptorantagonist, by electrochemistry coupled to mass spectrometry | Chira, R.; Fangmeyer, J.; Neaga, I. O. et al. | Journal of Pharmaceutical Analysis - in press, 2021 | https://doi.org/10.1016/j.jpha.2021.03.011 | 2021 | Chemistry – Basic Research |
| Retro Diels–Alder Fragmentation of Fulvene–Maleimide Bioconjugates for Mass Spectrometric Detection of Biomolecules | Stevens, K. G.; McFarlene, L. O.; Platts, K. et al. | Analytical Chemistry 93(36), 2021, 12204-12212 | https://pubs.acs.org/doi/10.1021/acs.analchem.1c00193 | 2021 | Chemistry – Basic Research |
| Removal of optimal cutting temperature (O.C.T.) compound from embedded tissue for MALDI imaging of lipids | Truong, J. X. M.; Spotbeen, X.; White, J. et al. | Analytical and Bioanalytical Chemistry 413, 2021, 2695-2708 | https://doi.org/10.1007/s00216-020-03128-z | 2021 | Method Development |
| Rapid visualization of lipopeptides and potential bioactive groups of compounds by combining ion mobility and MALDI imaging mass spectrometry | McCann, A.; Kune, C.; La Rocca, R. et al. | Drug Discovery Today: Technologies - in press, 2021 | https://doi.org/10.1016/j.ddtec.2021.08.003 | 2021 | Chemistry – Basic Research |
| Protocol for multimodal analysis of human kidney tissue by imaging mass spectrometry and CODEX multiplexed immunofluorescence | Neumann, E. K.; Patterson, N. H.; Allen, J. L. et al. | STAR Protocols 2(3), 2021 100747 | https://doi.org/10.1016/j.xpro.2021.100747 | 2021 | Protocol |
| Poly(2-vinylpyridine) as a reference compound for mass calibration in positive-ion matrix-assisted laser desorption/ionization-mass spectrometry on different instrumental platforms | Gross, J. H. | European Journal of Mass Spectrometry 27(5), 2021, 191-204 | https://doi.org/10.1177/14690667211055 | 2021 | Method Development |
| Oxygen‐Doped PAH Electrochromes: Difurano, Dipyrano, and Furano‐Pyrano Containing Naphthalene‐Cored Molecules | Fletcher-Charles, J.; Ferreira, R.R.; Abraham, M. et al. | European Journal of Organic Chemistry, 2021 | https://doi.org/10.1002/ejoc.202101166 | 2021 | Chemistry – Basic Research |
| OpenTIMS, TimsPy, and TimsR: Open and Easy Access to timsTOF Raw Data | Łącki, M. K.; Startek, M. P.; Brehmer, S. et al. | Journal of Proteome Research 20, 2021, 2122-2129 | https://doi.org/10.1021/acs.jproteome.0c00962 | 2021 | Method Development |
| Microfluidic Electrochemistry Meets Trapped Ion Mobility Spectrometry and High-Resolution Mass Spectrometry—In Situ Generation, Separation, and Detection of Isomeric Conjugates of Paracetamol and Ethoxyquin | Korzhenko, O.; Führer, P.; Göldner, V. et al. | Analytical Chemistry 93(37), 2021, 12740-12747 | https://pubs.acs.org/doi/10.1021/acs.analchem.1c02791 | 2021 | Chemistry – Basic Research |
| Mass Spectrometry Imaging of Low-Molecular-Weight Phenols Liberated from Plastics | Xu, Q.; Tian, R.; Lu, C. et al. | Analytical Chemistry 93(40), 2021, 13703-13710 | https://pubs.acs.org/doi/10.1021/acs.analchem.1c03397 | 2021 | Chemistry – Basic Research |
| Evaluation of Therapeutic Collagen-Based Biomaterials in the Infarcted Mouse Heart by Extracellular Matrix Targeted MALDI Imaging Mass Spectrometry | Clift, C. L.; McLaughlin, S.; Muñoz, M. et al. | Journal of The American Society for Mass Spectrometry 32 (12), 2021, 2746-2754 | https://pubs.acs.org/doi/10.1021/jasms.1c00189 | 2021 | Biology - Clinical |
| Development of an electrochemical flow‐through cell for the fast and easy generation of isotopically labeled metabolite standards | Göldner, V.; Fangmeyer, J.; Karst, U. | Drug Testing and Analysis, 2021 | https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/dta.3175 | 2021 | Chemistry – Basic Research |
| Detection and mapping of haemoglobin variants in blood fingermarks by MALDI MS for suspect “profiling”. | Heaton, C.; Witt, M.; Cole, L. et al. | Analyst 146, 2021, 4290 | https://doi.org/10.1039/d1an00578b | 2021 | Chemistry – Basic Research |
| Complementing Matrix-Assisted Laser Desorption Ionization-Mass Spectrometry Imaging with Chromatography Data for Improved Assignment of Isobaric and Isomeric Phospholipids Utilizing Trapped Ion Mobility-Mass Spectrometry | Helmer, P. O.; Nordhorn, I. D.; Korf, A. et al. | Analytical Chemistry 93, 2021, 2135-2143 | https://doi.org/10.1021/acs.analchem.0c03942 | 2021 | Chemistry – Basic Research |
| Automated Chiral Analysis of Amino Acids Based on Chiral Derivatization and Trapped Ion Mobility–Mass Spectrometry | Will, J. M.; Behrens, A.; Macke, M. | Analytical Chemistry 93(2), 2021, 878-885 | https://doi.org/10.1021/acs.analchem.0c03481 | 2021 | Chemistry – Basic Research |
| Automated Biomarker Candidate Discovery in Imaging Mass Spectrometry Data Through Spatially Localized Shapley Additive Explanations | Tideman, L. E. M.; Migas, L. G.; Djambazova, K. V. et al. | Analytica Chimica Acta 1177, 2021, 338522 | https://doi.org/10.1016/j.aca.2021.338522 | 2021 | Chemistry – Basic Research |
| Aliquoting of isobaric labeling reagents for low concentration and single cell proteomics samples | Yuan, Y.; Orsburn, B. C. | bioRxiv pre-print, 2021 | https://doi.org/10.1101/2021.06.23.449560 | 2021 | Chemistry – Basic Research |
| A TIMS-TOF mass spectrometry study of disaccharides from in-situ derivatization ESI with 3-pyridinylboronate | Lia, L.; Yua, J.; Xiea, C. et al. | Analyst 146, 2021, 75 | https://doi.org/10.1039/D0AN01677B | 2021 | Chemistry – Basic Research |
| Absolute quantification of 2-hydroxyglutarate on tissue by matrix-assisted laser desorption/ionization mass spectrometry imaging for rapid and precise identification of isocitrate dehydrogenase mutations in human glioma | Chunyan, L.; Hainan, L.; Lei, W. et al. Rumeng Zhang, Xiaoai Yuan, Taihua Wu, Jie Wu, Ming Lu, Xu Ma | Int. J. Cancer. 2021;1–8 | https://doi: 10.1002/ijc.33729 | 2021 | Biology - Clinical |
| Traumatic brain injury induces region-specific glutamate metabolism changes as measured by multiple mass spectrometry methods | Sowers, J. L.; Sowers, M. L.; Shavkunov, A. S. et al. | iScience 24(10), 2021, 103108 | https://doi.org/10.1016/j.isci.2021.103108 | 2021 | Biology - Clinical |
| Preserved and variable spatial-chemical changes of lipids across tomato leaves in response to central vein wounding reveals potential origin of linolenic acid in signal transduction cascade. | Veličković, D.; Chu, R. K.; Henkel. C. et al. | Journal of Plant-Environment Interactions 2(1), 2021, 28-35 | https://doi.org/10.1002/pei3.10038 | 2021 | Biology |
| Multiplexed imaging mass spectrometry of the extracellular matrix using serial enzyme digests from formalin-fixed paraffin-embedded tissue sections | Clift, C. L.; Drake, R. R.; Mehta, A. et al. | Analytical and Bioanalytical Chemistry 413, 2021, 2709-2719 | https://doi.org/10.1007/s00216-020-03047-z | 2021 | Biology |
| Imaging Mass Spectrometry and Lectin Analysis of N-linked Glycans in Carbohydrate Antigen Defined Pancreatic Cancer Tissues | McDowell, C. T.; Klamer, Z.; Hall, J. et al. | Molecular & Cellular Proteomics 20, 2021, 100012 | https://doi.org/10.1074/mcp.RA120.002256 | 2021 | Biology - Clinical |
| Direct N-Glycosylation Profiling of Urine and Prostatic Fluid Glycoproteins and Extracellular Vesicles | Blaschke, C. R. K.; Hartig, J. P.; Grimsley, G. et al. | Frontiers in Chemistry 9, 2021, 734280 | https://www.frontiersin.org/articles/10.3389/fchem.2021.734280/full | 2021 | Biology |
| CRL4AMBRA1 is a master regulator of D-type cyclins. | Simoneschi, D.; Rona, G.; Zhou, N. et al. | Nature 592, 2021, 789-793 | https://doi.org/10.1038/s41586-021-03445-y | 2021 | Biology - Clinical |
| Complete spatial characterisation of N-glycosylation upon striatal neuroinflammation in the rodent brain. | Rebelo, A. L.; Gubinelli, F.; Roost, P. et al. | Journal of Neuroinflammation 18, 2021, Article number: 116 | https://doi.org/10.1186/s12974-021-02163-6 | 2021 | Biology |
| Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH | Dudek, M.; Pfister, D.; Donakonda, S. et al. | Nature 592, 2021, 444-449 | https://doi.org/10.1038/s41586-021-03233-8 | 2021 | Biology - Clinical |
| Absolute Quantification of 2‐Hydroxyglutarate on Tissue by MALDI MSI for Rapid and Precise Identification of IDH Mutations in Human Glioma | Lan, C.; Li, H.; Wang, L. et al. | International Journal of Cancer, 2021 | https://doi.org/10.1002/ijc.33729 | 2021 | Biology - Clinical |
| β‑Cyclodextrin-poly (β-Amino Ester) Nanoparticles Are a Generalizable Strategy for High Loading and Sustained Release of HDAC Inhibitors | Chaudhuri, S.; Fowler, M. J.; Baker, C. et al. | Applied Materials & Interface 13, 2021, 20960-20973 | https://doi.org/10.1021/acsami.0c22587 | 2021 | Biology - Clinical |
| Rapid N-Glycan Profiling of Serum and Plasma by a Novel Slide-Based Imaging Mass Spectrometry Workflow | Blaschke, C. R. K.; Black, A. P.; Mehta, A. S. et al. | Journal of the American Society for Mass Spectrometry 31, 2020, 2511-2520 | https://doi.org/10.1021/jasms.0c00213 | 2020 | Chemistry – Basic Research |
| MS Imaging‐Guided Microproteomics for Spatial Omics on a Single Instrument | Dewez, F.; Oetjen, J.; Henkel, C. et al. | Proteomics 20, 2020, 1900369 | https://doi.org/10.1002/pmic.201900369 | 2020 | Chemistry – Basic Research |
| A mass spectrometry-based approach gives new insight into organotin–protein interactions | Will, J. M.; Erbacher, C.; Sperling, M. et al. | Metallomics 12(11), 2020, 1702-1712 | https://doi.org/10.1039/d0mt00171f | 2020 | Chemistry – Basic Research |
| Spatial Metabolomics of the Human Kidney using MALDI Trapped Ion Mobility Imaging Mass Spectrometry. | Neumann, E. K.;Migas, L. G.; Allen, J. L. et al. | Analytical Chemistry 92(19), 2020, 13084-13091 | https://doi.org/10.1021/acs.analchem.0c02051 | 2020 | Biology |
| Resolving the Complexity of Spatial Lipidomics Using MALDI TIMS Imaging Mass Spectrometry | Djambazova, K. V.; Klein, D. R.; Migas, L. G. et al. | Analytical Chemistry 92(19), 2020, 13290-13297 | https://doi.org/10.1021/acs.analchem.0c02520 | 2020 | Biology |
| Morphometric Cell Classification for Single-Cell MALDI-Mass Spectrometry Imaging | Ščupáková,, K.; Dewez, F.; Walch, A. K. et al. | Angewandte Chemie International Edition 59(40), 2020, 17447-17450 | https://doi.org/10.1002/anie.202007315 | 2020 | Biology - Clinical |
| Modulating Isoprenoid Biosynthesis Increases Lipooligosaccharides and Restores Acinetobacter baumannii Resistance to Host and Antibiotic Stress | Palmer, L. D.; Minor, K. E.; Mettlach, J. A. et al. | Cell Reports 32(10), 2020, 108129 | https://doi.org/10.1016/j.celrep.2020.108129 | 2020 | Biology - Clinical |
| Mass‐Spectrometric Imaging of Electrode Surfaces—a View on Electrochemical Side Reactions | Fangmeyer, J.; Behrens, A.; Gleede, B. et al. | Angewandte Chemie 132(46), 2020, 20608-20613 | https://doi.org/10.1002/ange.202010134 | 2020 | Chemistry – Basic Research |
| Lipidomic profiling of clinical prostate cancer reveals targetable alterations in membrane lipid composition | Butler, L. M.; Mah, C. Y.; Machiels, J. et al. | Cancer Research, 2020, 3863 | https://doi.org/10.1158/0008-5472.CAN-20-3863 | 2020 | Biology - Clinical |
| In situ isobaric lipid mapping by MALDI–ion mobility separation–mass spectrometry imaging | Fu, T.; Oetjen, J.; Chapelle, M. et al. | Journal of Mass Spectrometry 55(9), 2020, e4531 | https://doi.org/10.1002/jms.4531 | 2020 | Biology |
| Hydroperoxylated vs Dihydroxylated Lipids: Differentiation of Isomeric Cardiolipin Oxidation Products by Multidimensional Separation Techniques | Helmer, P.O.; Behrens, A.; Rudt, E. et al. | Analytical Chemistry 92(17), 2020, 12010-12016 | https://doi.org/10.1021/acs.analchem.0c02605 | 2020 | Biology |
| High-Performance Molecular Imaging with MALDI Trapped Ion-Mobility Time-of-Flight (timsTOF) Mass Spectrometry | Spraggins, J. M.; Djambazova, K. V.; Rivera, E. S. et al. | Analytical Chemistry 91(22), 2019, 14552-14560 | https://doi.org/10.1021/acs.analchem.9b03612 | 2019 | Chemistry – Basic Research |
| Detection of small molecule concentration gradients in ocular tissues and humours | Boughton, B.A.; Thomas, O. R. B.; Demarais, N. J. et al. | Journal of Mass Spectrometry 55(4), 2019, e4460 | https://doi.org/10.1002/jms.4460 | 2019 | Biology |
timsTOF fleX MALDI-2
| TITLE | AUTHOR | PUBLICATION | LINK | YEAR | APPLICATION |
|---|---|---|---|---|---|
| De novo phytosterol synthesis in animals | Michellod, D.; Bien, T.; Birgel, D. et al. | Science, 2023, 380, 6644, 520-526 | https://doi.org/10.1126/science.add7830 | 2023 | |
| MALDI coupled with laser-postionization and trapped ion mobility spectrometry contribute to the enhanced detection of lipids in cancer cell spheroids | Chen, J.; Xie, P.; Wu, P. et al. | Chinese Chemical Letters, 2023, 108895 | https://doi.org/10.1016/j.cclet.2023.108895 | 2023 | |
| Spatial lipidomics and metabolomics of multicellular tumor spheroids using MALDI-2 and trapped ion mobility imaging | Chen, J.; Xie, P.; Dai, Q. et al. | Talanta, 2023, 124795 | https://doi.org/10.1016/j.talanta.2023.124795 | 2023 | |
| Spatial Metabolomics and Lipidomics Reveal the Mechanisms of the Enhanced Growth of Breast Cancer Cell Spheroids Exposed to Triclosan | Chen, Jing; Xie, Peisi; Wu, Pengfei; Lin, Zian; He, Yu; Cai, Zongwei | Environmental Science and Technology 6, 2023, 1, 509 | https://doi.org/10.1021/acs.est.3c01746 | 2023 | Biology - Clinical |
| Mass spectrometry imaging and single-cell transcriptional profiling reveal the tissue-specific regulation of bioactive ingredient biosynthesis in Taxus leaves | Zhan, Xiaori; Qiu, Tian; Zhang, Hongshan; Hou, Kailin; Liang, Xueshuang; Chen, Cheng; Wang, Zhijing; Wu, Qicong; Wang, Xiaojia; Li, Xiao-Lin; Wang, Mingshuang; Feng, Shangguo; Zeng, Houqing; Yu, Chunna; Wang, Huizhong; Shen, Chenjia | Plant Communications 9, 2023, 1, eade8898 | https://doi.org/10.1016/j.xplc.2023.100630 | 2023 | Biology |
| Negative Ion-Mode N-Glycan Mass Spectrometry Imaging by MALDI-2-TOF-MS | Soltwisch, Jens; Heijs, Bram | Methods in Molecular Biology, 2023, 2023.01.03.522543 | https://doi.org/10.1007/978-1-0716-3319-9_15 | 2023 | Protocol |
| Cryo-ultramicrotomy and Mass Spectrometry Imaging Analysis of Nudibranch Microstructures | Hamilton, B.R.; Chan, W.; Cheney, K. L.; Sullivan, R.K.P.; Floetenmeyer, M.; Garson, M. J.; Wepf, R. | J. Am. Soc. Mass Spectrom. 2022, 33, 3, 592–597 | https://doi.org/10.1021/jasms.1c00254 | 2022 | Biology |
| SETD2 deficiency promotes the transition from PKD to ccRCC by dysregulation of sphingomyelin metabolism | Zhang, Y., Liui, Changwei, Ye, T. et. al. | bioRxiv | https://doi.org/10.1101/2022.11.10.515911 | 2022 | Biology - Clinical |
| Three-Dimensional Mass Spectrometry Imaging Reveals Distributions of Lipids and the Drug Metabolite Associated with the Enhanced Growth of Colon Cancer Cell Spheroids Treated with Triclosan | Xie, P., Zhang, H., Wu, P. et. al. | Analytical Chemistry, 94(40), 13667-13675 | https://doi.org/10.1021/acs.analchem.2c00768 | 2022 | Biology - Clinical |
| Spatial Distribution of Isobaric Androgens in Target Tissues Using Chemical Derivatization and MALDI-2 on a Trapped Ion Mobility Quadrupole Time-of-Flight Instrument | Mackay, C. L.; Soltwisch, J.; Heijs, B.; Smith, K. W.; Cruickshank, F. L.; Nyhuis, A.; Dreisewerd, K.; Cobice, D. | RSC Advances, 54, 2021 in-print | https://doi.org/10.1039/d1ra06086d | 2021 | Biology - Clinical |
| Spatial differentiation of metabolism in prostate cancer tissue by MALDI-TOF MSI | Andersen, M. K.; Høiem, T. S.; Claes, B. S. R. et al. | Cancer & Metabolism 9, 2021, Article number: 9 | https://doi.org/10.1186/s40170-021-00242-z | 2021 | Biology - Clinical |
| Molecular insights into symbiosis — mapping sterols in a marine flatworm-algae-system using high spatial resolution MALDI-2-MS imaging with ion mobility separation | Bien, T; Hambleton, E. A; Dreisewerd, K. et al. | Analytical and Bioanalytical Chemistry 413, 2021, 2767-2777 | https://doi.org/10.1007/s00216-020-03070-0 | 2021 | Biology |
| MALDI-2 on a Trapped Ion Mobility Quadrupole Time-of-Flight Instrument for Rapid Mass Spectrometry Imaging and Ion Mobility Separation of Complex Lipid Profiles | Soltwisch, J.; Heijs, B.; Koch, A. et. al | Analytical Chemistry 92, 2020, 8697-8703 | https://doi.org/10.1021/acs.analchem.0c01747 | 2020 | Chemistry – Basic Research |
| MALDI‑2 for the Enhanced Analysis of N‑Linked Glycans by Mass Spectrometry Imaging | Heijs, B.; Potthoff, A.; Soltwisch, J. et al. | Analytical Chemistry 92, 2020, 13904-13911 | https://doi.org/10.1021/acs.analchem.0c02732 | 2020 | Chemistry – Basic Research |
For Research Use Only. Not for use in clinical diagnostic procedures.